WEBVTT 00:00.000 --> 00:02.000 You 00:30.000 --> 00:32.000 You 01:00.000 --> 01:02.000 You 01:30.000 --> 01:32.000 You 02:00.000 --> 02:02.000 I 02:17.580 --> 02:23.280 Think truth is good for kids. We're so busy lying. We don't even recognize the truth no more in this society 02:23.680 --> 02:27.960 We want everybody to feel good. That's not that's not the way life is 02:30.720 --> 02:39.440 Let's check that right now. How is this sound that we lined up or not? 02:40.240 --> 02:44.240 Talk to me goose if we're not lined up. We'll just start again 02:47.200 --> 02:50.840 All good Arthur says good step says good we're out 02:50.840 --> 03:00.640 This episode is sponsored by mink. That's moo plus link 03:04.720 --> 03:11.440 This my point is that if if we were able to just like we're trying to get everybody to take the vaccine 03:11.440 --> 03:17.640 If we had put that into getting everybody to take hypermectin and fluvoxamine for for a month 03:17.960 --> 03:21.880 If we and if we could accomplish that then COVID would be wiped out 03:21.880 --> 03:28.320 We could do it and actually any municipality that could regulate its borders could clear the disease if it could accomplish that 03:28.320 --> 03:30.320 I believe 03:30.680 --> 03:34.980 But you can tell if someone's you know you can sort of feel it and people 03:36.320 --> 03:41.240 And I have lied I'm sure I don't want a lot. You know, I don't think I'm a liar 03:41.240 --> 03:43.240 I try not to be a liar. I don't want to be a liar 03:43.760 --> 03:46.600 It's like really important not to be a liar 03:47.640 --> 03:49.640 You 04:17.640 --> 04:19.640 You 04:47.640 --> 04:54.600 Three people with thyroid cancer sounds not good 04:55.600 --> 05:01.000 It's not the kind of correlation we want to be having here, but I'm afraid this is the kind of truth 05:01.960 --> 05:06.360 This is the only kind of truth that will save us people need to start having 05:08.280 --> 05:10.280 Feeling pain 05:10.320 --> 05:11.720 Somehow 05:11.720 --> 05:16.840 If enough placebos were rolled out, we're always gonna have problems 05:17.640 --> 05:22.240 So crazy like yeah, it's it's not good. This is so crazy 05:23.920 --> 05:25.920 Nervous like what in the world man 05:25.920 --> 05:27.920 Oh 05:43.760 --> 05:47.360 Well, thank you very much for 35 people being here at 05:47.360 --> 05:49.360 1313 05:50.920 --> 05:56.240 Another weekday it is Monday again. We are still working on dispelling the enchantment 05:59.560 --> 06:02.920 For the first time you might be a skilled TV watcher 06:02.920 --> 06:10.120 But I suspect most of the people who are here already are are at the top of this wave where we are staying focused on the biology 06:10.120 --> 06:13.920 We aren't taking the bait on television and social media. We are loving our neighbors 06:14.000 --> 06:16.000 As 06:16.000 --> 06:21.000 You know the way this works is if people spread this around the new biology finds 06:21.600 --> 06:26.000 people each week and that's how we grow our roots are at 06:26.640 --> 06:33.840 Gigalombiological.com and also giga home.bio as well as screen dot giga home.bio where you can see it live and afterwards 06:34.560 --> 06:38.480 And it's all provided by us here at giga home biological 06:39.640 --> 06:42.120 We are completely supported by 06:44.000 --> 06:46.000 Hello, well, hello 06:47.520 --> 06:57.080 We are completely supported by viewers and viewers only there are a couple people who are responsible for having funded more than more than a year of our work 06:57.840 --> 07:04.320 People like Greg James and Rodney Mullen and a few other people have donated very significant amounts of money to keep this 07:08.400 --> 07:13.800 And it's the start of something really cool like an independent bright web that I think actually maybe 07:13.920 --> 07:15.280 Jimmy Gore 07:15.280 --> 07:17.280 Could in theory be a part of 07:19.120 --> 07:26.480 I don't know if you're aware of why I was not on air last night, but my wife and I this this lovely person photographed 07:27.080 --> 07:30.680 There 20 years ago. That's us 20 years ago 07:31.800 --> 07:33.800 In the Brookfield Zoo 07:33.800 --> 07:38.920 I have a friend who may still be a keeper there. I have to admit that I'm out of touch with him now 07:39.760 --> 07:45.960 But at the time he was the only keeper in the world who would free swim with walruses during training 07:46.880 --> 07:52.400 Keep in mind that that animal right there is about a thousand pounds and so if you have a thousand pound 07:53.480 --> 07:57.480 Aquatic golden retriever bump into you between you and the wall 07:57.480 --> 08:02.160 It can be a very dangerous position to be in there's lots of funny stories that he told us 08:02.560 --> 08:07.360 That's why we got to make that photograph. We got to hold a penguin that day 08:07.360 --> 08:09.840 I got attacked by octopus that day 08:09.840 --> 08:11.040 I got to 08:11.040 --> 08:17.320 Pet a dolphin in the middle of a dolphin show and like all the kids are like who the hell is this guy that gets to pet a dolphin? 08:17.840 --> 08:22.520 It was a really cool day and one of the things we got to do look at all those people in the window back there 08:23.240 --> 08:25.240 Thinking what in the hell are those people doing? 08:25.800 --> 08:31.640 Getting to play with that walrus and then there's another walrus over there that keeper's got to keep that one busy while 08:31.640 --> 08:33.640 This one was over here posing with us 08:34.640 --> 08:41.280 Anyway, this is gigo and biological a high-resistance low-noise information brief brought to you by a biologist that biologist is me 08:41.920 --> 08:46.760 Jonathan Cooley United non-compliance is something we all need to start trying to understand 08:46.760 --> 08:53.400 What does it really mean in the context of of our current scenario where there isn't too much to obviously? 08:54.080 --> 08:59.640 Not comply with but in reality, there's a lot you can you can not comply with there's a lot 09:00.120 --> 09:06.080 Going on at your school that you cannot comply with there's a lot going on at the barbecues and at at 09:07.400 --> 09:10.240 basketball games that you cannot comply with and 09:11.600 --> 09:17.840 Yeah, this is gigo and biological the safest way to get biology in your head. It is the 22nd of April 09:18.920 --> 09:20.920 2024 09:20.920 --> 09:22.920 2024 how is that even possible? 09:22.960 --> 09:29.580 We have been here for a while still fighting this conscious and intelligent manipulation of the organized habits and opinions of the 09:29.640 --> 09:35.760 masses which is how they got us to accept this pandemic as real and all the consequences of it 09:36.200 --> 09:43.960 Being a result of you know, nobody's nobody's got anybody. Nobody's got any bad intentions. It's just how it happened 09:44.520 --> 09:50.040 And that's how they got us to discard the principle of informed consent 09:52.320 --> 09:57.200 Hello, my name is Jonathan Cooley. This is gigo and biological coming to you live from Pittsburgh, Pennsylvania 09:57.200 --> 09:59.200 We 10:00.240 --> 10:02.240 Have a hypothesis that in 10:03.040 --> 10:10.720 2020 a number of mass casualty events were staged around the world and used and misconstrued as evidence of impending doom 10:11.240 --> 10:17.640 That a novel virus had just started to spread around the world. New York City was one of the key illusions 10:17.640 --> 10:23.560 That was used as a sort of seating event where here if you can see my little tiny arrow there 10:24.560 --> 10:32.080 That little slope right there was used to extrapolate that we were at the at the doorstep of impending doom and 10:32.600 --> 10:33.760 they 10:33.760 --> 10:42.840 Told this story using non-specific PCR tests that were actually rolled out on a very hot background and this hot background resulted in what 10:43.000 --> 10:45.000 effectively was 10:45.000 --> 10:48.720 The idea that wow we're finding it everywhere. We're finding it everywhere 10:48.800 --> 10:53.560 in fact, wherever you look for it you found it because it was always there in the background a combination of 10:53.960 --> 10:56.720 Always there in the background in non-specific tests 10:57.360 --> 11:03.160 This enabled a larger percentage of all-cause mortality than ever before to be converted to a 11:03.720 --> 11:09.120 National security threat in the form of not influenza, but a novel virus for which we were all 11:09.880 --> 11:11.880 vulnerable and that story 11:11.880 --> 11:18.160 That one particular line a novel virus for which we were all vulnerable with an unknown set of 11:18.440 --> 11:26.120 Consequences for an unknown number of people was the mythology that allowed them to justify everything up and to and including the 11:26.480 --> 11:30.520 Transfection the coercion of transfection the coercion of accepting 11:30.880 --> 11:32.880 Transfection as a countermeasure 11:33.000 --> 11:40.280 to this potential impending doom and I do think it's very possible that if they felt it was necessary in 11:40.640 --> 11:45.840 Order to bamboozle academic science as a whole around the world. It is possible very easy 11:46.480 --> 11:54.920 to seed PCR positivity in the form of a spike protein and end protein or an entire genome using DNA or RNA 11:55.200 --> 12:01.920 Combinations there of recombinant technologies used to produce mass quantities of a signal that then would be misconstrued as 12:02.880 --> 12:04.680 spread and 12:04.680 --> 12:07.320 Because the goal is a total inversion of our 12:08.040 --> 12:13.560 National sovereignty and also our individual sovereignty or sovereignty over our children that complete conversion 12:14.120 --> 12:18.080 To us as experimental animals who are given permission to do things 12:19.280 --> 12:21.280 Since that's the goal 12:21.800 --> 12:29.640 Then a spectacular commitment to this lie is is what's required and it shouldn't be surprising to many of us 12:29.640 --> 12:34.200 But it will be surprising to people joining the stream for the first time that we are actually 12:35.440 --> 12:42.600 Working under the the hypothesis that that everyone is coordinated in their lying spectacularly committed to the lie 12:43.200 --> 12:49.400 Because it is a national security situation. They understand that there will be dire consequences because 12:52.120 --> 12:58.720 Interfering with or obstructing a national security operation would have very dire consequences 13:00.240 --> 13:05.080 And of course we're all humans right and so as these people rushed into the fire in 13:05.400 --> 13:11.440 2020 many of them ended up being co-opted by this national security event giving given two choices 13:11.440 --> 13:13.120 You can either help us 13:13.120 --> 13:16.200 Make sure that people take the worst-case scenario seriously 13:16.200 --> 13:24.040 You can either help us and make sure that people comply with our edicts and our rules until we're ready for the next shift 13:24.040 --> 13:26.460 Or we can give that job to somebody else 13:27.800 --> 13:34.160 And so it's very likely that people like Peter McCullough and Pierre Corey and many other people were read in 13:34.480 --> 13:41.040 To the situation in so far as they needed to know and given a set of talking points that they were 13:42.240 --> 13:46.080 Required to stick to in order to make sure that they didn't encroach on 13:46.440 --> 13:51.080 The operation that was going on in the background that was this national security thing 13:52.240 --> 13:54.600 And I think once you start to see it this way 13:54.680 --> 14:00.960 You can actually forgive a lot of these people for making two hundred and thirty thousand dollars a year as the head of a 14:01.440 --> 14:08.800 doctor group or you can forgive them for for selling a book about Ivermectin and nothing else or a book about 14:09.360 --> 14:11.360 Lab leak and nothing else 14:14.400 --> 14:19.880 Before I do the the the study hall today with Judy Mikovitz's video from 14:20.880 --> 14:27.600 2018 did I say 2008 in the description I did it should be 2018 so I'm gonna fix that 14:28.120 --> 14:29.880 I'll do that post 14:29.880 --> 14:31.880 But I wanted to make a couple 14:32.200 --> 14:37.440 Mentions of some things that are going on in my world that I thought would be worth mentioning 14:37.440 --> 14:40.120 The first thing is is that I've been making subtle 14:40.680 --> 14:42.680 Remarks about my friend at the gym 14:43.680 --> 14:49.680 As you may well be aware if you're a viewer here my boys and I have joined a basketball workout gym 14:50.800 --> 14:57.480 so that they can work on their basketball and then if I get their membership then I get one kind of a free because I'm just a dad and 14:57.840 --> 15:02.960 So I've been shooting around very consistently for the last 50 odd days or so 15:02.960 --> 15:07.040 I think I've missed three days in the last 50 shooting around jumping rope this kind of thing 15:07.440 --> 15:12.560 Getting in shape and I've been making friends with the guys that work there. There aren't that many guys that work there actually 15:12.560 --> 15:14.560 It's really crazy. I got two stories for you 15:14.800 --> 15:21.320 The first one is is that one of the guys that works there actually coaches high school where my kids go and my son will start next year 15:21.320 --> 15:25.680 and it turns out that that dude played in the game where 15:26.160 --> 15:33.040 Chris Weber like called the timeout and and played for North Carolina and like won a national championship and was a pro 15:33.560 --> 15:36.840 For 16 years in Europe, which doesn't even make sense to me 15:38.320 --> 15:44.240 And so this guy is now one of the managers there and gives you know shooting coaching lessons 15:44.240 --> 15:49.040 And and is the high school coach at this high school that we're currently in that township up 15:49.040 --> 15:50.120 So it's really exciting 15:50.120 --> 15:53.360 House have found out that he might not be there anymore, which would kind of suck 15:53.360 --> 15:56.800 But he's a nice guy. He invited me to work out with him and his friends 15:57.520 --> 16:00.400 Downtown Pittsburgh during the week, which is also very flattering 16:00.400 --> 16:02.880 I don't know if I'm gonna be able to swing that but it sounds really cool 16:03.120 --> 16:10.520 And then the other guy working there the older guy actually has been a coach at more than 10 division one schools in his career 16:10.520 --> 16:15.600 And as he characterized himself, there's probably nobody that spent more time in a gym than me 16:16.880 --> 16:18.880 Really really nice guy 16:18.880 --> 16:20.560 White hair 16:20.560 --> 16:23.960 Short white hair, you know old white dude from somewhere. I don't know where 16:24.760 --> 16:28.200 Real humble helps everybody gives a little lessons to kids 16:28.200 --> 16:32.480 But also just you know when he comes walks past my kids and they're working out 16:32.480 --> 16:38.080 He'll knock the ball out of their hand and tell them to protect the ball or he'll try to block their shot real sweet old guy 16:39.320 --> 16:45.000 And last week I had to help him carry a ladder because he had to get to one of the the screens 16:45.000 --> 16:50.280 That's above the shooting machines and it was a long heavy fiberglass ladder that opened up like this 16:50.280 --> 16:55.200 So it's pretty heavy and me and another kid carried it for him because he couldn't even carry it with his one arm 16:55.200 --> 16:59.040 And he last week he told me that he'd gotten a shingles shot and this week 16:59.680 --> 17:06.040 Yesterday I was at the gym and and that gentleman was there again and when I was talking to him. He was he was like this 17:08.120 --> 17:13.080 And I was like dude what's up with your neck and he said oh man, I know I 17:14.040 --> 17:15.600 Don't know 17:15.600 --> 17:18.800 And he was kind of hesitant. He says, you know, I'm not an anti-vaxxer 17:19.480 --> 17:23.440 But I think last week I told you that I got a single shingles shot remember 17:23.920 --> 17:27.440 I had to I had you help me carry that ladder. I said I definitely remember man 17:27.840 --> 17:32.760 And he said well, it's gotten worse like I don't know I don't like I said 17:32.760 --> 17:36.040 I'm not an anti-vaxxer, but it happened like immediately after the shot 17:36.040 --> 17:41.120 I had this pain in my arm and it goes all the way up the back of my head and in my neck and 17:41.680 --> 17:43.680 I'm thinking right away 17:43.680 --> 17:50.400 Ossipital neuropathy. I'm thinking right away isn't that what people get from shingles like holy shit. So 17:51.160 --> 17:53.840 It's it's extraordinary because 17:54.400 --> 18:01.600 He's he's making apologies. He's telling his doctor this the doctor says nah, it's a stiff neck and gets him a chiropractor 18:03.320 --> 18:05.840 recommends a chiropractor for this guy 18:06.000 --> 18:11.840 He can't sleep he hasn't slept in three nights because when he lays down the pain is so unbearable and 18:12.480 --> 18:14.480 I was I couldn't really 18:15.360 --> 18:17.800 Process it all because I don't know what to say to him 18:17.800 --> 18:24.960 You know because he's already airing on the side of caution that I might not understand that he's he's not an anti-vaxxer 18:24.960 --> 18:30.520 But you know this can happen and he had to really walk on those eggshells afraid that I might be like, oh, you know 18:31.680 --> 18:38.360 Of course I talked to him and told him who I was and what I had done and where I'd been as briefly as I could and 18:39.360 --> 18:42.600 Now I don't have anything else really to say to him. What can I say to him? 18:42.600 --> 18:46.760 He took a he didn't take shingrix. He took the other one, which is recombinant 18:47.120 --> 18:50.240 It's recombinant virus, you know, it's weakened somehow 18:50.240 --> 18:52.840 I don't know they got rid of some jeans or something. I have no idea 18:52.840 --> 18:57.040 I haven't looked into it yet, but it's just terrible because he's got neuropathy now 18:57.040 --> 19:02.480 And I know I'm not a doctor, but I know that neuropathy is not something you can just take vitamin C4 19:04.160 --> 19:05.720 And so it terrifies me 19:05.720 --> 19:08.880 I don't know if I'm gonna see that guy today when I go to the gym with my kids 19:08.880 --> 19:10.880 I don't know if I'm gonna see him next month and 19:11.840 --> 19:16.880 And will this ever go away from or is it gonna be a devastating thing that ruins this guy's life forever 19:17.120 --> 19:19.800 He says to me at some point in the conversation 19:19.800 --> 19:22.440 No, I never have reactions when I get these vaccines 19:22.440 --> 19:24.480 And then I'm thinking holy shit 19:24.480 --> 19:32.200 How many vaccines are they telling you to take when you go on the CDC website the CDC recommends everybody over 50 to take two shots of the singles 19:32.280 --> 19:34.280 vaccine and 19:34.280 --> 19:36.280 That's what they told him I 19:37.040 --> 19:39.040 I 19:40.520 --> 19:46.440 Think that you know quite frankly we should be telling all of our old people all of our friends everybody not to take any 19:46.600 --> 19:52.640 Vaccines none new no they don't need new vaccines. They're old people. They should eat better take vitamin whatever, but not 19:53.440 --> 19:56.440 Vaccines we've got to stop this nonsense. I 19:57.600 --> 20:03.560 Did tell him I was an anti-vaxxer. I told him that I worked for one of the the top 12 anti-vaxxers for a while 20:04.520 --> 20:06.520 Yeah, it was pretty funny 20:07.440 --> 20:11.040 Pretty pretty funny conversation. Okay, so now Jimmy door 20:11.840 --> 20:13.840 Guess who I saw yesterday? 20:13.840 --> 20:17.720 I saw Jimmy door yesterday and I gave him a book 20:18.800 --> 20:25.840 Robert can it Robert F. Kennedy's book and I had highlighted all the places where I was where I was 20:26.320 --> 20:32.040 quoted I also put my phone number everything in there and I said in the inside of the cover I 20:32.280 --> 20:37.360 Wrote we are being lied to by the people now riding white horses 20:37.360 --> 20:39.360 we should talk and 20:39.360 --> 20:46.120 I have little tabs in every place in the book where I'm found so that he can find me and it says that's me and stuff 20:46.120 --> 20:49.400 I I ruined the book basically, but I used it as a business card 20:49.960 --> 20:55.720 I talked to him very briefly here in this little meet-and-greet where there were like 10 people so it wasn't very long 20:55.720 --> 20:57.120 I could have talked to him for longer 20:57.160 --> 21:03.760 We also got to meet Steph and we took a picture with her after the show and I'm not really sure why I'm not wearing the t-shirt 21:03.760 --> 21:05.760 But I will put it on 21:05.760 --> 21:11.280 And so we didn't talk for very long. I just said hey I helped Robert F. Kennedy, Jr. 21:11.280 --> 21:16.360 Write this book you can see my name here. Here's my phone number, you know, we should talk and it was really cool 21:16.920 --> 21:21.800 The guy who was selling the t-shirt said thanks for the book and then Steph on the way out took 21:21.800 --> 21:25.280 I said took a picture with us on the way out and said thanks for the book 21:25.440 --> 21:28.760 I don't know if they're gonna get back to me. I don't know what's gonna happen 21:29.880 --> 21:31.080 but 21:31.080 --> 21:34.280 That's as close as I can get to making some kind of 21:35.520 --> 21:39.600 Penetration into this more mainstream media area 21:40.160 --> 21:43.000 And it was really a great show. He took a lot of risks 21:43.800 --> 21:48.040 I have to commend him for the amount of time he spent talking about how 21:48.600 --> 21:52.800 angry he was about being lied to about the vaccine and and 21:53.040 --> 21:56.520 Defending the people in the room, you know 21:56.520 --> 22:00.720 He asked everybody to raise their hand if they had not taken the shot and a lot of people 22:00.720 --> 22:04.880 I mean it's Pittsburgh right and it's a Jimmy Dorshow a lot of people raised their hand 22:04.880 --> 22:10.520 But the people that didn't raise their hand he showed and spoke solidarity with them and said that you know 22:10.520 --> 22:16.680 You shouldn't be ashamed of being fooled. They frickin lied and it was really wonderful the way that he said it now 22:16.680 --> 22:22.240 There were caveats he he gave Robert Malone credit for having predicted that Omicron would be 22:23.440 --> 22:26.400 Would be less or less severe and more mild 22:27.560 --> 22:33.080 He's definitely convinced that there was a virus still right but he is very very 22:33.640 --> 22:40.160 Advanced in terms of his understanding that they lie about everything and so I don't think it would be that far of a leap for him 22:40.480 --> 22:43.560 To think that some of these people have lied about the biology 22:43.560 --> 22:47.960 I don't think it would be very hard for him to take that leap at all. He ended his 22:48.440 --> 22:51.480 So I'll tell you a first a funny story about Jimmy Dors 22:52.360 --> 22:54.360 He made a joke 22:54.560 --> 22:55.480 about 22:55.480 --> 22:56.840 circumcision and 22:56.840 --> 23:00.680 it was something to do with with cutting heads off and 23:01.120 --> 23:07.160 People don't care if they cut this off or whatever and it being Jewish. I can't remember exactly, but then he said 23:08.200 --> 23:13.420 And I'm not Jewish, but somehow I ended up circumcised and it just 23:13.920 --> 23:19.520 Blurted it out from my table in the back and it was dead quiet. Everybody heard it 23:19.600 --> 23:22.680 I said they needed it for cell culture and 23:23.400 --> 23:28.920 his immediate response like right whip snap fast as it could be hey 23:28.920 --> 23:34.480 Alex Jones is in the audience today ladies and gentlemen. Well welcome Alex and everybody laughed 23:34.480 --> 23:38.200 I got a couple fist bumps from people around me. It was really cute 23:38.840 --> 23:41.080 and he ended the stream with 23:42.280 --> 23:48.280 They're lying to us to divide us. They tell us lies to divide us. They don't want us to become united 23:48.360 --> 23:52.440 They don't want us to unite and we need to unite. We need to love our neighbor 23:52.640 --> 23:58.240 We need to come together as one country. He said a lot of really cool things. He wants a revolution 23:58.240 --> 24:00.440 He's be happy to be a leader of it. I 24:02.200 --> 24:03.880 Do think that he's a good soul 24:03.880 --> 24:10.440 I think he's a good guy and I just think that it's very easy to be in his position and not have the requisite 24:10.600 --> 24:16.640 Knowledge to know whether somebody like Robert Malone really is a whistleblower or or or kind of a two-faced 24:17.080 --> 24:21.600 You know insider and and I do think that that it's not impossible 24:23.720 --> 24:26.760 Jimmy's been doing some great stuff with regard to RFK 24:26.880 --> 24:32.280 He said I saw some people in the audience with some and and some people at the meet and greet that had 24:32.680 --> 24:36.240 Kennedy shirts on gosh. I really like that guy. He's really cool. It's too bad 24:36.240 --> 24:40.200 He's a fucking Zionist and it's sorry to swear. I was just quoting him 24:40.280 --> 24:42.320 But he got really mad about it 24:42.320 --> 24:47.440 He got really mad about Cornell West and really mad about Bernie Sanders and was a real 24:47.920 --> 24:49.680 Well spread out, you know 24:49.680 --> 24:56.720 I am very disappointed in how many people I have put my trust in and belief in that have let me down and I had a real I 24:57.160 --> 25:02.320 Had the feeling that he was really working things out. He's real be an honest on stage. It's real 25:02.840 --> 25:07.060 he's trying kind of to resurrect a little bit of the of the 25:08.060 --> 25:14.420 Of the George Carlin stick, but it's a much more raw presentation. It's a guy who got screwed 25:14.420 --> 25:20.180 He is not happy about having taken that shot. He's not happy about these people having gotten away with it 25:20.180 --> 25:27.460 And I like he's he's angry in the right way because he's also really he's a whip. He's whip funny. I mean he was really good 25:29.380 --> 25:34.700 He was really good and I really enjoyed it a lot. I know that fear the laughed a lot apparently 25:34.780 --> 25:38.780 He's been doing comedy since before women had dicks that was his first joke 25:38.780 --> 25:44.020 And I thought that at that point we were already lost like it was I was just laughing and the nice thing about it 25:44.020 --> 25:47.500 Was is fearless and I had not been out on any kind of date without the kids 25:48.420 --> 25:49.700 in 25:49.700 --> 25:51.700 In memory 25:51.700 --> 25:54.340 It's certainly the first time we've gone out like that 25:54.340 --> 26:00.940 I think since covid and so it was a really nice dinner together and really nice time together and 26:01.820 --> 26:07.860 The kids did really well while we were gone and and so overall was really great and who knows? 26:07.860 --> 26:12.380 I mean, we planted a seed with Jimmy right and and that's all we can really hope to do 26:12.380 --> 26:18.420 I hope that you agree with me that that's it couldn't have been better than that. I don't think 26:20.060 --> 26:25.500 Basically I used the book in the worst way possible in their imagination, I guess 26:26.460 --> 26:28.460 But yeah 26:28.500 --> 26:29.820 Anyway 26:29.820 --> 26:33.460 Judy McAvitt study hall cannabis sciences virtual event 26:33.460 --> 26:37.540 I thought this was interesting because of the emphasis on 26:38.100 --> 26:41.820 cannabinoids and the cannabinoid system with regard to immune regulation 26:42.460 --> 26:50.060 And I thought it was very curious that somebody like Judy McAvitt's would present this at the cannabis sciences virtual event 26:50.940 --> 26:55.380 In 2018 and since I haven't done very much work on Judy McAvitt's 26:55.380 --> 26:57.740 I don't really have a good idea of what's going on with her 26:57.740 --> 27:01.740 I thought this was also a really nice way for me to be able to plug 27:02.620 --> 27:04.620 my friend's work 27:05.180 --> 27:07.420 My friend mark usatonic so 27:08.180 --> 27:10.620 Mark Koolack has a website called 27:11.580 --> 27:15.420 usatonic ITS and if you go to his research page 27:17.580 --> 27:19.580 Like this and you go all 27:19.860 --> 27:25.860 Then you basically get to the A's and then you have this alphabet underneath here and you can look up anybody that he's 27:26.180 --> 27:29.460 He's stored things on and so you know 27:29.460 --> 27:35.700 You can find a page on Judy McAvitt's there and you can find a page on some of the people that have worked with her and and 27:35.980 --> 27:40.900 And a long you know all the all the stuff is there. That's the nice thing about it 27:40.900 --> 27:47.860 It's not a Wikipedia because a Wikipedia is pretty incomplete mark has taken a lot of these original sources and compiled them together 27:48.660 --> 27:52.700 And so you can get a good idea of her her background there 27:52.700 --> 27:57.500 And so I would like to encourage you to do that and also just to go back one step 27:57.620 --> 28:03.780 There's also quite a bit on shingles vaccination with the CDC and one of the things that's there 28:03.980 --> 28:08.140 You can find is occipital neurology, which is I think what my friend at the gym has 28:08.700 --> 28:10.620 And you can find 28:10.620 --> 28:16.340 Complications long term nerve pain nerve pain is the most common complications of shingles 28:16.660 --> 28:18.660 So it terrifies me to think that this 28:19.220 --> 28:25.020 Hossipital neurology that I think that my friend is now suffering from could be a long-term nerve pain problem 28:25.660 --> 28:30.900 Which is just disgusting the CDC recommends two doses of recombinant zoster vaccine 28:31.220 --> 28:35.780 To prevent shingles and related combinations in adults 50 years or older. I 28:37.140 --> 28:41.020 Just think it's disgusting and I think that this lie needs to be put to rest 28:41.980 --> 28:48.420 It just it frightens the heck out of me that we are we are doing this and that old people are in in the same 28:48.740 --> 28:53.580 Situation that that really where did the maybe I didn't have it in that one. Sorry. Oh 28:55.020 --> 28:57.020 Yeah, it's here 28:57.020 --> 29:04.500 That old that old people are now in the same situation that a lot of young parents are in except about themselves young parents are often 29:04.700 --> 29:07.180 You can characterize it as being bullied 29:08.140 --> 29:14.060 Into accepting the vaccine schedule as it is and even if you ask to have a delayed a couple years you will be 29:14.940 --> 29:16.940 given a lot of heck for that 29:17.660 --> 29:19.660 Nevermind if you want to 29:19.660 --> 29:22.060 abstain from participating in it and so 29:23.260 --> 29:25.260 It's it's a real 29:27.020 --> 29:31.100 It's really it's really a devastating place that we're in right now if we are coercing 29:31.900 --> 29:37.700 And it's normal to coerce elderly or even older people 50 years old. I'm 50 29:37.700 --> 29:42.300 I should take two of those things then right that's what they would say and that's just crazy talk 29:42.300 --> 29:47.500 I mean I had chickenpox real bad when I was 13 years old. I ain't messing with that shit again 29:47.740 --> 29:51.100 So there I'm swearing. I got a chill out. I got a cool out 29:52.260 --> 29:56.460 But yeah, here we go. This is a study hall 29:56.860 --> 30:02.380 And I am going to put the playback speed up to 1.5 until otherwise noted 30:03.660 --> 30:05.660 and 30:05.660 --> 30:12.780 Yeah, let's see what Judy mikovitch has got mikovitch has to say about these things cannabinoids as stem cell and immune therapy 30:13.260 --> 30:16.060 It's interesting right that sounds pretty much like a catch-all 30:16.780 --> 30:20.940 Like cannabinoids could be used for almost anything in future medicine 30:21.340 --> 30:26.380 Which is a really exciting thing that might be some that might be a very good reason why some 30:26.460 --> 30:30.860 But he might want to sequence cannabinoid genomes and work on variants 30:31.740 --> 30:37.980 In cannabinoids, you know, like get in on the ground floor with regard to the genetics of canada cannabis 30:37.980 --> 30:41.180 That might be a really good reason to get in on that 30:41.980 --> 30:46.220 Get out of that action. So let's see what Judy's got to say about that 30:46.780 --> 30:54.620 Action well everyone. I welcome to today's live broadcast cannabis as immunotherapy for 21st century acquired immune deficiencies presented by 30:54.700 --> 31:01.180 Dr. Judy mikovitch founder and consultant at mark ink and director of cancer biology at epi gen x pharmaceuticals 31:01.260 --> 31:03.580 I'm tz Valdez of lab roots and i'll be your moderator for today's event 31:03.820 --> 31:11.900 We're delighted to bring you this educational web seminar presented by lab roots lab roots is the leading scientific social networking website and producer of educational virtual events and webinars 31:12.300 --> 31:15.660 Before we begin. I want to remind you that this event is interactive 31:15.660 --> 31:20.380 We encourage you to participate by submitting as many questions as you want at any time you want during the presentation 31:20.700 --> 31:22.700 Just click on that ask a question box 31:22.940 --> 31:28.060 Located on the far left of your screen and type the questions into the dropdown box that appears on that screen 31:28.220 --> 31:31.420 We'll answer as many questions as we have time for at the end of the presentation 31:31.740 --> 31:33.740 If you have any trouble seeing or hearing this presentation 31:33.980 --> 31:40.220 Click on the help desk button located on the promotional board at the bottom center of your screen or use that ask a question and let us know 31:40.220 --> 31:45.100 You're having a problem this presentation is educational and offers continuing education credits 31:45.340 --> 31:52.620 Click on the continuing education credits tab located at the top right corner of your presentation window and follow the process to obtain those credits 31:53.100 --> 31:57.420 Please join me now and welcoming our presenter dr. Mikovitz. I will now turn the presentation over 31:58.140 --> 32:01.820 Welcome dr. Mikovitz. Thanks. Thanks so much. It's a delight to be here 32:02.620 --> 32:10.380 And talk about a really exciting topic as far as therapeutic potential for some of the most devastating diseases of our time 32:11.180 --> 32:13.180 And that's using cannabinoids 32:13.820 --> 32:16.140 as stem cell therapy and immune therapy 32:16.860 --> 32:18.860 So on that first slide 32:18.860 --> 32:25.260 There that you see ahead of you you see some of those diseases you see cancers a lot of hormone 32:26.220 --> 32:28.700 Sensitive cancers a lot of leukemia lymphoma 32:30.060 --> 32:37.500 Bladder cancers. These are these are cancers that that tend to respond to immune therapy. We also consider autoimmune diseases 32:38.460 --> 32:42.400 Lupus inflammatory bowel disease Crohn's disease polymyositis 32:43.500 --> 32:46.620 Syndrome Biches disease and primary biliary cirrhosis 32:47.020 --> 32:51.420 I think i'm already going to tap in here and suggest to you that this is already a list of 32:53.740 --> 32:58.140 Distractions and misnomers which are describing potential 32:58.780 --> 33:02.780 gene therapy side effects and vaccine side effects 33:03.740 --> 33:09.980 And so what we're looking at here is a list of things that happens with no explanation for why 33:10.620 --> 33:15.180 Nothing about the toxic environment and the toxic food that americans are given 33:15.660 --> 33:23.900 Nothing about the toxic lifestyle or the toxic environmental pollution that americans are exposed to and definitely not the toxic vaccine 33:23.980 --> 33:27.100 Schedule which i'm assuming in 2018 33:27.660 --> 33:33.260 Judy mikovitz is still totally and completely against right because it's not that long ago 33:33.260 --> 33:36.860 It's right before the pandemic. She must have been anti-vaccine already by now 33:39.340 --> 33:46.540 A chronic liver disease in the cns we think of myalgic encephalomyelitis skull for syndrome autism spectrum disorders 33:46.860 --> 33:49.500 ms parkinson's disease luke eric's disease 33:50.220 --> 33:52.380 on to the diseases which are 33:53.660 --> 33:55.660 Increasing in our world at 33:56.540 --> 34:03.500 It really extraordinary rates due to the environmental toxins in our world and interestingly as as we've learned 34:04.140 --> 34:06.140 only in the last two decades 34:06.460 --> 34:08.140 that are 34:08.140 --> 34:15.100 That are really diseases of the endo pinnabenoid system and and of stem cells where those toxins are 34:15.500 --> 34:22.140 Are affecting our immune system and the regulation of our immune system in really profound ways. So on the next slide 34:26.620 --> 34:31.660 On the next slide. I show a relatively recent paper review article 34:32.300 --> 34:35.260 from progress in lipid research and what this 34:35.820 --> 34:42.700 Review article talks about is is what we learned in in the early 90s the endo pinnabenoid system 34:43.420 --> 34:46.860 And how it's actually critical for stem cell development 34:47.740 --> 34:52.780 Really from the embryonic stem cell on and so what we're going to do today is we're going to talk about 34:53.420 --> 34:54.380 how 34:54.380 --> 35:01.740 The endo pinnabenoid system and the regulation of the endo pinnabenoid system is key to a healthy brain and a healthy immune system 35:02.300 --> 35:06.860 First of all, I want to make sure that everybody understands that they're they are going to 35:07.900 --> 35:09.420 confound 35:09.420 --> 35:15.820 the endo pinnabenoid system with cannabinoids as often as possible and it is a broad 35:17.500 --> 35:19.660 chemical family 35:19.660 --> 35:26.460 And you shouldn't assume that endo pinnabenoid receptors are all stimulated by cannabinoids and blah blah blah 35:26.460 --> 35:28.460 You shouldn't assume any of that 35:28.460 --> 35:31.180 Even though they're not going and I suspect 35:31.660 --> 35:36.620 She's not going to be very precise about this and in fact take advantage of that potential confusion 35:37.180 --> 35:40.140 and allow you and her listeners to 35:40.940 --> 35:45.020 Make as many of those assumptions as possible when she's talking about endo pinnabenoids 35:45.420 --> 35:46.940 She's also 35:46.940 --> 35:52.540 Implying because she's not saying it's not true implying that when you use cannabis that you can stimulate this 35:53.100 --> 35:56.860 System as well and so that's to a certain extent that's true 35:56.940 --> 35:59.900 But but you're missing the subtleties there of all the different 36:00.460 --> 36:06.380 You know chemical subcompounds and all you know and the receptor subtypes and all this other stuff that they know very well 36:07.020 --> 36:12.780 Individual people have studied these individual stories with individual mechanisms and so these are all 36:13.500 --> 36:20.460 Compartmentally well understood but to now we're going to misconstrue them as some kind of new way for us to 36:21.100 --> 36:28.860 You know sort of tap into the system as a whole and take advantage of something that we couldn't take advantage of before and I I think this 36:30.300 --> 36:33.820 This is essentially what what this talk is going to be about trying to 36:34.460 --> 36:37.740 Sell you on the idea that there is potent biologically 36:38.300 --> 36:40.300 there is so much potential for 36:41.260 --> 36:45.180 Cannabis produced cannabinoids to be designed 36:47.340 --> 36:51.260 To be used as immune modulators. They don't intend to grow pot 36:51.980 --> 37:00.380 They intend to use pot to to produce compounds that they can then identify and and synthetically synthesize 37:01.180 --> 37:03.420 I have they have no intention of using 37:04.380 --> 37:06.780 marijuana as a source 37:07.740 --> 37:10.300 Like like to use it as medicine or 37:10.620 --> 37:15.500 Consume it as medicine but to extract from it or to identify within it 37:15.980 --> 37:20.780 Compounds that can be made synthetically to use as medicine. So it's very different 37:22.380 --> 37:24.380 Couple things there anyway that are very different 37:25.020 --> 37:31.500 I know this paper is open access. So it's available to a lot of the audience and I've adapted or taken figures directly from 37:32.380 --> 37:37.580 This this paper and added some of our own as shown on slide three 37:38.380 --> 37:43.820 So so I would challenge you to go to mark's website and look up at the bottom of her her page 37:44.700 --> 37:50.220 Look up her resume because she does not have any problem getting employment 37:51.260 --> 37:53.260 Okay, so 37:53.820 --> 38:00.460 And and she doesn't not get good employment. It's not like she's worked at a basket robins because she can't be a scientist anymore 38:01.740 --> 38:03.260 and so 38:03.260 --> 38:05.260 There's a limited amount of 38:05.260 --> 38:07.980 Suffering that she's had and certainly in this 38:08.860 --> 38:14.060 In at this time in 2018. She's very gainfully employed from at least two different companies 38:14.540 --> 38:15.500 So 38:15.500 --> 38:23.020 And nevermind that also perhaps also advising investment firms, which appears also on her resume in various places 38:23.420 --> 38:24.940 stem cell level 38:24.940 --> 38:31.420 In the endocannabinoid system, there's really um cannabinoid receptor one and cannabinoid receptor two 38:32.060 --> 38:37.980 You see here in the lower part of the screen. Those are shown as these channel like receptors 38:38.060 --> 38:41.020 These are um deep protein coupled receptors 38:41.260 --> 38:45.660 And so they have um they they cross the membrane say six or seven times 38:45.900 --> 38:51.100 And the signal is occur and changes can occur in the loops and they have crossed off with many many 38:51.260 --> 38:55.740 Coupled receptors for signaling both in the brain and in the immune system 38:56.380 --> 39:00.940 What we've learned so a deep protein coupled receptor for those people who do not know 39:01.340 --> 39:03.340 um, this is 39:03.340 --> 39:05.340 What's that why didn't that work? 39:06.300 --> 39:08.780 Oh, no, sorry. That was not the right one. Um 39:09.500 --> 39:11.020 Yes, it is 39:11.020 --> 39:14.380 It's definitely the right one. Why didn't that work? This is not on 39:14.380 --> 39:16.380 Oh 39:17.500 --> 39:21.660 It wasn't on um g protein coupled receptors are different than 39:22.860 --> 39:24.060 a 39:24.060 --> 39:29.580 a let's say an ionic receptor and ionophore or something that just opens and allows things in 39:30.300 --> 39:31.420 um 39:31.420 --> 39:33.500 So you might have 39:33.500 --> 39:39.180 A couple different kinds of receptors just to think about things in general, right? There's receptors on the membrane 39:39.740 --> 39:41.740 That for example might gate 39:42.300 --> 39:45.100 The flow of things across the membrane 39:45.660 --> 39:52.540 And so if they do that, they might have an agonist that binds to them and then these proteins will change configuration 39:53.180 --> 39:54.940 to allow 39:54.940 --> 40:02.380 like an ion to transfer from one side of the membrane to another but a g protein coupled receptor is actually a 40:03.260 --> 40:05.260 a 40:05.660 --> 40:08.860 A receptor that has a number of subunits on it 40:09.500 --> 40:12.860 and there are g proteins are are these 40:14.220 --> 40:21.100 Like cyclic amp is usually these the messenger that they use so when the agonist binds the receptor 40:21.900 --> 40:26.780 Um, then a similar conformational change occurs, but then that allows 40:27.500 --> 40:31.660 uh cyclic amp to be released and it's a very local signal 40:32.300 --> 40:36.060 But that cyclic amp could open an ion channel 40:36.620 --> 40:41.020 That allows something in just like this one like this one did it could it could open 40:41.660 --> 40:46.780 That channel it could open many channels. It could also have downstream effects of causing 40:47.660 --> 40:50.780 gene expression and all kinds of other things as essentially 40:51.660 --> 40:57.100 Um a black box after the activation of g protein of a g protein coupled receptor 40:57.100 --> 41:01.740 They would like to tell you the story cyclic amp etc, but it's a cascade 41:02.540 --> 41:08.700 And so we don't have a very good idea of all the things that happen downstream from g protein coupled receptors 41:09.180 --> 41:15.820 because these these actions after agonist binding can have different timescales and 41:16.220 --> 41:23.500 Depending on the cell type can have very different ramifications depending on what happens after the initial activation here 41:25.260 --> 41:28.540 um, so a g protein coupled receptors kind of cool because 41:29.260 --> 41:34.700 Um, it could have a number of different effects on both a long a short-term effect could be 41:35.340 --> 41:39.260 That sodium comes in through channels, but a long-term effect could be 41:39.820 --> 41:43.900 Gene expression or actin skeleton remodeling or something like that 41:44.380 --> 41:47.180 And that's very different than a receptor which is 41:47.980 --> 41:53.980 Exclusively an ion channel opened and closed by the presence of the agonist or blocked by a toxin 41:54.620 --> 41:55.580 Um 41:55.660 --> 42:02.860 So that's interesting because if endocannabinoids are all g protein coupled receptors then even when we think we can activate them 42:02.860 --> 42:11.340 We we would still be much farther from understanding the consequences of their activation because it is not only the acute direct 42:11.820 --> 42:13.820 effects of ion 42:13.980 --> 42:17.660 Transfer or or proton pumping or something like that 42:18.140 --> 42:24.140 But rather it is downstream effects activated by cyclic amp and other second messengers inside of the cell 42:24.540 --> 42:26.780 That result from the activation of the receptor 42:27.180 --> 42:31.580 So it can can result in very very much bigger changes as well 42:32.060 --> 42:35.020 So it's not to say that that this isn't significant. It's to say 42:35.740 --> 42:40.700 That the complicated mechanisms that underlie the signaling of cannabinoid receptors 42:41.100 --> 42:45.100 Cannot be underestimated and when she says it's a g protein coupled receptor 42:45.500 --> 42:48.220 That's like the very very tip of the iceberg of that 42:48.780 --> 42:53.100 Complexity most of which we can't really adequately characterize. I hope I said that well 42:53.660 --> 43:01.020 Recently is the hematopoietic stem cell, which is the stem cell that's involved in your in the development of all of the lineages 43:01.340 --> 43:06.460 In your blood shown on this slide. We're showing. I'm showing you the myeloid lineage. That's um 43:07.100 --> 43:11.980 The megacariocytes the erythrocytes red blood cells mass cells myeloblast 43:12.540 --> 43:15.740 On the right hand side. I the figure wasn't long enough for this slide 43:15.740 --> 43:21.340 I just show also the base of field neutrophils eosinophils and critically the monocyte macrophage 43:21.500 --> 43:24.940 Which we're going to talk a lot about today the myeloid cells 43:25.580 --> 43:33.500 And and hematopoiesis of the myeloid cells. This is really your innate immune response your frontline defense from all of the toxins 43:33.740 --> 43:38.620 Um in our environment in our world not just so see she's saying it too complicated 43:38.620 --> 43:43.740 She wants you to the the myeloid cells the macrophages and the dendritic cells 43:44.460 --> 43:49.980 The hematopoiesis of these cells. Why does she use the word hematopoiesis? 43:51.580 --> 43:56.940 Why can't she just say that when these cells are in development hematopoiesis? Why not? 43:57.740 --> 43:59.740 Do I not define it? 44:00.780 --> 44:03.020 Again because I think this is a rehearsed 44:03.580 --> 44:07.900 Very carefully chosen set of words to bamboozle to make sure 44:08.460 --> 44:10.860 That if she lists all these words fast enough 44:10.860 --> 44:16.140 There's no way that you're going to notice that common is spelled wrong in her in her slides 44:16.460 --> 44:19.740 There's no way you're going to notice that that this is just uh 44:21.820 --> 44:26.620 An overwhelming set of data designed to get you to accept the conclusion slide 44:27.660 --> 44:32.780 Um, not just um environmental toxins, but including things like um viruses 44:33.420 --> 44:42.300 Um our expertise is in retroviruses and our work at epigenetics is is all about how retroviruses change the expression of genes and not the dna 44:42.300 --> 44:50.220 Or and including at the dna level, but primarily the expression of genes and this is one mechanisms how they cause diseases by so 2018 44:50.220 --> 44:56.220 She's still working for epigenetics. I don't think that that's really in her resume that mark has on his website 44:56.220 --> 45:01.500 I want to I want to look deeper into that, but this is 2018 and she's still talking like we 45:02.220 --> 45:05.820 Epigenetics, which is again a company that looks at 45:06.380 --> 45:16.460 Uh, epigenetic changes resulting in cancer and other other conditions. So, um, you're essentially dealing with somebody who is interested in sequencing everything 45:16.860 --> 45:21.580 You're dealing with somebody who is using blood samples to look for bloodborne markers of 45:22.300 --> 45:25.020 Of chronic fatigue syndrome for many many years 45:25.500 --> 45:31.500 Not that dissimilar from looking for bloodborne markers of other diseases like that blonde lady with the dark hair 45:31.980 --> 45:36.940 With the with the deep voice was doing before they before they discredited her as a fraud 45:38.860 --> 45:40.620 Just saying 45:40.620 --> 45:44.220 It's not like this is uh, obviously anti-vax talk where we're 45:45.020 --> 45:51.020 Where she is fighting for us to not believe in in the public health system or to doubt tony fauci here 45:53.260 --> 45:55.420 This is right now talking about how 45:56.460 --> 46:02.460 Canabenoids regulate the essential developmental processes of all blood cells and the amion system 46:05.260 --> 46:11.980 Disregulating, um, the, uh, hematopoietic stem cell and what you get is an accelerated aging 46:12.140 --> 46:17.660 Where we see cancers in those auto immune and neuro immune diseases on the first slide in younger 46:17.900 --> 46:20.380 I mean accelerated aging is what what 46:22.220 --> 46:27.820 Walter chestnut has been going on about the spike protein was going to do for like four years now 46:28.540 --> 46:31.740 and certainly going on and on about the transfections 46:32.700 --> 46:36.060 advancing aging and destroying mitochondria and 46:36.620 --> 46:38.140 And 46:38.140 --> 46:41.580 It's in it's incredible that this is 2018 46:41.580 --> 46:49.980 They're essentially seeding the narrative of the damage that will be done by the coming vaccine scheduled by coming counter measures by coming 46:51.660 --> 46:53.660 genetic technologies 46:56.380 --> 46:58.380 I don't understand 46:58.620 --> 47:02.780 Who judy mikovitz is but I do know from mark's work 47:03.420 --> 47:08.860 That it's hard to explain why the two people who came out and first published papers about her 47:09.500 --> 47:12.060 Data likely being fraudulent are dead 47:13.740 --> 47:20.540 It's weird that all of this stuff has to do with aids and vaccines. You could imagine a scenario 47:22.060 --> 47:23.660 credit to mark 47:23.660 --> 47:24.780 where 47:24.780 --> 47:31.660 The xm rv story was actually going to be queued up teed up as a way of pivoting from 47:32.780 --> 47:35.980 vaccine preparation to new methods like transfection 47:38.140 --> 47:39.100 But 47:39.100 --> 47:41.100 Unwitting non participating 47:41.980 --> 47:49.100 Biologists in the field said hey, this looks like bullshit and the story had to be changed. It had to be dealt with 47:51.740 --> 47:54.220 And now we have a different judy 47:55.420 --> 47:57.100 And twin 47:57.100 --> 48:02.860 Do you know the judy mikovitz just like jessica rose she has a twin too. It doesn't that eat didn't that meet 48:03.740 --> 48:06.460 Not twins are cool younger populations 48:06.940 --> 48:15.740 Driven by this somatopoietic stem cell. So what what this paper shows now is that in fact this cb2 endocannabinoid receptor 48:16.540 --> 48:22.860 Is is involved in the development of essentially every lineage of the myeloid 48:23.180 --> 48:27.260 Amatopoietic stem cell that it's involved in those diseases that I showed 48:27.900 --> 48:36.540 On the on the first slide if you notice the asterisks on the first slide what we were looking at is diseases associated with activated 48:37.260 --> 48:49.580 Macrophages activated micro glia cells in the brain. Um, so so now we know that there there's a primary disposition towards cb2 and the hematopoietic stem cell 48:50.380 --> 48:54.940 And that dysregulation of of these responses in these myeloid progenitors 48:55.660 --> 49:00.780 Is can be causal for these diseases and that we can reverse these diseases with 49:02.300 --> 49:09.820 With phytocannabinoids and modulating our endogenous produced cannabinoids on the next slide. We see that 49:10.700 --> 49:17.820 We continue to look at how the cb2 is associated with chronic inflammation of the nervous system 49:17.820 --> 49:23.820 Which is somewhat paradoxical and because in fact from the mesenchymal stems 49:23.820 --> 49:31.260 I'll shown on the left side of the slide. We see that the cb1 receptor that can have the canonical cannabinoid receptor number one 49:31.660 --> 49:33.420 Another g protein link 49:33.420 --> 49:38.220 signal its shown in blue and cb2 is shown in red for convenience is is actually 49:38.940 --> 49:45.820 Controls the development of neurons. So then development of neurons the development of a dipocytes bat set 49:45.820 --> 49:48.300 It's hard really to take this at face value 49:48.380 --> 49:51.580 You have to I just want to help you to see what I see here 49:51.980 --> 49:57.020 When somebody says that cannabinoid receptor one controls the development of neurons 49:57.020 --> 50:02.460 What they really mean is that if you mess around with it you can mess around with neuronal development of course 50:03.020 --> 50:11.020 She can't possibly mean that the development of neurons is controlled by a single receptor because that would be absurd 50:11.500 --> 50:15.500 Yet just like a lot of academic biologists that are still 50:16.140 --> 50:20.380 Not really teaching anybody including themselves the broad 50:20.940 --> 50:28.460 Sacred biology in which they operate she is not helping you understand that this is obviously infinitely more 50:29.100 --> 50:32.380 Complex than cannabinoid receptors controlling development 50:33.100 --> 50:35.100 And 50:35.100 --> 50:41.420 Yet they will continue to do this all biologists will continue to do it that are trained in this method of 50:42.380 --> 50:48.780 Creating a very sharp and narrow question that is so sharp and narrow that it actually doesn't even 50:49.660 --> 50:53.420 purport to validate the model that it purports to be a part of 50:53.580 --> 50:55.580 And 50:57.020 --> 51:03.260 So if you say that cannabinoid receptor one is involved in neuronal development 51:04.940 --> 51:09.740 What do you really mean? Well, she's saying that the receptor expression goes up 51:10.700 --> 51:12.700 Okay 51:13.740 --> 51:18.940 Peripheration is stopped by cannabinoids one over here and differentiation occurs 51:19.420 --> 51:25.740 So what can you increase differentiation? Is that stimulation required? Is it part of a suite of stimulations? 51:26.220 --> 51:31.100 Most of which have not even been identified never been manipulated in an experimental setting 51:33.740 --> 51:38.140 How many receptors are in neurons that we don't even have an even identified yet 51:38.380 --> 51:49.820 Don't take this at its words understand that this is the opposite of presenting you 51:50.300 --> 51:56.700 The complexity the irreducible complexity of the immune system the irreducible complexity of the development of the brain 51:58.220 --> 51:59.980 To simplify 51:59.980 --> 52:04.700 Down to cannabinoid receptors one and cannabinoid receptors two and how 52:05.180 --> 52:09.100 Finding substances which can stimulate those two might be fun 52:10.540 --> 52:13.180 Because of all this stuff that they're involved in 52:16.460 --> 52:19.980 Bells, pre and besides and and bone formation 52:20.300 --> 52:28.940 So that's somewhat paradoxical in thinking about that because if if I had on those slides cancers that metastasized to the bone 52:29.100 --> 52:33.020 And are primarily bone cancers such as multiple myeloma 52:33.980 --> 52:39.100 And in prostate cancer, which are two diseases in which bone formation is dysregulated 52:39.420 --> 52:46.220 So you see there on the left hand side though. The proteol osteoblasts is regulated by cannabinoid receptor number one 52:46.940 --> 52:50.060 and involved in in rankle is the receptor of 52:50.620 --> 52:57.260 NF Kappa B activation of NF. I mean isn't the implication here that you know way too much cannabinoid useful 52:57.740 --> 53:03.980 Will cause your your neurons to develop funny and your your bone resorption to go wrong and 53:04.540 --> 53:06.860 All of this stuff to go haywire. Isn't that 53:08.620 --> 53:13.020 Shouldn't that be the first question that's on your mind? How did all these hippies not just die? 53:13.740 --> 53:18.380 If everything in the body that's interesting is regulated by endocannabinoid one or two 53:18.380 --> 53:20.380 I 53:22.380 --> 53:27.660 Hope you're starting to see now what's happening here how this is done in academia where you try to take 53:28.380 --> 53:32.540 A story and conflate it to be the most important story to be told 53:33.980 --> 53:36.460 And what it does from the perspective of getting money 53:37.020 --> 53:42.300 What it does from the perspective of telling a story that's kind of I guess entertaining and singly focused 53:43.020 --> 53:47.100 but in no way shape or form acknowledges never mind tries to 53:48.060 --> 53:52.700 Pay any reverence to the irreducible complexity that all of these people are up against 53:53.100 --> 53:57.820 Applebee ligand and NF Kappa B, which we'll discuss in a moment is really key to 53:58.300 --> 54:01.580 Inflammatory responses and inflammation that drives 54:02.220 --> 54:05.900 In fact the breakdown of the proteol osteoclasts 54:06.220 --> 54:12.380 So what you see is you get osteoclasts favoring over osteoblasts that you're breaking down the bone progenitors 54:12.860 --> 54:15.980 And you're actually getting bone resort of resorption 54:16.460 --> 54:24.460 So we see in these cancers and in these diseases and of course osteoporosis in women of younger and younger ages driven by 54:25.180 --> 54:27.580 You know, it's now it's still a theory 54:27.580 --> 54:31.740 But driven by these interactions is the theory that we're working on in developing 54:32.140 --> 54:37.500 Therapeutics two months and so the problem with this model is how the hell do you test it? 54:38.460 --> 54:45.420 What kind of predictions does this model make? Are there predictions in the future that we can then verify using a measurement? 54:47.900 --> 54:52.140 That's what broken science is all about exposing this nonsense for what it is 54:52.140 --> 54:56.940 This is not a model and if it is a model, is it a model you intend to test? 54:58.300 --> 55:00.300 Absolutely not it's a model you assume 55:01.820 --> 55:05.020 Your experiments actually do not test this model 55:05.100 --> 55:09.580 They're not verifying it and you're not using this model to make any predictions 55:11.100 --> 55:16.620 You're collecting data to verify whether the parts of this model conform to data in the past 55:17.020 --> 55:22.060 You never make any predictions and they will never make any predictions because that's not how 55:22.620 --> 55:24.620 This kind of pseudoscience is done 55:24.780 --> 55:30.220 Ontulate the topic of this discussion. So on the right on the in the middle of the slide you can see how 55:31.100 --> 55:37.900 Red arrows blocking the the breakdown of the proteo osteo class and encouraging the build up and 55:38.140 --> 55:47.500 Development and lineage commitment to the osteoblasts and the bone formation is is critical is driven by blocking the cb1 receptor blocking 55:48.060 --> 55:53.820 And promoting I mean if this was done correctly you would drop these arrows in one at a time 55:53.900 --> 55:59.980 And every time you drop the arrows in there would be a little bibliography that would scroll past saying that these are the flabs that tested this 56:00.540 --> 56:05.020 And showed that mason chymal stem cells are inhibited by cb1 receptors 56:05.500 --> 56:13.180 In certain conditions in certain and every one of these steps would need to be explained in such a way so that we could really evaluate to what extent 56:13.260 --> 56:20.540 This part of this model cartoon is worth paying attention to holding in our mind or trying to mesh like a gear 56:20.940 --> 56:25.260 With some of these other things so that we can start to get a working model of how this system works 56:25.580 --> 56:31.500 But there's already 16 gears on this page and so no matter how good your your imagination is 56:31.500 --> 56:35.580 I don't care if you're nickel at tesla. You can't test this model in your head. You just can't 56:37.500 --> 56:43.260 And they can't test it with a simple experiment either using reductionist biological techniques. You can't do it 56:44.220 --> 56:46.220 Tan side where a cb2 56:47.020 --> 56:53.100 Is um is driving both it's directly activating the osteoplasts through a mechanism with the question mark 56:53.100 --> 56:58.060 We still don't know because that cb2 receptor hasn't necessarily been identified 56:58.540 --> 57:02.380 On that cell and and we have some ideas that we'll discuss in the next few slides 57:02.620 --> 57:05.500 Um, and that's why the question mark for the top arrow at arrow 57:05.500 --> 57:09.020 But we absolutely know when the cb1 receptor and cb2 57:09.820 --> 57:14.700 Cross talk interacts where the weight of the balance is I show on the left hand side 57:15.020 --> 57:18.060 It's not a honor off switch, but really a gradient 57:18.300 --> 57:23.580 So I look at um the endocannabinoid system as a dimmer switch on the immune system 57:23.740 --> 57:26.220 Really a master regulator at many different levels 57:26.300 --> 57:32.540 But via the stem cell via the mesenchymal stem cell via the amount of poetics stem cell and how it's a gradient 57:32.540 --> 57:37.900 So the more receptor that is expressed as it's up regulated the more you'll get the bad accumulation 57:37.980 --> 57:45.500 We can also think in our society about how the bad accumulation of metabolism is changing in in our teenagers and our young adults 57:45.820 --> 57:53.020 Um, you know through the dysregulation of this system. So one of the recent discoveries, um big discovery shown on the next slide 57:53.340 --> 57:58.220 Um, so the dysregulation of the endocannabinoid system is also causing kids to get fat 57:59.340 --> 58:00.380 Wow 58:00.380 --> 58:07.020 Is that that question mark may be addressed in a paper by brian gardener in his colleagues 58:07.260 --> 58:12.620 And that is that tetra hydro cannabinoid, which is the psychoactive t hc 58:13.180 --> 58:17.180 In medical marijuana actually turns on cb2 58:17.900 --> 58:22.060 Driving that g protein coupled receptor to breakdown atp 58:22.140 --> 58:27.420 This is called purinergic signaling where where atp is broken down into cyclic amp 58:27.900 --> 58:35.420 This activates the expression of a critical master regulator of chromatopoietic stem cells and stem cells in general 58:35.420 --> 58:38.700 Known as transforming growth factor beta or t so see here 58:39.020 --> 58:42.940 This is one of those cartoons where here you see a g protein coupled receptor 58:43.740 --> 58:46.940 G protein is now decreasing cyclic amp so 58:47.580 --> 58:53.820 Depending on the cell type depending on the context it can increase cyclic amp decrease cyclic amp 58:54.300 --> 58:59.020 And then those signals can be can result in expression of different proteins 58:59.100 --> 59:06.460 And so the the interesting thing about the cannabinoid system and indeed any g protein coupled system is that again 59:07.260 --> 59:08.780 like a 59:08.780 --> 59:14.620 A muscarinic receptor or a a muscarinic receptor is a subtype of a nicotinic receptor 59:15.020 --> 59:20.300 Where acetylcholine can bind and there are two kinds of acetylcholine receptors in general 59:20.380 --> 59:25.900 There's a nicotinic receptor, which is an ion channel and then a g protein coupled nicotinic receptor 59:26.300 --> 59:32.620 I'm sorry muscarinic receptor and they call it a muscarinic receptor because it is blocked by muscarin now are stimulated by muscarin 59:33.260 --> 59:37.660 So anyway, the point is is that depending on where those 59:38.700 --> 59:39.900 those 59:39.900 --> 59:41.900 G protein coupled receptors are 59:43.020 --> 59:45.020 And on what neuron? 59:45.100 --> 59:50.140 A muscarinic channel in some neurons could increase cyclic amp and increase 59:51.340 --> 59:57.420 Nmda channels in the membrane. It could change the mobility of actin membrane in a spine 59:57.900 --> 59:59.420 Um 59:59.420 --> 01:00:05.260 There's lots of possibilities with again with a g protein coupled receptor and that's why I think it's interesting here to note 01:00:05.820 --> 01:00:11.580 That every one of these receptors and every one of those contexts would need to be characterized in this way 01:00:12.060 --> 01:00:17.900 And you would never have a definitive answer. Is this the only thing that happens when cb do the cb 01:00:18.540 --> 01:00:21.500 cannabinoid receptor 2 in lymphocytes is stimulated 01:00:22.060 --> 01:00:24.540 So again, we're really at the very very very 01:00:25.340 --> 01:00:27.340 beginning of this whole thing 01:00:27.820 --> 01:00:30.860 And understanding cannabinoid receptors and 01:00:31.740 --> 01:00:33.980 cannabinoid receptor variants between people 01:00:34.940 --> 01:00:37.820 All of this stuff is going to be important because cb 01:00:38.380 --> 01:00:43.260 cannabinoid 2 receptor in you is different than me and so that's uh, this is this is all 01:00:43.900 --> 01:00:45.900 Just 01:00:45.900 --> 01:00:50.540 Any the other half of mark ink. It's my commits and resetting consulting here and and dr 01:00:50.540 --> 01:00:51.900 Aseti 01:00:51.900 --> 01:00:59.020 More than 25 years ago was the scientists who made the discovery that tgf beta acts on the stem cell as a 01:00:59.740 --> 01:01:04.380 Bifunctional regulator of hematophoresis. That means it can go both ways 01:01:05.020 --> 01:01:09.740 Tgf beta can be a really good general in in regulating immune responses 01:01:10.460 --> 01:01:16.780 A good soldier or a bad general. So if if if if if a pathway is on tgf beta can turn it off 01:01:17.100 --> 01:01:20.860 in as far as the immune system and if the pathway is off tgf beta 01:01:21.500 --> 01:01:27.660 Turns it on so it has both autocrine back on itself back on the stem cell to maintain the stem cells 01:01:27.980 --> 01:01:32.940 Thalness and paracrine to develop those effector lineages. I showed on that first slide 01:01:33.020 --> 01:01:39.420 So critical critical regulator and here we have thc. That's you know been really outlawed 01:01:40.540 --> 01:01:42.540 in our in our world for 01:01:43.500 --> 01:01:49.260 More than 70 years and and it's critical so cannabinoid formulations without thc 01:01:49.820 --> 01:01:55.180 Actually cannot regulate and cure diseases and in these therapies can be curative 01:01:55.340 --> 01:02:02.940 But you really can't spell health care without thc. So it's thc dependent and we have to think about formulations 01:02:03.660 --> 01:02:05.660 driving the cb2 01:02:06.300 --> 01:02:12.460 Interestingly enough the psychoactive effects of thc are are mediated through 01:02:13.020 --> 01:02:16.940 That cb1 receptor which I showed here on the last slide 01:02:17.260 --> 01:02:24.860 So it's those neurons and um that are are driven by thc because of course there's cross talk between the two receptors 01:02:25.020 --> 01:02:31.980 So so it's a it's a question of balance really but interestingly enough if we can develop and we're working to develop 01:02:32.620 --> 01:02:39.740 cb2 agonists that don't interact with cb1 that block that interaction and then you don't have the psychotropic effect 01:02:40.220 --> 01:02:41.740 um that is um 01:02:41.740 --> 01:02:44.540 um such a problem with with using these therapeutically 01:02:45.180 --> 01:02:49.820 Now that we can use them to still regulate the critical hematopoietic component 01:02:50.140 --> 01:02:52.140 So the next slide I show in some 01:02:52.460 --> 01:02:56.780 Respect that to go back to our first slide and think about what's causing 01:02:57.340 --> 01:03:02.380 the autoimmune neuroimmune and and um acquired immune deficiencies of our time 01:03:02.700 --> 01:03:09.260 Well, our expertise is in HIV aids and the reason I call these 21st century acquired immune deficiencies 01:03:09.340 --> 01:03:13.260 Because of course there's not HIV in all of these diseases 01:03:13.260 --> 01:03:16.300 But in every disease on the first slide where I showed an asterisk 01:03:16.620 --> 01:03:21.500 There's a retroviral component and um and we won't go into retrovirus biology 01:03:21.740 --> 01:03:24.540 But what we know is that in our treatment 01:03:24.540 --> 01:03:29.020 So she's saying there's a viral component in all of those things which I think is definitely 01:03:29.740 --> 01:03:31.740 definitely sketch 01:03:31.820 --> 01:03:35.500 um and so it seems like the broad stick 01:03:36.220 --> 01:03:37.260 of 01:03:37.260 --> 01:03:40.700 Judy mikovitz is that there are more viruses than we are told 01:03:41.340 --> 01:03:44.380 That are to be found in more places than we are told 01:03:44.940 --> 01:03:47.420 Causing more pain and suffering than we are told 01:03:50.540 --> 01:03:56.060 And she definitely doesn't question the existence of a novel virus that killed millions of people that millions more were saved from 01:03:56.060 --> 01:03:59.020 That probably came from a laboratory that was doing gave a function 01:04:00.940 --> 01:04:03.100 you see 01:04:03.100 --> 01:04:08.620 And at the beginning of the pandemic before the pandemic even started before it was anybody anybody's radar 01:04:09.180 --> 01:04:11.180 She was already out there 01:04:13.740 --> 01:04:16.940 Telling us that there would be this new 21st century 01:04:17.580 --> 01:04:23.100 acquired immune deficiency syndromes that don't all have aids viruses in them even though 01:04:23.900 --> 01:04:27.820 A lot of the people that she's worked with have worked with the aids people 01:04:29.820 --> 01:04:31.820 Like lots of papers with gallo 01:04:32.620 --> 01:04:34.860 Directly connected to gallo 01:04:36.780 --> 01:04:39.100 Remember that gallows 01:04:39.100 --> 01:04:44.940 Like buddy muri gardener was robert melones postdoc supervisor. This is a weird 01:04:45.900 --> 01:04:47.900 tiny little group of people 01:04:48.860 --> 01:04:53.340 Connected through a tiny little group of connected people all connected to the same 01:04:54.380 --> 01:04:56.380 Kind of parallel bullshit stories 01:04:56.780 --> 01:04:58.780 I 01:04:58.780 --> 01:05:04.300 Don't know the truth about hiv, but i'm pretty sure it's not a virus that came from bushmeat 01:05:05.260 --> 01:05:07.260 Brett Weinstein 01:05:08.620 --> 01:05:14.460 I don't know the story about polio vaccines, but i'm pretty sure it had a lot more to do with sanitation and 01:05:15.580 --> 01:05:17.580 pesticides and stuff like that 01:05:19.580 --> 01:05:22.620 And with regard to this talk 01:05:23.500 --> 01:05:25.500 And the discussion of 01:05:25.660 --> 01:05:32.300 21st century acquired immune deficiency syndromes that don't all include the aids virus. I think she's more or less seeding 01:05:33.740 --> 01:05:37.180 She's seeding the narrative of flying aids remember that's what 01:05:37.900 --> 01:05:40.300 Paul cottrell and those other people have been calling 01:05:41.020 --> 01:05:45.580 Coronavirus, it's it's flying aids. It's an acquired immune deficiency syndrome 01:05:45.580 --> 01:05:51.900 How many times have you heard it? They have been seeding the narrative of novel sources of an acquired immune 01:05:51.980 --> 01:05:53.820 Deficiency system 01:05:53.820 --> 01:05:58.780 Syndrome for a few years now so that long covid could be confounded with it 01:05:59.100 --> 01:06:02.300 And so that covid could be confounded with it ladies and gentlemen 01:06:02.620 --> 01:06:07.740 And they knew all along that they were seeding a narrative that would protect genetic vaccines 01:06:08.300 --> 01:06:10.220 genetic 01:06:10.220 --> 01:06:15.820 Genetic technologies they were they've been protecting them from the beginning and it takes a while 01:06:17.180 --> 01:06:19.580 That's why this talk is from 2018 01:06:19.580 --> 01:06:21.580 And 01:06:21.580 --> 01:06:28.940 Not saying anything about the vaccine schedule of uh in the development of have actually curative therapies for hiv 01:06:29.020 --> 01:06:35.660 Which dr. Said and I participated in at the national cancer institute in the 80s and in 90s those therapies 01:06:36.300 --> 01:06:41.420 Included at some level cannabis and so this the the people that survived 01:06:41.820 --> 01:06:48.940 And and and thrived with hiv were the ones that were using cannabinoids along with the anti retroviral therapies 01:06:48.940 --> 01:06:56.220 Which we developed in our laboratory and of course because of the stigma and and the legal problems with using it that that really wasn't known 01:06:56.620 --> 01:06:58.780 At that time and we've only recently known that 01:06:59.180 --> 01:07:03.980 So what we knew about cannabinoids is that they were antiviral and they reduce inflammation 01:07:04.220 --> 01:07:11.100 Because we see that blocking arrow on the right side so lps is uh lipopolysaccharide and it's on bacteria 01:07:11.340 --> 01:07:15.660 So bacteria and polyic mimics an RNA virus infection 01:07:15.740 --> 01:07:18.860 So RNA viruses are your flu viruses your 01:07:19.820 --> 01:07:21.820 hiv your retroviruses 01:07:22.220 --> 01:07:25.660 Your ebola your zika. These are all RNA viruses 01:07:25.900 --> 01:07:30.460 So probably i see mimics the activation of these all RNA viruses 01:07:30.540 --> 01:07:35.660 They're all RNA viruses and what do they have in common rna cannot pandemic 01:07:36.940 --> 01:07:42.940 And yet she lists all the viruses that these people responded to they're all the same small little family of 01:07:43.420 --> 01:07:49.260 Of outbreak specialists. Malone was on that list. She's on that list hat fills on that list 01:07:50.140 --> 01:07:53.820 Meryl nasa's on that list all these people are involved in this little list 01:07:55.180 --> 01:07:56.300 zika 01:07:56.300 --> 01:07:58.300 ebola 01:07:58.300 --> 01:08:02.700 Right. They're all in there somewhere complaining about that stuff at some point in time 01:08:04.060 --> 01:08:07.020 And for decades already for decades already 01:08:07.020 --> 01:08:13.900 When I was playing cyber ball 01:08:15.900 --> 01:08:20.060 At at the at at at oakwood mall and and ochlear, I mean 01:08:21.340 --> 01:08:23.340 These guys were already working on this 01:08:24.620 --> 01:08:31.020 Making sure that this virology as a field would be just impenetrable 01:08:31.500 --> 01:08:33.500 and 01:08:35.420 --> 01:08:43.340 Undifferentiable from a from a program that was just outright testing biological technologies on its population 01:08:45.340 --> 01:08:47.340 indistinguishable 01:08:47.340 --> 01:08:49.340 From a biotechnology 01:08:50.380 --> 01:08:54.060 National security priority that was looking for background signals 01:08:55.260 --> 01:08:57.820 That could be used and misconstrued as spread 01:08:57.900 --> 01:09:01.100 Characterizing background signals that they knew they were going to use 01:09:01.740 --> 01:09:03.900 as spread 01:09:03.900 --> 01:09:05.660 as evidence of 01:09:05.660 --> 01:09:08.620 Even more viruses in the background than before 01:09:10.380 --> 01:09:13.420 They all seem to have the basic same basic story here 01:09:13.900 --> 01:09:16.140 Now we're talking again about something 01:09:16.700 --> 01:09:22.300 and we're we're misconstruing the activation of the immune response by a bacterial protein 01:09:22.860 --> 01:09:23.900 with the 01:09:23.900 --> 01:09:27.340 the activation of the response to a virus and 01:09:27.980 --> 01:09:32.300 Without without giving adequate explanation for why those two can be parallels 01:09:32.620 --> 01:09:33.820 It's impressive 01:09:33.820 --> 01:09:38.780 And then these pathways that that generate type 1 interferons which are 01:09:39.100 --> 01:09:43.420 Curative for retroviruses almost all retroviruses and RNA viruses 01:09:43.900 --> 01:09:52.300 Actually tend to block this type 1 interferon pathway and we use type 1 interferons interferon alpha interferon beta as immune therapy 01:09:52.460 --> 01:09:55.660 In that disease I highlighted known as primary biliary cirrhosis 01:09:55.740 --> 01:10:00.220 Which is actually associated with a retrovirus known as human beta retrovirus 01:10:00.380 --> 01:10:03.500 So here we have and we know with HIV and hepatitis 01:10:03.500 --> 01:10:06.940 That's another disease she says is associated with yet another virus 01:10:07.500 --> 01:10:12.540 You see in various um liver diseases which are driven by um hepatitis B as a para retrovirus 01:10:12.540 --> 01:10:16.380 That means it has components of retroviruses and DNA retroviruses 01:10:16.380 --> 01:10:19.500 We use interferons as therapy. So here now we have 01:10:19.900 --> 01:10:26.220 An cannabinoids which are able to drive block these pro inflammatory mediators, which are so important 01:10:26.860 --> 01:10:32.700 For driving the disease process. It's the chronic inflammation and the chronic activation 01:10:33.180 --> 01:10:38.460 Of the monocyte lineage of that myeloid lineage which we discussed and we'll discuss a little a lot more today 01:10:38.940 --> 01:10:43.740 That is driving the disease processed in HIV associated dementias 01:10:44.460 --> 01:10:48.220 Um, we knew it had nothing to do with virus copy numbers. So 01:10:49.020 --> 01:10:52.380 Patients who were on anti retroviral therapy and had 01:10:52.860 --> 01:10:54.860 Non-detectable levels of HIV 01:10:55.340 --> 01:11:02.060 Still had a dementia and could develop diseases that look like early Alzheimer's disease that look like park and cineans 01:11:02.540 --> 01:11:06.780 And multiple sclerosis diseases and those are diseases that have all been associated 01:11:07.260 --> 01:11:14.300 But you don't need expression in the virus and it's the idea that we're driving these inflammatory mediators and and stopping the 01:11:15.100 --> 01:11:19.580 Interferon responses in in that way and this is where right in the middle of it 01:11:19.580 --> 01:11:27.420 The cannabinoids modulating that cb2 receptor are critical and actually curative if you drive it in the other direction 01:11:27.740 --> 01:11:31.500 So the next slide shows you a little bit more of that neural protection 01:11:31.580 --> 01:11:36.780 So we've talked about cannabinoids either phyto or endogenous those made by your body 01:11:37.260 --> 01:11:43.180 Being actually neuroprotective so therapeutics where you drive the neural protection through those 01:11:43.500 --> 01:11:51.420 Central mediators, but I show here in this slide critically. There are antioxidant cannabinoids and I show in the on the left hand side 01:11:51.500 --> 01:11:54.540 it's going through a factor known as um 01:11:55.500 --> 01:12:01.900 A rithroid factor to the nuclear rithroid factor to and that factor is is a key pathway 01:12:01.900 --> 01:12:05.420 It's a transcription factor in a pathway that is really key to sleep 01:12:05.900 --> 01:12:08.060 As you see it it drives the production 01:12:08.140 --> 01:12:13.660 It's upstream of the production of superoxide dismutase, which is a key liver enzyme for 01:12:14.460 --> 01:12:16.460 detoxing at the level of the liver and in 01:12:17.020 --> 01:12:20.140 Mutations and alterations genetically and epigenetically 01:12:20.860 --> 01:12:24.780 Silencing sod is critical to the development of Lou Gehrig's disease 01:12:24.780 --> 01:12:31.020 So these are the familial als and parkinsonians disease have a have a problem with making enough 01:12:31.820 --> 01:12:38.380 Superoxide dismutase or have dysfunctional enzyme at that level. So these antioxidant cannabinoids 01:12:39.020 --> 01:12:46.300 Actually, don't signal through cv1 or cv2 and we're unsure of what that of what the cross talk is and what the receptors are 01:12:46.540 --> 01:12:52.060 But no matter because they're lipid mediators and your membrane is shown here as lipid bilayers 01:12:52.220 --> 01:12:57.500 They go right through these lipids um cannabinoids or lipids and they go right through they stimulate and are up to 01:12:57.980 --> 01:13:02.380 Increase superoxide dismutase synthesis and decrease these 01:13:02.860 --> 01:13:07.420 Dounding brain damaging reactive oxygen and reactive nitrogen species 01:13:07.980 --> 01:13:13.420 So we all know about the antioxidants and so pro oxidation and oxidative stress 01:13:13.500 --> 01:13:21.820 It's known as is a key contributor to every disease on that first slide and particularly the neurological diseases. So it is those 01:13:22.540 --> 01:13:24.540 It's it's these pathways here 01:13:25.500 --> 01:13:27.500 That are really important for 01:13:29.660 --> 01:13:31.660 Turn off animals 01:13:31.660 --> 01:13:35.660 Are critically important for neural protection and neural inflammatory diseases 01:13:35.660 --> 01:13:40.700 So we can see the intersection right at that level for for the neural protection 01:13:41.020 --> 01:13:43.980 We also see introduced on the left hand side that the 01:13:44.540 --> 01:13:51.660 Not endogenous cannabinoids and cv1 agonists whether they be phyto cannabinoids other terpenes or synthetic 01:13:51.980 --> 01:13:57.580 um cv1 modulators are important for regulating brain derived neurotropic factor 01:13:57.660 --> 01:14:02.860 That's really a key neurotropic factor for developing new the development of new neurons 01:14:03.260 --> 01:14:10.940 So we the the key discovery here in the last um two decades since the um since the endogenous cannabinoid system 01:14:10.940 --> 01:14:18.220 Was discovered that we actually make and respond to cannabinoid molecules and they're critical to all of our development of both the brain and 01:14:19.100 --> 01:14:21.980 The immune system we can actually develop new brain cells 01:14:21.980 --> 01:14:27.100 We can actually drive through cv1 agonist and endogenous cannabinoids 01:14:28.060 --> 01:14:33.420 Neurogenesis, so that's really key to any of the diseases I showed like ALS 01:14:33.660 --> 01:14:39.580 Multiple sclerosis the demyelating diseases this actually shows the capacity to remyelinate to form 01:14:40.300 --> 01:14:45.340 New neurons and and and so far i'm not hearing a lot of downsides about weed, but 01:14:46.300 --> 01:14:49.980 You know, I'm not hearing a lot either. I mean it's a lot of word salad 01:14:51.420 --> 01:14:55.500 But there's lots of good things about stimulating the cannabinoid system 01:14:56.300 --> 01:15:03.180 Um, I don't think I disagree but again in general, right? We're talking about a very complex system. That's why 01:15:03.900 --> 01:15:05.180 you know 01:15:05.180 --> 01:15:08.780 Teenagers and young people that use extremely strong marijuana that are 01:15:09.420 --> 01:15:15.020 Already susceptible to depression or skits of Renee or any of these other conditions that we don't know very much about 01:15:15.500 --> 01:15:17.900 You can tip over into that attractor state 01:15:19.420 --> 01:15:21.420 And so when you when you 01:15:21.820 --> 01:15:27.420 You know, you make all these different claims about what's going on. These are just a very small tiny part 01:15:27.980 --> 01:15:32.540 Right, it's the tip of the iceberg of what this system does and how it works and 01:15:33.180 --> 01:15:38.620 How local versus systemic this signaling is and and what is affected by regular 01:15:39.180 --> 01:15:44.940 Cannabis use and how the body remodels those receptors remodels their expression in order to 01:15:45.660 --> 01:15:50.780 Tolerate or compensate for that being present in the system. So again 01:15:52.300 --> 01:15:55.980 We're talking about a million variables that are personal 01:15:56.860 --> 01:16:03.260 And we're simplifying down to a few arrows and a few pluses and minuses or reds and blue arrows up and down 01:16:05.820 --> 01:16:08.540 And the only real argument she's making is that 01:16:09.420 --> 01:16:13.340 Canabinoids are interesting because they're everywhere the receptors are everywhere 01:16:13.420 --> 01:16:18.940 They're involved in development and the immune system and the brain and everything that we are we think is important 01:16:20.380 --> 01:16:24.780 They're ubiquitous throughout the body. So what great that's interesting, but 01:16:25.580 --> 01:16:31.660 Again selling it as though this is the new be all end all is what I find most intriguing 01:16:32.700 --> 01:16:37.820 Really be cured of therapies for things even like autism spectrum disorders, um, which are 01:16:39.020 --> 01:16:44.780 In this family of myaltic encephalomyelitis that's inflammation of the brain and the muscles and adults 01:16:44.860 --> 01:16:47.500 They call it ME CFS and in in children 01:16:47.900 --> 01:16:50.060 They they end up with autism spectrum disorders 01:16:50.140 --> 01:16:56.780 But they're in the same they have the same types of immune disorders that an AIDS patient would have even in the absence of the virus 01:16:56.940 --> 01:17:04.460 Indicating other toxins going on so they're key to neural protection by cb1 driven endocannabinoids and phytopanhabinoids 01:17:05.180 --> 01:17:08.780 Right in the middle you see the intersection between the immune system 01:17:09.580 --> 01:17:10.380 and 01:17:10.380 --> 01:17:14.540 And the uh the brain and the immune system in the brain are really connected 01:17:15.020 --> 01:17:21.820 From conception and we and we know this now and the immune system is the brain is not what we used to consider 01:17:22.060 --> 01:17:24.300 immune privilege by immune privilege 01:17:24.300 --> 01:17:31.100 We means that you could have an inflammation of an antigen and it would not stimulate an inflammatory response 01:17:31.420 --> 01:17:33.420 That's simply not true 01:17:33.500 --> 01:17:35.500 Because the microglia 01:17:35.980 --> 01:17:40.620 Traffics the brain that means it starts in the bone marrow and those myeloid cells that I showed 01:17:40.780 --> 01:17:46.460 I'm that the first few slides and the brain derived monocyte macrophage is trafficked by 01:17:47.180 --> 01:17:53.020 Molecules known as chemokines those molecules known as chemokines are also regulated epigenetically that means 01:17:53.500 --> 01:17:57.180 At the expression level so while you can inherit changes in that 01:17:57.580 --> 01:18:04.700 Toxins in our environment like aluminum like mercury some of the things that they're shown to be so heavily associated with the development of 01:18:05.420 --> 01:18:11.660 Alzheimer's diseases those those and and autism spectrum disorders are that that pathogenesis is 01:18:12.060 --> 01:18:17.180 Hypothesized and and now more and more data support to be driven by activated microglia 01:18:17.500 --> 01:18:22.460 So you see the microglia is at the interface because they express both cb2 01:18:22.460 --> 01:18:24.460 um 01:18:24.460 --> 01:18:26.460 cannabinoid receptor number two 01:18:26.460 --> 01:18:35.500 And they cross talk they talk all day to the astraglia and the the astrocytes and the astraglia are important in glioblastoma the brain cancers 01:18:35.500 --> 01:18:43.260 We all um, you know, know of the upregulation and so really what we're listening to here is that endocannabinoid receptors are everywhere 01:18:43.260 --> 01:18:45.820 They're involved in a lot of things because they are everywhere 01:18:46.620 --> 01:18:50.460 And they can have some effect in an experimental setting on a lot of different things 01:18:50.540 --> 01:18:52.140 They can be shown to be 01:18:52.140 --> 01:18:56.220 Related to a lot of different systems again because they're g protein coupled receptors 01:18:56.220 --> 01:19:04.700 They can play a role in a lot of different systems and can be a a system wide regulator of things depending on how that that local circuit is organized 01:19:05.260 --> 01:19:09.740 But all these arrows pointing to neural protection all these arrows pointing to 01:19:10.380 --> 01:19:13.900 Regulation of the immune system is just making the argument to 01:19:14.620 --> 01:19:16.780 Look at cannabis as a plant 01:19:16.780 --> 01:19:18.780 To look at cannabis as a species 01:19:19.100 --> 01:19:22.220 To start dissecting its genome and start looking for 01:19:22.780 --> 01:19:28.380 candidate compounds that the pharmaceutical companies can synthetically make and use in these treatments 01:19:28.460 --> 01:19:33.420 Increase of the of the brain cancers the glioblastoma is in in our world 01:19:34.220 --> 01:19:40.060 And and it's it's proposed that cannabinoids and in fact really shown therapeutically 01:19:40.380 --> 01:19:45.820 That they can be not only helpful, but in this slide actually curative for these devastating brain cancers that 01:19:46.620 --> 01:19:51.500 That that killed vice president biden joe biden son a few years ago 01:19:51.580 --> 01:19:54.060 So crit it critical in thinking about therapeutic 01:19:54.540 --> 01:20:00.460 Opportunities where the micro glia by simply deactivating so it's the activated micro glia 01:20:00.460 --> 01:20:04.700 That is pathogenic because it releases that inflammatory nf cafe 01:20:05.260 --> 01:20:12.300 In that it releases the way way way way what this is 2018. Why did she say president biden son 01:20:13.260 --> 01:20:17.180 Did she say president biden son what in the hell wait? 01:20:18.380 --> 01:20:20.380 Is that right? 01:20:22.140 --> 01:20:28.620 What the full and thinking about therapeutic opportunities where the micro glia by simply deactivating 01:20:28.860 --> 01:20:35.260 So it's the activated micro glia that is pathogenic because it releases that inflammatory nf cafe 01:20:35.740 --> 01:20:42.060 In that it releases the activity pro inflammatory cytokines that reactivized oxygen and nitrogen species 01:20:42.380 --> 01:20:49.340 And really is driving the the breakdown so you want that cannabinoid receptor 2 through dgf beta through 01:20:49.580 --> 01:20:57.820 Thc to down regulate as we saw in the last slide to down regulate and actually allow cb1 to drive neural protection 01:20:58.140 --> 01:20:59.020 So 01:20:59.100 --> 01:21:02.060 The metabolic um substrates and the anti 01:21:02.460 --> 01:21:05.500 Undiant inflammatory tdf beta are really critical to it 01:21:05.660 --> 01:21:13.580 And it's this cross talk between the micro glia and the astraglia and the expression of both and probably through antioxidant in other 01:21:14.060 --> 01:21:19.500 Non-canonical cannabinoid receptors that modulate all of these processes non-canonical 01:21:20.140 --> 01:21:25.100 A non-canonical cannabinoid receptors are ones that they haven't identified and characterized yet 01:21:25.980 --> 01:21:32.700 See what we're talking about here. She's talking about cb1 and cb2, but then they're all non-canonical cannabinoid receptors 01:21:32.700 --> 01:21:34.700 How many of those are there Judy? 01:21:35.100 --> 01:21:42.300 The excitement is there for for all of us that um, um, that we we've probably uncovered a key therapeutic entity that can 01:21:42.780 --> 01:21:47.260 Um, that can actually cure some of the most devastating diseases of our time 01:21:47.740 --> 01:21:51.020 Um, the next slide shows even further to that 01:21:51.420 --> 01:21:55.820 Um, now they're being detected that they're actually cb1 receptors 01:21:57.660 --> 01:21:58.940 On the 01:21:58.940 --> 01:22:00.060 Mykandria 01:22:00.060 --> 01:22:04.780 So in on the astrocyte, I we blew up in in a paper that I've referenced 01:22:05.340 --> 01:22:12.140 Somewhere in here. I'll make sure I put the reference on paper. Um, but this is a january 2018 paper in the journal of neuro 01:22:12.860 --> 01:22:14.860 um, psychopharmacology 01:22:15.100 --> 01:22:18.060 And this paper talks about the the title of it is 01:22:18.620 --> 01:22:21.820 um, cb1 receptors from ubiquity to specificity 01:22:21.980 --> 01:22:26.940 So cb1 receptors in the endocannabinoid system they're expressed on essentially every cell 01:22:27.340 --> 01:22:33.420 In the body and every tissue and in every disease from cardiovascular disease to lung disease could be a part of those 01:22:33.740 --> 01:22:37.260 um neurons, um and and communications with the astrocytes 01:22:37.740 --> 01:22:41.500 Being dysregulated you see here the little um, G protein coupled receptor 01:22:41.740 --> 01:22:47.820 So they say they signaling through these G protein coupled receptors and the astrocyte there and the brain 01:22:48.380 --> 01:22:50.380 Um, we actually see these receptors 01:22:50.700 --> 01:22:52.060 um 01:22:52.060 --> 01:22:57.820 not only on the neuron and that the synaptic cleft driving um in the endogenous cannabinoid signaling 01:22:58.060 --> 01:23:00.780 For for neurological increase in apps and synapse 01:23:00.860 --> 01:23:02.300 This is driving all neurons 01:23:02.300 --> 01:23:03.980 So when we think about these 01:23:03.980 --> 01:23:09.340 fasticity diseases that that I talked about with ALS and and multiple sclerosis 01:23:09.900 --> 01:23:11.900 um, uh, lugere 01:23:11.900 --> 01:23:17.740 Parkinson's disease the fasciculations the um, the the seizures in the children with autism spectrum 01:23:17.740 --> 01:23:23.900 Disorders, it's these receptors that are being dysregulated the psychoses even the psychoses 01:23:23.900 --> 01:23:31.900 We see in young people who have dysregulated cb1 receptors. In fact, it's the it's the um, the agonist of the cb2 01:23:32.380 --> 01:23:38.220 Um, the thc that could actually stop the psychoses rather than driving the addiction as we think 01:23:38.460 --> 01:23:42.300 So here we have the communication between the neurons expressing 01:23:42.620 --> 01:23:49.020 Cross-talking receptors and the astrocytes and the calcium signaling that that is discussed in the ion channels 01:23:49.260 --> 01:23:54.940 And we show now the next point that the cannabinoids are actually there if we blow up in that 01:23:55.260 --> 01:23:56.220 um 01:23:56.220 --> 01:24:01.260 In that neuron the brain the heart and the muscles have the most mitochondria 01:24:01.580 --> 01:24:09.580 So this is because that's the energy powerhouses of of of your entire body with that without the mitochondria 01:24:09.820 --> 01:24:13.980 um, with the respiratory chain leading to 36 ATP versus two 01:24:14.300 --> 01:24:18.300 You can think about all of these diseases myaltic encephalomyelitis 01:24:18.860 --> 01:24:25.340 Um, is is inflammation of the brain and the muscles and it's long been been known to be a mitochondrial disease 01:24:25.580 --> 01:24:29.020 Um, and and now we can start begin to understand 01:24:29.580 --> 01:24:35.260 Um, that the cannabinoid signal through mitochondria right in the right hand slide. You see the mitochondria 01:24:35.660 --> 01:24:39.580 Actually has a mitochondrial cb1 signal 01:24:40.220 --> 01:24:42.860 So that so that you could actually generate 01:24:43.820 --> 01:24:51.580 Energy and and and read restore energy at the level of really restoring function and and these are the mitochondrial disease 01:24:51.580 --> 01:24:56.940 See wherever she finds a mitochondrial, uh, sorry wherever she finds a cannabinoid receptor 01:24:56.940 --> 01:25:02.140 Then she makes a story up about what you could potentially do with a cannabinoid that targeted that 01:25:02.860 --> 01:25:07.980 So now she's going to tell you that you could generate energy with cannabinoids you can you can be 01:25:08.860 --> 01:25:15.420 Protecting of neurons in five different ways because they're they're there and they're there and they're there and they're here and they're there and they 01:25:15.980 --> 01:25:22.620 They cause blood cells to differentiate into myeloid cells and they just you know it this kind of 01:25:24.060 --> 01:25:27.260 This kind of throwing a net over something 01:25:27.740 --> 01:25:31.340 Like a cannabinoid receptor and then claiming all of its 01:25:31.900 --> 01:25:33.900 relevance based on where it's found 01:25:34.300 --> 01:25:41.020 Is something that almost everyone in biology does when they have a pet receptor or a pet ion channel 01:25:41.660 --> 01:25:48.140 If you study calcium gated potassium channels and you notice that they're in every neuron 01:25:49.100 --> 01:25:56.700 That their expression changes during development that they're also found in cardiac neurons that they're also found in cardiac muscle 01:25:56.700 --> 01:26:01.580 That they're also found in all these places and then you can start to say that's that calcium 01:26:02.380 --> 01:26:07.340 Gated sodium channels are sorry calcium gated potassium channels are the most important 01:26:08.140 --> 01:26:09.420 channels 01:26:09.420 --> 01:26:13.100 In the whole body because they regulate neuronal function 01:26:13.100 --> 01:26:18.220 They regulate action potential half width they regulate and I could go on and on and on and on and on 01:26:19.980 --> 01:26:26.140 And then I can make a long argument about how conotoxins and and appamen from bees 01:26:26.540 --> 01:26:34.620 Are two things that interact with sk channels and we should look for more drugs that act with sk channels because sk channels are everywhere 01:26:39.420 --> 01:26:46.220 And it's no different than saying that well, we think we found some cannabinoid receptors subtypes on the mitochondria 01:26:46.300 --> 01:26:50.460 So obviously we can generate energy with it's just ridiculous 01:26:51.420 --> 01:26:53.420 But 01:26:53.420 --> 01:26:57.100 This is exactly how academic biology has been broken 01:26:58.300 --> 01:27:02.540 Because there is an impetus to to use this technique 01:27:04.300 --> 01:27:09.740 That gets you grants that makes you untouchable in this really narrow 01:27:10.300 --> 01:27:18.140 Fine band of understanding that no other academic can really encroach on because they don't study the cannabinoids that she does 01:27:18.460 --> 01:27:25.420 They don't study it at the level that she does they're they're not looking to modulate the things that she's looking to modulate 01:27:25.500 --> 01:27:27.980 And she doesn't they work for different companies. That's all 01:27:29.660 --> 01:27:32.540 These are devastated where children actually die before 01:27:33.180 --> 01:27:38.700 They're a few years old if they have a primary deficiency in any one of the chains of the mitochondria 01:27:39.180 --> 01:27:44.780 Respiratory chain in in any of these that that leads to certain death because you can't feel your brain 01:27:45.100 --> 01:27:48.940 Your heart or your muscles if you can't generate enough energy 01:27:48.940 --> 01:27:54.620 So here the cannabinoids are are even a key to the respiratory transport chain 01:27:54.780 --> 01:28:00.860 And there's that reference for that paper in neuropsycho pharmacology, but there's a question mark in the 01:28:01.260 --> 01:28:07.340 Cartoon for a discussion like this is we start to really dig into seeing it's a question mark 01:28:07.900 --> 01:28:10.460 Homeostasis that's a balance in our energy 01:28:11.100 --> 01:28:17.980 In in some of these devastating diseases of an inability to it's really an inability to fuel the brain and the heart 01:28:18.380 --> 01:28:19.980 So it's it's now energy 01:28:19.980 --> 01:28:26.060 It has nothing to do with misfolded proteins or any of the other stuff that we're supposed to pay attention to in those diseases 01:28:26.060 --> 01:28:28.060 Don't you see how cool this is? 01:28:28.460 --> 01:28:34.300 Some of those diseases have misfolded proteins in them and we're not even close to talking about that yet 01:28:35.820 --> 01:28:38.300 They haven't even come close. You see it 01:28:39.260 --> 01:28:43.500 Remember there's misfolded proteins in frickin cancer 01:28:44.140 --> 01:28:48.220 Don't you remember the lady from mit that we just watched a couple days ago 01:28:48.940 --> 01:28:50.940 She told us that these heat shock proteins 01:28:51.660 --> 01:28:54.620 Our vital responses in cancer and that cancer 01:28:54.940 --> 01:28:57.660 It happens because there's some misfolding stuff 01:28:59.100 --> 01:29:01.100 She works on cancer 01:29:01.260 --> 01:29:06.460 She worked at the national cancer institute for many a year. I don't hear anything about protein misfolding right now 01:29:06.540 --> 01:29:08.460 She's talking about all kinds of 01:29:08.460 --> 01:29:14.700 Cognitive developmental disorders that have protein mis I'm not hearing anything. It's just all cannabinoid receptors 01:29:16.380 --> 01:29:20.860 That is how academic biology has been broken ladies and gentlemen 01:29:22.860 --> 01:29:27.820 And the muscles at the same time because of of defects and pathogens on most viruses 01:29:28.220 --> 01:29:34.540 Will take out the mitochondria because they need the energy as well. So I show schematically on the next slide 01:29:35.340 --> 01:29:40.700 All of the ways that phyto cannabinoid so we've been talking about just our endogenous cannabinoids 01:29:40.700 --> 01:29:46.740 Which we which we produce on our own throughout our lifetime, but as toxins further and further 01:29:47.100 --> 01:29:48.460 dysregulate 01:29:48.460 --> 01:29:54.060 Our immune system in our endocannabinoid system because we haven't had plant sources 01:29:54.540 --> 01:29:59.100 Of cannabinoids whether it be hemp which has been outlawed since the 1930s 01:30:00.060 --> 01:30:02.060 Is from cannabis sativa 01:30:02.620 --> 01:30:04.460 And and the th she containing 01:30:05.100 --> 01:30:11.260 Medical marijuana. It's called they're all cannabis sativa or in the car the main major strains because that's been out of our diet 01:30:11.340 --> 01:30:16.540 Out of our world and the toxins that dysregulate the machinery that so now we need to eat 01:30:17.100 --> 01:30:22.460 Cannabinoids we need to ingest them because our body can't make them what is going on here 01:30:24.860 --> 01:30:27.260 That's a very interesting statement now, isn't it? 01:30:29.660 --> 01:30:34.300 Wow, I'm I'm and there they are all timers Parkinson's those are all 01:30:34.940 --> 01:30:42.620 Those are all misfolding disorders at least according to some academic biologists with a certain narrow point of view about them 01:30:44.780 --> 01:30:51.420 She thinks it's more related to endocannabinoid dysregulation of energy consumption and fueling the brain or whatever she said 01:30:52.380 --> 01:30:56.460 Maybe microglia responses being regulated by endocannabinoid receptors 01:30:57.020 --> 01:31:02.780 Amazing talk just shown you on the past few slides have been increasing in our world and we really have 01:31:03.420 --> 01:31:06.860 No response no therapeutic entity to simulate 01:31:07.580 --> 01:31:14.140 The phyto cannabinoids are are ones that have been used historically more than 14,000 years 01:31:14.700 --> 01:31:19.980 To to really mitigate and prevent the progression and development of these diseases 01:31:20.060 --> 01:31:23.100 So they mitigate neuro trauma ischemia is loss of oxidants 01:31:23.100 --> 01:31:27.020 So we talked about those reactive oxygen species and driving 01:31:27.340 --> 01:31:34.460 Oxidative stress starving off tissue. So ischemia is the problem in stroke major depressive disorders Alzheimer's disease. It's um 01:31:35.340 --> 01:31:39.340 Everything we've talked about in the last few slides are are interacting from that 01:31:40.140 --> 01:31:45.740 neuron where the immune cells the microglia the oligodendrocyte and the astrocyte are communicating 01:31:45.980 --> 01:31:48.780 Viya the cytokines chemokines growth factors 01:31:49.020 --> 01:31:54.860 Neuro transmitters like nrf2 and and neuro hormones like for instance vitamin D critical 01:31:55.340 --> 01:32:01.660 So these all of these things go to disrupt the balance we call it the homeostasis at the at the level of the brain 01:32:02.300 --> 01:32:06.780 And and this is what's driving. So if we can take phyto cannabinoids from plants 01:32:07.100 --> 01:32:11.260 We can dampen that tissue injury we can prevent the progression of diseases 01:32:11.420 --> 01:32:18.060 And in fact, as we saw a few slides ago, we could um, we could target neurogenesis once we once we've stopped the issue 01:32:18.060 --> 01:32:22.540 So essentially she's saying that none of these diseases have to do with diet 01:32:22.700 --> 01:32:25.900 None of these diseases have to do with environmental toxins 01:32:26.860 --> 01:32:28.860 They have to do with our lack of phyto 01:32:29.900 --> 01:32:35.260 cannabinoids and not using these and eating these plants anymore or something like that 01:32:35.420 --> 01:32:39.260 I'm assuming that there are other plants that have phyto cannabinoids besides marijuana 01:32:39.900 --> 01:32:41.100 um 01:32:41.260 --> 01:32:43.260 What an interesting talk 01:32:44.140 --> 01:32:51.660 And actually regenerate healthy neurons and neurological um function and and you know, literally, um cure these diseases 01:32:51.980 --> 01:32:53.980 Um, and cure these diseases 01:32:54.620 --> 01:32:55.980 scientific opinion 01:32:55.980 --> 01:32:58.540 Um, as as slide as the next slide shows 01:32:58.940 --> 01:33:04.860 It's really the tissue macrophage that is driving all of these processes. We've talked about micro glia 01:33:05.100 --> 01:33:08.860 Um, and and that's the brain macrophage. Well, the keratinocyte 01:33:08.940 --> 01:33:13.260 Let's stop here and just marvel at the number of macrophages there are 01:33:14.220 --> 01:33:20.380 Number marvel at the macrophage diversity that no one ever acknowledges at all 01:33:25.980 --> 01:33:33.100 Is the skin macrophage so we think of all of the uh, we think of all the skin diseases and that we see um, the very 01:33:33.660 --> 01:33:42.300 Devastating skin diseases that that could in fact, um, be be regulated by a cannabinoids via, um, the the cb2 receptor 01:33:42.620 --> 01:33:48.780 That that we show thc the psychoactive thc actually acts to drive, um, the various macrophages 01:33:48.780 --> 01:33:55.260 So each different organ system from the lung alveolar macrophage. So here we can use cannabinoids for 01:33:56.060 --> 01:34:02.620 Lung cancer as part of immune therapy in in our world. We've developed we developed, um, drugs at the national cancer institute 01:34:02.780 --> 01:34:09.100 And through various pharmaceutical companies like epigenetics, um, for the last 30 or 40 years getting old here 01:34:09.500 --> 01:34:13.500 But but you can you can target in copd the alveolar macrophage 01:34:13.500 --> 01:34:18.860 So we can think of all the allergens and microorganisms that are that are driving more and more copd 01:34:18.860 --> 01:34:23.660 Which is, um, chronic obstructive pulmonary diseases. Um, we look at the liver cup for cells 01:34:23.660 --> 01:34:27.820 So this is the cell that's critical to hepatitis c hepatitis b 01:34:27.980 --> 01:34:34.300 Um, hbrb and primary billery cirrhosis cirrhosis of the liver. We think of fatty liver disease 01:34:34.300 --> 01:34:39.740 I, um, I think, um of all of the um, stories. I've been reading, uh, in the in the journals lately 01:34:39.740 --> 01:34:43.020 It's the huge incidence in fatty liver diseases 01:34:43.740 --> 01:34:46.220 In people under 50 whether it be men or women 01:34:46.300 --> 01:34:49.660 And I showed you that the dipisite slide in the in the fat progenitor 01:34:49.740 --> 01:34:54.780 So if you're driving the cb1 because of toxins because you don't have enough cb2 01:34:55.100 --> 01:35:00.700 Driving the monocyte macrophage then you can see how all of the diseases and then some that I put 01:35:00.700 --> 01:35:02.700 See you don't have enough cbd 01:35:03.580 --> 01:35:10.300 Do you don't have enough cannabinoids driving the cb2 receptor? It is exactly this kind of ridiculous 01:35:11.180 --> 01:35:18.940 Simplification reductionist biology that has contaminated and destroyed our academic biological fields our medical science 01:35:19.580 --> 01:35:22.220 And this is just a use of that technique 01:35:22.860 --> 01:35:30.460 To present the primacy of the cb1 and cb2 receptors to make an argument that these are a new kind of 01:35:31.180 --> 01:35:34.380 Of receptor to target a new novel idea 01:35:34.940 --> 01:35:39.740 Um, that's just gaining traction that has all kinds of applications in the future 01:35:40.300 --> 01:35:46.380 For the coming 21st century of acquired immune deficiency syndromes, you know like flying aids 01:35:47.340 --> 01:35:49.820 on that on that first introductory slide 01:35:50.220 --> 01:35:54.220 Could be mitigated at some level by the right combination of 01:35:54.780 --> 01:36:00.140 Fido cannabinoids now from plants because of course our endogenous ones simply aren't enough to overcome 01:36:00.540 --> 01:36:05.340 Um, what is already not enough process because we've been without them. We don't have enough last time 01:36:06.060 --> 01:36:10.940 Most people experience the endogenous cannabinoids is during breastfeeding 01:36:11.420 --> 01:36:17.260 Because that's when mom is elaborating and producing many of them through the milk and babies getting that calming pain free 01:36:17.820 --> 01:36:20.780 Learn to suckle and mom and baby or go. That's the last time 01:36:21.100 --> 01:36:24.620 That's the last time we've had endocannabinoids is when we were breastfeeding 01:36:25.100 --> 01:36:29.260 Wow, that's a weird statement our brain makes them all the time 01:36:30.140 --> 01:36:35.100 Where does she think they come from idea of of joy anandamide one of the key 01:36:35.820 --> 01:36:39.500 Endogenous cannabinoids anandamide is sanskrit meaning joy 01:36:39.580 --> 01:36:45.980 So the cannabinoid system could be seen as joy pain free happy stress-free living and you can see at every level 01:36:45.980 --> 01:36:47.980 The macropage that cb2 01:36:48.940 --> 01:36:50.860 Endogenous 01:36:50.860 --> 01:36:52.620 Babies are broken 01:36:52.620 --> 01:36:58.380 Not in a like over, you know, I don't want to be overly dramatic but there is no question 01:36:59.340 --> 01:37:03.980 That breastfeeding if it can be done without pain and suffering by the mom 01:37:04.620 --> 01:37:12.300 Breastfeeding is so far beyond superior to anything else that should never be considered to be dropped 01:37:14.060 --> 01:37:19.900 There should be a full-time effort by the husband and the wife over many days to make that work 01:37:20.780 --> 01:37:22.780 with the help of a 01:37:23.020 --> 01:37:25.020 anyone 01:37:25.340 --> 01:37:31.580 And that should be given up at the very last resort and I don't I don't think everybody's going to be really happy hearing me say that 01:37:32.700 --> 01:37:35.580 But i'm saying it as I defend my my 01:37:36.460 --> 01:37:38.460 best friend 01:37:38.460 --> 01:37:44.940 For maybe the only reason why our daughter who's had the entire goddamn schedule since we got here in america 01:37:45.420 --> 01:37:48.140 Is not damaged as much as she could be 01:37:48.540 --> 01:37:53.180 Is because my wife had the wherewithal to breastfeed her until she was almost five years old 01:37:55.580 --> 01:37:58.540 Now our middle son was actually treated very differently 01:37:58.620 --> 01:38:03.420 But our middle son was grow grew up in with his toddler years in the netherland 01:38:03.500 --> 01:38:08.300 So he didn't have the same kind of assault on his immune system that my daughter did here 01:38:11.580 --> 01:38:13.580 But oh my gosh 01:38:15.180 --> 01:38:19.500 If there is anything that bonds a woman with a child that is breastfeeding 01:38:20.300 --> 01:38:21.820 And 01:38:21.820 --> 01:38:26.780 Just talking about missing out on that can make my wife break down in tears 01:38:29.820 --> 01:38:34.780 I think she considers these some of the most important moments of her life 01:38:37.260 --> 01:38:43.420 And I think that every day that she think that she's asked to think about it. She thinks maybe she would want another child 01:38:44.700 --> 01:38:46.700 That's how beautiful it is 01:38:49.500 --> 01:38:51.500 And 01:38:53.980 --> 01:38:58.700 It is impossible as a man to understand the kinds of things that a woman goes through 01:38:59.420 --> 01:39:03.660 From the moment of conception until a child leaves the house 01:39:05.340 --> 01:39:11.740 And no matter what you want to think of yourself as a father, there's no way that you can possibly understand we can possibly understand 01:39:13.020 --> 01:39:17.500 What it will means to carry a child to give birth to a child to breastfeed a child 01:39:19.660 --> 01:39:21.660 And the idea that we would 01:39:22.380 --> 01:39:26.140 Abbreviate that process or punctuate that process in any way 01:39:28.220 --> 01:39:32.060 It's just it's an abomination ladies and gentlemen. It's an abomination 01:39:36.300 --> 01:39:39.420 And so I don't know what she's talking about here with endocannabinoids and breastfeeding 01:39:39.420 --> 01:39:43.740 But I am pretty sure that your brain makes endocannabinoids all the time there necessary they're there 01:39:44.140 --> 01:39:49.420 But they are a modulator they play a role in the background like all the other instruments in a symphony does 01:39:49.500 --> 01:39:56.300 And if you take the piccolo out of the symphony, you can still recognize the song and it still goes and everybody can make it to the coda 01:39:57.820 --> 01:40:03.660 But there will be something missing and with cannabinoid receptors. This is a yet another knob to turn 01:40:03.740 --> 01:40:04.860 It's another 01:40:04.860 --> 01:40:08.220 Slider on the equalizer, but it's not the be-all end-all that 01:40:08.700 --> 01:40:12.380 Decides whether macrophages are working or whether they're sitting in the corner 01:40:13.180 --> 01:40:19.260 It's not the difference between well, my kid's brain is developing or it's not developing or my kids 01:40:19.820 --> 01:40:24.140 Got skits if any or it doesn't have skits if any because he doesn't have enough cannabinoids in his brain 01:40:24.220 --> 01:40:26.220 I guess we better give him some more 01:40:29.900 --> 01:40:36.940 Abenoid key to the development of the hematopaedic poetics stem cell is could be modulated in a in a way by cannabinoids 01:40:36.940 --> 01:40:41.580 In a positive way rather than a damaging way with the bone resorption here at the bottom of the screen 01:40:41.740 --> 01:40:43.740 some chronic um 01:40:43.740 --> 01:40:44.540 the 01:40:44.540 --> 01:40:47.980 IBD the inflammatory bio disease and Crohn's disease at the level of the 01:40:48.780 --> 01:40:55.580 Intestinal macrophages. So so many of these diseases by gently modulating the macrophages at the level of the mild 01:40:55.580 --> 01:41:01.100 So rather than take care of the result the pathogenic state whatever poison you have 01:41:01.100 --> 01:41:02.300 What other 01:41:02.300 --> 01:41:06.220 Environmental toxin you're exposed to or whatever other thing was dysregulated 01:41:06.700 --> 01:41:12.620 Let's just give them a substance which fixes that they're not on the right medication is the answer here 01:41:13.500 --> 01:41:15.500 People aren't on the right medications 01:41:16.220 --> 01:41:19.900 We need to get new medications to these people so we can cure their problems 01:41:20.380 --> 01:41:25.260 Rather than going to the root cause which would be real health and well-being right 01:41:25.980 --> 01:41:29.660 That's health and wellness. This is not medicine. This is pharmaceuticals 01:41:30.460 --> 01:41:35.580 Once you see it you can't unsee it. I think this is this was the best thing 01:41:35.580 --> 01:41:36.940 We could have done with Judy 01:41:36.940 --> 01:41:40.940 But stem cell could actually be curative by looking at in these ways 01:41:41.260 --> 01:41:43.820 I highlight the cross talk in in the next slide 01:41:44.380 --> 01:41:51.580 To show you the pairing so cross talk of receptor. So opioid receptors are also a little deep 01:41:51.580 --> 01:41:57.500 But that's the great this is the perfect slide for which to do this right? So what happens? How do they target this? 01:41:58.460 --> 01:42:04.220 How do they get the serotonin receptors to be hit or the dopamine receptors to be hit 01:42:04.620 --> 01:42:09.820 And modulated by the cv1 stimulation, but not the orexin receptors or the chemokine receptors 01:42:09.820 --> 01:42:11.980 How do they manage to do that? 01:42:13.580 --> 01:42:15.580 Put a tag on it 01:42:15.580 --> 01:42:20.460 Electropyrated in the right places. Come on guys. You can see it Pamela sees it 01:42:21.020 --> 01:42:23.260 Link receptors there to these channels 01:42:23.260 --> 01:42:28.620 I show you cv1 and that cross talk doesn't only have to happen between the cv1 and cv2 01:42:29.020 --> 01:42:32.060 It can happen through these to these opioid receptors 01:42:32.220 --> 01:42:38.220 So anxiety and depression and chronic diseases anxieties a type of pain. It's called it's a no-siception 01:42:38.460 --> 01:42:42.940 It's a different idea when we think of anxiety. So that's simply using cv1 01:42:43.500 --> 01:42:48.220 Rich and targeting agonists and preparations of cannabinoids can actually 01:42:48.940 --> 01:42:55.660 lead to tolerance and brain blocking pain blocking effects of opiate so it could actually reduce our opioid addiction 01:42:56.060 --> 01:42:58.220 And so again, we're talking about could 01:42:58.780 --> 01:43:04.140 Maybe because this receptor is there and that receptor is there and these things are involved in that 01:43:04.460 --> 01:43:07.020 We might be able to use this thing to do stuff 01:43:10.060 --> 01:43:15.260 And this is exactly how academic biology is broken because that's how they all talk 01:43:15.740 --> 01:43:21.900 That's how they always talk at the end of their talk. How many things can I catch with my net? 01:43:23.100 --> 01:43:24.060 Holy 01:43:24.060 --> 01:43:31.980 Cannabis, you know, and this is this is where understanding of biology and biochemistry helps us to break down these cultural walls that says oh no 01:43:32.380 --> 01:43:34.540 Cannabis is addictive and we can't have THC 01:43:34.780 --> 01:43:39.980 Well, as long as you prevent THC from signaling cv1 you won't get this psychoactive effects 01:43:40.300 --> 01:43:43.260 And we can do that because we can just build a stronger magnet 01:43:44.060 --> 01:43:47.820 Then THC to block those effects with that that happens now 01:43:48.060 --> 01:43:55.340 See so what she's actually suggesting is is that in order to get this right we're going to have to have a THC receptor one blocker 01:43:56.140 --> 01:44:03.820 Put in your brain so you don't get high and then we'll we'll we'll use a different one that the oh my gosh 01:44:03.980 --> 01:44:05.980 It's just disturbing how 01:44:06.540 --> 01:44:13.180 Ridiculous she sounds not only do you have no way of targeting any of these specific targets with your 01:44:14.140 --> 01:44:18.540 Hit cv1 receptor and every one of these pictures. So how is it specific? 01:44:20.780 --> 01:44:27.340 And then you're going to block specific cv2 receptors or cv1 receptors in the brain to get the cv2 receptors 01:44:27.820 --> 01:44:29.820 it's just all 01:44:32.860 --> 01:44:35.020 It's all hot air actually through 01:44:36.380 --> 01:44:39.980 Blockers of various immune molecules like inflammatory cytokine 01:44:40.220 --> 01:44:45.660 IL-1 which is central to many diseases of pain as an IL-1 receptor and hagginess 01:44:45.740 --> 01:44:52.940 So it actually is expressed in high levels IL-1 RA to block IL-1 once IL-1's job is done 01:44:53.180 --> 01:44:58.380 So that you don't overdo it and cause these addictions so on to depression and anxiety 01:44:58.380 --> 01:45:05.260 We think of serotonin receptors so soo spider billions of dollars are spent spinning wheels like this 01:45:05.500 --> 01:45:11.580 billions of dollars in grants are given to people who can talk exactly like this about a million different 01:45:12.220 --> 01:45:16.460 subjects of a tiny little flimsy part of some story 01:45:18.540 --> 01:45:25.340 And there are there are actually hundreds and hundreds of g protein coupled receptors that people are interested in 01:45:25.340 --> 01:45:28.700 Hundreds and hundreds of ionic receptors that people are interested in 01:45:29.180 --> 01:45:32.380 And it's it's each one of those can tell the same story 01:45:32.380 --> 01:45:35.500 I wasn't joking when I was saying that calcium 01:45:36.300 --> 01:45:38.300 small conductance 01:45:38.620 --> 01:45:42.940 Calcium activated potassium channels are one of many 01:45:43.660 --> 01:45:46.300 different subtypes of potassium channels 01:45:47.020 --> 01:45:53.660 Potassium channel biophysicists are very firm in their belief that potassium channels because they turn off 01:45:54.300 --> 01:46:00.460 the action potential because they reset the membrane of neurons and all electrical 01:46:01.260 --> 01:46:03.260 membrane 01:46:03.260 --> 01:46:05.020 in the body 01:46:05.020 --> 01:46:08.140 The potassium channels are the most important things to regulate 01:46:08.140 --> 01:46:10.300 They're the most important things to target 01:46:10.300 --> 01:46:14.140 They're the most important things that conduct the timing of the symphony 01:46:14.140 --> 01:46:18.060 And you can hear all of these people over many decades talking about how 01:46:18.780 --> 01:46:22.620 Primal they are to brain function even though they are a very tiny 01:46:23.500 --> 01:46:29.020 Channel that produces a very tiny amount of current only in response to the presence of calcium 01:46:30.460 --> 01:46:36.380 And so only at when synapses are learning which is also really reason why everybody's so interested in them for a long time 01:46:36.780 --> 01:46:41.020 And she's doing exactly the same thing with cannabinoids right now 01:46:41.420 --> 01:46:46.780 With regard to the brain and the immune system and inflammation and all of the major 01:46:47.660 --> 01:46:51.740 Acquired immune deficiencies of the 21st century. It's an incredible 01:46:52.540 --> 01:46:56.380 Talk so here again. This is where a therapeutic opportunity exists 01:46:57.180 --> 01:47:01.020 With with these memory impairments and these these diseases of serotonin 01:47:01.420 --> 01:47:05.900 receptors, which of course serotonin and dopamine receptors are key to Parkinson's disease 01:47:06.700 --> 01:47:08.700 And and a number of other 01:47:09.100 --> 01:47:14.940 You know, literally untreatable diseases at least thought of and until very recently Huntington's disease 01:47:15.340 --> 01:47:19.660 Is these adenosine receptors which are highly immune suppressive and and this is again 01:47:19.740 --> 01:47:24.060 It's usually a familial disease by a problem with the a2a receptors the adenosine receptors 01:47:24.300 --> 01:47:30.860 Where if you can come in here and have some cross talk in agonists of cb1 and up regulate you can ameliorate 01:47:30.860 --> 01:47:32.860 You can lessen the damage 01:47:33.260 --> 01:47:39.500 Of that genetic disease and stop the expression. So in in epigenetic worlds. It's it's the expression of the diseases 01:47:40.300 --> 01:47:46.940 Not not the genetic component which which are these familial diseases. So Huntington's disease runs in families 01:47:46.940 --> 01:47:51.500 But you don't have to die and you don't have to progress if you think of curative therapies 01:47:52.140 --> 01:47:54.140 Via modulating cb1 01:47:54.540 --> 01:47:56.620 You know finally at the bottom of the screen we have 01:47:57.340 --> 01:48:01.660 The chemokine receptors. Um, so the chemokine receptors are the trafficking molecules 01:48:01.900 --> 01:48:04.940 There what takes those blood monocytes to the brain 01:48:05.340 --> 01:48:10.380 So if you can down module there what takes cancer cells and leads to tumor metastasis 01:48:10.700 --> 01:48:16.460 If a prostate canter or any other cancer doesn't metastasize to the bone doesn't spread to the bone 01:48:16.780 --> 01:48:22.540 Via the trafficking molecule that takes them along by the hand and takes them to the place where they can live and thrive 01:48:22.860 --> 01:48:26.220 Then you don't die of cancer if you stop see that's weird 01:48:26.220 --> 01:48:30.140 She's talking about chemokines as if they deliver things that I don't think they do 01:48:30.140 --> 01:48:34.300 I think chemokines are are a concentration gradient signal 01:48:36.380 --> 01:48:38.620 And immune cells 01:48:39.740 --> 01:48:41.740 Will migrate 01:48:42.380 --> 01:48:47.580 Based on the concentration of chemokines and follow the concentration gradient to the source 01:48:48.540 --> 01:48:53.500 Which is a very different set of biological mechanisms and circumstances than a 01:48:53.980 --> 01:48:57.740 Something that takes things somewhere or delivers them places 01:48:58.220 --> 01:49:01.740 Which that's I don't think chemokine receptors do that 01:49:02.460 --> 01:49:04.460 It's so weird 01:49:04.460 --> 01:49:11.180 To the bone via the trafficking molecule that takes them along by the hand and takes them to the place where they can live and thrive 01:49:11.420 --> 01:49:15.500 Then you don't they do not get taken along by the hand. This is not this is wrong 01:49:15.580 --> 01:49:21.180 I I don't I don't know why we're die of cancer if you stop them metastasis 01:49:21.180 --> 01:49:26.860 And we have any number of drugs we've made over the last few years like andeogenesis inhibitors to stop cancer 01:49:27.180 --> 01:49:32.700 Spread because then you can you can live with it and and not die of it. So the next slide 01:49:33.420 --> 01:49:39.900 Highlights that that very cross talk idea when we talk about the pure allergic receptors. So purines 01:49:40.780 --> 01:49:44.380 Are our molecules like caffeine is a purine adenosine 01:49:44.780 --> 01:49:49.180 Guanine we have purines and perimeters that make up the base pairs of our DNA 01:49:49.580 --> 01:49:56.540 So in this open pain journal from 2010 it again earlier than then the the papers I could discussing today 01:49:56.940 --> 01:50:03.660 It showed where there were actually there was actually cross talk between that adenosine receptor on that monocyte macrophage 01:50:03.900 --> 01:50:09.500 And that activated M1 is it's the bad macrophage no matter if you're in cancer or anything else 01:50:09.900 --> 01:50:13.020 They're they're they're bad pro inflammatory when they get to M2 01:50:13.100 --> 01:50:20.940 That's driving the cancer or driving the neurological disease. And as you've shown here. It's affecting what we call it damage in a distance 01:50:21.740 --> 01:50:23.740 Venera, so that's by ATP 01:50:24.300 --> 01:50:31.820 Which is appearing and and so when these when ATP and those energy molecules get outside the cells because the cells are dying 01:50:32.140 --> 01:50:33.660 They become danger signals 01:50:33.660 --> 01:50:37.420 So they tell the immune system to shut down and become immune suppressive 01:50:37.500 --> 01:50:41.820 And so it's this cross talk and and and the suppression of these inflammatory cytokines 01:50:42.540 --> 01:50:50.220 That that is a problem because an immune suppressed person will develop cancer or progress in cancer because you need the right immunity 01:50:50.380 --> 01:50:57.500 And that's what I'm pretty sure that this very poorly cited volume three pain journal from 2010 does not 01:50:58.300 --> 01:51:01.020 Actually establish this any of this is fact 01:51:01.420 --> 01:51:05.020 But it's really neat that she can explain it as though it does 01:51:05.500 --> 01:51:09.580 And that again is exactly how academic biology has been broken 01:51:09.980 --> 01:51:15.100 Where you need that stem cell at the very beginning with TGFa to driving that hematopoietic stem cell 01:51:15.340 --> 01:51:20.060 Away from the myeloid lineage that is toxic the activated and inflammatory 01:51:20.300 --> 01:51:25.980 See she's going all the way back to the first stage to try and tell you that we're already talking about how 01:51:26.620 --> 01:51:29.740 Blood cells are generated how their differentiation is is 01:51:30.220 --> 01:51:35.260 Is controlled like a plinko machine with different. I mean this is amazing 01:51:36.380 --> 01:51:40.940 It is amazing because this is not informing anyone. This is not 01:51:41.580 --> 01:51:48.860 Teaching anybody this has nothing to do with protein misfolding nothing to do with vaccines and it's 2018 01:51:51.580 --> 01:51:57.660 If you just paid attention to Judy mikovitt since the start of the pandemic you would never know that she didn't work for chd 01:51:58.460 --> 01:52:02.620 You would know you would think that she has done lots of streams with like 01:52:03.180 --> 01:52:07.660 All the major anti-vaxxers for a very long time and has been on their team for years 01:52:09.020 --> 01:52:11.020 Apparently not 01:52:11.260 --> 01:52:15.740 Apparently she made her money in other ways apparently she wasn't always an anti-vaccine grifter 01:52:19.500 --> 01:52:23.820 If that's what people characterize her as now it's the resting um microglia 01:52:23.820 --> 01:52:26.940 Which is doing its job of surveilling and removing toxins 01:52:27.260 --> 01:52:31.340 So the next slide shows you just a list of all of the effects 01:52:31.340 --> 01:52:35.820 So the plant derived phytocannabinoids are known as dHC as we've discussed it linked 01:52:36.060 --> 01:52:39.660 CBD which canabidiols are really the main constituents of 01:52:40.380 --> 01:52:42.940 Canab a big girl. I didn't know what that was. What's that? 01:52:43.580 --> 01:52:48.380 THC opportunity in most but from sativa and indica these have been traditionally known 01:52:48.940 --> 01:52:55.020 To to benefit patients with these various diseases and the canabajera which metabolizes into more 01:52:55.260 --> 01:52:56.140 THC 01:52:56.140 --> 01:53:00.940 Also again now we understand that's because of its regulation of the amatopoietic stem cell 01:53:01.580 --> 01:53:08.380 Having the anti-inflammatory and inflammatory agents so we can use these depending on the concentrations of the drugs 01:53:08.780 --> 01:53:14.140 To to actually help anti-psychotics work better. Um, essentially every drug we use 01:53:14.460 --> 01:53:16.460 Oh 01:53:16.540 --> 01:53:18.540 There it is 01:53:18.540 --> 01:53:24.780 We're going to use canabinoids to make every drug we have work better 01:53:29.740 --> 01:53:34.540 You just heard it right there. I'm going to play it again. That's the end. That's that's it 01:53:34.620 --> 01:53:37.420 That there we solved the problem now. That was pretty easy 01:53:37.820 --> 01:53:45.420 Health anti-psychotics work better. Um, essentially every drug we used in in cancer or immune diseases right now 01:53:45.740 --> 01:53:48.860 We can just supplement and we can take advantage of synergies 01:53:48.940 --> 01:53:55.980 Absolutely take advantage of synergies now we can repurpose all kinds of previously on useless patented drugs 01:53:56.300 --> 01:54:03.980 And and confound the effects of those drugs by applying them co-applying them with cannabinoids that stimulate everything 01:54:04.540 --> 01:54:08.380 That makes perfect sense. How else were we going to end all 01:54:09.260 --> 01:54:12.460 Clinical trials of anything meaningful if we didn't do it like this 01:54:12.460 --> 01:54:14.460 And derive 01:54:15.020 --> 01:54:23.980 Um, the phytocannabinoids here shown here and and and lessen the actual drug that the therapy that we're using and lessen the off-target or side effects 01:54:24.540 --> 01:54:30.780 So lesson that side effects. Do you see it? This is exactly the plan 01:54:32.380 --> 01:54:38.140 Cannabis is going to come to the rescue as we change our vaccine schedule over to genetic therapies 01:54:38.620 --> 01:54:47.500 It's going to come to the rescue as we as we barrel forward into this era of health public health injury disguised as 01:54:49.020 --> 01:54:52.700 21st century acquired immune deficiency syndromes whole 01:54:53.260 --> 01:54:58.700 There are so can cannabinoids phytocannabinoids are part of a class of compounds known as terpies 01:54:58.940 --> 01:55:06.380 So on this next slide. I show you um, all of the immunomodulatory and anti-inflammatory terpies 01:55:06.700 --> 01:55:14.060 So this starts to give us some insight starts to give us some insight in the fact that a lot of these terpines that are found in pine are actually 01:55:14.540 --> 01:55:18.140 I think probably the least investigated most valuable 01:55:18.940 --> 01:55:25.340 Potential organic compounds out there. I actually had a really interesting conversation with a crazy person 01:55:25.820 --> 01:55:31.020 When I was at society for neuroscience meeting in new Orleans in 2008 01:55:31.980 --> 01:55:36.780 I was walking on the street and some random guy stopped me. He was carrying a gigantic 01:55:37.980 --> 01:55:41.420 Walking staff and at the top of the walking staff had a carved 01:55:41.660 --> 01:55:43.660 Uh a pinecone 01:55:43.660 --> 01:55:48.780 And he insisted that I sit down on this bench and listen to him talk about how pinecone and 01:55:49.260 --> 01:55:54.540 The terpines in pine actually were a secret that have been known since the Egyptians 01:55:55.260 --> 01:55:57.500 And that's the reason why the papal 01:55:57.980 --> 01:55:59.500 the papal 01:55:59.500 --> 01:56:06.060 Crucifix has a pinecone on it and why there's pine cones in in Egypt and all sort of stuff and it was crazy how 01:56:06.620 --> 01:56:08.620 I mean this dude 01:56:08.860 --> 01:56:11.020 Was telling me something like he thought 01:56:12.860 --> 01:56:15.420 It was his last chance to tell somebody the truth 01:56:16.220 --> 01:56:19.340 Was a very moving presentation that ended with me 01:56:19.900 --> 01:56:24.380 Shaking his hand and walking back to my hotel, but it was it's interesting that she brings this up 01:56:25.020 --> 01:56:26.380 as to the plants 01:56:26.380 --> 01:56:32.860 So one of the things that indica or hemp have the most of is the other terpine known as mercy 01:56:33.660 --> 01:56:40.060 And so this is why the indica is thought to be relaxing because the mercy as an essential oil 01:56:40.140 --> 01:56:46.140 These could be thought of as essential oils or oils and though they're they help induce sleep and relaxation 01:56:46.300 --> 01:56:50.380 Well, the indica strains are very much higher in these additional terpines 01:56:51.180 --> 01:56:54.700 And and and they obviously have the smells that you taste with various 01:56:55.180 --> 01:56:59.420 Cannabis tinctures and oils other terpines like lemonine linole 01:57:00.460 --> 01:57:06.780 Carbofyline the peppery spicy is a is a compound known it interacts with a receptor known as tarpv1 01:57:07.100 --> 01:57:10.140 Tarpv1 is a key pain receptor 01:57:10.380 --> 01:57:17.340 And the only known natural ligand is the only unknown natural product that binds that is tarpv1 is hot chili peppers 01:57:17.580 --> 01:57:22.380 So a lot of the preparation we make with cannabinoids where they're from from cannabis 01:57:22.940 --> 01:57:25.260 The the activity of the cannabis could be 01:57:26.060 --> 01:57:29.100 modulated more by the terpine and not at all by 01:57:29.740 --> 01:57:32.700 The cannabinoids the cbds the cbns or the cbgs 01:57:33.420 --> 01:57:38.780 And even thc, so we could think of thinking about the anti-inflammatory terpines and and 01:57:39.260 --> 01:57:45.900 Since cannabis is terpines and thinking about how we can formulate and reduce as much as possible to psychoactive effects and yet get 01:57:46.380 --> 01:57:49.180 A healing therapeutic. She said that a few times 01:57:49.260 --> 01:57:57.340 We have to find a way to get rid of the psychoactive effects of of cannabis while keeping all of these wonderful pharmaceutical effects 01:57:58.220 --> 01:58:01.020 Benefit really at almost no cost 01:58:01.740 --> 01:58:07.260 So I've talked a lot about the cannabinoids and here's two recent reviews and I think your audience can see 01:58:07.820 --> 01:58:12.540 Um, maybe 2015 and 2000 the lead author of this is named bandana 01:58:12.620 --> 01:58:19.820 I just thought you'd like that in tenor 11 where there's there's um, these are very long lengthy reviews that give you all kinds of 01:58:19.900 --> 01:58:21.900 Agonists that we've used in the lab 01:58:21.900 --> 01:58:26.300 Nearly hundreds of respirances to show you what I just talked about briefly here today 01:58:26.700 --> 01:58:33.020 How these cannabinoids and how targeting and building the specificity out of the ubiquity getting specificity out of 01:58:33.500 --> 01:58:37.740 Everywhere and making it yes, they're everywhere, but can we can we be sure it is? 01:58:38.460 --> 01:58:42.140 Using a shall it be a rational or a thoughtful process in using 01:58:42.140 --> 01:58:44.780 They're everywhere see i'm starting to see it 01:58:44.780 --> 01:58:48.540 I'm starting to feel that there needs to be a huge survey of cannabinoids 01:58:49.020 --> 01:58:55.100 I'm starting to feel that there needs to be a huge genetic survey of all plants that produce cannabinoids and terpenes 01:58:55.500 --> 01:59:00.140 So that we can understand them and better identify them and maybe even genetically modify them 01:59:00.700 --> 01:59:08.540 So we can do it both for cancer and we can do it both for Parkinson's disease and really alleviate the motor neuron symptoms and regenerate 01:59:09.260 --> 01:59:14.620 New neurons and replacing those damage neurons. So very much in the literature, not at all 01:59:15.740 --> 01:59:21.420 Hypothesis at this point in time and you will see hundreds of references there. That's why I included it 01:59:21.900 --> 01:59:24.140 So finally we can just summarize to say that 01:59:24.780 --> 01:59:28.380 The endocannabinoid system is the new regulation and neural 01:59:28.380 --> 01:59:34.300 I don't know what that sound was all a balance of the brain and the immune system could be thought to be mediated through receptor 01:59:34.380 --> 01:59:35.420 crosstalk 01:59:35.420 --> 01:59:40.300 Not only with perinergic receptors. I just gave that example because it's key in our therapies today 01:59:40.780 --> 01:59:42.220 but also through 01:59:42.220 --> 01:59:49.020 The regulation and blocking the toxic effects of aluminum glyphosate and many of the causative agents 01:59:50.060 --> 01:59:53.260 An autoimmune and neural new diseases. They're lipid mediators 01:59:53.260 --> 01:59:54.140 They exert you know 01:59:54.140 --> 01:59:58.620 Pliotropic effects and complex effects on on the immune system and the brain 01:59:59.020 --> 02:00:04.540 The endocannabinoids are really the master regulators of the innate and the adaptive immune axis just like 02:00:05.340 --> 02:00:11.900 Small conductance calcium activated potassium channels are the master regulators of neuronal function. You see 02:00:13.740 --> 02:00:15.100 It's really the same thing 02:00:15.100 --> 02:00:22.540 And we used to say it all the time when I was working in college lab that sk channels do everything because they regulate the width of the action potential 02:00:22.540 --> 02:00:24.060 therefore 02:00:24.060 --> 02:00:26.300 signaling in the brain is 02:00:26.380 --> 02:00:28.780 master regulated by sk channels 02:00:29.980 --> 02:00:36.940 She's making the exact same kind of statement. It's an academic biological statement that is designed to get grants and funding 02:00:37.980 --> 02:00:42.540 And make your little sliver of expertise the most important one 02:00:42.940 --> 02:00:45.980 That's why you use words like master regulators 02:00:46.300 --> 02:00:50.060 But some reason or another when people use pot for 60 years 02:00:50.540 --> 02:00:55.100 That master regulator doesn't seem to go too far off center like I don't I don't 02:00:55.900 --> 02:00:57.900 It's really it's really 02:00:58.700 --> 02:01:01.180 disingenuous, but it's perfect academic 02:01:02.220 --> 02:01:07.420 It's a perfect academic biology presentation given by the perfect academic 02:01:08.140 --> 02:01:13.500 What that's that axis between astroglia and t you know t-cells and the monocyte 02:01:14.940 --> 02:01:21.100 So we can use these we can we can affect you we can effectively think about them on the orchestrators of immune response 02:01:21.260 --> 02:01:25.020 And make these a key therapeutic target and just like we could turn 02:01:25.500 --> 02:01:30.860 HIV aids into a disease you could live with we can we can use these combination therapies to 02:01:31.260 --> 02:01:37.020 To cure these 21st century acquired immune deficiencies and with that I'll thank you and take question 02:01:37.100 --> 02:01:42.220 We can cure these 21st century acquired immune deficiencies 02:01:44.220 --> 02:01:48.700 And I think that's a wonderful place to end this you can see it right this is this is 02:01:49.500 --> 02:01:55.100 Pre-pandemic biological bamboozlement. This is pre-pandemic confusion 02:01:56.140 --> 02:01:58.140 and and misconstruing 02:01:59.580 --> 02:02:01.900 understanding with noise 02:02:03.020 --> 02:02:11.020 And it is seeding a narrative where many of these 21st century acquired immune deficiency syndromes are expected to increase 02:02:11.500 --> 02:02:14.140 And why would that be well? We don't know 02:02:15.020 --> 02:02:21.020 But i'm sure endocannabinoids and the sequencing of all the pot in the world and looking at all these different 02:02:21.420 --> 02:02:28.940 Compounds and screening them for their ability to synergistically work with other things that we already have patents for and already want to sell you 02:02:29.420 --> 02:02:31.420 Would be perfect 02:02:33.260 --> 02:02:38.460 I think you can see now why there might be other people that are interested in sequencing the cannabis genome 02:02:38.780 --> 02:02:40.780 Um 02:02:41.740 --> 02:02:44.140 Why it's not such a trivial thing after all 02:02:47.580 --> 02:02:52.220 Hope you can see it ladies and gentlemen. I definitely hope that you can see it 02:02:52.860 --> 02:02:54.860 um 02:02:54.860 --> 02:02:56.860 It's really important that you can see it 02:02:59.260 --> 02:03:04.860 Uh because they are trying very very hard for you not to be able to see it 02:03:05.500 --> 02:03:11.100 I'm going to go right back down here and I am going to say it once and 02:03:11.820 --> 02:03:15.580 Always as I usually do ladies and gentlemen, they are trying to 02:03:16.540 --> 02:03:21.820 Eliminate the control group by any means necessary. I don't know if they transfected my friend at the gym 02:03:22.780 --> 02:03:24.780 But I do know that that 02:03:25.100 --> 02:03:27.100 Reinforced this idea 02:03:27.740 --> 02:03:34.060 Vaccines are something that he couldn't say no to vaccines are something that you can't question and he defended himself as he 02:03:34.700 --> 02:03:38.700 Described to me the pain that he's in and I just my heart breaks for these people 02:03:39.180 --> 02:03:41.660 And it's only through our work through our 02:03:42.540 --> 02:03:46.460 What we're doing these are one of the few ways that we can save these people and so 02:03:47.100 --> 02:03:48.220 um 02:03:48.220 --> 02:03:52.540 Stop all transfections stop all vaccinations and adults for shit sake 02:03:54.940 --> 02:03:59.100 And uh remember that they are trying to eliminate the control group now that they've got him 02:03:59.740 --> 02:04:02.140 Now that he's got all sippetal neuropathy 02:04:02.940 --> 02:04:05.420 You know they can give him all the shots they want now 02:04:09.020 --> 02:04:11.020 Once they transfect your kids 02:04:11.660 --> 02:04:13.660 How the hell you gonna know where it comes from 02:04:14.620 --> 02:04:16.620 the Crohn's disease 02:04:16.620 --> 02:04:18.620 or the allergies 02:04:18.620 --> 02:04:20.620 eczema 02:04:21.260 --> 02:04:25.740 How are you gonna know where the where it comes from when they get cancer when they're 22 years old 02:04:26.700 --> 02:04:28.860 You'll know 02:04:28.860 --> 02:04:33.100 Because transfection in healthy humans was always criminally negligent because RNA 02:04:33.500 --> 02:04:40.700 Campendemic and because gosh dang it intramuscular injection of any combination of substances with the intent of augmenting our 02:04:42.140 --> 02:04:44.300 Beautiful immune system is dumb 02:04:47.660 --> 02:04:50.220 It's been an independent bright web presentation 02:04:51.180 --> 02:04:54.220 Um Star Trek is coming soon as is the wheel 02:04:55.180 --> 02:04:57.180 um 02:04:57.180 --> 02:05:03.180 Ladies and gentlemen, you can find me at giggle on biological.com deal that bio and stream dot giggle home dot bio also 02:05:03.820 --> 02:05:07.740 uh jc on a bike on youtube and on twitter and on twitch 02:05:09.180 --> 02:05:14.300 Thanks very much to everybody who subscribes to this channel who subscribes to my sub stack who sent me 02:05:15.260 --> 02:05:17.260 letters emails 02:05:17.820 --> 02:05:22.540 anything um you're all very very much appreciated by me and my family and 02:05:23.500 --> 02:05:27.900 This wouldn't happen without you ladies and gentlemen. Thank you very much share this stream 02:05:27.900 --> 02:05:32.380 We'll see you tomorrow 1313 is the time we may be switching 02:05:33.580 --> 02:05:36.620 We may be switching to 10 10 in the morning for the first show 02:05:37.420 --> 02:05:38.860 um 02:05:38.860 --> 02:05:42.700 I'm pretty sure i'm going to be switching to 10 10 a.m. In the morning 02:05:42.700 --> 02:05:46.300 I hope that's not going to be too much trouble for a lot of people. It's going to be better 02:05:46.300 --> 02:05:50.140 A little bit better for me and it will open up the afternoon for possible second shows 02:05:50.300 --> 02:05:51.340 um 02:05:51.340 --> 02:05:53.340 right now 02:05:53.340 --> 02:05:56.940 The the variable show can't be the first one so I can't do it that way 02:05:56.940 --> 02:05:58.300 I think I have to shift to the morning 02:05:58.300 --> 02:06:02.700 So it's probably going to be 10 10 in the morning next week and the nice thing about 10 10 02:06:03.260 --> 02:06:07.980 Is that that's the time that you set your watch to when you want to sell it right? That's the prettiest 02:06:08.780 --> 02:06:10.780 Time on an analog clock 02:06:11.580 --> 02:06:16.140 So I think it's kind of a fun time to start in 10 10 is is the second cup of coffee 02:06:16.220 --> 02:06:20.460 That's also really good and it'll give me time to walk the dog would be and and that kind of thing in the morning 02:06:20.460 --> 02:06:25.580 So 10 10 next week. I think the schedule will be changed to reflect that. Um, so don't worry 02:06:25.820 --> 02:06:29.180 I won't it won't happen at random and in the meantime this week 02:06:29.180 --> 02:06:36.300 It's uh 13 13 for the remainder of the week as far as I can tell and we are working on setting up some people to 02:06:36.780 --> 02:06:39.900 Uh join us for an interview over a fire this kind of thing 02:06:40.540 --> 02:06:46.060 Um, we have a few people in mind. It's just uh getting this other momentum in the background 02:06:46.220 --> 02:06:51.100 Solid and I think we're really close to getting there. So I can't thank everybody enough 02:06:51.340 --> 02:06:52.300 Um 02:06:52.300 --> 02:06:58.540 I'm pretty convinced that this illusion of consensus is about to break because a lot of people actually do know the truth 02:06:59.260 --> 02:07:01.500 And uh, they're going to do something about it soon 02:07:02.700 --> 02:07:05.100 Thanks very much ladies and gentlemen and we'll see you tomorrow 02:07:16.140 --> 02:07:19.020 You