Stream.Transcripts/twitch/2126749083 (2024-04-22) - Dr Mikovits 2008 STUDY HALL -- (22 Apr 2024)/2126749083 (2024-04-22) - Dr Mikovits 2008 STUDY HALL -- (22 Apr 2024).vtt

WEBVTT

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You

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You

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You

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You

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I

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Think truth is good for kids. We're so busy lying. We don't even recognize the truth no more in this society

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We want everybody to feel good. That's not that's not the way life is

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Let's check that right now. How is this sound that we lined up or not?

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Talk to me goose if we're not lined up. We'll just start again

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All good Arthur says good step says good we're out

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This episode is sponsored by mink. That's moo plus link

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This my point is that if if we were able to just like we're trying to get everybody to take the vaccine

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If we had put that into getting everybody to take hypermectin and fluvoxamine for for a month

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If we and if we could accomplish that then COVID would be wiped out

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We could do it and actually any municipality that could regulate its borders could clear the disease if it could accomplish that

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I believe

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But you can tell if someone's you know you can sort of feel it and people

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And I have lied I'm sure I don't want a lot. You know, I don't think I'm a liar

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I try not to be a liar. I don't want to be a liar

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It's like really important not to be a liar

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You

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You

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Three people with thyroid cancer sounds not good

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It's not the kind of correlation we want to be having here, but I'm afraid this is the kind of truth

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This is the only kind of truth that will save us people need to start having

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Feeling pain

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Somehow

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If enough placebos were rolled out, we're always gonna have problems

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So crazy like yeah, it's it's not good. This is so crazy

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Nervous like what in the world man

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Oh

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Well, thank you very much for 35 people being here at

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1313

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Another weekday it is Monday again. We are still working on dispelling the enchantment

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For the first time you might be a skilled TV watcher

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But I suspect most of the people who are here already are are at the top of this wave where we are staying focused on the biology

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We aren't taking the bait on television and social media. We are loving our neighbors

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As

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You know the way this works is if people spread this around the new biology finds

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people each week and that's how we grow our roots are at

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Gigalombiological.com and also giga home.bio as well as screen dot giga home.bio where you can see it live and afterwards

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And it's all provided by us here at giga home biological

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We are completely supported by

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Hello, well, hello

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We are completely supported by viewers and viewers only there are a couple people who are responsible for having funded more than more than a year of our work

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People like Greg James and Rodney Mullen and a few other people have donated very significant amounts of money to keep this

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And it's the start of something really cool like an independent bright web that I think actually maybe

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Jimmy Gore

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Could in theory be a part of

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I don't know if you're aware of why I was not on air last night, but my wife and I this this lovely person photographed

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There 20 years ago. That's us 20 years ago

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In the Brookfield Zoo

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I have a friend who may still be a keeper there. I have to admit that I'm out of touch with him now

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But at the time he was the only keeper in the world who would free swim with walruses during training

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Keep in mind that that animal right there is about a thousand pounds and so if you have a thousand pound

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Aquatic golden retriever bump into you between you and the wall

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It can be a very dangerous position to be in there's lots of funny stories that he told us

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That's why we got to make that photograph. We got to hold a penguin that day

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I got attacked by octopus that day

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I got to

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Pet a dolphin in the middle of a dolphin show and like all the kids are like who the hell is this guy that gets to pet a dolphin?

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It was a really cool day and one of the things we got to do look at all those people in the window back there

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Thinking what in the hell are those people doing?

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Getting to play with that walrus and then there's another walrus over there that keeper's got to keep that one busy while

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This one was over here posing with us

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Anyway, this is gigo and biological a high-resistance low-noise information brief brought to you by a biologist that biologist is me

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Jonathan Cooley United non-compliance is something we all need to start trying to understand

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What does it really mean in the context of of our current scenario where there isn't too much to obviously?

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Not comply with but in reality, there's a lot you can you can not comply with there's a lot

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Going on at your school that you cannot comply with there's a lot going on at the barbecues and at at

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basketball games that you cannot comply with and

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Yeah, this is gigo and biological the safest way to get biology in your head. It is the 22nd of April

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2024

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2024 how is that even possible?

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We have been here for a while still fighting this conscious and intelligent manipulation of the organized habits and opinions of the

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masses which is how they got us to accept this pandemic as real and all the consequences of it

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Being a result of you know, nobody's nobody's got anybody. Nobody's got any bad intentions. It's just how it happened

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And that's how they got us to discard the principle of informed consent

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Hello, my name is Jonathan Cooley. This is gigo and biological coming to you live from Pittsburgh, Pennsylvania

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We

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Have a hypothesis that in

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2020 a number of mass casualty events were staged around the world and used and misconstrued as evidence of impending doom

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That a novel virus had just started to spread around the world. New York City was one of the key illusions

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That was used as a sort of seating event where here if you can see my little tiny arrow there

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That little slope right there was used to extrapolate that we were at the at the doorstep of impending doom and

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they

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Told this story using non-specific PCR tests that were actually rolled out on a very hot background and this hot background resulted in what

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effectively was

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The idea that wow we're finding it everywhere. We're finding it everywhere

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in fact, wherever you look for it you found it because it was always there in the background a combination of

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Always there in the background in non-specific tests

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This enabled a larger percentage of all-cause mortality than ever before to be converted to a

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National security threat in the form of not influenza, but a novel virus for which we were all

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vulnerable and that story

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That one particular line a novel virus for which we were all vulnerable with an unknown set of

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Consequences for an unknown number of people was the mythology that allowed them to justify everything up and to and including the

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Transfection the coercion of transfection the coercion of accepting

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Transfection as a countermeasure

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to this potential impending doom and I do think it's very possible that if they felt it was necessary in

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Order to bamboozle academic science as a whole around the world. It is possible very easy

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to seed PCR positivity in the form of a spike protein and end protein or an entire genome using DNA or RNA

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Combinations there of recombinant technologies used to produce mass quantities of a signal that then would be misconstrued as

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spread and

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Because the goal is a total inversion of our

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National sovereignty and also our individual sovereignty or sovereignty over our children that complete conversion

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To us as experimental animals who are given permission to do things

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Since that's the goal

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Then a spectacular commitment to this lie is is what's required and it shouldn't be surprising to many of us

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But it will be surprising to people joining the stream for the first time that we are actually

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Working under the the hypothesis that that everyone is coordinated in their lying spectacularly committed to the lie

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Because it is a national security situation. They understand that there will be dire consequences because

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Interfering with or obstructing a national security operation would have very dire consequences

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And of course we're all humans right and so as these people rushed into the fire in

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2020 many of them ended up being co-opted by this national security event giving given two choices

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You can either help us

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Make sure that people take the worst-case scenario seriously

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You can either help us and make sure that people comply with our edicts and our rules until we're ready for the next shift

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Or we can give that job to somebody else

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And so it's very likely that people like Peter McCullough and Pierre Corey and many other people were read in

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To the situation in so far as they needed to know and given a set of talking points that they were

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Required to stick to in order to make sure that they didn't encroach on

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The operation that was going on in the background that was this national security thing

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And I think once you start to see it this way

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You can actually forgive a lot of these people for making two hundred and thirty thousand dollars a year as the head of a

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doctor group or you can forgive them for for selling a book about Ivermectin and nothing else or a book about

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Lab leak and nothing else

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Before I do the the the study hall today with Judy Mikovitz's video from

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2018 did I say 2008 in the description I did it should be 2018 so I'm gonna fix that

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I'll do that post

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But I wanted to make a couple

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Mentions of some things that are going on in my world that I thought would be worth mentioning

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The first thing is is that I've been making subtle

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Remarks about my friend at the gym

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As you may well be aware if you're a viewer here my boys and I have joined a basketball workout gym

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so that they can work on their basketball and then if I get their membership then I get one kind of a free because I'm just a dad and

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So I've been shooting around very consistently for the last 50 odd days or so

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I think I've missed three days in the last 50 shooting around jumping rope this kind of thing

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Getting in shape and I've been making friends with the guys that work there. There aren't that many guys that work there actually

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It's really crazy. I got two stories for you

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The first one is is that one of the guys that works there actually coaches high school where my kids go and my son will start next year

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and it turns out that that dude played in the game where

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Chris Weber like called the timeout and and played for North Carolina and like won a national championship and was a pro

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For 16 years in Europe, which doesn't even make sense to me

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And so this guy is now one of the managers there and gives you know shooting coaching lessons

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And and is the high school coach at this high school that we're currently in that township up

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So it's really exciting

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House have found out that he might not be there anymore, which would kind of suck

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But he's a nice guy. He invited me to work out with him and his friends

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Downtown Pittsburgh during the week, which is also very flattering

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I don't know if I'm gonna be able to swing that but it sounds really cool

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And then the other guy working there the older guy actually has been a coach at more than 10 division one schools in his career

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And as he characterized himself, there's probably nobody that spent more time in a gym than me

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Really really nice guy

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White hair

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Short white hair, you know old white dude from somewhere. I don't know where

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Real humble helps everybody gives a little lessons to kids

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But also just you know when he comes walks past my kids and they're working out

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He'll knock the ball out of their hand and tell them to protect the ball or he'll try to block their shot real sweet old guy

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And last week I had to help him carry a ladder because he had to get to one of the the screens

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That's above the shooting machines and it was a long heavy fiberglass ladder that opened up like this

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So it's pretty heavy and me and another kid carried it for him because he couldn't even carry it with his one arm

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And he last week he told me that he'd gotten a shingles shot and this week

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Yesterday I was at the gym and and that gentleman was there again and when I was talking to him. He was he was like this

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And I was like dude what's up with your neck and he said oh man, I know I

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Don't know

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And he was kind of hesitant. He says, you know, I'm not an anti-vaxxer

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But I think last week I told you that I got a single shingles shot remember

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I had to I had you help me carry that ladder. I said I definitely remember man

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And he said well, it's gotten worse like I don't know I don't like I said

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I'm not an anti-vaxxer, but it happened like immediately after the shot

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I had this pain in my arm and it goes all the way up the back of my head and in my neck and

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I'm thinking right away

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Ossipital neuropathy. I'm thinking right away isn't that what people get from shingles like holy shit. So

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It's it's extraordinary because

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He's he's making apologies. He's telling his doctor this the doctor says nah, it's a stiff neck and gets him a chiropractor

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recommends a chiropractor for this guy

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He can't sleep he hasn't slept in three nights because when he lays down the pain is so unbearable and

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I was I couldn't really

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Process it all because I don't know what to say to him

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You know because he's already airing on the side of caution that I might not understand that he's he's not an anti-vaxxer

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But you know this can happen and he had to really walk on those eggshells afraid that I might be like, oh, you know

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Of course I talked to him and told him who I was and what I had done and where I'd been as briefly as I could and

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Now I don't have anything else really to say to him. What can I say to him?

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He took a he didn't take shingrix. He took the other one, which is recombinant

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It's recombinant virus, you know, it's weakened somehow

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I don't know they got rid of some jeans or something. I have no idea

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I haven't looked into it yet, but it's just terrible because he's got neuropathy now

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And I know I'm not a doctor, but I know that neuropathy is not something you can just take vitamin C4

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And so it terrifies me

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I don't know if I'm gonna see that guy today when I go to the gym with my kids

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I don't know if I'm gonna see him next month and

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And will this ever go away from or is it gonna be a devastating thing that ruins this guy's life forever

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He says to me at some point in the conversation

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No, I never have reactions when I get these vaccines

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And then I'm thinking holy shit

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How many vaccines are they telling you to take when you go on the CDC website the CDC recommends everybody over 50 to take two shots of the singles

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vaccine and

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That's what they told him I

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I

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Think that you know quite frankly we should be telling all of our old people all of our friends everybody not to take any

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Vaccines none new no they don't need new vaccines. They're old people. They should eat better take vitamin whatever, but not

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Vaccines we've got to stop this nonsense. I

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Did tell him I was an anti-vaxxer. I told him that I worked for one of the the top 12 anti-vaxxers for a while

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Yeah, it was pretty funny

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Pretty pretty funny conversation. Okay, so now Jimmy door

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Guess who I saw yesterday?

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I saw Jimmy door yesterday and I gave him a book

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Robert can it Robert F. Kennedy's book and I had highlighted all the places where I was where I was

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quoted I also put my phone number everything in there and I said in the inside of the cover I

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Wrote we are being lied to by the people now riding white horses

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we should talk and

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I have little tabs in every place in the book where I'm found so that he can find me and it says that's me and stuff

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I I ruined the book basically, but I used it as a business card

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I talked to him very briefly here in this little meet-and-greet where there were like 10 people so it wasn't very long

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I could have talked to him for longer

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We also got to meet Steph and we took a picture with her after the show and I'm not really sure why I'm not wearing the t-shirt

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But I will put it on

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And so we didn't talk for very long. I just said hey I helped Robert F. Kennedy, Jr.

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Write this book you can see my name here. Here's my phone number, you know, we should talk and it was really cool

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The guy who was selling the t-shirt said thanks for the book and then Steph on the way out took

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I said took a picture with us on the way out and said thanks for the book

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I don't know if they're gonna get back to me. I don't know what's gonna happen

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but

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That's as close as I can get to making some kind of

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Penetration into this more mainstream media area

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And it was really a great show. He took a lot of risks

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I have to commend him for the amount of time he spent talking about how

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angry he was about being lied to about the vaccine and and

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Defending the people in the room, you know

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He asked everybody to raise their hand if they had not taken the shot and a lot of people

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I mean it's Pittsburgh right and it's a Jimmy Dorshow a lot of people raised their hand

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But the people that didn't raise their hand he showed and spoke solidarity with them and said that you know

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You shouldn't be ashamed of being fooled. They frickin lied and it was really wonderful the way that he said it now

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There were caveats he he gave Robert Malone credit for having predicted that Omicron would be

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Would be less or less severe and more mild

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He's definitely convinced that there was a virus still right but he is very very

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Advanced in terms of his understanding that they lie about everything and so I don't think it would be that far of a leap for him

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To think that some of these people have lied about the biology

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I don't think it would be very hard for him to take that leap at all. He ended his

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So I'll tell you a first a funny story about Jimmy Dors

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He made a joke

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about

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circumcision and

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it was something to do with with cutting heads off and

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People don't care if they cut this off or whatever and it being Jewish. I can't remember exactly, but then he said

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And I'm not Jewish, but somehow I ended up circumcised and it just

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Blurted it out from my table in the back and it was dead quiet. Everybody heard it

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I said they needed it for cell culture and

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his immediate response like right whip snap fast as it could be hey

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Alex Jones is in the audience today ladies and gentlemen. Well welcome Alex and everybody laughed

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I got a couple fist bumps from people around me. It was really cute

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and he ended the stream with

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They're lying to us to divide us. They tell us lies to divide us. They don't want us to become united

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They don't want us to unite and we need to unite. We need to love our neighbor

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We need to come together as one country. He said a lot of really cool things. He wants a revolution

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He's be happy to be a leader of it. I

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Do think that he's a good soul

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I think he's a good guy and I just think that it's very easy to be in his position and not have the requisite

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Knowledge to know whether somebody like Robert Malone really is a whistleblower or or or kind of a two-faced

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You know insider and and I do think that that it's not impossible

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Jimmy's been doing some great stuff with regard to RFK

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He said I saw some people in the audience with some and and some people at the meet and greet that had

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Kennedy shirts on gosh. I really like that guy. He's really cool. It's too bad

24:36.240 --> 24:40.200
He's a fucking Zionist and it's sorry to swear. I was just quoting him

24:40.280 --> 24:42.320
But he got really mad about it

24:42.320 --> 24:47.440
He got really mad about Cornell West and really mad about Bernie Sanders and was a real

24:47.920 --> 24:49.680
Well spread out, you know

24:49.680 --> 24:56.720
I am very disappointed in how many people I have put my trust in and belief in that have let me down and I had a real I

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Had the feeling that he was really working things out. He's real be an honest on stage. It's real

25:02.840 --> 25:07.060
he's trying kind of to resurrect a little bit of the of the

25:08.060 --> 25:14.420
Of the George Carlin stick, but it's a much more raw presentation. It's a guy who got screwed

25:14.420 --> 25:20.180
He is not happy about having taken that shot. He's not happy about these people having gotten away with it

25:20.180 --> 25:27.460
And I like he's he's angry in the right way because he's also really he's a whip. He's whip funny. I mean he was really good

25:29.380 --> 25:34.700
He was really good and I really enjoyed it a lot. I know that fear the laughed a lot apparently

25:34.780 --> 25:38.780
He's been doing comedy since before women had dicks that was his first joke

25:38.780 --> 25:44.020
And I thought that at that point we were already lost like it was I was just laughing and the nice thing about it

25:44.020 --> 25:47.500
Was is fearless and I had not been out on any kind of date without the kids

25:48.420 --> 25:49.700
in

25:49.700 --> 25:51.700
In memory

25:51.700 --> 25:54.340
It's certainly the first time we've gone out like that

25:54.340 --> 26:00.940
I think since covid and so it was a really nice dinner together and really nice time together and

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The kids did really well while we were gone and and so overall was really great and who knows?

26:07.860 --> 26:12.380
I mean, we planted a seed with Jimmy right and and that's all we can really hope to do

26:12.380 --> 26:18.420
I hope that you agree with me that that's it couldn't have been better than that. I don't think

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Basically I used the book in the worst way possible in their imagination, I guess

26:26.460 --> 26:28.460
But yeah

26:28.500 --> 26:29.820
Anyway

26:29.820 --> 26:33.460
Judy McAvitt study hall cannabis sciences virtual event

26:33.460 --> 26:37.540
I thought this was interesting because of the emphasis on

26:38.100 --> 26:41.820
cannabinoids and the cannabinoid system with regard to immune regulation

26:42.460 --> 26:50.060
And I thought it was very curious that somebody like Judy McAvitt's would present this at the cannabis sciences virtual event

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In 2018 and since I haven't done very much work on Judy McAvitt's

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I don't really have a good idea of what's going on with her

26:57.740 --> 27:01.740
I thought this was also a really nice way for me to be able to plug

27:02.620 --> 27:04.620
my friend's work

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My friend mark usatonic so

27:08.180 --> 27:10.620
Mark Koolack has a website called

27:11.580 --> 27:15.420
usatonic ITS and if you go to his research page

27:17.580 --> 27:19.580
Like this and you go all

27:19.860 --> 27:25.860
Then you basically get to the A's and then you have this alphabet underneath here and you can look up anybody that he's

27:26.180 --> 27:29.460
He's stored things on and so you know

27:29.460 --> 27:35.700
You can find a page on Judy McAvitt's there and you can find a page on some of the people that have worked with her and and

27:35.980 --> 27:40.900
And a long you know all the all the stuff is there. That's the nice thing about it

27:40.900 --> 27:47.860
It's not a Wikipedia because a Wikipedia is pretty incomplete mark has taken a lot of these original sources and compiled them together

27:48.660 --> 27:52.700
And so you can get a good idea of her her background there

27:52.700 --> 27:57.500
And so I would like to encourage you to do that and also just to go back one step

27:57.620 --> 28:03.780
There's also quite a bit on shingles vaccination with the CDC and one of the things that's there

28:03.980 --> 28:08.140
You can find is occipital neurology, which is I think what my friend at the gym has

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And you can find

28:10.620 --> 28:16.340
Complications long term nerve pain nerve pain is the most common complications of shingles

28:16.660 --> 28:18.660
So it terrifies me to think that this

28:19.220 --> 28:25.020
Hossipital neurology that I think that my friend is now suffering from could be a long-term nerve pain problem

28:25.660 --> 28:30.900
Which is just disgusting the CDC recommends two doses of recombinant zoster vaccine

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To prevent shingles and related combinations in adults 50 years or older. I

28:37.140 --> 28:41.020
Just think it's disgusting and I think that this lie needs to be put to rest

28:41.980 --> 28:48.420
It just it frightens the heck out of me that we are we are doing this and that old people are in in the same

28:48.740 --> 28:53.580
Situation that that really where did the maybe I didn't have it in that one. Sorry. Oh

28:55.020 --> 28:57.020
Yeah, it's here

28:57.020 --> 29:04.500
That old that old people are now in the same situation that a lot of young parents are in except about themselves young parents are often

29:04.700 --> 29:07.180
You can characterize it as being bullied

29:08.140 --> 29:14.060
Into accepting the vaccine schedule as it is and even if you ask to have a delayed a couple years you will be

29:14.940 --> 29:16.940
given a lot of heck for that

29:17.660 --> 29:19.660
Nevermind if you want to

29:19.660 --> 29:22.060
abstain from participating in it and so

29:23.260 --> 29:25.260
It's it's a real

29:27.020 --> 29:31.100
It's really it's really a devastating place that we're in right now if we are coercing

29:31.900 --> 29:37.700
And it's normal to coerce elderly or even older people 50 years old. I'm 50

29:37.700 --> 29:42.300
I should take two of those things then right that's what they would say and that's just crazy talk

29:42.300 --> 29:47.500
I mean I had chickenpox real bad when I was 13 years old. I ain't messing with that shit again

29:47.740 --> 29:51.100
So there I'm swearing. I got a chill out. I got a cool out

29:52.260 --> 29:56.460
But yeah, here we go. This is a study hall

29:56.860 --> 30:02.380
And I am going to put the playback speed up to 1.5 until otherwise noted

30:03.660 --> 30:05.660
and

30:05.660 --> 30:12.780
Yeah, let's see what Judy mikovitch has got mikovitch has to say about these things cannabinoids as stem cell and immune therapy

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It's interesting right that sounds pretty much like a catch-all

30:16.780 --> 30:20.940
Like cannabinoids could be used for almost anything in future medicine

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Which is a really exciting thing that might be some that might be a very good reason why some

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But he might want to sequence cannabinoid genomes and work on variants

30:31.740 --> 30:37.980
In cannabinoids, you know, like get in on the ground floor with regard to the genetics of canada cannabis

30:37.980 --> 30:41.180
That might be a really good reason to get in on that

30:41.980 --> 30:46.220
Get out of that action. So let's see what Judy's got to say about that

30:46.780 --> 30:54.620
Action well everyone. I welcome to today's live broadcast cannabis as immunotherapy for 21st century acquired immune deficiencies presented by

30:54.700 --> 31:01.180
Dr. Judy mikovitch founder and consultant at mark ink and director of cancer biology at epi gen x pharmaceuticals

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I'm tz Valdez of lab roots and i'll be your moderator for today's event

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We're delighted to bring you this educational web seminar presented by lab roots lab roots is the leading scientific social networking website and producer of educational virtual events and webinars

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Before we begin. I want to remind you that this event is interactive

31:15.660 --> 31:20.380
We encourage you to participate by submitting as many questions as you want at any time you want during the presentation

31:20.700 --> 31:22.700
Just click on that ask a question box

31:22.940 --> 31:28.060
Located on the far left of your screen and type the questions into the dropdown box that appears on that screen

31:28.220 --> 31:31.420
We'll answer as many questions as we have time for at the end of the presentation

31:31.740 --> 31:33.740
If you have any trouble seeing or hearing this presentation

31:33.980 --> 31:40.220
Click on the help desk button located on the promotional board at the bottom center of your screen or use that ask a question and let us know

31:40.220 --> 31:45.100
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31:45.340 --> 31:52.620
Click on the continuing education credits tab located at the top right corner of your presentation window and follow the process to obtain those credits

31:53.100 --> 31:57.420
Please join me now and welcoming our presenter dr. Mikovitz. I will now turn the presentation over

31:58.140 --> 32:01.820
Welcome dr. Mikovitz. Thanks. Thanks so much. It's a delight to be here

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And talk about a really exciting topic as far as therapeutic potential for some of the most devastating diseases of our time

32:11.180 --> 32:13.180
And that's using cannabinoids

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as stem cell therapy and immune therapy

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So on that first slide

32:18.860 --> 32:25.260
There that you see ahead of you you see some of those diseases you see cancers a lot of hormone

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Sensitive cancers a lot of leukemia lymphoma

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Bladder cancers. These are these are cancers that that tend to respond to immune therapy. We also consider autoimmune diseases

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Lupus inflammatory bowel disease Crohn's disease polymyositis

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Syndrome Biches disease and primary biliary cirrhosis

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I think i'm already going to tap in here and suggest to you that this is already a list of

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Distractions and misnomers which are describing potential

32:58.780 --> 33:02.780
gene therapy side effects and vaccine side effects

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And so what we're looking at here is a list of things that happens with no explanation for why

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Nothing about the toxic environment and the toxic food that americans are given

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Nothing about the toxic lifestyle or the toxic environmental pollution that americans are exposed to and definitely not the toxic vaccine

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Schedule which i'm assuming in 2018

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Judy mikovitz is still totally and completely against right because it's not that long ago

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It's right before the pandemic. She must have been anti-vaccine already by now

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A chronic liver disease in the cns we think of myalgic encephalomyelitis skull for syndrome autism spectrum disorders

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ms parkinson's disease luke eric's disease

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on to the diseases which are

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Increasing in our world at

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It really extraordinary rates due to the environmental toxins in our world and interestingly as as we've learned

34:04.140 --> 34:06.140
only in the last two decades

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that are

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That are really diseases of the endo pinnabenoid system and and of stem cells where those toxins are

34:15.500 --> 34:22.140
Are affecting our immune system and the regulation of our immune system in really profound ways. So on the next slide

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On the next slide. I show a relatively recent paper review article

34:32.300 --> 34:35.260
from progress in lipid research and what this

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Review article talks about is is what we learned in in the early 90s the endo pinnabenoid system

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And how it's actually critical for stem cell development

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Really from the embryonic stem cell on and so what we're going to do today is we're going to talk about

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how

34:54.380 --> 35:01.740
The endo pinnabenoid system and the regulation of the endo pinnabenoid system is key to a healthy brain and a healthy immune system

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First of all, I want to make sure that everybody understands that they're they are going to

35:07.900 --> 35:09.420
confound

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the endo pinnabenoid system with cannabinoids as often as possible and it is a broad

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chemical family

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And you shouldn't assume that endo pinnabenoid receptors are all stimulated by cannabinoids and blah blah blah

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You shouldn't assume any of that

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Even though they're not going and I suspect

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She's not going to be very precise about this and in fact take advantage of that potential confusion

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and allow you and her listeners to

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Make as many of those assumptions as possible when she's talking about endo pinnabenoids

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She's also

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Implying because she's not saying it's not true implying that when you use cannabis that you can stimulate this

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System as well and so that's to a certain extent that's true

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But but you're missing the subtleties there of all the different

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You know chemical subcompounds and all you know and the receptor subtypes and all this other stuff that they know very well

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Individual people have studied these individual stories with individual mechanisms and so these are all

36:13.500 --> 36:20.460
Compartmentally well understood but to now we're going to misconstrue them as some kind of new way for us to

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You know sort of tap into the system as a whole and take advantage of something that we couldn't take advantage of before and I I think this

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This is essentially what what this talk is going to be about trying to

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Sell you on the idea that there is potent biologically

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there is so much potential for

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Cannabis produced cannabinoids to be designed

36:47.340 --> 36:51.260
To be used as immune modulators. They don't intend to grow pot

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They intend to use pot to to produce compounds that they can then identify and and synthetically synthesize

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I have they have no intention of using

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marijuana as a source

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Like like to use it as medicine or

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Consume it as medicine but to extract from it or to identify within it

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Compounds that can be made synthetically to use as medicine. So it's very different

37:22.380 --> 37:24.380
Couple things there anyway that are very different

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I know this paper is open access. So it's available to a lot of the audience and I've adapted or taken figures directly from

37:32.380 --> 37:37.580
This this paper and added some of our own as shown on slide three

37:38.380 --> 37:43.820
So so I would challenge you to go to mark's website and look up at the bottom of her her page

37:44.700 --> 37:50.220
Look up her resume because she does not have any problem getting employment

37:51.260 --> 37:53.260
Okay, so

37:53.820 --> 38:00.460
And and she doesn't not get good employment. It's not like she's worked at a basket robins because she can't be a scientist anymore

38:01.740 --> 38:03.260
and so

38:03.260 --> 38:05.260
There's a limited amount of

38:05.260 --> 38:07.980
Suffering that she's had and certainly in this

38:08.860 --> 38:14.060
In at this time in 2018. She's very gainfully employed from at least two different companies

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So

38:15.500 --> 38:23.020
And nevermind that also perhaps also advising investment firms, which appears also on her resume in various places

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stem cell level

38:24.940 --> 38:31.420
In the endocannabinoid system, there's really um cannabinoid receptor one and cannabinoid receptor two

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You see here in the lower part of the screen. Those are shown as these channel like receptors

38:38.060 --> 38:41.020
These are um deep protein coupled receptors

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And so they have um they they cross the membrane say six or seven times

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And the signal is occur and changes can occur in the loops and they have crossed off with many many

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Coupled receptors for signaling both in the brain and in the immune system

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What we've learned so a deep protein coupled receptor for those people who do not know

39:01.340 --> 39:03.340
um, this is

39:03.340 --> 39:05.340
What's that why didn't that work?

39:06.300 --> 39:08.780
Oh, no, sorry. That was not the right one. Um

39:09.500 --> 39:11.020
Yes, it is

39:11.020 --> 39:14.380
It's definitely the right one. Why didn't that work? This is not on

39:14.380 --> 39:16.380
Oh

39:17.500 --> 39:21.660
It wasn't on um g protein coupled receptors are different than

39:22.860 --> 39:24.060
a

39:24.060 --> 39:29.580
a let's say an ionic receptor and ionophore or something that just opens and allows things in

39:30.300 --> 39:31.420
um

39:31.420 --> 39:33.500
So you might have

39:33.500 --> 39:39.180
A couple different kinds of receptors just to think about things in general, right? There's receptors on the membrane

39:39.740 --> 39:41.740
That for example might gate

39:42.300 --> 39:45.100
The flow of things across the membrane

39:45.660 --> 39:52.540
And so if they do that, they might have an agonist that binds to them and then these proteins will change configuration

39:53.180 --> 39:54.940
to allow

39:54.940 --> 40:02.380
like an ion to transfer from one side of the membrane to another but a g protein coupled receptor is actually a

40:03.260 --> 40:05.260
a

40:05.660 --> 40:08.860
A receptor that has a number of subunits on it

40:09.500 --> 40:12.860
and there are g proteins are are these

40:14.220 --> 40:21.100
Like cyclic amp is usually these the messenger that they use so when the agonist binds the receptor

40:21.900 --> 40:26.780
Um, then a similar conformational change occurs, but then that allows

40:27.500 --> 40:31.660
uh cyclic amp to be released and it's a very local signal

40:32.300 --> 40:36.060
But that cyclic amp could open an ion channel

40:36.620 --> 40:41.020
That allows something in just like this one like this one did it could it could open

40:41.660 --> 40:46.780
That channel it could open many channels. It could also have downstream effects of causing

40:47.660 --> 40:50.780
gene expression and all kinds of other things as essentially

40:51.660 --> 40:57.100
Um a black box after the activation of g protein of a g protein coupled receptor

40:57.100 --> 41:01.740
They would like to tell you the story cyclic amp etc, but it's a cascade

41:02.540 --> 41:08.700
And so we don't have a very good idea of all the things that happen downstream from g protein coupled receptors

41:09.180 --> 41:15.820
because these these actions after agonist binding can have different timescales and

41:16.220 --> 41:23.500
Depending on the cell type can have very different ramifications depending on what happens after the initial activation here

41:25.260 --> 41:28.540
um, so a g protein coupled receptors kind of cool because

41:29.260 --> 41:34.700
Um, it could have a number of different effects on both a long a short-term effect could be

41:35.340 --> 41:39.260
That sodium comes in through channels, but a long-term effect could be

41:39.820 --> 41:43.900
Gene expression or actin skeleton remodeling or something like that

41:44.380 --> 41:47.180
And that's very different than a receptor which is

41:47.980 --> 41:53.980
Exclusively an ion channel opened and closed by the presence of the agonist or blocked by a toxin

41:54.620 --> 41:55.580
Um

41:55.660 --> 42:02.860
So that's interesting because if endocannabinoids are all g protein coupled receptors then even when we think we can activate them

42:02.860 --> 42:11.340
We we would still be much farther from understanding the consequences of their activation because it is not only the acute direct

42:11.820 --> 42:13.820
effects of ion

42:13.980 --> 42:17.660
Transfer or or proton pumping or something like that

42:18.140 --> 42:24.140
But rather it is downstream effects activated by cyclic amp and other second messengers inside of the cell

42:24.540 --> 42:26.780
That result from the activation of the receptor

42:27.180 --> 42:31.580
So it can can result in very very much bigger changes as well

42:32.060 --> 42:35.020
So it's not to say that that this isn't significant. It's to say

42:35.740 --> 42:40.700
That the complicated mechanisms that underlie the signaling of cannabinoid receptors

42:41.100 --> 42:45.100
Cannot be underestimated and when she says it's a g protein coupled receptor

42:45.500 --> 42:48.220
That's like the very very tip of the iceberg of that

42:48.780 --> 42:53.100
Complexity most of which we can't really adequately characterize. I hope I said that well

42:53.660 --> 43:01.020
Recently is the hematopoietic stem cell, which is the stem cell that's involved in your in the development of all of the lineages

43:01.340 --> 43:06.460
In your blood shown on this slide. We're showing. I'm showing you the myeloid lineage. That's um

43:07.100 --> 43:11.980
The megacariocytes the erythrocytes red blood cells mass cells myeloblast

43:12.540 --> 43:15.740
On the right hand side. I the figure wasn't long enough for this slide

43:15.740 --> 43:21.340
I just show also the base of field neutrophils eosinophils and critically the monocyte macrophage

43:21.500 --> 43:24.940
Which we're going to talk a lot about today the myeloid cells

43:25.580 --> 43:33.500
And and hematopoiesis of the myeloid cells. This is really your innate immune response your frontline defense from all of the toxins

43:33.740 --> 43:38.620
Um in our environment in our world not just so see she's saying it too complicated

43:38.620 --> 43:43.740
She wants you to the the myeloid cells the macrophages and the dendritic cells

43:44.460 --> 43:49.980
The hematopoiesis of these cells. Why does she use the word hematopoiesis?

43:51.580 --> 43:56.940
Why can't she just say that when these cells are in development hematopoiesis? Why not?

43:57.740 --> 43:59.740
Do I not define it?

44:00.780 --> 44:03.020
Again because I think this is a rehearsed

44:03.580 --> 44:07.900
Very carefully chosen set of words to bamboozle to make sure

44:08.460 --> 44:10.860
That if she lists all these words fast enough

44:10.860 --> 44:16.140
There's no way that you're going to notice that common is spelled wrong in her in her slides

44:16.460 --> 44:19.740
There's no way you're going to notice that that this is just uh

44:21.820 --> 44:26.620
An overwhelming set of data designed to get you to accept the conclusion slide

44:27.660 --> 44:32.780
Um, not just um environmental toxins, but including things like um viruses

44:33.420 --> 44:42.300
Um our expertise is in retroviruses and our work at epigenetics is is all about how retroviruses change the expression of genes and not the dna

44:42.300 --> 44:50.220
Or and including at the dna level, but primarily the expression of genes and this is one mechanisms how they cause diseases by so 2018

44:50.220 --> 44:56.220
She's still working for epigenetics. I don't think that that's really in her resume that mark has on his website

44:56.220 --> 45:01.500
I want to I want to look deeper into that, but this is 2018 and she's still talking like we

45:02.220 --> 45:05.820
Epigenetics, which is again a company that looks at

45:06.380 --> 45:16.460
Uh, epigenetic changes resulting in cancer and other other conditions. So, um, you're essentially dealing with somebody who is interested in sequencing everything

45:16.860 --> 45:21.580
You're dealing with somebody who is using blood samples to look for bloodborne markers of

45:22.300 --> 45:25.020
Of chronic fatigue syndrome for many many years

45:25.500 --> 45:31.500
Not that dissimilar from looking for bloodborne markers of other diseases like that blonde lady with the dark hair

45:31.980 --> 45:36.940
With the with the deep voice was doing before they before they discredited her as a fraud

45:38.860 --> 45:40.620
Just saying

45:40.620 --> 45:44.220
It's not like this is uh, obviously anti-vax talk where we're

45:45.020 --> 45:51.020
Where she is fighting for us to not believe in in the public health system or to doubt tony fauci here

45:53.260 --> 45:55.420
This is right now talking about how

45:56.460 --> 46:02.460
Canabenoids regulate the essential developmental processes of all blood cells and the amion system

46:05.260 --> 46:11.980
Disregulating, um, the, uh, hematopoietic stem cell and what you get is an accelerated aging

46:12.140 --> 46:17.660
Where we see cancers in those auto immune and neuro immune diseases on the first slide in younger

46:17.900 --> 46:20.380
I mean accelerated aging is what what

46:22.220 --> 46:27.820
Walter chestnut has been going on about the spike protein was going to do for like four years now

46:28.540 --> 46:31.740
and certainly going on and on about the transfections

46:32.700 --> 46:36.060
advancing aging and destroying mitochondria and

46:36.620 --> 46:38.140
And

46:38.140 --> 46:41.580
It's in it's incredible that this is 2018

46:41.580 --> 46:49.980
They're essentially seeding the narrative of the damage that will be done by the coming vaccine scheduled by coming counter measures by coming

46:51.660 --> 46:53.660
genetic technologies

46:56.380 --> 46:58.380
I don't understand

46:58.620 --> 47:02.780
Who judy mikovitz is but I do know from mark's work

47:03.420 --> 47:08.860
That it's hard to explain why the two people who came out and first published papers about her

47:09.500 --> 47:12.060
Data likely being fraudulent are dead

47:13.740 --> 47:20.540
It's weird that all of this stuff has to do with aids and vaccines. You could imagine a scenario

47:22.060 --> 47:23.660
credit to mark

47:23.660 --> 47:24.780
where

47:24.780 --> 47:31.660
The xm rv story was actually going to be queued up teed up as a way of pivoting from

47:32.780 --> 47:35.980
vaccine preparation to new methods like transfection

47:38.140 --> 47:39.100
But

47:39.100 --> 47:41.100
Unwitting non participating

47:41.980 --> 47:49.100
Biologists in the field said hey, this looks like bullshit and the story had to be changed. It had to be dealt with

47:51.740 --> 47:54.220
And now we have a different judy

47:55.420 --> 47:57.100
And twin

47:57.100 --> 48:02.860
Do you know the judy mikovitz just like jessica rose she has a twin too. It doesn't that eat didn't that meet

48:03.740 --> 48:06.460
Not twins are cool younger populations

48:06.940 --> 48:15.740
Driven by this somatopoietic stem cell. So what what this paper shows now is that in fact this cb2 endocannabinoid receptor

48:16.540 --> 48:22.860
Is is involved in the development of essentially every lineage of the myeloid

48:23.180 --> 48:27.260
Amatopoietic stem cell that it's involved in those diseases that I showed

48:27.900 --> 48:36.540
On the on the first slide if you notice the asterisks on the first slide what we were looking at is diseases associated with activated

48:37.260 --> 48:49.580
Macrophages activated micro glia cells in the brain. Um, so so now we know that there there's a primary disposition towards cb2 and the hematopoietic stem cell

48:50.380 --> 48:54.940
And that dysregulation of of these responses in these myeloid progenitors

48:55.660 --> 49:00.780
Is can be causal for these diseases and that we can reverse these diseases with

49:02.300 --> 49:09.820
With phytocannabinoids and modulating our endogenous produced cannabinoids on the next slide. We see that

49:10.700 --> 49:17.820
We continue to look at how the cb2 is associated with chronic inflammation of the nervous system

49:17.820 --> 49:23.820
Which is somewhat paradoxical and because in fact from the mesenchymal stems

49:23.820 --> 49:31.260
I'll shown on the left side of the slide. We see that the cb1 receptor that can have the canonical cannabinoid receptor number one

49:31.660 --> 49:33.420
Another g protein link

49:33.420 --> 49:38.220
signal its shown in blue and cb2 is shown in red for convenience is is actually

49:38.940 --> 49:45.820
Controls the development of neurons. So then development of neurons the development of a dipocytes bat set

49:45.820 --> 49:48.300
It's hard really to take this at face value

49:48.380 --> 49:51.580
You have to I just want to help you to see what I see here

49:51.980 --> 49:57.020
When somebody says that cannabinoid receptor one controls the development of neurons

49:57.020 --> 50:02.460
What they really mean is that if you mess around with it you can mess around with neuronal development of course

50:03.020 --> 50:11.020
She can't possibly mean that the development of neurons is controlled by a single receptor because that would be absurd

50:11.500 --> 50:15.500
Yet just like a lot of academic biologists that are still

50:16.140 --> 50:20.380
Not really teaching anybody including themselves the broad

50:20.940 --> 50:28.460
Sacred biology in which they operate she is not helping you understand that this is obviously infinitely more

50:29.100 --> 50:32.380
Complex than cannabinoid receptors controlling development

50:33.100 --> 50:35.100
And

50:35.100 --> 50:41.420
Yet they will continue to do this all biologists will continue to do it that are trained in this method of

50:42.380 --> 50:48.780
Creating a very sharp and narrow question that is so sharp and narrow that it actually doesn't even

50:49.660 --> 50:53.420
purport to validate the model that it purports to be a part of

50:53.580 --> 50:55.580
And

50:57.020 --> 51:03.260
So if you say that cannabinoid receptor one is involved in neuronal development

51:04.940 --> 51:09.740
What do you really mean? Well, she's saying that the receptor expression goes up

51:10.700 --> 51:12.700
Okay

51:13.740 --> 51:18.940
Peripheration is stopped by cannabinoids one over here and differentiation occurs

51:19.420 --> 51:25.740
So what can you increase differentiation? Is that stimulation required? Is it part of a suite of stimulations?

51:26.220 --> 51:31.100
Most of which have not even been identified never been manipulated in an experimental setting

51:33.740 --> 51:38.140
How many receptors are in neurons that we don't even have an even identified yet

51:38.380 --> 51:49.820
Don't take this at its words understand that this is the opposite of presenting you

51:50.300 --> 51:56.700
The complexity the irreducible complexity of the immune system the irreducible complexity of the development of the brain

51:58.220 --> 51:59.980
To simplify

51:59.980 --> 52:04.700
Down to cannabinoid receptors one and cannabinoid receptors two and how

52:05.180 --> 52:09.100
Finding substances which can stimulate those two might be fun

52:10.540 --> 52:13.180
Because of all this stuff that they're involved in

52:16.460 --> 52:19.980
Bells, pre and besides and and bone formation

52:20.300 --> 52:28.940
So that's somewhat paradoxical in thinking about that because if if I had on those slides cancers that metastasized to the bone

52:29.100 --> 52:33.020
And are primarily bone cancers such as multiple myeloma

52:33.980 --> 52:39.100
And in prostate cancer, which are two diseases in which bone formation is dysregulated

52:39.420 --> 52:46.220
So you see there on the left hand side though. The proteol osteoblasts is regulated by cannabinoid receptor number one

52:46.940 --> 52:50.060
and involved in in rankle is the receptor of

52:50.620 --> 52:57.260
NF Kappa B activation of NF. I mean isn't the implication here that you know way too much cannabinoid useful

52:57.740 --> 53:03.980
Will cause your your neurons to develop funny and your your bone resorption to go wrong and

53:04.540 --> 53:06.860
All of this stuff to go haywire. Isn't that

53:08.620 --> 53:13.020
Shouldn't that be the first question that's on your mind? How did all these hippies not just die?

53:13.740 --> 53:18.380
If everything in the body that's interesting is regulated by endocannabinoid one or two

53:18.380 --> 53:20.380
I

53:22.380 --> 53:27.660
Hope you're starting to see now what's happening here how this is done in academia where you try to take

53:28.380 --> 53:32.540
A story and conflate it to be the most important story to be told

53:33.980 --> 53:36.460
And what it does from the perspective of getting money

53:37.020 --> 53:42.300
What it does from the perspective of telling a story that's kind of I guess entertaining and singly focused

53:43.020 --> 53:47.100
but in no way shape or form acknowledges never mind tries to

53:48.060 --> 53:52.700
Pay any reverence to the irreducible complexity that all of these people are up against

53:53.100 --> 53:57.820
Applebee ligand and NF Kappa B, which we'll discuss in a moment is really key to

53:58.300 --> 54:01.580
Inflammatory responses and inflammation that drives

54:02.220 --> 54:05.900
In fact the breakdown of the proteol osteoclasts

54:06.220 --> 54:12.380
So what you see is you get osteoclasts favoring over osteoblasts that you're breaking down the bone progenitors

54:12.860 --> 54:15.980
And you're actually getting bone resort of resorption

54:16.460 --> 54:24.460
So we see in these cancers and in these diseases and of course osteoporosis in women of younger and younger ages driven by

54:25.180 --> 54:27.580
You know, it's now it's still a theory

54:27.580 --> 54:31.740
But driven by these interactions is the theory that we're working on in developing

54:32.140 --> 54:37.500
Therapeutics two months and so the problem with this model is how the hell do you test it?

54:38.460 --> 54:45.420
What kind of predictions does this model make? Are there predictions in the future that we can then verify using a measurement?

54:47.900 --> 54:52.140
That's what broken science is all about exposing this nonsense for what it is

54:52.140 --> 54:56.940
This is not a model and if it is a model, is it a model you intend to test?

54:58.300 --> 55:00.300
Absolutely not it's a model you assume

55:01.820 --> 55:05.020
Your experiments actually do not test this model

55:05.100 --> 55:09.580
They're not verifying it and you're not using this model to make any predictions

55:11.100 --> 55:16.620
You're collecting data to verify whether the parts of this model conform to data in the past

55:17.020 --> 55:22.060
You never make any predictions and they will never make any predictions because that's not how

55:22.620 --> 55:24.620
This kind of pseudoscience is done

55:24.780 --> 55:30.220
Ontulate the topic of this discussion. So on the right on the in the middle of the slide you can see how

55:31.100 --> 55:37.900
Red arrows blocking the the breakdown of the proteo osteo class and encouraging the build up and

55:38.140 --> 55:47.500
Development and lineage commitment to the osteoblasts and the bone formation is is critical is driven by blocking the cb1 receptor blocking

55:48.060 --> 55:53.820
And promoting I mean if this was done correctly you would drop these arrows in one at a time

55:53.900 --> 55:59.980
And every time you drop the arrows in there would be a little bibliography that would scroll past saying that these are the flabs that tested this

56:00.540 --> 56:05.020
And showed that mason chymal stem cells are inhibited by cb1 receptors

56:05.500 --> 56:13.180
In certain conditions in certain and every one of these steps would need to be explained in such a way so that we could really evaluate to what extent

56:13.260 --> 56:20.540
This part of this model cartoon is worth paying attention to holding in our mind or trying to mesh like a gear

56:20.940 --> 56:25.260
With some of these other things so that we can start to get a working model of how this system works

56:25.580 --> 56:31.500
But there's already 16 gears on this page and so no matter how good your your imagination is

56:31.500 --> 56:35.580
I don't care if you're nickel at tesla. You can't test this model in your head. You just can't

56:37.500 --> 56:43.260
And they can't test it with a simple experiment either using reductionist biological techniques. You can't do it

56:44.220 --> 56:46.220
Tan side where a cb2

56:47.020 --> 56:53.100
Is um is driving both it's directly activating the osteoplasts through a mechanism with the question mark

56:53.100 --> 56:58.060
We still don't know because that cb2 receptor hasn't necessarily been identified

56:58.540 --> 57:02.380
On that cell and and we have some ideas that we'll discuss in the next few slides

57:02.620 --> 57:05.500
Um, and that's why the question mark for the top arrow at arrow

57:05.500 --> 57:09.020
But we absolutely know when the cb1 receptor and cb2

57:09.820 --> 57:14.700
Cross talk interacts where the weight of the balance is I show on the left hand side

57:15.020 --> 57:18.060
It's not a honor off switch, but really a gradient

57:18.300 --> 57:23.580
So I look at um the endocannabinoid system as a dimmer switch on the immune system

57:23.740 --> 57:26.220
Really a master regulator at many different levels

57:26.300 --> 57:32.540
But via the stem cell via the mesenchymal stem cell via the amount of poetics stem cell and how it's a gradient

57:32.540 --> 57:37.900
So the more receptor that is expressed as it's up regulated the more you'll get the bad accumulation

57:37.980 --> 57:45.500
We can also think in our society about how the bad accumulation of metabolism is changing in in our teenagers and our young adults

57:45.820 --> 57:53.020
Um, you know through the dysregulation of this system. So one of the recent discoveries, um big discovery shown on the next slide

57:53.340 --> 57:58.220
Um, so the dysregulation of the endocannabinoid system is also causing kids to get fat

57:59.340 --> 58:00.380
Wow

58:00.380 --> 58:07.020
Is that that question mark may be addressed in a paper by brian gardener in his colleagues

58:07.260 --> 58:12.620
And that is that tetra hydro cannabinoid, which is the psychoactive t hc

58:13.180 --> 58:17.180
In medical marijuana actually turns on cb2

58:17.900 --> 58:22.060
Driving that g protein coupled receptor to breakdown atp

58:22.140 --> 58:27.420
This is called purinergic signaling where where atp is broken down into cyclic amp

58:27.900 --> 58:35.420
This activates the expression of a critical master regulator of chromatopoietic stem cells and stem cells in general

58:35.420 --> 58:38.700
Known as transforming growth factor beta or t so see here

58:39.020 --> 58:42.940
This is one of those cartoons where here you see a g protein coupled receptor

58:43.740 --> 58:46.940
G protein is now decreasing cyclic amp so

58:47.580 --> 58:53.820
Depending on the cell type depending on the context it can increase cyclic amp decrease cyclic amp

58:54.300 --> 58:59.020
And then those signals can be can result in expression of different proteins

58:59.100 --> 59:06.460
And so the the interesting thing about the cannabinoid system and indeed any g protein coupled system is that again

59:07.260 --> 59:08.780
like a

59:08.780 --> 59:14.620
A muscarinic receptor or a a muscarinic receptor is a subtype of a nicotinic receptor

59:15.020 --> 59:20.300
Where acetylcholine can bind and there are two kinds of acetylcholine receptors in general

59:20.380 --> 59:25.900
There's a nicotinic receptor, which is an ion channel and then a g protein coupled nicotinic receptor

59:26.300 --> 59:32.620
I'm sorry muscarinic receptor and they call it a muscarinic receptor because it is blocked by muscarin now are stimulated by muscarin

59:33.260 --> 59:37.660
So anyway, the point is is that depending on where those

59:38.700 --> 59:39.900
those

59:39.900 --> 59:41.900
G protein coupled receptors are

59:43.020 --> 59:45.020
And on what neuron?

59:45.100 --> 59:50.140
A muscarinic channel in some neurons could increase cyclic amp and increase

59:51.340 --> 59:57.420
Nmda channels in the membrane. It could change the mobility of actin membrane in a spine

59:57.900 --> 59:59.420
Um

59:59.420 --> 01:00:05.260
There's lots of possibilities with again with a g protein coupled receptor and that's why I think it's interesting here to note

01:00:05.820 --> 01:00:11.580
That every one of these receptors and every one of those contexts would need to be characterized in this way

01:00:12.060 --> 01:00:17.900
And you would never have a definitive answer. Is this the only thing that happens when cb do the cb

01:00:18.540 --> 01:00:21.500
cannabinoid receptor 2 in lymphocytes is stimulated

01:00:22.060 --> 01:00:24.540
So again, we're really at the very very very

01:00:25.340 --> 01:00:27.340
beginning of this whole thing

01:00:27.820 --> 01:00:30.860
And understanding cannabinoid receptors and

01:00:31.740 --> 01:00:33.980
cannabinoid receptor variants between people

01:00:34.940 --> 01:00:37.820
All of this stuff is going to be important because cb

01:00:38.380 --> 01:00:43.260
cannabinoid 2 receptor in you is different than me and so that's uh, this is this is all

01:00:43.900 --> 01:00:45.900
Just

01:00:45.900 --> 01:00:50.540
Any the other half of mark ink. It's my commits and resetting consulting here and and dr

01:00:50.540 --> 01:00:51.900
Aseti

01:00:51.900 --> 01:00:59.020
More than 25 years ago was the scientists who made the discovery that tgf beta acts on the stem cell as a

01:00:59.740 --> 01:01:04.380
Bifunctional regulator of hematophoresis. That means it can go both ways

01:01:05.020 --> 01:01:09.740
Tgf beta can be a really good general in in regulating immune responses

01:01:10.460 --> 01:01:16.780
A good soldier or a bad general. So if if if if if a pathway is on tgf beta can turn it off

01:01:17.100 --> 01:01:20.860
in as far as the immune system and if the pathway is off tgf beta

01:01:21.500 --> 01:01:27.660
Turns it on so it has both autocrine back on itself back on the stem cell to maintain the stem cells

01:01:27.980 --> 01:01:32.940
Thalness and paracrine to develop those effector lineages. I showed on that first slide

01:01:33.020 --> 01:01:39.420
So critical critical regulator and here we have thc. That's you know been really outlawed

01:01:40.540 --> 01:01:42.540
in our in our world for

01:01:43.500 --> 01:01:49.260
More than 70 years and and it's critical so cannabinoid formulations without thc

01:01:49.820 --> 01:01:55.180
Actually cannot regulate and cure diseases and in these therapies can be curative

01:01:55.340 --> 01:02:02.940
But you really can't spell health care without thc. So it's thc dependent and we have to think about formulations

01:02:03.660 --> 01:02:05.660
driving the cb2

01:02:06.300 --> 01:02:12.460
Interestingly enough the psychoactive effects of thc are are mediated through

01:02:13.020 --> 01:02:16.940
That cb1 receptor which I showed here on the last slide

01:02:17.260 --> 01:02:24.860
So it's those neurons and um that are are driven by thc because of course there's cross talk between the two receptors

01:02:25.020 --> 01:02:31.980
So so it's a it's a question of balance really but interestingly enough if we can develop and we're working to develop

01:02:32.620 --> 01:02:39.740
cb2 agonists that don't interact with cb1 that block that interaction and then you don't have the psychotropic effect

01:02:40.220 --> 01:02:41.740
um that is um

01:02:41.740 --> 01:02:44.540
um such a problem with with using these therapeutically

01:02:45.180 --> 01:02:49.820
Now that we can use them to still regulate the critical hematopoietic component

01:02:50.140 --> 01:02:52.140
So the next slide I show in some

01:02:52.460 --> 01:02:56.780
Respect that to go back to our first slide and think about what's causing

01:02:57.340 --> 01:03:02.380
the autoimmune neuroimmune and and um acquired immune deficiencies of our time

01:03:02.700 --> 01:03:09.260
Well, our expertise is in HIV aids and the reason I call these 21st century acquired immune deficiencies

01:03:09.340 --> 01:03:13.260
Because of course there's not HIV in all of these diseases

01:03:13.260 --> 01:03:16.300
But in every disease on the first slide where I showed an asterisk

01:03:16.620 --> 01:03:21.500
There's a retroviral component and um and we won't go into retrovirus biology

01:03:21.740 --> 01:03:24.540
But what we know is that in our treatment

01:03:24.540 --> 01:03:29.020
So she's saying there's a viral component in all of those things which I think is definitely

01:03:29.740 --> 01:03:31.740
definitely sketch

01:03:31.820 --> 01:03:35.500
um and so it seems like the broad stick

01:03:36.220 --> 01:03:37.260
of

01:03:37.260 --> 01:03:40.700
Judy mikovitz is that there are more viruses than we are told

01:03:41.340 --> 01:03:44.380
That are to be found in more places than we are told

01:03:44.940 --> 01:03:47.420
Causing more pain and suffering than we are told

01:03:50.540 --> 01:03:56.060
And she definitely doesn't question the existence of a novel virus that killed millions of people that millions more were saved from

01:03:56.060 --> 01:03:59.020
That probably came from a laboratory that was doing gave a function

01:04:00.940 --> 01:04:03.100
you see

01:04:03.100 --> 01:04:08.620
And at the beginning of the pandemic before the pandemic even started before it was anybody anybody's radar

01:04:09.180 --> 01:04:11.180
She was already out there

01:04:13.740 --> 01:04:16.940
Telling us that there would be this new 21st century

01:04:17.580 --> 01:04:23.100
acquired immune deficiency syndromes that don't all have aids viruses in them even though

01:04:23.900 --> 01:04:27.820
A lot of the people that she's worked with have worked with the aids people

01:04:29.820 --> 01:04:31.820
Like lots of papers with gallo

01:04:32.620 --> 01:04:34.860
Directly connected to gallo

01:04:36.780 --> 01:04:39.100
Remember that gallows

01:04:39.100 --> 01:04:44.940
Like buddy muri gardener was robert melones postdoc supervisor. This is a weird

01:04:45.900 --> 01:04:47.900
tiny little group of people

01:04:48.860 --> 01:04:53.340
Connected through a tiny little group of connected people all connected to the same

01:04:54.380 --> 01:04:56.380
Kind of parallel bullshit stories

01:04:56.780 --> 01:04:58.780
I

01:04:58.780 --> 01:05:04.300
Don't know the truth about hiv, but i'm pretty sure it's not a virus that came from bushmeat

01:05:05.260 --> 01:05:07.260
Brett Weinstein

01:05:08.620 --> 01:05:14.460
I don't know the story about polio vaccines, but i'm pretty sure it had a lot more to do with sanitation and

01:05:15.580 --> 01:05:17.580
pesticides and stuff like that

01:05:19.580 --> 01:05:22.620
And with regard to this talk

01:05:23.500 --> 01:05:25.500
And the discussion of

01:05:25.660 --> 01:05:32.300
21st century acquired immune deficiency syndromes that don't all include the aids virus. I think she's more or less seeding

01:05:33.740 --> 01:05:37.180
She's seeding the narrative of flying aids remember that's what

01:05:37.900 --> 01:05:40.300
Paul cottrell and those other people have been calling

01:05:41.020 --> 01:05:45.580
Coronavirus, it's it's flying aids. It's an acquired immune deficiency syndrome

01:05:45.580 --> 01:05:51.900
How many times have you heard it? They have been seeding the narrative of novel sources of an acquired immune

01:05:51.980 --> 01:05:53.820
Deficiency system

01:05:53.820 --> 01:05:58.780
Syndrome for a few years now so that long covid could be confounded with it

01:05:59.100 --> 01:06:02.300
And so that covid could be confounded with it ladies and gentlemen

01:06:02.620 --> 01:06:07.740
And they knew all along that they were seeding a narrative that would protect genetic vaccines

01:06:08.300 --> 01:06:10.220
genetic

01:06:10.220 --> 01:06:15.820
Genetic technologies they were they've been protecting them from the beginning and it takes a while

01:06:17.180 --> 01:06:19.580
That's why this talk is from 2018

01:06:19.580 --> 01:06:21.580
And

01:06:21.580 --> 01:06:28.940
Not saying anything about the vaccine schedule of uh in the development of have actually curative therapies for hiv

01:06:29.020 --> 01:06:35.660
Which dr. Said and I participated in at the national cancer institute in the 80s and in 90s those therapies

01:06:36.300 --> 01:06:41.420
Included at some level cannabis and so this the the people that survived

01:06:41.820 --> 01:06:48.940
And and and thrived with hiv were the ones that were using cannabinoids along with the anti retroviral therapies

01:06:48.940 --> 01:06:56.220
Which we developed in our laboratory and of course because of the stigma and and the legal problems with using it that that really wasn't known

01:06:56.620 --> 01:06:58.780
At that time and we've only recently known that

01:06:59.180 --> 01:07:03.980
So what we knew about cannabinoids is that they were antiviral and they reduce inflammation

01:07:04.220 --> 01:07:11.100
Because we see that blocking arrow on the right side so lps is uh lipopolysaccharide and it's on bacteria

01:07:11.340 --> 01:07:15.660
So bacteria and polyic mimics an RNA virus infection

01:07:15.740 --> 01:07:18.860
So RNA viruses are your flu viruses your

01:07:19.820 --> 01:07:21.820
hiv your retroviruses

01:07:22.220 --> 01:07:25.660
Your ebola your zika. These are all RNA viruses

01:07:25.900 --> 01:07:30.460
So probably i see mimics the activation of these all RNA viruses

01:07:30.540 --> 01:07:35.660
They're all RNA viruses and what do they have in common rna cannot pandemic

01:07:36.940 --> 01:07:42.940
And yet she lists all the viruses that these people responded to they're all the same small little family of

01:07:43.420 --> 01:07:49.260
Of outbreak specialists. Malone was on that list. She's on that list hat fills on that list

01:07:50.140 --> 01:07:53.820
Meryl nasa's on that list all these people are involved in this little list

01:07:55.180 --> 01:07:56.300
zika

01:07:56.300 --> 01:07:58.300
ebola

01:07:58.300 --> 01:08:02.700
Right. They're all in there somewhere complaining about that stuff at some point in time

01:08:04.060 --> 01:08:07.020
And for decades already for decades already

01:08:07.020 --> 01:08:13.900
When I was playing cyber ball

01:08:15.900 --> 01:08:20.060
At at the at at at oakwood mall and and ochlear, I mean

01:08:21.340 --> 01:08:23.340
These guys were already working on this

01:08:24.620 --> 01:08:31.020
Making sure that this virology as a field would be just impenetrable

01:08:31.500 --> 01:08:33.500
and

01:08:35.420 --> 01:08:43.340
Undifferentiable from a from a program that was just outright testing biological technologies on its population

01:08:45.340 --> 01:08:47.340
indistinguishable

01:08:47.340 --> 01:08:49.340
From a biotechnology

01:08:50.380 --> 01:08:54.060
National security priority that was looking for background signals

01:08:55.260 --> 01:08:57.820
That could be used and misconstrued as spread

01:08:57.900 --> 01:09:01.100
Characterizing background signals that they knew they were going to use

01:09:01.740 --> 01:09:03.900
as spread

01:09:03.900 --> 01:09:05.660
as evidence of

01:09:05.660 --> 01:09:08.620
Even more viruses in the background than before

01:09:10.380 --> 01:09:13.420
They all seem to have the basic same basic story here

01:09:13.900 --> 01:09:16.140
Now we're talking again about something

01:09:16.700 --> 01:09:22.300
and we're we're misconstruing the activation of the immune response by a bacterial protein

01:09:22.860 --> 01:09:23.900
with the

01:09:23.900 --> 01:09:27.340
the activation of the response to a virus and

01:09:27.980 --> 01:09:32.300
Without without giving adequate explanation for why those two can be parallels

01:09:32.620 --> 01:09:33.820
It's impressive

01:09:33.820 --> 01:09:38.780
And then these pathways that that generate type 1 interferons which are

01:09:39.100 --> 01:09:43.420
Curative for retroviruses almost all retroviruses and RNA viruses

01:09:43.900 --> 01:09:52.300
Actually tend to block this type 1 interferon pathway and we use type 1 interferons interferon alpha interferon beta as immune therapy

01:09:52.460 --> 01:09:55.660
In that disease I highlighted known as primary biliary cirrhosis

01:09:55.740 --> 01:10:00.220
Which is actually associated with a retrovirus known as human beta retrovirus

01:10:00.380 --> 01:10:03.500
So here we have and we know with HIV and hepatitis

01:10:03.500 --> 01:10:06.940
That's another disease she says is associated with yet another virus

01:10:07.500 --> 01:10:12.540
You see in various um liver diseases which are driven by um hepatitis B as a para retrovirus

01:10:12.540 --> 01:10:16.380
That means it has components of retroviruses and DNA retroviruses

01:10:16.380 --> 01:10:19.500
We use interferons as therapy. So here now we have

01:10:19.900 --> 01:10:26.220
An cannabinoids which are able to drive block these pro inflammatory mediators, which are so important

01:10:26.860 --> 01:10:32.700
For driving the disease process. It's the chronic inflammation and the chronic activation

01:10:33.180 --> 01:10:38.460
Of the monocyte lineage of that myeloid lineage which we discussed and we'll discuss a little a lot more today

01:10:38.940 --> 01:10:43.740
That is driving the disease processed in HIV associated dementias

01:10:44.460 --> 01:10:48.220
Um, we knew it had nothing to do with virus copy numbers. So

01:10:49.020 --> 01:10:52.380
Patients who were on anti retroviral therapy and had

01:10:52.860 --> 01:10:54.860
Non-detectable levels of HIV

01:10:55.340 --> 01:11:02.060
Still had a dementia and could develop diseases that look like early Alzheimer's disease that look like park and cineans

01:11:02.540 --> 01:11:06.780
And multiple sclerosis diseases and those are diseases that have all been associated

01:11:07.260 --> 01:11:14.300
But you don't need expression in the virus and it's the idea that we're driving these inflammatory mediators and and stopping the

01:11:15.100 --> 01:11:19.580
Interferon responses in in that way and this is where right in the middle of it

01:11:19.580 --> 01:11:27.420
The cannabinoids modulating that cb2 receptor are critical and actually curative if you drive it in the other direction

01:11:27.740 --> 01:11:31.500
So the next slide shows you a little bit more of that neural protection

01:11:31.580 --> 01:11:36.780
So we've talked about cannabinoids either phyto or endogenous those made by your body

01:11:37.260 --> 01:11:43.180
Being actually neuroprotective so therapeutics where you drive the neural protection through those

01:11:43.500 --> 01:11:51.420
Central mediators, but I show here in this slide critically. There are antioxidant cannabinoids and I show in the on the left hand side

01:11:51.500 --> 01:11:54.540
it's going through a factor known as um

01:11:55.500 --> 01:12:01.900
A rithroid factor to the nuclear rithroid factor to and that factor is is a key pathway

01:12:01.900 --> 01:12:05.420
It's a transcription factor in a pathway that is really key to sleep

01:12:05.900 --> 01:12:08.060
As you see it it drives the production

01:12:08.140 --> 01:12:13.660
It's upstream of the production of superoxide dismutase, which is a key liver enzyme for

01:12:14.460 --> 01:12:16.460
detoxing at the level of the liver and in

01:12:17.020 --> 01:12:20.140
Mutations and alterations genetically and epigenetically

01:12:20.860 --> 01:12:24.780
Silencing sod is critical to the development of Lou Gehrig's disease

01:12:24.780 --> 01:12:31.020
So these are the familial als and parkinsonians disease have a have a problem with making enough

01:12:31.820 --> 01:12:38.380
Superoxide dismutase or have dysfunctional enzyme at that level. So these antioxidant cannabinoids

01:12:39.020 --> 01:12:46.300
Actually, don't signal through cv1 or cv2 and we're unsure of what that of what the cross talk is and what the receptors are

01:12:46.540 --> 01:12:52.060
But no matter because they're lipid mediators and your membrane is shown here as lipid bilayers

01:12:52.220 --> 01:12:57.500
They go right through these lipids um cannabinoids or lipids and they go right through they stimulate and are up to

01:12:57.980 --> 01:13:02.380
Increase superoxide dismutase synthesis and decrease these

01:13:02.860 --> 01:13:07.420
Dounding brain damaging reactive oxygen and reactive nitrogen species

01:13:07.980 --> 01:13:13.420
So we all know about the antioxidants and so pro oxidation and oxidative stress

01:13:13.500 --> 01:13:21.820
It's known as is a key contributor to every disease on that first slide and particularly the neurological diseases. So it is those

01:13:22.540 --> 01:13:24.540
It's it's these pathways here

01:13:25.500 --> 01:13:27.500
That are really important for

01:13:29.660 --> 01:13:31.660
Turn off animals

01:13:31.660 --> 01:13:35.660
Are critically important for neural protection and neural inflammatory diseases

01:13:35.660 --> 01:13:40.700
So we can see the intersection right at that level for for the neural protection

01:13:41.020 --> 01:13:43.980
We also see introduced on the left hand side that the

01:13:44.540 --> 01:13:51.660
Not endogenous cannabinoids and cv1 agonists whether they be phyto cannabinoids other terpenes or synthetic

01:13:51.980 --> 01:13:57.580
um cv1 modulators are important for regulating brain derived neurotropic factor

01:13:57.660 --> 01:14:02.860
That's really a key neurotropic factor for developing new the development of new neurons

01:14:03.260 --> 01:14:10.940
So we the the key discovery here in the last um two decades since the um since the endogenous cannabinoid system

01:14:10.940 --> 01:14:18.220
Was discovered that we actually make and respond to cannabinoid molecules and they're critical to all of our development of both the brain and

01:14:19.100 --> 01:14:21.980
The immune system we can actually develop new brain cells

01:14:21.980 --> 01:14:27.100
We can actually drive through cv1 agonist and endogenous cannabinoids

01:14:28.060 --> 01:14:33.420
Neurogenesis, so that's really key to any of the diseases I showed like ALS

01:14:33.660 --> 01:14:39.580
Multiple sclerosis the demyelating diseases this actually shows the capacity to remyelinate to form

01:14:40.300 --> 01:14:45.340
New neurons and and and so far i'm not hearing a lot of downsides about weed, but

01:14:46.300 --> 01:14:49.980
You know, I'm not hearing a lot either. I mean it's a lot of word salad

01:14:51.420 --> 01:14:55.500
But there's lots of good things about stimulating the cannabinoid system

01:14:56.300 --> 01:15:03.180
Um, I don't think I disagree but again in general, right? We're talking about a very complex system. That's why

01:15:03.900 --> 01:15:05.180
you know

01:15:05.180 --> 01:15:08.780
Teenagers and young people that use extremely strong marijuana that are

01:15:09.420 --> 01:15:15.020
Already susceptible to depression or skits of Renee or any of these other conditions that we don't know very much about

01:15:15.500 --> 01:15:17.900
You can tip over into that attractor state

01:15:19.420 --> 01:15:21.420
And so when you when you

01:15:21.820 --> 01:15:27.420
You know, you make all these different claims about what's going on. These are just a very small tiny part

01:15:27.980 --> 01:15:32.540
Right, it's the tip of the iceberg of what this system does and how it works and

01:15:33.180 --> 01:15:38.620
How local versus systemic this signaling is and and what is affected by regular

01:15:39.180 --> 01:15:44.940
Cannabis use and how the body remodels those receptors remodels their expression in order to

01:15:45.660 --> 01:15:50.780
Tolerate or compensate for that being present in the system. So again

01:15:52.300 --> 01:15:55.980
We're talking about a million variables that are personal

01:15:56.860 --> 01:16:03.260
And we're simplifying down to a few arrows and a few pluses and minuses or reds and blue arrows up and down

01:16:05.820 --> 01:16:08.540
And the only real argument she's making is that

01:16:09.420 --> 01:16:13.340
Canabinoids are interesting because they're everywhere the receptors are everywhere

01:16:13.420 --> 01:16:18.940
They're involved in development and the immune system and the brain and everything that we are we think is important

01:16:20.380 --> 01:16:24.780
They're ubiquitous throughout the body. So what great that's interesting, but

01:16:25.580 --> 01:16:31.660
Again selling it as though this is the new be all end all is what I find most intriguing

01:16:32.700 --> 01:16:37.820
Really be cured of therapies for things even like autism spectrum disorders, um, which are

01:16:39.020 --> 01:16:44.780
In this family of myaltic encephalomyelitis that's inflammation of the brain and the muscles and adults

01:16:44.860 --> 01:16:47.500
They call it ME CFS and in in children

01:16:47.900 --> 01:16:50.060
They they end up with autism spectrum disorders

01:16:50.140 --> 01:16:56.780
But they're in the same they have the same types of immune disorders that an AIDS patient would have even in the absence of the virus

01:16:56.940 --> 01:17:04.460
Indicating other toxins going on so they're key to neural protection by cb1 driven endocannabinoids and phytopanhabinoids

01:17:05.180 --> 01:17:08.780
Right in the middle you see the intersection between the immune system

01:17:09.580 --> 01:17:10.380
and

01:17:10.380 --> 01:17:14.540
And the uh the brain and the immune system in the brain are really connected

01:17:15.020 --> 01:17:21.820
From conception and we and we know this now and the immune system is the brain is not what we used to consider

01:17:22.060 --> 01:17:24.300
immune privilege by immune privilege

01:17:24.300 --> 01:17:31.100
We means that you could have an inflammation of an antigen and it would not stimulate an inflammatory response

01:17:31.420 --> 01:17:33.420
That's simply not true

01:17:33.500 --> 01:17:35.500
Because the microglia

01:17:35.980 --> 01:17:40.620
Traffics the brain that means it starts in the bone marrow and those myeloid cells that I showed

01:17:40.780 --> 01:17:46.460
I'm that the first few slides and the brain derived monocyte macrophage is trafficked by

01:17:47.180 --> 01:17:53.020
Molecules known as chemokines those molecules known as chemokines are also regulated epigenetically that means

01:17:53.500 --> 01:17:57.180
At the expression level so while you can inherit changes in that

01:17:57.580 --> 01:18:04.700
Toxins in our environment like aluminum like mercury some of the things that they're shown to be so heavily associated with the development of

01:18:05.420 --> 01:18:11.660
Alzheimer's diseases those those and and autism spectrum disorders are that that pathogenesis is

01:18:12.060 --> 01:18:17.180
Hypothesized and and now more and more data support to be driven by activated microglia

01:18:17.500 --> 01:18:22.460
So you see the microglia is at the interface because they express both cb2

01:18:22.460 --> 01:18:24.460
um

01:18:24.460 --> 01:18:26.460
cannabinoid receptor number two

01:18:26.460 --> 01:18:35.500
And they cross talk they talk all day to the astraglia and the the astrocytes and the astraglia are important in glioblastoma the brain cancers

01:18:35.500 --> 01:18:43.260
We all um, you know, know of the upregulation and so really what we're listening to here is that endocannabinoid receptors are everywhere

01:18:43.260 --> 01:18:45.820
They're involved in a lot of things because they are everywhere

01:18:46.620 --> 01:18:50.460
And they can have some effect in an experimental setting on a lot of different things

01:18:50.540 --> 01:18:52.140
They can be shown to be

01:18:52.140 --> 01:18:56.220
Related to a lot of different systems again because they're g protein coupled receptors

01:18:56.220 --> 01:19:04.700
They can play a role in a lot of different systems and can be a a system wide regulator of things depending on how that that local circuit is organized

01:19:05.260 --> 01:19:09.740
But all these arrows pointing to neural protection all these arrows pointing to

01:19:10.380 --> 01:19:13.900
Regulation of the immune system is just making the argument to

01:19:14.620 --> 01:19:16.780
Look at cannabis as a plant

01:19:16.780 --> 01:19:18.780
To look at cannabis as a species

01:19:19.100 --> 01:19:22.220
To start dissecting its genome and start looking for

01:19:22.780 --> 01:19:28.380
candidate compounds that the pharmaceutical companies can synthetically make and use in these treatments

01:19:28.460 --> 01:19:33.420
Increase of the of the brain cancers the glioblastoma is in in our world

01:19:34.220 --> 01:19:40.060
And and it's it's proposed that cannabinoids and in fact really shown therapeutically

01:19:40.380 --> 01:19:45.820
That they can be not only helpful, but in this slide actually curative for these devastating brain cancers that

01:19:46.620 --> 01:19:51.500
That that killed vice president biden joe biden son a few years ago

01:19:51.580 --> 01:19:54.060
So crit it critical in thinking about therapeutic

01:19:54.540 --> 01:20:00.460
Opportunities where the micro glia by simply deactivating so it's the activated micro glia

01:20:00.460 --> 01:20:04.700
That is pathogenic because it releases that inflammatory nf cafe

01:20:05.260 --> 01:20:12.300
In that it releases the way way way way what this is 2018. Why did she say president biden son

01:20:13.260 --> 01:20:17.180
Did she say president biden son what in the hell wait?

01:20:18.380 --> 01:20:20.380
Is that right?

01:20:22.140 --> 01:20:28.620
What the full and thinking about therapeutic opportunities where the micro glia by simply deactivating

01:20:28.860 --> 01:20:35.260
So it's the activated micro glia that is pathogenic because it releases that inflammatory nf cafe

01:20:35.740 --> 01:20:42.060
In that it releases the activity pro inflammatory cytokines that reactivized oxygen and nitrogen species

01:20:42.380 --> 01:20:49.340
And really is driving the the breakdown so you want that cannabinoid receptor 2 through dgf beta through

01:20:49.580 --> 01:20:57.820
Thc to down regulate as we saw in the last slide to down regulate and actually allow cb1 to drive neural protection

01:20:58.140 --> 01:20:59.020
So

01:20:59.100 --> 01:21:02.060
The metabolic um substrates and the anti

01:21:02.460 --> 01:21:05.500
Undiant inflammatory tdf beta are really critical to it

01:21:05.660 --> 01:21:13.580
And it's this cross talk between the micro glia and the astraglia and the expression of both and probably through antioxidant in other

01:21:14.060 --> 01:21:19.500
Non-canonical cannabinoid receptors that modulate all of these processes non-canonical

01:21:20.140 --> 01:21:25.100
A non-canonical cannabinoid receptors are ones that they haven't identified and characterized yet

01:21:25.980 --> 01:21:32.700
See what we're talking about here. She's talking about cb1 and cb2, but then they're all non-canonical cannabinoid receptors

01:21:32.700 --> 01:21:34.700
How many of those are there Judy?

01:21:35.100 --> 01:21:42.300
The excitement is there for for all of us that um, um, that we we've probably uncovered a key therapeutic entity that can

01:21:42.780 --> 01:21:47.260
Um, that can actually cure some of the most devastating diseases of our time

01:21:47.740 --> 01:21:51.020
Um, the next slide shows even further to that

01:21:51.420 --> 01:21:55.820
Um, now they're being detected that they're actually cb1 receptors

01:21:57.660 --> 01:21:58.940
On the

01:21:58.940 --> 01:22:00.060
Mykandria

01:22:00.060 --> 01:22:04.780
So in on the astrocyte, I we blew up in in a paper that I've referenced

01:22:05.340 --> 01:22:12.140
Somewhere in here. I'll make sure I put the reference on paper. Um, but this is a january 2018 paper in the journal of neuro

01:22:12.860 --> 01:22:14.860
um, psychopharmacology

01:22:15.100 --> 01:22:18.060
And this paper talks about the the title of it is

01:22:18.620 --> 01:22:21.820
um, cb1 receptors from ubiquity to specificity

01:22:21.980 --> 01:22:26.940
So cb1 receptors in the endocannabinoid system they're expressed on essentially every cell

01:22:27.340 --> 01:22:33.420
In the body and every tissue and in every disease from cardiovascular disease to lung disease could be a part of those

01:22:33.740 --> 01:22:37.260
um neurons, um and and communications with the astrocytes

01:22:37.740 --> 01:22:41.500
Being dysregulated you see here the little um, G protein coupled receptor

01:22:41.740 --> 01:22:47.820
So they say they signaling through these G protein coupled receptors and the astrocyte there and the brain

01:22:48.380 --> 01:22:50.380
Um, we actually see these receptors

01:22:50.700 --> 01:22:52.060
um

01:22:52.060 --> 01:22:57.820
not only on the neuron and that the synaptic cleft driving um in the endogenous cannabinoid signaling

01:22:58.060 --> 01:23:00.780
For for neurological increase in apps and synapse

01:23:00.860 --> 01:23:02.300
This is driving all neurons

01:23:02.300 --> 01:23:03.980
So when we think about these

01:23:03.980 --> 01:23:09.340
fasticity diseases that that I talked about with ALS and and multiple sclerosis

01:23:09.900 --> 01:23:11.900
um, uh, lugere

01:23:11.900 --> 01:23:17.740
Parkinson's disease the fasciculations the um, the the seizures in the children with autism spectrum

01:23:17.740 --> 01:23:23.900
Disorders, it's these receptors that are being dysregulated the psychoses even the psychoses

01:23:23.900 --> 01:23:31.900
We see in young people who have dysregulated cb1 receptors. In fact, it's the it's the um, the agonist of the cb2

01:23:32.380 --> 01:23:38.220
Um, the thc that could actually stop the psychoses rather than driving the addiction as we think

01:23:38.460 --> 01:23:42.300
So here we have the communication between the neurons expressing

01:23:42.620 --> 01:23:49.020
Cross-talking receptors and the astrocytes and the calcium signaling that that is discussed in the ion channels

01:23:49.260 --> 01:23:54.940
And we show now the next point that the cannabinoids are actually there if we blow up in that

01:23:55.260 --> 01:23:56.220
um

01:23:56.220 --> 01:24:01.260
In that neuron the brain the heart and the muscles have the most mitochondria

01:24:01.580 --> 01:24:09.580
So this is because that's the energy powerhouses of of of your entire body with that without the mitochondria

01:24:09.820 --> 01:24:13.980
um, with the respiratory chain leading to 36 ATP versus two

01:24:14.300 --> 01:24:18.300
You can think about all of these diseases myaltic encephalomyelitis

01:24:18.860 --> 01:24:25.340
Um, is is inflammation of the brain and the muscles and it's long been been known to be a mitochondrial disease

01:24:25.580 --> 01:24:29.020
Um, and and now we can start begin to understand

01:24:29.580 --> 01:24:35.260
Um, that the cannabinoid signal through mitochondria right in the right hand slide. You see the mitochondria

01:24:35.660 --> 01:24:39.580
Actually has a mitochondrial cb1 signal

01:24:40.220 --> 01:24:42.860
So that so that you could actually generate

01:24:43.820 --> 01:24:51.580
Energy and and and read restore energy at the level of really restoring function and and these are the mitochondrial disease

01:24:51.580 --> 01:24:56.940
See wherever she finds a mitochondrial, uh, sorry wherever she finds a cannabinoid receptor

01:24:56.940 --> 01:25:02.140
Then she makes a story up about what you could potentially do with a cannabinoid that targeted that

01:25:02.860 --> 01:25:07.980
So now she's going to tell you that you could generate energy with cannabinoids you can you can be

01:25:08.860 --> 01:25:15.420
Protecting of neurons in five different ways because they're they're there and they're there and they're there and they're here and they're there and they

01:25:15.980 --> 01:25:22.620
They cause blood cells to differentiate into myeloid cells and they just you know it this kind of

01:25:24.060 --> 01:25:27.260
This kind of throwing a net over something

01:25:27.740 --> 01:25:31.340
Like a cannabinoid receptor and then claiming all of its

01:25:31.900 --> 01:25:33.900
relevance based on where it's found

01:25:34.300 --> 01:25:41.020
Is something that almost everyone in biology does when they have a pet receptor or a pet ion channel

01:25:41.660 --> 01:25:48.140
If you study calcium gated potassium channels and you notice that they're in every neuron

01:25:49.100 --> 01:25:56.700
That their expression changes during development that they're also found in cardiac neurons that they're also found in cardiac muscle

01:25:56.700 --> 01:26:01.580
That they're also found in all these places and then you can start to say that's that calcium

01:26:02.380 --> 01:26:07.340
Gated sodium channels are sorry calcium gated potassium channels are the most important

01:26:08.140 --> 01:26:09.420
channels

01:26:09.420 --> 01:26:13.100
In the whole body because they regulate neuronal function

01:26:13.100 --> 01:26:18.220
They regulate action potential half width they regulate and I could go on and on and on and on and on

01:26:19.980 --> 01:26:26.140
And then I can make a long argument about how conotoxins and and appamen from bees

01:26:26.540 --> 01:26:34.620
Are two things that interact with sk channels and we should look for more drugs that act with sk channels because sk channels are everywhere

01:26:39.420 --> 01:26:46.220
And it's no different than saying that well, we think we found some cannabinoid receptors subtypes on the mitochondria

01:26:46.300 --> 01:26:50.460
So obviously we can generate energy with it's just ridiculous

01:26:51.420 --> 01:26:53.420
But

01:26:53.420 --> 01:26:57.100
This is exactly how academic biology has been broken

01:26:58.300 --> 01:27:02.540
Because there is an impetus to to use this technique

01:27:04.300 --> 01:27:09.740
That gets you grants that makes you untouchable in this really narrow

01:27:10.300 --> 01:27:18.140
Fine band of understanding that no other academic can really encroach on because they don't study the cannabinoids that she does

01:27:18.460 --> 01:27:25.420
They don't study it at the level that she does they're they're not looking to modulate the things that she's looking to modulate

01:27:25.500 --> 01:27:27.980
And she doesn't they work for different companies. That's all

01:27:29.660 --> 01:27:32.540
These are devastated where children actually die before

01:27:33.180 --> 01:27:38.700
They're a few years old if they have a primary deficiency in any one of the chains of the mitochondria

01:27:39.180 --> 01:27:44.780
Respiratory chain in in any of these that that leads to certain death because you can't feel your brain

01:27:45.100 --> 01:27:48.940
Your heart or your muscles if you can't generate enough energy

01:27:48.940 --> 01:27:54.620
So here the cannabinoids are are even a key to the respiratory transport chain

01:27:54.780 --> 01:28:00.860
And there's that reference for that paper in neuropsycho pharmacology, but there's a question mark in the

01:28:01.260 --> 01:28:07.340
Cartoon for a discussion like this is we start to really dig into seeing it's a question mark

01:28:07.900 --> 01:28:10.460
Homeostasis that's a balance in our energy

01:28:11.100 --> 01:28:17.980
In in some of these devastating diseases of an inability to it's really an inability to fuel the brain and the heart

01:28:18.380 --> 01:28:19.980
So it's it's now energy

01:28:19.980 --> 01:28:26.060
It has nothing to do with misfolded proteins or any of the other stuff that we're supposed to pay attention to in those diseases

01:28:26.060 --> 01:28:28.060
Don't you see how cool this is?

01:28:28.460 --> 01:28:34.300
Some of those diseases have misfolded proteins in them and we're not even close to talking about that yet

01:28:35.820 --> 01:28:38.300
They haven't even come close. You see it

01:28:39.260 --> 01:28:43.500
Remember there's misfolded proteins in frickin cancer

01:28:44.140 --> 01:28:48.220
Don't you remember the lady from mit that we just watched a couple days ago

01:28:48.940 --> 01:28:50.940
She told us that these heat shock proteins

01:28:51.660 --> 01:28:54.620
Our vital responses in cancer and that cancer

01:28:54.940 --> 01:28:57.660
It happens because there's some misfolding stuff

01:28:59.100 --> 01:29:01.100
She works on cancer

01:29:01.260 --> 01:29:06.460
She worked at the national cancer institute for many a year. I don't hear anything about protein misfolding right now

01:29:06.540 --> 01:29:08.460
She's talking about all kinds of

01:29:08.460 --> 01:29:14.700
Cognitive developmental disorders that have protein mis I'm not hearing anything. It's just all cannabinoid receptors

01:29:16.380 --> 01:29:20.860
That is how academic biology has been broken ladies and gentlemen

01:29:22.860 --> 01:29:27.820
And the muscles at the same time because of of defects and pathogens on most viruses

01:29:28.220 --> 01:29:34.540
Will take out the mitochondria because they need the energy as well. So I show schematically on the next slide

01:29:35.340 --> 01:29:40.700
All of the ways that phyto cannabinoid so we've been talking about just our endogenous cannabinoids

01:29:40.700 --> 01:29:46.740
Which we which we produce on our own throughout our lifetime, but as toxins further and further

01:29:47.100 --> 01:29:48.460
dysregulate

01:29:48.460 --> 01:29:54.060
Our immune system in our endocannabinoid system because we haven't had plant sources

01:29:54.540 --> 01:29:59.100
Of cannabinoids whether it be hemp which has been outlawed since the 1930s

01:30:00.060 --> 01:30:02.060
Is from cannabis sativa

01:30:02.620 --> 01:30:04.460
And and the th she containing

01:30:05.100 --> 01:30:11.260
Medical marijuana. It's called they're all cannabis sativa or in the car the main major strains because that's been out of our diet

01:30:11.340 --> 01:30:16.540
Out of our world and the toxins that dysregulate the machinery that so now we need to eat

01:30:17.100 --> 01:30:22.460
Cannabinoids we need to ingest them because our body can't make them what is going on here

01:30:24.860 --> 01:30:27.260
That's a very interesting statement now, isn't it?

01:30:29.660 --> 01:30:34.300
Wow, I'm I'm and there they are all timers Parkinson's those are all

01:30:34.940 --> 01:30:42.620
Those are all misfolding disorders at least according to some academic biologists with a certain narrow point of view about them

01:30:44.780 --> 01:30:51.420
She thinks it's more related to endocannabinoid dysregulation of energy consumption and fueling the brain or whatever she said

01:30:52.380 --> 01:30:56.460
Maybe microglia responses being regulated by endocannabinoid receptors

01:30:57.020 --> 01:31:02.780
Amazing talk just shown you on the past few slides have been increasing in our world and we really have

01:31:03.420 --> 01:31:06.860
No response no therapeutic entity to simulate

01:31:07.580 --> 01:31:14.140
The phyto cannabinoids are are ones that have been used historically more than 14,000 years

01:31:14.700 --> 01:31:19.980
To to really mitigate and prevent the progression and development of these diseases

01:31:20.060 --> 01:31:23.100
So they mitigate neuro trauma ischemia is loss of oxidants

01:31:23.100 --> 01:31:27.020
So we talked about those reactive oxygen species and driving

01:31:27.340 --> 01:31:34.460
Oxidative stress starving off tissue. So ischemia is the problem in stroke major depressive disorders Alzheimer's disease. It's um

01:31:35.340 --> 01:31:39.340
Everything we've talked about in the last few slides are are interacting from that

01:31:40.140 --> 01:31:45.740
neuron where the immune cells the microglia the oligodendrocyte and the astrocyte are communicating

01:31:45.980 --> 01:31:48.780
Viya the cytokines chemokines growth factors

01:31:49.020 --> 01:31:54.860
Neuro transmitters like nrf2 and and neuro hormones like for instance vitamin D critical

01:31:55.340 --> 01:32:01.660
So these all of these things go to disrupt the balance we call it the homeostasis at the at the level of the brain

01:32:02.300 --> 01:32:06.780
And and this is what's driving. So if we can take phyto cannabinoids from plants

01:32:07.100 --> 01:32:11.260
We can dampen that tissue injury we can prevent the progression of diseases

01:32:11.420 --> 01:32:18.060
And in fact, as we saw a few slides ago, we could um, we could target neurogenesis once we once we've stopped the issue

01:32:18.060 --> 01:32:22.540
So essentially she's saying that none of these diseases have to do with diet

01:32:22.700 --> 01:32:25.900
None of these diseases have to do with environmental toxins

01:32:26.860 --> 01:32:28.860
They have to do with our lack of phyto

01:32:29.900 --> 01:32:35.260
cannabinoids and not using these and eating these plants anymore or something like that

01:32:35.420 --> 01:32:39.260
I'm assuming that there are other plants that have phyto cannabinoids besides marijuana

01:32:39.900 --> 01:32:41.100
um

01:32:41.260 --> 01:32:43.260
What an interesting talk

01:32:44.140 --> 01:32:51.660
And actually regenerate healthy neurons and neurological um function and and you know, literally, um cure these diseases

01:32:51.980 --> 01:32:53.980
Um, and cure these diseases

01:32:54.620 --> 01:32:55.980
scientific opinion

01:32:55.980 --> 01:32:58.540
Um, as as slide as the next slide shows

01:32:58.940 --> 01:33:04.860
It's really the tissue macrophage that is driving all of these processes. We've talked about micro glia

01:33:05.100 --> 01:33:08.860
Um, and and that's the brain macrophage. Well, the keratinocyte

01:33:08.940 --> 01:33:13.260
Let's stop here and just marvel at the number of macrophages there are

01:33:14.220 --> 01:33:20.380
Number marvel at the macrophage diversity that no one ever acknowledges at all

01:33:25.980 --> 01:33:33.100
Is the skin macrophage so we think of all of the uh, we think of all the skin diseases and that we see um, the very

01:33:33.660 --> 01:33:42.300
Devastating skin diseases that that could in fact, um, be be regulated by a cannabinoids via, um, the the cb2 receptor

01:33:42.620 --> 01:33:48.780
That that we show thc the psychoactive thc actually acts to drive, um, the various macrophages

01:33:48.780 --> 01:33:55.260
So each different organ system from the lung alveolar macrophage. So here we can use cannabinoids for

01:33:56.060 --> 01:34:02.620
Lung cancer as part of immune therapy in in our world. We've developed we developed, um, drugs at the national cancer institute

01:34:02.780 --> 01:34:09.100
And through various pharmaceutical companies like epigenetics, um, for the last 30 or 40 years getting old here

01:34:09.500 --> 01:34:13.500
But but you can you can target in copd the alveolar macrophage

01:34:13.500 --> 01:34:18.860
So we can think of all the allergens and microorganisms that are that are driving more and more copd

01:34:18.860 --> 01:34:23.660
Which is, um, chronic obstructive pulmonary diseases. Um, we look at the liver cup for cells

01:34:23.660 --> 01:34:27.820
So this is the cell that's critical to hepatitis c hepatitis b

01:34:27.980 --> 01:34:34.300
Um, hbrb and primary billery cirrhosis cirrhosis of the liver. We think of fatty liver disease

01:34:34.300 --> 01:34:39.740
I, um, I think, um of all of the um, stories. I've been reading, uh, in the in the journals lately

01:34:39.740 --> 01:34:43.020
It's the huge incidence in fatty liver diseases

01:34:43.740 --> 01:34:46.220
In people under 50 whether it be men or women

01:34:46.300 --> 01:34:49.660
And I showed you that the dipisite slide in the in the fat progenitor

01:34:49.740 --> 01:34:54.780
So if you're driving the cb1 because of toxins because you don't have enough cb2

01:34:55.100 --> 01:35:00.700
Driving the monocyte macrophage then you can see how all of the diseases and then some that I put

01:35:00.700 --> 01:35:02.700
See you don't have enough cbd

01:35:03.580 --> 01:35:10.300
Do you don't have enough cannabinoids driving the cb2 receptor? It is exactly this kind of ridiculous

01:35:11.180 --> 01:35:18.940
Simplification reductionist biology that has contaminated and destroyed our academic biological fields our medical science

01:35:19.580 --> 01:35:22.220
And this is just a use of that technique

01:35:22.860 --> 01:35:30.460
To present the primacy of the cb1 and cb2 receptors to make an argument that these are a new kind of

01:35:31.180 --> 01:35:34.380
Of receptor to target a new novel idea

01:35:34.940 --> 01:35:39.740
Um, that's just gaining traction that has all kinds of applications in the future

01:35:40.300 --> 01:35:46.380
For the coming 21st century of acquired immune deficiency syndromes, you know like flying aids

01:35:47.340 --> 01:35:49.820
on that on that first introductory slide

01:35:50.220 --> 01:35:54.220
Could be mitigated at some level by the right combination of

01:35:54.780 --> 01:36:00.140
Fido cannabinoids now from plants because of course our endogenous ones simply aren't enough to overcome

01:36:00.540 --> 01:36:05.340
Um, what is already not enough process because we've been without them. We don't have enough last time

01:36:06.060 --> 01:36:10.940
Most people experience the endogenous cannabinoids is during breastfeeding

01:36:11.420 --> 01:36:17.260
Because that's when mom is elaborating and producing many of them through the milk and babies getting that calming pain free

01:36:17.820 --> 01:36:20.780
Learn to suckle and mom and baby or go. That's the last time

01:36:21.100 --> 01:36:24.620
That's the last time we've had endocannabinoids is when we were breastfeeding

01:36:25.100 --> 01:36:29.260
Wow, that's a weird statement our brain makes them all the time

01:36:30.140 --> 01:36:35.100
Where does she think they come from idea of of joy anandamide one of the key

01:36:35.820 --> 01:36:39.500
Endogenous cannabinoids anandamide is sanskrit meaning joy

01:36:39.580 --> 01:36:45.980
So the cannabinoid system could be seen as joy pain free happy stress-free living and you can see at every level

01:36:45.980 --> 01:36:47.980
The macropage that cb2

01:36:48.940 --> 01:36:50.860
Endogenous

01:36:50.860 --> 01:36:52.620
Babies are broken

01:36:52.620 --> 01:36:58.380
Not in a like over, you know, I don't want to be overly dramatic but there is no question

01:36:59.340 --> 01:37:03.980
That breastfeeding if it can be done without pain and suffering by the mom

01:37:04.620 --> 01:37:12.300
Breastfeeding is so far beyond superior to anything else that should never be considered to be dropped

01:37:14.060 --> 01:37:19.900
There should be a full-time effort by the husband and the wife over many days to make that work

01:37:20.780 --> 01:37:22.780
with the help of a

01:37:23.020 --> 01:37:25.020
anyone

01:37:25.340 --> 01:37:31.580
And that should be given up at the very last resort and I don't I don't think everybody's going to be really happy hearing me say that

01:37:32.700 --> 01:37:35.580
But i'm saying it as I defend my my

01:37:36.460 --> 01:37:38.460
best friend

01:37:38.460 --> 01:37:44.940
For maybe the only reason why our daughter who's had the entire goddamn schedule since we got here in america

01:37:45.420 --> 01:37:48.140
Is not damaged as much as she could be

01:37:48.540 --> 01:37:53.180
Is because my wife had the wherewithal to breastfeed her until she was almost five years old

01:37:55.580 --> 01:37:58.540
Now our middle son was actually treated very differently

01:37:58.620 --> 01:38:03.420
But our middle son was grow grew up in with his toddler years in the netherland

01:38:03.500 --> 01:38:08.300
So he didn't have the same kind of assault on his immune system that my daughter did here

01:38:11.580 --> 01:38:13.580
But oh my gosh

01:38:15.180 --> 01:38:19.500
If there is anything that bonds a woman with a child that is breastfeeding

01:38:20.300 --> 01:38:21.820
And

01:38:21.820 --> 01:38:26.780
Just talking about missing out on that can make my wife break down in tears

01:38:29.820 --> 01:38:34.780
I think she considers these some of the most important moments of her life

01:38:37.260 --> 01:38:43.420
And I think that every day that she think that she's asked to think about it. She thinks maybe she would want another child

01:38:44.700 --> 01:38:46.700
That's how beautiful it is

01:38:49.500 --> 01:38:51.500
And

01:38:53.980 --> 01:38:58.700
It is impossible as a man to understand the kinds of things that a woman goes through

01:38:59.420 --> 01:39:03.660
From the moment of conception until a child leaves the house

01:39:05.340 --> 01:39:11.740
And no matter what you want to think of yourself as a father, there's no way that you can possibly understand we can possibly understand

01:39:13.020 --> 01:39:17.500
What it will means to carry a child to give birth to a child to breastfeed a child

01:39:19.660 --> 01:39:21.660
And the idea that we would

01:39:22.380 --> 01:39:26.140
Abbreviate that process or punctuate that process in any way

01:39:28.220 --> 01:39:32.060
It's just it's an abomination ladies and gentlemen. It's an abomination

01:39:36.300 --> 01:39:39.420
And so I don't know what she's talking about here with endocannabinoids and breastfeeding

01:39:39.420 --> 01:39:43.740
But I am pretty sure that your brain makes endocannabinoids all the time there necessary they're there

01:39:44.140 --> 01:39:49.420
But they are a modulator they play a role in the background like all the other instruments in a symphony does

01:39:49.500 --> 01:39:56.300
And if you take the piccolo out of the symphony, you can still recognize the song and it still goes and everybody can make it to the coda

01:39:57.820 --> 01:40:03.660
But there will be something missing and with cannabinoid receptors. This is a yet another knob to turn

01:40:03.740 --> 01:40:04.860
It's another

01:40:04.860 --> 01:40:08.220
Slider on the equalizer, but it's not the be-all end-all that

01:40:08.700 --> 01:40:12.380
Decides whether macrophages are working or whether they're sitting in the corner

01:40:13.180 --> 01:40:19.260
It's not the difference between well, my kid's brain is developing or it's not developing or my kids

01:40:19.820 --> 01:40:24.140
Got skits if any or it doesn't have skits if any because he doesn't have enough cannabinoids in his brain

01:40:24.220 --> 01:40:26.220
I guess we better give him some more

01:40:29.900 --> 01:40:36.940
Abenoid key to the development of the hematopaedic poetics stem cell is could be modulated in a in a way by cannabinoids

01:40:36.940 --> 01:40:41.580
In a positive way rather than a damaging way with the bone resorption here at the bottom of the screen

01:40:41.740 --> 01:40:43.740
some chronic um

01:40:43.740 --> 01:40:44.540
the

01:40:44.540 --> 01:40:47.980
IBD the inflammatory bio disease and Crohn's disease at the level of the

01:40:48.780 --> 01:40:55.580
Intestinal macrophages. So so many of these diseases by gently modulating the macrophages at the level of the mild

01:40:55.580 --> 01:41:01.100
So rather than take care of the result the pathogenic state whatever poison you have

01:41:01.100 --> 01:41:02.300
What other

01:41:02.300 --> 01:41:06.220
Environmental toxin you're exposed to or whatever other thing was dysregulated

01:41:06.700 --> 01:41:12.620
Let's just give them a substance which fixes that they're not on the right medication is the answer here

01:41:13.500 --> 01:41:15.500
People aren't on the right medications

01:41:16.220 --> 01:41:19.900
We need to get new medications to these people so we can cure their problems

01:41:20.380 --> 01:41:25.260
Rather than going to the root cause which would be real health and well-being right

01:41:25.980 --> 01:41:29.660
That's health and wellness. This is not medicine. This is pharmaceuticals

01:41:30.460 --> 01:41:35.580
Once you see it you can't unsee it. I think this is this was the best thing

01:41:35.580 --> 01:41:36.940
We could have done with Judy

01:41:36.940 --> 01:41:40.940
But stem cell could actually be curative by looking at in these ways

01:41:41.260 --> 01:41:43.820
I highlight the cross talk in in the next slide

01:41:44.380 --> 01:41:51.580
To show you the pairing so cross talk of receptor. So opioid receptors are also a little deep

01:41:51.580 --> 01:41:57.500
But that's the great this is the perfect slide for which to do this right? So what happens? How do they target this?

01:41:58.460 --> 01:42:04.220
How do they get the serotonin receptors to be hit or the dopamine receptors to be hit

01:42:04.620 --> 01:42:09.820
And modulated by the cv1 stimulation, but not the orexin receptors or the chemokine receptors

01:42:09.820 --> 01:42:11.980
How do they manage to do that?

01:42:13.580 --> 01:42:15.580
Put a tag on it

01:42:15.580 --> 01:42:20.460
Electropyrated in the right places. Come on guys. You can see it Pamela sees it

01:42:21.020 --> 01:42:23.260
Link receptors there to these channels

01:42:23.260 --> 01:42:28.620
I show you cv1 and that cross talk doesn't only have to happen between the cv1 and cv2

01:42:29.020 --> 01:42:32.060
It can happen through these to these opioid receptors

01:42:32.220 --> 01:42:38.220
So anxiety and depression and chronic diseases anxieties a type of pain. It's called it's a no-siception

01:42:38.460 --> 01:42:42.940
It's a different idea when we think of anxiety. So that's simply using cv1

01:42:43.500 --> 01:42:48.220
Rich and targeting agonists and preparations of cannabinoids can actually

01:42:48.940 --> 01:42:55.660
lead to tolerance and brain blocking pain blocking effects of opiate so it could actually reduce our opioid addiction

01:42:56.060 --> 01:42:58.220
And so again, we're talking about could

01:42:58.780 --> 01:43:04.140
Maybe because this receptor is there and that receptor is there and these things are involved in that

01:43:04.460 --> 01:43:07.020
We might be able to use this thing to do stuff

01:43:10.060 --> 01:43:15.260
And this is exactly how academic biology is broken because that's how they all talk

01:43:15.740 --> 01:43:21.900
That's how they always talk at the end of their talk. How many things can I catch with my net?

01:43:23.100 --> 01:43:24.060
Holy

01:43:24.060 --> 01:43:31.980
Cannabis, you know, and this is this is where understanding of biology and biochemistry helps us to break down these cultural walls that says oh no

01:43:32.380 --> 01:43:34.540
Cannabis is addictive and we can't have THC

01:43:34.780 --> 01:43:39.980
Well, as long as you prevent THC from signaling cv1 you won't get this psychoactive effects

01:43:40.300 --> 01:43:43.260
And we can do that because we can just build a stronger magnet

01:43:44.060 --> 01:43:47.820
Then THC to block those effects with that that happens now

01:43:48.060 --> 01:43:55.340
See so what she's actually suggesting is is that in order to get this right we're going to have to have a THC receptor one blocker

01:43:56.140 --> 01:44:03.820
Put in your brain so you don't get high and then we'll we'll we'll use a different one that the oh my gosh

01:44:03.980 --> 01:44:05.980
It's just disturbing how

01:44:06.540 --> 01:44:13.180
Ridiculous she sounds not only do you have no way of targeting any of these specific targets with your

01:44:14.140 --> 01:44:18.540
Hit cv1 receptor and every one of these pictures. So how is it specific?

01:44:20.780 --> 01:44:27.340
And then you're going to block specific cv2 receptors or cv1 receptors in the brain to get the cv2 receptors

01:44:27.820 --> 01:44:29.820
it's just all

01:44:32.860 --> 01:44:35.020
It's all hot air actually through

01:44:36.380 --> 01:44:39.980
Blockers of various immune molecules like inflammatory cytokine

01:44:40.220 --> 01:44:45.660
IL-1 which is central to many diseases of pain as an IL-1 receptor and hagginess

01:44:45.740 --> 01:44:52.940
So it actually is expressed in high levels IL-1 RA to block IL-1 once IL-1's job is done

01:44:53.180 --> 01:44:58.380
So that you don't overdo it and cause these addictions so on to depression and anxiety

01:44:58.380 --> 01:45:05.260
We think of serotonin receptors so soo spider billions of dollars are spent spinning wheels like this

01:45:05.500 --> 01:45:11.580
billions of dollars in grants are given to people who can talk exactly like this about a million different

01:45:12.220 --> 01:45:16.460
subjects of a tiny little flimsy part of some story

01:45:18.540 --> 01:45:25.340
And there are there are actually hundreds and hundreds of g protein coupled receptors that people are interested in

01:45:25.340 --> 01:45:28.700
Hundreds and hundreds of ionic receptors that people are interested in

01:45:29.180 --> 01:45:32.380
And it's it's each one of those can tell the same story

01:45:32.380 --> 01:45:35.500
I wasn't joking when I was saying that calcium

01:45:36.300 --> 01:45:38.300
small conductance

01:45:38.620 --> 01:45:42.940
Calcium activated potassium channels are one of many

01:45:43.660 --> 01:45:46.300
different subtypes of potassium channels

01:45:47.020 --> 01:45:53.660
Potassium channel biophysicists are very firm in their belief that potassium channels because they turn off

01:45:54.300 --> 01:46:00.460
the action potential because they reset the membrane of neurons and all electrical

01:46:01.260 --> 01:46:03.260
membrane

01:46:03.260 --> 01:46:05.020
in the body

01:46:05.020 --> 01:46:08.140
The potassium channels are the most important things to regulate

01:46:08.140 --> 01:46:10.300
They're the most important things to target

01:46:10.300 --> 01:46:14.140
They're the most important things that conduct the timing of the symphony

01:46:14.140 --> 01:46:18.060
And you can hear all of these people over many decades talking about how

01:46:18.780 --> 01:46:22.620
Primal they are to brain function even though they are a very tiny

01:46:23.500 --> 01:46:29.020
Channel that produces a very tiny amount of current only in response to the presence of calcium

01:46:30.460 --> 01:46:36.380
And so only at when synapses are learning which is also really reason why everybody's so interested in them for a long time

01:46:36.780 --> 01:46:41.020
And she's doing exactly the same thing with cannabinoids right now

01:46:41.420 --> 01:46:46.780
With regard to the brain and the immune system and inflammation and all of the major

01:46:47.660 --> 01:46:51.740
Acquired immune deficiencies of the 21st century. It's an incredible

01:46:52.540 --> 01:46:56.380
Talk so here again. This is where a therapeutic opportunity exists

01:46:57.180 --> 01:47:01.020
With with these memory impairments and these these diseases of serotonin

01:47:01.420 --> 01:47:05.900
receptors, which of course serotonin and dopamine receptors are key to Parkinson's disease

01:47:06.700 --> 01:47:08.700
And and a number of other

01:47:09.100 --> 01:47:14.940
You know, literally untreatable diseases at least thought of and until very recently Huntington's disease

01:47:15.340 --> 01:47:19.660
Is these adenosine receptors which are highly immune suppressive and and this is again

01:47:19.740 --> 01:47:24.060
It's usually a familial disease by a problem with the a2a receptors the adenosine receptors

01:47:24.300 --> 01:47:30.860
Where if you can come in here and have some cross talk in agonists of cb1 and up regulate you can ameliorate

01:47:30.860 --> 01:47:32.860
You can lessen the damage

01:47:33.260 --> 01:47:39.500
Of that genetic disease and stop the expression. So in in epigenetic worlds. It's it's the expression of the diseases

01:47:40.300 --> 01:47:46.940
Not not the genetic component which which are these familial diseases. So Huntington's disease runs in families

01:47:46.940 --> 01:47:51.500
But you don't have to die and you don't have to progress if you think of curative therapies

01:47:52.140 --> 01:47:54.140
Via modulating cb1

01:47:54.540 --> 01:47:56.620
You know finally at the bottom of the screen we have

01:47:57.340 --> 01:48:01.660
The chemokine receptors. Um, so the chemokine receptors are the trafficking molecules

01:48:01.900 --> 01:48:04.940
There what takes those blood monocytes to the brain

01:48:05.340 --> 01:48:10.380
So if you can down module there what takes cancer cells and leads to tumor metastasis

01:48:10.700 --> 01:48:16.460
If a prostate canter or any other cancer doesn't metastasize to the bone doesn't spread to the bone

01:48:16.780 --> 01:48:22.540
Via the trafficking molecule that takes them along by the hand and takes them to the place where they can live and thrive

01:48:22.860 --> 01:48:26.220
Then you don't die of cancer if you stop see that's weird

01:48:26.220 --> 01:48:30.140
She's talking about chemokines as if they deliver things that I don't think they do

01:48:30.140 --> 01:48:34.300
I think chemokines are are a concentration gradient signal

01:48:36.380 --> 01:48:38.620
And immune cells

01:48:39.740 --> 01:48:41.740
Will migrate

01:48:42.380 --> 01:48:47.580
Based on the concentration of chemokines and follow the concentration gradient to the source

01:48:48.540 --> 01:48:53.500
Which is a very different set of biological mechanisms and circumstances than a

01:48:53.980 --> 01:48:57.740
Something that takes things somewhere or delivers them places

01:48:58.220 --> 01:49:01.740
Which that's I don't think chemokine receptors do that

01:49:02.460 --> 01:49:04.460
It's so weird

01:49:04.460 --> 01:49:11.180
To the bone via the trafficking molecule that takes them along by the hand and takes them to the place where they can live and thrive

01:49:11.420 --> 01:49:15.500
Then you don't they do not get taken along by the hand. This is not this is wrong

01:49:15.580 --> 01:49:21.180
I I don't I don't know why we're die of cancer if you stop them metastasis

01:49:21.180 --> 01:49:26.860
And we have any number of drugs we've made over the last few years like andeogenesis inhibitors to stop cancer

01:49:27.180 --> 01:49:32.700
Spread because then you can you can live with it and and not die of it. So the next slide

01:49:33.420 --> 01:49:39.900
Highlights that that very cross talk idea when we talk about the pure allergic receptors. So purines

01:49:40.780 --> 01:49:44.380
Are our molecules like caffeine is a purine adenosine

01:49:44.780 --> 01:49:49.180
Guanine we have purines and perimeters that make up the base pairs of our DNA

01:49:49.580 --> 01:49:56.540
So in this open pain journal from 2010 it again earlier than then the the papers I could discussing today

01:49:56.940 --> 01:50:03.660
It showed where there were actually there was actually cross talk between that adenosine receptor on that monocyte macrophage

01:50:03.900 --> 01:50:09.500
And that activated M1 is it's the bad macrophage no matter if you're in cancer or anything else

01:50:09.900 --> 01:50:13.020
They're they're they're bad pro inflammatory when they get to M2

01:50:13.100 --> 01:50:20.940
That's driving the cancer or driving the neurological disease. And as you've shown here. It's affecting what we call it damage in a distance

01:50:21.740 --> 01:50:23.740
Venera, so that's by ATP

01:50:24.300 --> 01:50:31.820
Which is appearing and and so when these when ATP and those energy molecules get outside the cells because the cells are dying

01:50:32.140 --> 01:50:33.660
They become danger signals

01:50:33.660 --> 01:50:37.420
So they tell the immune system to shut down and become immune suppressive

01:50:37.500 --> 01:50:41.820
And so it's this cross talk and and and the suppression of these inflammatory cytokines

01:50:42.540 --> 01:50:50.220
That that is a problem because an immune suppressed person will develop cancer or progress in cancer because you need the right immunity

01:50:50.380 --> 01:50:57.500
And that's what I'm pretty sure that this very poorly cited volume three pain journal from 2010 does not

01:50:58.300 --> 01:51:01.020
Actually establish this any of this is fact

01:51:01.420 --> 01:51:05.020
But it's really neat that she can explain it as though it does

01:51:05.500 --> 01:51:09.580
And that again is exactly how academic biology has been broken

01:51:09.980 --> 01:51:15.100
Where you need that stem cell at the very beginning with TGFa to driving that hematopoietic stem cell

01:51:15.340 --> 01:51:20.060
Away from the myeloid lineage that is toxic the activated and inflammatory

01:51:20.300 --> 01:51:25.980
See she's going all the way back to the first stage to try and tell you that we're already talking about how

01:51:26.620 --> 01:51:29.740
Blood cells are generated how their differentiation is is

01:51:30.220 --> 01:51:35.260
Is controlled like a plinko machine with different. I mean this is amazing

01:51:36.380 --> 01:51:40.940
It is amazing because this is not informing anyone. This is not

01:51:41.580 --> 01:51:48.860
Teaching anybody this has nothing to do with protein misfolding nothing to do with vaccines and it's 2018

01:51:51.580 --> 01:51:57.660
If you just paid attention to Judy mikovitt since the start of the pandemic you would never know that she didn't work for chd

01:51:58.460 --> 01:52:02.620
You would know you would think that she has done lots of streams with like

01:52:03.180 --> 01:52:07.660
All the major anti-vaxxers for a very long time and has been on their team for years

01:52:09.020 --> 01:52:11.020
Apparently not

01:52:11.260 --> 01:52:15.740
Apparently she made her money in other ways apparently she wasn't always an anti-vaccine grifter

01:52:19.500 --> 01:52:23.820
If that's what people characterize her as now it's the resting um microglia

01:52:23.820 --> 01:52:26.940
Which is doing its job of surveilling and removing toxins

01:52:27.260 --> 01:52:31.340
So the next slide shows you just a list of all of the effects

01:52:31.340 --> 01:52:35.820
So the plant derived phytocannabinoids are known as dHC as we've discussed it linked

01:52:36.060 --> 01:52:39.660
CBD which canabidiols are really the main constituents of

01:52:40.380 --> 01:52:42.940
Canab a big girl. I didn't know what that was. What's that?

01:52:43.580 --> 01:52:48.380
THC opportunity in most but from sativa and indica these have been traditionally known

01:52:48.940 --> 01:52:55.020
To to benefit patients with these various diseases and the canabajera which metabolizes into more

01:52:55.260 --> 01:52:56.140
THC

01:52:56.140 --> 01:53:00.940
Also again now we understand that's because of its regulation of the amatopoietic stem cell

01:53:01.580 --> 01:53:08.380
Having the anti-inflammatory and inflammatory agents so we can use these depending on the concentrations of the drugs

01:53:08.780 --> 01:53:14.140
To to actually help anti-psychotics work better. Um, essentially every drug we use

01:53:14.460 --> 01:53:16.460
Oh

01:53:16.540 --> 01:53:18.540
There it is

01:53:18.540 --> 01:53:24.780
We're going to use canabinoids to make every drug we have work better

01:53:29.740 --> 01:53:34.540
You just heard it right there. I'm going to play it again. That's the end. That's that's it

01:53:34.620 --> 01:53:37.420
That there we solved the problem now. That was pretty easy

01:53:37.820 --> 01:53:45.420
Health anti-psychotics work better. Um, essentially every drug we used in in cancer or immune diseases right now

01:53:45.740 --> 01:53:48.860
We can just supplement and we can take advantage of synergies

01:53:48.940 --> 01:53:55.980
Absolutely take advantage of synergies now we can repurpose all kinds of previously on useless patented drugs

01:53:56.300 --> 01:54:03.980
And and confound the effects of those drugs by applying them co-applying them with cannabinoids that stimulate everything

01:54:04.540 --> 01:54:08.380
That makes perfect sense. How else were we going to end all

01:54:09.260 --> 01:54:12.460
Clinical trials of anything meaningful if we didn't do it like this

01:54:12.460 --> 01:54:14.460
And derive

01:54:15.020 --> 01:54:23.980
Um, the phytocannabinoids here shown here and and and lessen the actual drug that the therapy that we're using and lessen the off-target or side effects

01:54:24.540 --> 01:54:30.780
So lesson that side effects. Do you see it? This is exactly the plan

01:54:32.380 --> 01:54:38.140
Cannabis is going to come to the rescue as we change our vaccine schedule over to genetic therapies

01:54:38.620 --> 01:54:47.500
It's going to come to the rescue as we as we barrel forward into this era of health public health injury disguised as

01:54:49.020 --> 01:54:52.700
21st century acquired immune deficiency syndromes whole

01:54:53.260 --> 01:54:58.700
There are so can cannabinoids phytocannabinoids are part of a class of compounds known as terpies

01:54:58.940 --> 01:55:06.380
So on this next slide. I show you um, all of the immunomodulatory and anti-inflammatory terpies

01:55:06.700 --> 01:55:14.060
So this starts to give us some insight starts to give us some insight in the fact that a lot of these terpines that are found in pine are actually

01:55:14.540 --> 01:55:18.140
I think probably the least investigated most valuable

01:55:18.940 --> 01:55:25.340
Potential organic compounds out there. I actually had a really interesting conversation with a crazy person

01:55:25.820 --> 01:55:31.020
When I was at society for neuroscience meeting in new Orleans in 2008

01:55:31.980 --> 01:55:36.780
I was walking on the street and some random guy stopped me. He was carrying a gigantic

01:55:37.980 --> 01:55:41.420
Walking staff and at the top of the walking staff had a carved

01:55:41.660 --> 01:55:43.660
Uh a pinecone

01:55:43.660 --> 01:55:48.780
And he insisted that I sit down on this bench and listen to him talk about how pinecone and

01:55:49.260 --> 01:55:54.540
The terpines in pine actually were a secret that have been known since the Egyptians

01:55:55.260 --> 01:55:57.500
And that's the reason why the papal

01:55:57.980 --> 01:55:59.500
the papal

01:55:59.500 --> 01:56:06.060
Crucifix has a pinecone on it and why there's pine cones in in Egypt and all sort of stuff and it was crazy how

01:56:06.620 --> 01:56:08.620
I mean this dude

01:56:08.860 --> 01:56:11.020
Was telling me something like he thought

01:56:12.860 --> 01:56:15.420
It was his last chance to tell somebody the truth

01:56:16.220 --> 01:56:19.340
Was a very moving presentation that ended with me

01:56:19.900 --> 01:56:24.380
Shaking his hand and walking back to my hotel, but it was it's interesting that she brings this up

01:56:25.020 --> 01:56:26.380
as to the plants

01:56:26.380 --> 01:56:32.860
So one of the things that indica or hemp have the most of is the other terpine known as mercy

01:56:33.660 --> 01:56:40.060
And so this is why the indica is thought to be relaxing because the mercy as an essential oil

01:56:40.140 --> 01:56:46.140
These could be thought of as essential oils or oils and though they're they help induce sleep and relaxation

01:56:46.300 --> 01:56:50.380
Well, the indica strains are very much higher in these additional terpines

01:56:51.180 --> 01:56:54.700
And and and they obviously have the smells that you taste with various

01:56:55.180 --> 01:56:59.420
Cannabis tinctures and oils other terpines like lemonine linole

01:57:00.460 --> 01:57:06.780
Carbofyline the peppery spicy is a is a compound known it interacts with a receptor known as tarpv1

01:57:07.100 --> 01:57:10.140
Tarpv1 is a key pain receptor

01:57:10.380 --> 01:57:17.340
And the only known natural ligand is the only unknown natural product that binds that is tarpv1 is hot chili peppers

01:57:17.580 --> 01:57:22.380
So a lot of the preparation we make with cannabinoids where they're from from cannabis

01:57:22.940 --> 01:57:25.260
The the activity of the cannabis could be

01:57:26.060 --> 01:57:29.100
modulated more by the terpine and not at all by

01:57:29.740 --> 01:57:32.700
The cannabinoids the cbds the cbns or the cbgs

01:57:33.420 --> 01:57:38.780
And even thc, so we could think of thinking about the anti-inflammatory terpines and and

01:57:39.260 --> 01:57:45.900
Since cannabis is terpines and thinking about how we can formulate and reduce as much as possible to psychoactive effects and yet get

01:57:46.380 --> 01:57:49.180
A healing therapeutic. She said that a few times

01:57:49.260 --> 01:57:57.340
We have to find a way to get rid of the psychoactive effects of of cannabis while keeping all of these wonderful pharmaceutical effects

01:57:58.220 --> 01:58:01.020
Benefit really at almost no cost

01:58:01.740 --> 01:58:07.260
So I've talked a lot about the cannabinoids and here's two recent reviews and I think your audience can see

01:58:07.820 --> 01:58:12.540
Um, maybe 2015 and 2000 the lead author of this is named bandana

01:58:12.620 --> 01:58:19.820
I just thought you'd like that in tenor 11 where there's there's um, these are very long lengthy reviews that give you all kinds of

01:58:19.900 --> 01:58:21.900
Agonists that we've used in the lab

01:58:21.900 --> 01:58:26.300
Nearly hundreds of respirances to show you what I just talked about briefly here today

01:58:26.700 --> 01:58:33.020
How these cannabinoids and how targeting and building the specificity out of the ubiquity getting specificity out of

01:58:33.500 --> 01:58:37.740
Everywhere and making it yes, they're everywhere, but can we can we be sure it is?

01:58:38.460 --> 01:58:42.140
Using a shall it be a rational or a thoughtful process in using

01:58:42.140 --> 01:58:44.780
They're everywhere see i'm starting to see it

01:58:44.780 --> 01:58:48.540
I'm starting to feel that there needs to be a huge survey of cannabinoids

01:58:49.020 --> 01:58:55.100
I'm starting to feel that there needs to be a huge genetic survey of all plants that produce cannabinoids and terpenes

01:58:55.500 --> 01:59:00.140
So that we can understand them and better identify them and maybe even genetically modify them

01:59:00.700 --> 01:59:08.540
So we can do it both for cancer and we can do it both for Parkinson's disease and really alleviate the motor neuron symptoms and regenerate

01:59:09.260 --> 01:59:14.620
New neurons and replacing those damage neurons. So very much in the literature, not at all

01:59:15.740 --> 01:59:21.420
Hypothesis at this point in time and you will see hundreds of references there. That's why I included it

01:59:21.900 --> 01:59:24.140
So finally we can just summarize to say that

01:59:24.780 --> 01:59:28.380
The endocannabinoid system is the new regulation and neural

01:59:28.380 --> 01:59:34.300
I don't know what that sound was all a balance of the brain and the immune system could be thought to be mediated through receptor

01:59:34.380 --> 01:59:35.420
crosstalk

01:59:35.420 --> 01:59:40.300
Not only with perinergic receptors. I just gave that example because it's key in our therapies today

01:59:40.780 --> 01:59:42.220
but also through

01:59:42.220 --> 01:59:49.020
The regulation and blocking the toxic effects of aluminum glyphosate and many of the causative agents

01:59:50.060 --> 01:59:53.260
An autoimmune and neural new diseases. They're lipid mediators

01:59:53.260 --> 01:59:54.140
They exert you know

01:59:54.140 --> 01:59:58.620
Pliotropic effects and complex effects on on the immune system and the brain

01:59:59.020 --> 02:00:04.540
The endocannabinoids are really the master regulators of the innate and the adaptive immune axis just like

02:00:05.340 --> 02:00:11.900
Small conductance calcium activated potassium channels are the master regulators of neuronal function. You see

02:00:13.740 --> 02:00:15.100
It's really the same thing

02:00:15.100 --> 02:00:22.540
And we used to say it all the time when I was working in college lab that sk channels do everything because they regulate the width of the action potential

02:00:22.540 --> 02:00:24.060
therefore

02:00:24.060 --> 02:00:26.300
signaling in the brain is

02:00:26.380 --> 02:00:28.780
master regulated by sk channels

02:00:29.980 --> 02:00:36.940
She's making the exact same kind of statement. It's an academic biological statement that is designed to get grants and funding

02:00:37.980 --> 02:00:42.540
And make your little sliver of expertise the most important one

02:00:42.940 --> 02:00:45.980
That's why you use words like master regulators

02:00:46.300 --> 02:00:50.060
But some reason or another when people use pot for 60 years

02:00:50.540 --> 02:00:55.100
That master regulator doesn't seem to go too far off center like I don't I don't

02:00:55.900 --> 02:00:57.900
It's really it's really

02:00:58.700 --> 02:01:01.180
disingenuous, but it's perfect academic

02:01:02.220 --> 02:01:07.420
It's a perfect academic biology presentation given by the perfect academic

02:01:08.140 --> 02:01:13.500
What that's that axis between astroglia and t you know t-cells and the monocyte

02:01:14.940 --> 02:01:21.100
So we can use these we can we can affect you we can effectively think about them on the orchestrators of immune response

02:01:21.260 --> 02:01:25.020
And make these a key therapeutic target and just like we could turn

02:01:25.500 --> 02:01:30.860
HIV aids into a disease you could live with we can we can use these combination therapies to

02:01:31.260 --> 02:01:37.020
To cure these 21st century acquired immune deficiencies and with that I'll thank you and take question

02:01:37.100 --> 02:01:42.220
We can cure these 21st century acquired immune deficiencies

02:01:44.220 --> 02:01:48.700
And I think that's a wonderful place to end this you can see it right this is this is

02:01:49.500 --> 02:01:55.100
Pre-pandemic biological bamboozlement. This is pre-pandemic confusion

02:01:56.140 --> 02:01:58.140
and and misconstruing

02:01:59.580 --> 02:02:01.900
understanding with noise

02:02:03.020 --> 02:02:11.020
And it is seeding a narrative where many of these 21st century acquired immune deficiency syndromes are expected to increase

02:02:11.500 --> 02:02:14.140
And why would that be well? We don't know

02:02:15.020 --> 02:02:21.020
But i'm sure endocannabinoids and the sequencing of all the pot in the world and looking at all these different

02:02:21.420 --> 02:02:28.940
Compounds and screening them for their ability to synergistically work with other things that we already have patents for and already want to sell you

02:02:29.420 --> 02:02:31.420
Would be perfect

02:02:33.260 --> 02:02:38.460
I think you can see now why there might be other people that are interested in sequencing the cannabis genome

02:02:38.780 --> 02:02:40.780
Um

02:02:41.740 --> 02:02:44.140
Why it's not such a trivial thing after all

02:02:47.580 --> 02:02:52.220
Hope you can see it ladies and gentlemen. I definitely hope that you can see it

02:02:52.860 --> 02:02:54.860
um

02:02:54.860 --> 02:02:56.860
It's really important that you can see it

02:02:59.260 --> 02:03:04.860
Uh because they are trying very very hard for you not to be able to see it

02:03:05.500 --> 02:03:11.100
I'm going to go right back down here and I am going to say it once and

02:03:11.820 --> 02:03:15.580
Always as I usually do ladies and gentlemen, they are trying to

02:03:16.540 --> 02:03:21.820
Eliminate the control group by any means necessary. I don't know if they transfected my friend at the gym

02:03:22.780 --> 02:03:24.780
But I do know that that

02:03:25.100 --> 02:03:27.100
Reinforced this idea

02:03:27.740 --> 02:03:34.060
Vaccines are something that he couldn't say no to vaccines are something that you can't question and he defended himself as he

02:03:34.700 --> 02:03:38.700
Described to me the pain that he's in and I just my heart breaks for these people

02:03:39.180 --> 02:03:41.660
And it's only through our work through our

02:03:42.540 --> 02:03:46.460
What we're doing these are one of the few ways that we can save these people and so

02:03:47.100 --> 02:03:48.220
um

02:03:48.220 --> 02:03:52.540
Stop all transfections stop all vaccinations and adults for shit sake

02:03:54.940 --> 02:03:59.100
And uh remember that they are trying to eliminate the control group now that they've got him

02:03:59.740 --> 02:04:02.140
Now that he's got all sippetal neuropathy

02:04:02.940 --> 02:04:05.420
You know they can give him all the shots they want now

02:04:09.020 --> 02:04:11.020
Once they transfect your kids

02:04:11.660 --> 02:04:13.660
How the hell you gonna know where it comes from

02:04:14.620 --> 02:04:16.620
the Crohn's disease

02:04:16.620 --> 02:04:18.620
or the allergies

02:04:18.620 --> 02:04:20.620
eczema

02:04:21.260 --> 02:04:25.740
How are you gonna know where the where it comes from when they get cancer when they're 22 years old

02:04:26.700 --> 02:04:28.860
You'll know

02:04:28.860 --> 02:04:33.100
Because transfection in healthy humans was always criminally negligent because RNA

02:04:33.500 --> 02:04:40.700
Campendemic and because gosh dang it intramuscular injection of any combination of substances with the intent of augmenting our

02:04:42.140 --> 02:04:44.300
Beautiful immune system is dumb

02:04:47.660 --> 02:04:50.220
It's been an independent bright web presentation

02:04:51.180 --> 02:04:54.220
Um Star Trek is coming soon as is the wheel

02:04:55.180 --> 02:04:57.180
um

02:04:57.180 --> 02:05:03.180
Ladies and gentlemen, you can find me at giggle on biological.com deal that bio and stream dot giggle home dot bio also

02:05:03.820 --> 02:05:07.740
uh jc on a bike on youtube and on twitter and on twitch

02:05:09.180 --> 02:05:14.300
Thanks very much to everybody who subscribes to this channel who subscribes to my sub stack who sent me

02:05:15.260 --> 02:05:17.260
letters emails

02:05:17.820 --> 02:05:22.540
anything um you're all very very much appreciated by me and my family and

02:05:23.500 --> 02:05:27.900
This wouldn't happen without you ladies and gentlemen. Thank you very much share this stream

02:05:27.900 --> 02:05:32.380
We'll see you tomorrow 1313 is the time we may be switching

02:05:33.580 --> 02:05:36.620
We may be switching to 10 10 in the morning for the first show

02:05:37.420 --> 02:05:38.860
um

02:05:38.860 --> 02:05:42.700
I'm pretty sure i'm going to be switching to 10 10 a.m. In the morning

02:05:42.700 --> 02:05:46.300
I hope that's not going to be too much trouble for a lot of people. It's going to be better

02:05:46.300 --> 02:05:50.140
A little bit better for me and it will open up the afternoon for possible second shows

02:05:50.300 --> 02:05:51.340
um

02:05:51.340 --> 02:05:53.340
right now

02:05:53.340 --> 02:05:56.940
The the variable show can't be the first one so I can't do it that way

02:05:56.940 --> 02:05:58.300
I think I have to shift to the morning

02:05:58.300 --> 02:06:02.700
So it's probably going to be 10 10 in the morning next week and the nice thing about 10 10

02:06:03.260 --> 02:06:07.980
Is that that's the time that you set your watch to when you want to sell it right? That's the prettiest

02:06:08.780 --> 02:06:10.780
Time on an analog clock

02:06:11.580 --> 02:06:16.140
So I think it's kind of a fun time to start in 10 10 is is the second cup of coffee

02:06:16.220 --> 02:06:20.460
That's also really good and it'll give me time to walk the dog would be and and that kind of thing in the morning

02:06:20.460 --> 02:06:25.580
So 10 10 next week. I think the schedule will be changed to reflect that. Um, so don't worry

02:06:25.820 --> 02:06:29.180
I won't it won't happen at random and in the meantime this week

02:06:29.180 --> 02:06:36.300
It's uh 13 13 for the remainder of the week as far as I can tell and we are working on setting up some people to

02:06:36.780 --> 02:06:39.900
Uh join us for an interview over a fire this kind of thing

02:06:40.540 --> 02:06:46.060
Um, we have a few people in mind. It's just uh getting this other momentum in the background

02:06:46.220 --> 02:06:51.100
Solid and I think we're really close to getting there. So I can't thank everybody enough

02:06:51.340 --> 02:06:52.300
Um

02:06:52.300 --> 02:06:58.540
I'm pretty convinced that this illusion of consensus is about to break because a lot of people actually do know the truth

02:06:59.260 --> 02:07:01.500
And uh, they're going to do something about it soon

02:07:02.700 --> 02:07:05.100
Thanks very much ladies and gentlemen and we'll see you tomorrow

02:07:16.140 --> 02:07:19.020
You