WEBVTT 00:00.000 --> 00:13.000 I may need to just briefly check to see if I can find myself on YouTube and then see 00:13.000 --> 00:24.120 what's going on here should be live right now but I'm not which is weird go live I 00:24.200 --> 00:30.080 should be live right now because I using that same key excellent connection it says 00:30.080 --> 00:39.280 so why am I not live it says viewers will be able to find your stream once you go 00:39.280 --> 00:53.840 live but the privacy is unlisted so it should be public done save but I'm not 00:53.840 --> 01:04.520 there I don't see any copy I'm gonna stop this and I'm gonna modify it I'm 01:04.520 --> 01:09.100 gonna put this key in I'm gonna paste it down I'm gonna say okay and then I'm 01:09.100 --> 01:16.440 gonna start it what does it do now it says I'm not doing it anymore on there 01:16.440 --> 01:24.520 goes live on YouTube it's yes live on YouTube it's alright we're there we're 01:24.520 --> 01:29.080 live on the YouTube as well so here we go ladies and gentlemen thank you very 01:29.080 --> 01:33.560 much for joining me let's do this thing peer tube should be up can you check 01:33.560 --> 01:39.320 that for me peer tube should be up we should be live there I see myself live 01:39.320 --> 01:44.400 there I should also be on rumble peer to good here we go ladies and gentlemen 01:44.400 --> 01:47.120 thanks for joining me 02:14.400 --> 02:36.160 thank you very much the latest data tells us that we're dealing with 02:36.160 --> 02:39.160 essentially a worst case 02:56.560 --> 03:03.240 what kind of link did you put in there that YouTube video what is that and enjoy 03:03.240 --> 03:14.600 skip to six minutes and enjoy what's that all about I'm curious what that is I 03:14.600 --> 03:19.600 think truth is good for kids we're so busy lying we don't even recognize the 03:19.600 --> 03:24.240 truth no more in this society we want everybody to feel good that's not that's 03:24.240 --> 03:31.000 not the way life is but you can tell if someone's lying you know you can sort of 03:31.000 --> 03:36.360 feel it in people and I have lied I'm sure I'll lie again I don't want to lie 03:36.360 --> 03:40.000 you know I don't think I'm a liar I try not to be a liar I don't want to be a 03:40.000 --> 03:45.600 liar I think it's like really important not to be a liar 04:01.000 --> 04:31.000 I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar 04:31.000 --> 05:01.000 I'm a liar I'm a liar I am a liar I am a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a modifier I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a liar I'm a 05:01.000 --> 05:03.480 Afternoon, I'm 20 minutes late again, 05:03.480 --> 05:06.120 but that seems to be the way it is. 05:06.120 --> 05:09.960 20 minutes late, but on time, so to speak. 05:11.720 --> 05:13.320 Business can go on biological. 05:16.720 --> 05:19.080 We are still trying to dispel the mythology 05:19.080 --> 05:21.360 that people are doubling and tripling down on, 05:21.360 --> 05:23.240 and we're trying to dispel that mythology, 05:23.240 --> 05:25.240 that enchantment with some knowledge. 05:26.600 --> 05:29.160 If you've been staying focused on the biology, 05:29.160 --> 05:30.840 you are not drowning in this way. 05:31.720 --> 05:34.440 You've been skillfully using TV and social media. 05:34.440 --> 05:35.560 You might be in big trouble, 05:35.560 --> 05:37.280 but if you stay focused on the biology, 05:37.280 --> 05:39.680 you don't take the pain on those systems, 05:39.680 --> 05:41.720 and you love your neighbor, you can escape. 05:41.720 --> 05:42.720 I do believe that. 05:42.720 --> 05:44.560 I do believe there's hope. 05:44.560 --> 05:46.320 And most of the hope comes from the fact 05:46.320 --> 05:49.360 that people are still sharing this work after four years. 05:49.360 --> 05:52.720 Still think that this is a viable message. 05:52.720 --> 05:55.240 You can find it at gigahomebiological.com, 05:55.240 --> 06:00.200 gigahome.bio, and stream.gigahome.bio. 06:00.200 --> 06:04.400 There are ways to support the links, share the links. 06:04.400 --> 06:05.960 We're trying to do our best to make sure 06:05.960 --> 06:09.120 that we can get it out as far as we can. 06:09.120 --> 06:10.720 My friends and friends next day. 06:14.320 --> 06:16.960 And so that's why I haven't done a sub stack 06:16.960 --> 06:18.800 in more than a week, which is not good, 06:18.800 --> 06:20.440 but I do have one translated. 06:20.440 --> 06:23.720 I just haven't done the transcript, 06:23.720 --> 06:26.520 which is, I admit, is frustrating. 06:26.520 --> 06:28.000 I also have an updated this list, 06:28.000 --> 06:29.520 which is also frustrating. 06:30.360 --> 06:32.320 But I have a lot of things that I'm working on 06:32.320 --> 06:35.040 that I think are more important than updating this list, 06:35.040 --> 06:36.680 even though I do appreciate it. 06:36.680 --> 06:39.440 We are going to update it soon. 06:39.440 --> 06:41.120 I really think there's work to be done. 06:41.120 --> 06:42.720 Everybody that's supporting this stream, 06:42.720 --> 06:47.080 I think, understands very well what we're up against. 06:47.080 --> 06:49.840 And so, if your name is not on this list 06:49.840 --> 06:51.200 and it should be, please forgive me. 06:51.200 --> 06:54.200 It will be there in a couple of days. 06:54.200 --> 06:56.360 And the list is slowly growing, 06:56.360 --> 06:58.880 but we could use always more subscribers. 06:58.880 --> 07:01.200 We're far lower than we need to be. 07:01.200 --> 07:03.800 If this is gonna be a real sustainable action, 07:05.000 --> 07:06.600 we can't run on fumes forever, 07:06.600 --> 07:10.280 but my wife and my family will do it as long as I can. 07:10.280 --> 07:11.840 This is the independent bright web. 07:11.840 --> 07:15.080 That means that we're not sponsored by anybody but you. 07:15.080 --> 07:18.520 We don't have, we're not selling lotion or soap 07:18.520 --> 07:23.520 or neutraceuticals, none of that stuff. 07:24.280 --> 07:27.680 We are just supported by people with kids, 07:27.680 --> 07:29.200 people who lost jobs, 07:30.520 --> 07:34.040 people who are trying to engage in United Noncompliance 07:34.040 --> 07:38.560 and establish the system, 07:38.560 --> 07:41.520 the network of people that can help you 07:41.520 --> 07:43.480 engage in United Noncompliance. 07:43.480 --> 07:45.640 I hope that's what GINGO and biological will be 07:45.640 --> 07:49.200 in the future is a network hub for people engaged 07:49.200 --> 07:51.640 in United Non Compliance. 07:57.680 --> 08:04.680 Good afternoon ladies and gentlemen, 08:04.680 --> 08:07.680 this is GINGO, biological and high resistance. 08:07.680 --> 08:10.240 Low noise information we've brought to you by a biologist. 08:10.240 --> 08:12.200 I'm coming to you live from Pittsburgh, Pennsylvania 08:12.200 --> 08:13.280 in the back of my garage. 08:13.280 --> 08:16.560 It is the 27th of March, 2024. 08:16.560 --> 08:18.320 I am a human just like you fighting 08:18.320 --> 08:19.880 for our grandchildren's future, 08:19.880 --> 08:21.680 our grandchildren's freedom, 08:21.680 --> 08:23.920 our grandchildren's informed consent. 08:23.920 --> 08:25.360 And I hope you are too. 08:25.360 --> 08:27.360 If you're joining me for the first time, 08:27.360 --> 08:32.000 GINGO and biological is a news source 08:32.000 --> 08:34.600 that is more than well aware of the idea 08:34.600 --> 08:37.240 that we've been consciously and intelligently manipulated 08:37.240 --> 08:40.200 in our habits and in our opinions for decades 08:40.200 --> 08:42.560 and that this has only increased in power 08:42.560 --> 08:47.560 and in its all encompassing application to our lives 08:48.240 --> 08:50.880 with the advent of the cell phone and the internet. 08:52.200 --> 08:55.800 These social media apps have been weaponized also 08:55.840 --> 08:58.600 from the perspective of who these people are 08:58.600 --> 09:00.080 and who is on them. 09:00.080 --> 09:03.200 You can see all kinds of people in this picture 09:03.200 --> 09:07.240 that I believe are very much in on this. 09:07.240 --> 09:09.640 You can look at the picture behind me 09:09.640 --> 09:11.760 and you can find lots of people 09:11.760 --> 09:14.520 who have wittingly and unwittingly contributed 09:14.520 --> 09:19.120 to this slow motion demolition of Western society 09:19.120 --> 09:22.360 and particular the jewel of Western society, 09:22.360 --> 09:23.640 the United States of America. 09:23.640 --> 09:25.280 And it's not because we do everything right 09:25.400 --> 09:27.040 because all of our teams are the best 09:27.040 --> 09:30.560 or because we win the gold medals. 09:30.560 --> 09:33.000 It's because our system is the one 09:33.000 --> 09:34.960 that has that inertia built into it 09:34.960 --> 09:38.760 around free speech and other protected freedoms. 09:38.760 --> 09:43.120 That inertia is what they need us to kind of discount 09:43.120 --> 09:46.840 as valuable and not be vigilant enough to guard 09:46.840 --> 09:50.680 and to eventually just give up for our children 09:50.680 --> 09:55.000 or not teach our children the level of vigilance 09:55.000 --> 09:57.720 that's necessary in order to preserve those freedoms. 09:57.720 --> 09:58.880 I think that's where we are. 09:58.880 --> 10:01.440 And they have been consciously manipulating our opinions 10:01.440 --> 10:04.000 about these freedoms for decades on purpose. 10:04.000 --> 10:06.360 And the last manipulation that occurred indeed 10:06.360 --> 10:10.440 was the declaration of a coronavirus pandemic 10:10.440 --> 10:13.760 wherein most of our understanding of public health 10:13.760 --> 10:17.720 was permanently shaken and we are now just basically 10:17.720 --> 10:19.640 under the influence of a mythology 10:19.640 --> 10:21.400 and those people who are willing 10:21.400 --> 10:24.280 to spectacularly commit to it. 10:25.920 --> 10:26.960 To the mythology. 10:28.320 --> 10:29.680 And that's why we haven't been able 10:29.680 --> 10:31.200 to exercise informed consent. 10:31.200 --> 10:36.040 That mythology is based around an ongoing RNA viral pandemic 10:36.040 --> 10:39.320 that has changed color, that has changed flavor 10:39.320 --> 10:43.360 and has changed flavor in a very uniform planetary manner. 10:43.360 --> 10:46.360 It is a phenomenon at a molecular level 10:46.360 --> 10:49.720 that we have never witnessed anything remotely close to it 10:49.720 --> 10:50.760 in the past. 10:50.760 --> 10:54.320 It is blamed on things as simple as a few bases 10:54.320 --> 10:56.600 or a few amino acids which encode 10:56.600 --> 10:58.160 an extra fear and cleavage site 10:58.160 --> 11:00.360 or an extra poly basic cleavage site. 11:00.360 --> 11:04.600 And with with those a few basic mythological assumptions 11:04.600 --> 11:07.200 inserted into the storyline carefully on the left 11:07.200 --> 11:10.280 and the right by actors that were agreed to disagree. 11:10.280 --> 11:12.480 We now believe that variants are trackable 11:12.480 --> 11:14.000 and that their evidence of evolution. 11:14.000 --> 11:16.520 We believe that lockdown would have done correctly 11:16.520 --> 11:19.440 prevents the spread of dangerous viruses like this one. 11:19.440 --> 11:22.160 And that we believe that without strictly regulations 11:22.200 --> 11:25.200 these kinds of gain of function things will happen again. 11:25.200 --> 11:28.560 We are being led to believe that this faith 11:28.560 --> 11:30.440 is something that we cannot question 11:30.440 --> 11:33.440 and we've been led to believe it by different narratives. 11:33.440 --> 11:35.000 Narratives were different in Australia 11:35.000 --> 11:37.200 than they were in Europe than they were in America. 11:37.200 --> 11:40.240 The number of participants that come out of the audience 11:40.240 --> 11:43.560 pretending to be innocent audience members 11:43.560 --> 11:46.160 when really they're participating in the illusion 11:46.160 --> 11:48.440 was different depending on what country you're in. 11:48.440 --> 11:52.000 But I in America, I assure you that we were involved 11:52.000 --> 11:55.480 in a magic show and audience members 11:55.480 --> 11:57.920 were pulled out of the audience and brought on stage. 11:57.920 --> 12:00.120 And we were made to believe that those people 12:00.120 --> 12:02.120 were innocently participating in the show 12:02.120 --> 12:03.840 when they were not. 12:03.840 --> 12:05.440 They were definitely not. 12:08.440 --> 12:11.240 And those same people now agree across the board 12:11.240 --> 12:13.040 that transfection isn't bad. 12:13.040 --> 12:15.440 Transfection probably saved millions of lives 12:15.440 --> 12:18.100 even if it also injured hundreds of thousands. 12:19.320 --> 12:20.360 That's where we are. 12:21.360 --> 12:24.160 And unfortunately, the faith in the novel virus 12:24.160 --> 12:26.520 going on for five years is now converting 12:26.520 --> 12:28.400 into a faith in a novel biology 12:28.400 --> 12:30.680 that again includes the biology of the virus, 12:30.680 --> 12:32.760 which is the fear and cleavage site 12:32.760 --> 12:34.680 as evidence of laboratory leak 12:34.680 --> 12:39.160 and then the complete unnecessary effort 12:39.160 --> 12:42.920 to track this thing all over the place 12:42.920 --> 12:44.720 but then not look at any epitopes 12:44.720 --> 12:48.040 that we were told to be afraid of from the very beginning. 12:48.080 --> 12:51.360 It's laughable to me that people who have claimed 12:51.360 --> 12:52.720 that the fear and cleavage site 12:52.720 --> 12:57.280 is a singular attribute of the virus 12:57.280 --> 13:00.040 which can contribute to both its infectivity 13:00.040 --> 13:02.960 and also its rapid spread around the world 13:02.960 --> 13:05.480 never bothered to keep track of it. 13:05.480 --> 13:08.040 Not even in one strain, not even commenting 13:08.040 --> 13:10.960 on whether the fear and cleavage site had optimized 13:10.960 --> 13:12.640 or disappeared in any of the strains 13:12.640 --> 13:14.040 and they still don't care. 13:15.680 --> 13:17.840 And if that doesn't strike you as odd, 13:17.840 --> 13:19.080 I don't know what to tell you 13:19.080 --> 13:21.600 because those same people are also convinced 13:21.600 --> 13:23.840 as they were in 2020, 13:23.840 --> 13:25.840 that there would be neurological side effects 13:25.840 --> 13:29.160 that at first started from the traveling of the virus 13:29.160 --> 13:33.480 up the olfactory bulb and into the brain directly 13:33.480 --> 13:35.480 but it also had to do with the spike protein 13:35.480 --> 13:37.920 and its ability to cause other proteins to fold 13:37.920 --> 13:40.920 by some heretofore, undescribed pre-onogenic 13:40.920 --> 13:43.520 or amyloidogenic mechanisms. 13:43.520 --> 13:46.680 These terms and these potentials 13:46.680 --> 13:51.680 were thrown around as often and as frequently as possible 13:52.520 --> 13:55.240 by a number of actors on the left and the right, 13:55.240 --> 13:57.800 on the front and the back in the mainstream media 13:57.800 --> 14:00.480 and on social media backwaters. 14:00.480 --> 14:03.240 And they were all united on these things very early 14:03.240 --> 14:06.000 which is odd because they're still central 14:06.000 --> 14:08.360 to the faith in this novel biology. 14:09.240 --> 14:11.520 We keep coming back to these same storylines 14:11.520 --> 14:15.240 that just don't have a basis in biology 14:15.240 --> 14:18.320 playing little clips where virologists complain 14:18.320 --> 14:21.640 about fear and cleavage sites is not sufficient evidence 14:21.640 --> 14:25.240 to explain how a few amino acids or a few bases 14:25.240 --> 14:30.240 in an mRNA, a modified RNA, a synthetic RNA spilled 14:30.240 --> 14:33.360 on the ground could result in pandemic coverage 14:33.360 --> 14:37.680 of that same molecule and insists that it has to do 14:37.680 --> 14:41.200 with this particular set of bases, it's absurd 14:41.200 --> 14:43.400 but they're still doing it now. 14:43.400 --> 14:47.880 The same fake people that claim to be really interested 14:47.880 --> 14:50.040 in finding the origin and really interested 14:50.040 --> 14:53.400 in catching the bad guys that are really interested 14:53.400 --> 14:56.480 in blaming eco-health alliance and the diffuse proposal. 14:56.480 --> 15:00.200 These clowns are the same clowns who were saying this stuff 15:00.200 --> 15:02.440 in 2020 with less evidence, 15:04.040 --> 15:06.600 with less basis for these speculations 15:06.600 --> 15:08.800 but they were just as certain back then. 15:09.800 --> 15:13.800 And there's still video evidence of these people 15:13.800 --> 15:16.800 and their certainty online freely available for you 15:16.800 --> 15:19.800 to go and check that these aren't new ideas. 15:19.800 --> 15:21.800 These are ideas that were planted very early 15:21.800 --> 15:26.800 by a coordinated obviously group of people loosely connected 15:27.800 --> 15:29.800 to a couple of weaponized piles of money. 15:29.800 --> 15:31.800 That's the best way I can describe it 15:31.800 --> 15:35.800 and if we don't break this faith in a novel virus 15:35.800 --> 15:37.800 that was probably a conflated background signal 15:37.800 --> 15:42.800 be it actual endosomes, exosomes, viruses, whatever 15:43.800 --> 15:47.800 or be it just genetic noise in the background 15:47.800 --> 15:49.800 as the cartoon up there just changed to. 15:50.800 --> 15:53.800 Either way, a noise signal in the background 15:53.800 --> 15:55.800 that we weren't detecting but could be detected 15:55.800 --> 15:58.800 that was then misconstrued as spread 15:58.800 --> 16:02.800 is a very parsimonious explanation for what really happened. 16:03.800 --> 16:07.800 It's funny because no one with any social media reach 16:07.800 --> 16:10.800 has ever even bothered to consider the possibility. 16:10.800 --> 16:13.800 That's the one possibility that Kevin McCurnan, 16:13.800 --> 16:17.800 Jessica Rose, John Bodewin, Steve Kirsch, 16:17.800 --> 16:22.800 Robert Malone, Robbie Kennedy Jr., Peter McCullough, 16:22.800 --> 16:25.800 Jay Bhattacharya, anybody that's ever talked to me 16:25.800 --> 16:28.800 when they hear me say that, that's the one thing that they, 16:28.800 --> 16:31.800 I don't know, I can't really understand that. 16:31.800 --> 16:34.800 I don't fully get it. You'll have to explain that. 16:34.800 --> 16:36.800 I can't really think about that hypothesis. 16:36.800 --> 16:39.800 That's hard for me. That's outside of my expertise. 16:39.800 --> 16:42.800 How many times have I heard that nonsense about clones? 16:42.800 --> 16:45.800 How about transfection and about previous 16:45.800 --> 16:48.800 and conflated background signals over and over again? 16:48.800 --> 16:51.800 These people who see me in person meet me at parties, 16:51.800 --> 16:55.800 take selfies with me and tell me how great they love my stream 16:55.800 --> 16:59.800 but they just can't verify or think about some of the ideas. 16:59.800 --> 17:03.800 They're really compelling, but it's not my expertise. 17:03.800 --> 17:10.800 They've had four years, just like I have, just like Mark has, 17:10.800 --> 17:12.800 just like George Webb has. 17:12.800 --> 17:14.800 We've all had four years and somehow or another, 17:14.800 --> 17:18.800 they still have their heads in the exact same holes. 17:22.800 --> 17:23.800 That's how you know that they're... 17:23.800 --> 17:26.800 Scientific questions, I think, are very hard to get a handle on. 17:26.800 --> 17:30.800 The reason for this is that in late modernity, 17:30.800 --> 17:34.800 which we're living in, there's simply too much knowledge 17:34.800 --> 17:37.800 for any individual human to understand all of it. 17:37.800 --> 17:43.800 In this world of extreme paper specialization 17:43.800 --> 17:48.800 where it's narrower and narrower subsets of experts policing themselves 17:48.800 --> 17:50.800 and talking about how great they are, 17:50.800 --> 17:52.800 the string theorists talking about how great string theory is, 17:52.800 --> 17:55.800 the cancer researchers talking about how they're just about to cure cancer, 17:55.800 --> 17:59.800 the quantum computer researchers are just about to build a quantum computer 17:59.800 --> 18:01.800 that will be a massive breakthrough. 18:01.800 --> 18:04.800 If you were to say that all these fields, not much is happening, 18:04.800 --> 18:06.800 people just don't have the authority for this. 18:06.800 --> 18:11.800 This is somehow a very different feel for science or knowledge 18:11.800 --> 18:15.800 than you would have had in 1800 or even in 1900. 18:15.800 --> 18:18.800 1800 Goethe could still understand just about everything. 18:18.800 --> 18:23.800 1900, Hilbert could still understand just about all of mathematics. 18:23.800 --> 18:25.800 And so the sort of... 18:25.800 --> 18:27.800 Oh, I'm in the wrong... 18:27.800 --> 18:31.800 I think it has made it a much harder question to get a handle on. 18:31.800 --> 18:35.800 So I would say that he is misleading the young with this presentation 18:35.800 --> 18:38.800 because he is calling knowledge that's not knowledge. 18:38.800 --> 18:40.800 It should be called noise. 18:40.800 --> 18:43.800 We have come to acknowledge those of us who understand 18:43.800 --> 18:46.800 what academic biology and science has become 18:46.800 --> 18:51.800 with the P-value hypothesis falsification thing 18:51.800 --> 18:56.800 from Paparian science has created a scenario where 18:56.800 --> 19:03.800 there is much more noise in our academic understanding of the world. 19:03.800 --> 19:06.800 And so he's suggesting that that noise is knowledge 19:06.800 --> 19:10.800 and it's just so specialized and so detailed 19:10.800 --> 19:13.800 that people can't be general scholars anymore. 19:13.800 --> 19:16.800 And that's absolutely not true. 19:16.800 --> 19:20.800 What he is suggesting is that young people don't bother to try. 19:20.800 --> 19:25.800 What he is suggesting is that young people don't bother to try. 19:25.800 --> 19:28.800 Now, with a little bit of work, 19:28.800 --> 19:30.800 I feel like that I've always been there. 19:30.800 --> 19:34.800 I've always been trying to integrate across fields as best I can 19:34.800 --> 19:36.800 as a biologist at heart. 19:36.800 --> 19:41.800 And so for me, this has always been the shortcoming of neuroscience. 19:41.800 --> 19:45.800 Is that the specialization makes it very hard for us to evaluate 19:45.800 --> 19:47.800 what each other is doing. 19:47.800 --> 19:52.800 And very hard to understand where the real cutting edge of understanding is. 19:52.800 --> 19:55.800 And it's almost by design. 19:55.800 --> 19:58.800 And I was frustrated by it, but I didn't know how to express that. 19:58.800 --> 20:00.800 I didn't know why I was frustrated. 20:00.800 --> 20:04.800 And I didn't know at the heart of it was this ritual of probability 20:04.800 --> 20:09.800 and falsification that created the illusion of progress. 20:09.800 --> 20:15.800 And so he's not saying that even though I assure you he understands it perfectly. 20:16.800 --> 20:21.800 He is signaling to some people and he is enchanting others. 20:21.800 --> 20:23.800 That's the beauty of this. 20:24.800 --> 20:28.800 Using the right code words, everybody that knows that he's the head 20:28.800 --> 20:33.800 of a giant weaponized pile of money and that he's the head of a information 20:33.800 --> 20:39.800 algorithmic mining DoD operation called Palantir. 20:40.800 --> 20:43.800 Then you know that he's not saying exactly what he means. 20:44.800 --> 20:48.800 But if you're just a casual listener to the portal podcast on its eighth episode 20:48.800 --> 20:51.800 or its second episode or its first episode. 20:53.800 --> 20:56.800 And then what you hear is somebody you think is telling the truth. 20:58.800 --> 21:01.800 But if he was telling you the truth, then he would have listed cancer 21:01.800 --> 21:06.800 and quantum computing and virology. 21:07.800 --> 21:12.800 And molecular biology and neuroscience. 21:13.800 --> 21:17.800 As places where it's very hard to tell how much progress is really being made. 21:17.800 --> 21:21.800 And in fact, in many of these fields, it may not be being made. 21:22.800 --> 21:26.800 So he listed a couple, but he didn't list them all. 21:28.800 --> 21:30.800 And so is that lying? 21:30.800 --> 21:35.800 But you can tell if someone's lying, you know, you can sort of feel it in people. 21:36.800 --> 21:37.800 And I have lied. 21:37.800 --> 21:38.800 I'm sure I'll lie again. 21:38.800 --> 21:39.800 I don't want to lie. 21:39.800 --> 21:41.800 You know, I don't think I'm a liar. 21:41.800 --> 21:42.800 I try not to be a liar. 21:42.800 --> 21:43.800 I don't want to be a liar. 21:43.800 --> 21:46.800 I think it's like really important not to be a liar. 21:47.800 --> 21:51.800 It's really important not to be a liar, says Tucker Carlson, the professional liar. 21:51.800 --> 21:56.800 The critical cut I have on the specialization is always that if you analyze 21:56.800 --> 21:59.800 the politics of science, the specialization should make you suspicious. 22:00.800 --> 22:03.800 It's because it's gotten harder to evaluate what's going on. 22:03.800 --> 22:06.800 And it's presumably gotten easier for people to lie and to exaggerate. 22:07.800 --> 22:09.800 And then one should be a little bit suspicious. 22:09.800 --> 22:14.800 So they are lying and exaggerating. 22:14.800 --> 22:19.800 Just like Peter Thiel says, they are lying and exaggerating about the fidelity of 22:19.800 --> 22:24.800 understanding in virology, the fidelity of understanding in cancer biology, 22:24.800 --> 22:28.800 the fidelity of understanding in the genetic causes of childhood diseases. 22:28.800 --> 22:31.800 They are feigning this. 22:32.800 --> 22:36.800 Every time they do a TED talk about what's going to happen in 10 years and about what 22:36.800 --> 22:39.800 the AI is going to do and about what climate change is going to happen, 22:39.800 --> 22:41.800 they are feigning this knowledge. 22:41.800 --> 22:45.800 They are feigning this certainty because the hyperspecialization of science 22:45.800 --> 22:50.800 and the use of reiterative, prepare and falsification of hypotheses has 22:50.800 --> 22:55.800 allowed the creation of this noise that is being misconstrued by people as 22:55.800 --> 22:58.800 powerful as Peter Thiel as knowledge. 22:59.800 --> 23:04.800 And if people as powerful as Peter Thiel and the puppets that he puts on the 23:04.800 --> 23:08.800 internet and promotes, like the Weinstein brothers are going to say that 23:08.800 --> 23:12.800 this guy is right, then we have an illusion of consensus. 23:13.800 --> 23:16.800 And that's what the intellectual dark web provided them. 23:16.800 --> 23:20.800 An illusion of consensus that could be used to govern, that could be used to 23:20.800 --> 23:25.800 influence the very opinions and habits of the masses. 23:28.800 --> 23:32.800 Just like Edward Bernays described, just like Noam Chomsky described a 23:32.800 --> 23:36.800 limited spectrum of debate within which there is a very lively discussion 23:38.800 --> 23:42.800 within which you can even encourage the most critical views 23:43.800 --> 23:49.800 because even the most critical views reinforce the presuppositions of the state. 23:49.800 --> 23:53.800 In this case, the presuppositions are the model of reality. 23:55.800 --> 23:59.800 The model of reality that they have been enforcing is one of lots of viruses, 23:59.800 --> 24:03.800 lots of pathogens, lots of dirty in the nature. 24:05.800 --> 24:10.800 And lots of things that you need as products to protect you from that, 24:10.800 --> 24:15.800 to detect that, to monitor that, to administer 24:16.800 --> 24:18.800 prophylactic for that. 24:19.800 --> 24:26.800 And it's a giant mythology created by our willingness to give over our attention 24:27.800 --> 24:32.800 and our trust to people like him and the applications that they sell us 24:32.800 --> 24:33.800 on our phones. 24:36.800 --> 24:39.800 So I wanted to go back to the video that I watched the other day because we 24:39.800 --> 24:40.800 didn't finish it yesterday. 24:40.800 --> 24:42.800 So this is, I'm just going to start it right away. 24:42.800 --> 24:43.800 Here we go. 24:43.800 --> 24:47.800 This is when Venner comes on stage and he talks about how we've, 24:47.800 --> 24:51.800 we've gone from understanding protein as a genetic material to DNA. 24:51.800 --> 24:52.800 It's a genetic material. 24:52.800 --> 24:54.800 I'm going to speed it up through that part. 24:54.800 --> 24:57.800 And then I'm going to set it back to somewhat normal when he gets done 24:57.800 --> 24:59.800 with the part that we saw yesterday. 24:59.800 --> 25:00.800 Thanks for joining me. 25:02.800 --> 25:03.800 Here for yourself as well. 25:03.800 --> 25:06.800 I'd like to welcome Craig Venter who's going to speak about what is life, 25:06.800 --> 25:07.800 a 21st century perspective. 25:07.800 --> 25:08.800 Craig. 25:16.800 --> 25:18.800 I see in the chat there that somebody's talking about. 25:18.800 --> 25:19.800 Thank you for that. 25:19.800 --> 25:20.800 We already heard this part. 25:20.800 --> 25:25.800 I can't stress enough how the power of AI is being used to distort what's 25:25.800 --> 25:26.800 actually going on. 25:26.800 --> 25:31.800 I'm going to watch a video tomorrow from 2017 where someone explains to us 25:31.800 --> 25:33.800 what's really happening on social media. 25:33.800 --> 25:38.800 It has nothing to do with, with neuronal networks and AI spontaneously 25:38.800 --> 25:42.800 becoming intelligent or, or algorithms that we don't really, 25:42.800 --> 25:43.800 I don't know. 25:43.800 --> 25:44.800 I don't know. 25:44.800 --> 25:45.800 I don't know. 25:45.800 --> 25:46.800 I don't know. 25:46.800 --> 25:47.800 I don't know. 25:48.800 --> 25:51.800 It's a simple, intelligent or, or algorithms that we don't really understand. 25:51.800 --> 25:54.800 It has to do with, as I've said in the last few days, very succinctly, 25:54.800 --> 25:55.800 it has to do with simple programming. 25:55.800 --> 26:00.800 If then else, that's it. 26:00.800 --> 26:04.800 Simple programming is enough to put Robert Malone at the top of the feed 26:04.800 --> 26:07.800 and put Jonathan Cooey on somebody else's feed. 26:07.800 --> 26:11.800 It's, it's simple programming is enough to make Jonathan Cooey think his 26:11.800 --> 26:14.800 message is getting out while everybody else doesn't see it. 26:14.800 --> 26:20.980 doesn't see it. It's as simple as that. It doesn't have to be a magic algorithm. You 26:20.980 --> 26:27.920 know what? Approving Remdesivir is as simple as saying that an AI chose it. And that AI 26:27.920 --> 26:33.640 could have been a simple one line code as Mark Housatonic has so eloquently said, if 26:33.640 --> 26:43.120 then else, Remdesivir. And so one of the bamboozledments, one of the greatest illusions that's currently 26:43.120 --> 26:51.840 being foisted upon us is the idea that AI is at the cusp of becoming more than just machine to 26:51.840 --> 26:59.320 control other people more than just a fancy machine. They want you to believe it's something 26:59.320 --> 27:06.600 that's going to have emergent properties very similar to life. And that's an illusion. That's a 27:06.600 --> 27:12.480 mythology. That's not going to happen. Can they use these algorithms and these, these, these 27:12.600 --> 27:22.200 software to control people to manipulate their opinions and their habits? Absolutely. But 27:22.200 --> 27:31.120 it's not gain a function in AI. It's not quantum computing that they were waiting for, or the 27:31.120 --> 27:36.960 big and a big enough computer, or a fast enough CPU. It's already happening right now with if 27:36.960 --> 27:46.400 then else statements, just programming the application to do it. And so when we talk about this, make 27:46.400 --> 27:50.960 sure you understand that part of this long term programming is getting people to think of 27:50.960 --> 27:57.160 themselves as a machine that the ghost in the machine doesn't matter that the sum of the whole 27:57.160 --> 28:03.920 doesn't matter. The whatever the pattern integrity becomes doesn't matter. We are, we are the 28:03.920 --> 28:10.720 Manila rope, we are the hemp rope, we are the nylon rope. That's what he wants us to believe chemistry 28:10.720 --> 28:18.800 and physics to be here for this event. And I was asked earlier whether the goal is to dissect what 28:18.800 --> 28:24.480 Schrodinger had spoken about in Britain, what to prevent, to present the new summary. And I always 28:24.480 --> 28:29.640 like to be forward looking. So I won't give you a history lesson except for very briefly. I will 28:29.640 --> 28:34.320 present our findings on first on reading the genetic code and then learning to synthesize and write 28:34.320 --> 28:38.600 the genetic code. And as many of you know, we synthesized an entire genome, booted it up to 28:38.600 --> 28:44.720 create an entirely new synthetic cell where every protein in the cell was based on the synthetic 28:44.720 --> 28:50.120 DNA code. So as you all know, Schrodinger's book was published in 1944. It was based on a series of 28:50.120 --> 28:55.440 three lectures here starting in February of 1943. And he had to repeat the lectures I read on the 28:55.440 --> 28:59.960 following Monday because the room on the other side of campus was too small. And I understand people 28:59.960 --> 29:03.640 were turned away tonight but were grateful for internet streaming so I don't have to do this 29:03.640 --> 29:10.560 twice. So also do clearly do his historical role and it's interesting to be sharing this event with 29:10.560 --> 29:15.120 Jim Watson who have known and had multiple interactions with over the last 25 years and including most 29:15.120 --> 29:19.080 recently sharing the double helix prize for human genome sequencing with him from Cold Spring Harbor 29:19.080 --> 29:25.320 laboratory a few years ago. Now Schrodinger started his lecture with a key question in an 29:25.320 --> 29:29.040 interesting insight on it. The question was I'll read it. How can the events in space and time which 29:29.040 --> 29:33.000 take place within the boundaries of a living organism be accounted for by physics and chemistry? 29:33.000 --> 29:36.880 It's a pretty straightforward, disembow question. And then he sort of answered what he could at the 29:36.880 --> 29:41.160 time. The obvious inability of present day physics and chemistry to account for such events is no 29:41.160 --> 29:47.400 reason at all for doubting that they will be accounted for by those sciences. So while I only have around 29:47.400 --> 29:52.120 40 minutes not three lectures I hope to convince you that there has been substantial progress in the 29:52.120 --> 29:57.240 last nearly 70 years since Schrodinger initially asked that question to the point where the answer is 29:57.240 --> 30:03.360 at least nearly at hand if not in hand. So I view that we're now in what I'm calling the digital age 30:03.360 --> 30:09.920 of biology. My teams work on synthesizing genomes based on digital code in the computer and four 30:09.920 --> 30:14.520 bottles of chemicals illustrates the ultimate link between the computer code and the digital code. 30:15.240 --> 30:20.120 Life is code as you heard in the introduction. It was very clearly articulated by Schrodinger. 30:21.320 --> 30:26.040 I know he's already starting out with a simplification that I didn't plug yesterday but I will now 30:26.680 --> 30:35.720 in that the DNA and the four bases can be translated into a computer code and digitized and then we 30:35.720 --> 30:41.320 have essentially taken that data and transferred it to another medium. What does that assume? 30:42.280 --> 30:47.880 It assumes a lot of things. First of all it assumes that any proteins or RNA that are 30:47.880 --> 30:54.600 associated with that DNA molecule are completely irrelevant and contain no information at all. 30:55.480 --> 31:02.440 It also suggests that the methylation state of the DNA doesn't matter at all and contains no 31:02.440 --> 31:09.800 information relevant to understanding its function. Now we could go on and on and on and on and on 31:10.360 --> 31:15.720 about all the things that's saying that taking DNA in the four bases and turning it into computer 31:15.720 --> 31:21.480 code is digitizing that information. Even if you can take that and make synthetic copy of it and 31:21.480 --> 31:27.000 put it back into a cell structure and get something resembling cell division to occur 31:28.680 --> 31:36.120 still does not say that you understand how that DNA works after you put it into that context that 31:36.120 --> 31:42.920 you can no longer probe. They don't have a bunch of cameras inside of their synthetic cell to 31:42.920 --> 31:48.120 see that everything is functioning and working the way that they think it does and that the DNA 31:48.120 --> 31:54.680 is not being chemically altered or that proteins and chaperone proteins and facilitating proteins 31:54.680 --> 32:00.440 and enzymes and RNA are not binding to that DNA and causing it to integrate back with that 32:00.440 --> 32:08.920 machinery to work properly. And so there are an extraordinary number of assumptions that are 32:08.920 --> 32:15.000 being made in order to simplify our own understanding of this irreducible complexity to make it seem 32:15.000 --> 32:21.080 like it's pretty it's not that complex at all. Code script. I think perhaps even more importantly 32:21.080 --> 32:26.120 and something I missed on the first few readings of his book early in my career was as far as I 32:26.200 --> 32:31.800 can tell it's the first mention that this code could be as simple as a binary code and he used 32:31.800 --> 32:37.400 the example of Morris code with just dots and dashes could be sufficient to give 34 different 32:37.400 --> 32:44.440 specifications. I've searched and I have not find any earlier references to the Morris code although 32:44.440 --> 32:50.920 historian that I know wrote a quick letter asking about that then and Chris response was 32:50.920 --> 32:53.800 it was a metaphor that was obvious to everybody. So I don't know if it was obvious to everybody 32:53.800 --> 32:59.240 after Schrodinger's book or sometime before. One of the things though Schrodinger was right 32:59.240 --> 33:03.320 about a lot of things which is why in fact I think we celebrate what he talked about and what he 33:03.320 --> 33:09.400 wrote about but some things he was clearly wrong about like most scientists in his time and he 33:09.400 --> 33:14.840 relied on the biologist of the day. They thought that protein not DNA was the genetic information 33:16.120 --> 33:21.720 and I think it's really quite extraordinary because just in 1944 in the same year that he 33:21.720 --> 33:27.400 published his book is when the famous experiment by Oswald Avery who was actually 65 and about 33:27.400 --> 33:32.360 ready to retire along with his colleagues Colin McCloud and McLean McCartney published their 33:32.360 --> 33:39.240 key paper demonstrating that DNA was actually the Colin McCloud of the clan McCloud is that the 33:39.240 --> 33:44.600 the immortal in Highlander one of the best movies of all time in case you haven't seen it Highlander 33:44.600 --> 33:48.360 great movie substance that causes bacterial transformation and therefore was the genetic 33:48.360 --> 33:55.080 material. His experiment was remarkably simple and I sort of wonder why it wasn't done 50 years 33:55.080 --> 33:59.240 earlier because with all the wonderful genetics work going on in Drosophila certainly people were 33:59.240 --> 34:03.640 looking at chromosomes. He simply used proteolytic enzymes to destroy all the proteins associated 34:03.640 --> 34:08.440 with the DNA and showed that the DNA the naked DNA was in fact of the transforming factor. 34:09.800 --> 34:15.560 The impact of this paper was far from instantaneous as has happened in this field I think in part 34:15.560 --> 34:20.920 because there was so much bias against DNA and towards proteins that it took a long time 34:20.920 --> 34:26.120 for that to sink. Now if you were paying attention there he's citing a paper that that tried to 34:26.120 --> 34:31.240 address the issue that I just said earlier which is if you just take that DNA and you don't have 34:31.240 --> 34:35.320 any chemical information about it you don't have any of the chaperone proteins or proteins or 34:35.320 --> 34:40.920 RNA that bound to it in in vivo then how do you know what you're really getting out of there and 34:41.080 --> 34:46.280 to a certain extent that experiment is valid in the sense of that the DNA transferred from 34:46.280 --> 34:53.960 one bacteria to another transferred those genes and those traits and so I'm totally willing to 34:53.960 --> 35:02.040 accept that some of these experiments are real and demonstrate that DNA is a genetic material that 35:02.040 --> 35:08.680 can carry a code that can be translated into proteins. I'm not suggesting that those kinds of broad 35:08.680 --> 35:15.320 ideas are incorrect. Please don't misunderstand me what I am suggesting though is that as they 35:15.320 --> 35:19.560 are described they are described in a very cartoonishly simple way 35:22.840 --> 35:28.680 and that cartoonishly simple thing involves DNA to RNA to protein with some ribosome in the middle. 35:29.000 --> 35:37.880 Not thinking about okay for example when we read RNA don't we isn't that basically this a very 35:40.760 --> 35:46.600 there are two steps there right understanding how those work in different tissues in different 35:46.600 --> 35:53.320 species with different ribosomes in different enzymes in different nucleic nuclear enzymes 35:53.320 --> 36:00.600 and nuclear chaperone proteins and and the variable list is endless and we're not talking 36:00.600 --> 36:04.920 about that variable list at all we're trying to ignore it we're doing as much reductionist 36:05.960 --> 36:11.160 discussion as we can about DNA here and reductionist experiments are important 36:13.160 --> 36:20.760 but not exhaustive and certainly not the experiments that are going to get across 36:20.760 --> 36:27.480 get us across the finish line of trying to crack this irreducible complexity. Ken in 1949 36:27.480 --> 36:33.960 obviously was the first sequencing of a protein by Fred Sanger and the protein was insulin and 36:33.960 --> 36:40.520 this work showed in fact that proteins consisted of linear amino acid codes so and he won the Nobel 36:40.520 --> 36:46.600 Prize in 1958 for that achievement and was very key in terms of leader understanding of the link 36:46.600 --> 36:51.560 between DNA and proteins but as you heard in the introduction obviously the discovery that 36:51.560 --> 36:59.080 changed the whole field and started us down to DNA root was the 1953 work by Watson and Crick 36:59.080 --> 37:03.560 with help from Maurice Wilkins and Roslyn Franklin showing that DNA was in fact a double helix 37:03.560 --> 37:08.760 and had a clear explanation of how it could be self-replicated. Again this was not as I 37:08.760 --> 37:14.440 understand instantly perceived as a breakthrough because the biochemists were still hanging on 37:14.440 --> 37:21.000 to genetic code but soon with a few more experiments from others the world changed 37:21.000 --> 37:25.640 pretty dramatically. I think the next big thing came from the work obviously of Carana and Marshall 37:25.640 --> 37:31.480 Nuremberg in 1961 where they worked out the triplet genetic codes of three letters of genetic 37:31.480 --> 37:37.080 code coding for a single amino acid and then this became clear how the linear DNA code encoded for 37:37.080 --> 37:42.520 the linear protein code. This was followed a few years later by Robert Holly's discovery of the 37:42.520 --> 37:48.440 structure of tRNA and tRNA is the key the key a link between the messenger RNA and bringing the 37:48.440 --> 37:54.840 amino acids in for protein synthesis though Holly Nuremberg and Carana shared the Nobel Prize in 1968 37:54.840 --> 37:59.320 for that work. The next decade brought us restriction enzymes so my friend and colleague Ham Smith 37:59.320 --> 38:04.360 who was at the Venture Institute now in 1970 that found the first restriction enzymes these are 38:04.360 --> 38:09.640 the molecular scissors that cut DNA very precisely and enabled the entire field of a molecular 38:09.640 --> 38:13.560 engineering and molecular biology and Ham Smith and Warner Arbor and Dan Nathan shared the prize 38:13.560 --> 38:19.240 in 1978 for that work. The 70s brought not only some interesting dress codes and characters 38:20.440 --> 38:25.720 but the beginning of the molecular splicing revolution using restriction enzymes Conan Boyer 38:25.720 --> 38:31.800 and Paul Berg published the first papers on recombinant DNA and Conan Boyer at Stanford 38:31.800 --> 38:36.520 as Stanford father patent on their work and this was used by Genentech and Eli Lilly to produce 38:36.520 --> 38:43.800 a human insulin as the first recombinant drug. DNA sequencing and reading the genetic code 38:43.800 --> 38:50.360 progressed much more slowly so in 1973 a maximum Gilbert published a paper on 24 base pairs 24 38:50.360 --> 38:56.920 letters of genetic code RNA sequencing progressed a little bit faster so the first actual genome 38:56.920 --> 39:03.000 viral genome an RNA viral genome was sequenced in 1976 by Walter Fier is it from Belgium and this 39:03.080 --> 39:08.280 was followed the following year by Fred Sanger again a sequence in the first DNA virus and this was 39:08.280 --> 39:15.640 phi X 174 that I'll bring back to mind with you so this became the first DNA virus in the first 39:15.640 --> 39:20.040 viral DNA genome and it was also accompanied by this new sequencing technique called now referring 39:20.040 --> 39:25.720 to a Sanger sequencing that Sanger introduced. This is a picture of Sanger's team that sequenced 39:25.720 --> 39:30.760 phi X the second guy from the left on the bottom is Clyde Hutchinson who was also a member of the 39:30.760 --> 39:36.120 Adventure Institute and joined us after retiring from the University of North Carolina and took 39:36.120 --> 39:41.960 played a key role in some of the synthetic genome work. So in 1975 I was just getting my Ph.D. as 39:41.960 --> 39:47.080 the first genes were being sequenced 20 years later I led the team to sequence the first genome 39:47.080 --> 39:52.040 of a living species and Cam Smith was a key part of that team this was homophilus influenza 39:52.040 --> 39:56.520 instead of 5000 letters of genetic code this was 1.8 million letters of genetic code 39:56.600 --> 40:02.600 or about 300 times the size of the phi X genome. Five years later we up the ante another 1,600 40:02.600 --> 40:07.800 times with the first draft of the human genome using these new whole genome shotgun techniques 40:07.800 --> 40:12.920 and the smaller papers the the public genome effort size doesn't reflect its significance 40:12.920 --> 40:17.720 only its relative significance to me. So the human genome is about a half a million times 40:17.720 --> 40:22.440 larger than the phi X genome so it shows how fast things were developing and reading genomes is 40:22.440 --> 40:27.320 now progressed extremely rapidly so instead of years or decades it now takes about two hours 40:27.320 --> 40:33.240 to sequence a human genome instead of genomes per day or genomes per hour or hours per genome 40:33.240 --> 40:37.320 we can now in a recently done a demonstration sequencing 2000 complete microbial genomes 40:37.320 --> 40:45.320 in one run in one hour so the pace is changing quite substantially. Now I view DNA as an analog 40:45.320 --> 40:50.120 coding molecule and when we sequence the DNA we're converting that analog code into digital code 40:50.840 --> 40:56.680 the ones and zeros in the computer very similar to the dots and dashes that Schrodinger 40:56.680 --> 41:00.280 indicated might be the original code and I call this process digitizing biology. 41:01.080 --> 41:06.520 A numerous scientists have drawn the analogy between computers and biology I take these even 41:06.520 --> 41:11.560 further I describe DNA as the software of life and when we activate a synthetic genome in a cell 41:11.560 --> 41:15.880 we call we describe it as booting up a genome in a cell the same way we talk about booting up 41:15.960 --> 41:20.280 software. Now June 23rd of this year was Alan Turing's would have been his hundredth birthday 41:21.080 --> 41:26.040 and Turing described what has become be known as Turing machines and the machine described a 41:26.040 --> 41:30.600 set of instructions written on a tape. He also described the universal Turing machine which was a 41:30.600 --> 41:37.240 machine that could take that set of instructions. I hope you can already feel how inadequate this is 41:38.040 --> 41:46.440 that our existence is really a machine that reads a tape. I hope you can understand how 41:46.440 --> 41:51.880 ridiculous it is that he is trying to convince this audience after years of failure that they 41:51.880 --> 41:58.520 are almost there to understanding the machine that reads the tape. Computers equal life, 41:58.600 --> 42:09.320 computers equal biology is one of the most absurd insults to God's creation one of the most absurd 42:09.320 --> 42:16.760 insults and it's a verbal abomination of the beauty of life. But that's what we're doing here 42:16.760 --> 42:22.040 right it's it's chemistry and physics which essentially means it's a bunch of zeros and ones 42:22.040 --> 42:27.640 it's a bunch of variables that if we had sufficient ability to measure them we could predict all of 42:27.720 --> 42:31.960 them. It essentially means we have no free will because we're just machines. 42:33.560 --> 42:36.040 The free will is an illusion. Do you see where this goes? 42:38.360 --> 42:46.120 This is from years ago this is one of the granddaddies of this mythology. This guy has been claiming 42:46.120 --> 42:53.240 that if we just had enough sequences like every baby on earth we would have a chance at figuring 42:53.240 --> 42:58.040 out how the genome works. This guy says that. This guy's got a foundation that has that as a goal. 42:59.000 --> 43:07.240 They charge you to sequence you and then they also use your sequence and sell it to pharmaceutical 43:07.240 --> 43:15.640 companies. That's his company. This is one of the darkest players in this mythology that understands 43:15.640 --> 43:23.160 that the value of the people on the planet right now is is there what they represent as data. 43:24.120 --> 43:29.800 And rewrite them and this was the original origin of the digital computer. His ideas were 43:29.800 --> 43:36.040 carried further in the 1940s by John Van Neumann as many people know and he conceived of the self 43:36.040 --> 43:41.000 replicating machine. So Von Neumann's machine consisted of a series of cells which encoded a 43:41.000 --> 43:45.320 sequence of actions that be performed by the machine and using a writing head the machine can print 43:45.320 --> 43:50.840 out a new pattern of cells allowing it to make a complete copy of itself on the tape. So many 43:50.920 --> 43:55.800 of people have certainly made the analogy most recently in nature Sydney Brenner who played a role 43:55.800 --> 44:01.640 in almost all these stages of early biology wrote an article about Turing and biology and in this 44:01.640 --> 44:06.600 he argued that the best examples of a Turing and von Neumann machine is found in biology with the 44:06.600 --> 44:13.400 self replicating code the internal description of itself and that this is the key kernel of 44:13.400 --> 44:18.840 biological theory. So while software was pouring out of sequencing machines around the world 44:18.840 --> 44:25.000 substantial progress was going on describing the hardware of life or proteins. So in biochemistry 44:25.000 --> 44:29.880 the first two decades of the 20th century were dominated by what was called the colloid theory. 44:29.880 --> 44:34.120 So life itself is explained in terms of the aggregate properties of all the colloidal substances 44:34.120 --> 44:38.920 in an organism. We now know that these substances are a collection of three-dimensional protein 44:38.920 --> 44:45.320 machines each evolved to carry out a very specific task. Now these proteins have been 44:45.320 --> 44:50.840 described as nature robots and if you think about it for every single task in a cell every 44:50.840 --> 44:55.480 imaginable task is described by a Tanford and Reynolds there is a unique protein to carry out 44:55.480 --> 45:01.720 that task. It's programmed when to go on when to go off and it does this based on its structure 45:01.720 --> 45:07.160 it doesn't have consciousness it doesn't have a control from a mind or a higher center everything 45:07.160 --> 45:14.280 a protein does is built in to its linear code derived from the DNA code. Just so that's a pretty 45:14.360 --> 45:21.240 bold bold certainty there with no room for subtleties that I hope he's going to build in later. 45:21.240 --> 45:24.920 Briefly there's multiple protein types everything you know about your own life 45:24.920 --> 45:29.080 most of it is protein derived about a quarter of your body is collagen it's a matrix protein 45:29.080 --> 45:34.200 that's built up in multiple layers we have rubber-like proteins that form blood vessels in the lung 45:34.200 --> 45:39.160 we have transporters that move things in and out of cells enzymes that copy DNA metabolized sugars 45:39.160 --> 45:45.960 etc. Now the most important breakthrough I think outside of the genetic code is determining the 45:45.960 --> 45:50.520 process of protein synthesis. To show you how recent all of this is this is the three-dimensional 45:50.520 --> 45:58.360 structure of the bacterial ribosome determined in 2005 and the three angstrom structure of the 45:58.360 --> 46:01.880 eukaryotic chromosome was just determined and published in December of last year that this is 46:01.880 --> 46:08.120 all recent science in recent history and these are extraordinary molecules but that's a weird 46:08.120 --> 46:12.760 thing right I mean if we sequence the whole human genome already then why do we wait so long 46:12.760 --> 46:22.360 to sequence a bacterial ribosome what did he say exactly because it doesn't make sense we sequence 46:22.360 --> 46:29.640 the whole human genome two decades ago already this is this is the three-dimensional structure 46:29.640 --> 46:37.720 of the bacterial ribosome determined in 2005 and the three angstrom structure of the eukaryotic 46:37.880 --> 46:42.520 weird because 2005 was one of the first I think it's one of the first years where we started to 46:42.520 --> 46:48.760 actually get coronavirus sequences did you know that the first human coronavirus that was actually 46:48.760 --> 46:50.200 sequenced and understood 46:53.000 --> 46:57.960 around 2005-2006 what a weird time for all these narratives to start right 46:59.240 --> 47:04.920 all together so it was just determined and published in December of last year that this is all 47:04.920 --> 47:09.160 weir of the eukaryotic chromosome was just determined and published in December and the 47:09.160 --> 47:13.640 three angstrom structure of the eukaryotic chromosome was just determined and published in December of 47:13.640 --> 47:17.960 last year is that the bacteria chromosome then I don't know what he's talking about there but 47:17.960 --> 47:23.240 it seems really weird this is all recent science in recent history and these are extraordinary 47:23.240 --> 47:30.360 molecules there it's the most complex machinery we have in the cell as you can see 47:31.160 --> 47:36.920 there's numerous components to it I tried to think of this as maybe the Ferrari engine of the cell 47:38.040 --> 47:42.040 if the engine can't convert the enmester RNA tape into proteins there is no life 47:42.760 --> 47:47.000 and if you interfere with that process you kill life so major antibiotics that we all know about 47:47.000 --> 47:52.360 the immunoglycosides, ceterocycline, quorum phenylchol, erythromycin, etc all kill bacterial cells 47:52.360 --> 47:57.320 by interfering with the function of this structure how many people knew that how many 47:57.400 --> 48:05.800 people knew that a ribosome was composed mostly of RNA so ribo proteins ribonucleic proteins 48:06.520 --> 48:13.000 and that it had 47 different proteins subunits or whatever that come together to form it including 48:13.000 --> 48:19.400 the RNA molecules that are hybrid in there does that sound like something that we understand 48:22.040 --> 48:25.880 or does that sound like something that they desperately want to understand if they don't 48:25.960 --> 48:33.800 understand that machine then what do they really understand about DNA to RNA to protein not very 48:33.800 --> 48:42.360 much think back to the violin analogy from the last couple days if they can explain to you why 48:42.360 --> 48:48.200 a crack in the neck can be absolutely catastrophic for a strativarius violin do they understand anything 48:48.200 --> 48:53.960 about the varnish process or about how a perfect violin works or how a violinist produces the music 48:54.040 --> 49:01.560 on a violin they haven't even bothered to study it and so by sequencing the human genome using 49:01.560 --> 49:10.120 restriction enzyme maps they haven't even started actually studying it by sequencing or crystallizing 49:10.120 --> 49:18.280 the bacterial ribosome we're just getting started studying it in 2005 at the same time where 49:18.920 --> 49:24.600 we're just starting to study coronavirus biology and and and able to find them in the wild 49:26.040 --> 49:30.440 and now we're supposed to believe that this is basically subject matter that is mastered 49:31.640 --> 49:39.960 that we can feed mRNA into a child's body through the muscle and expect ribosomes in their tissue 49:40.520 --> 49:46.680 to faithfully translate the protein that we want them to translate and for their immune system 49:46.680 --> 49:54.040 to faithfully respond to it with a useful response that's the model of reality that these guys 49:54.040 --> 50:01.720 want us to accept right now that the that the original story line was written for and laid down 50:01.720 --> 50:11.080 by charlatans like this man who are telling the same mythology the same nonsense story about how 50:11.080 --> 50:18.920 eventually we're going to be able to do all this stuff 50:20.920 --> 50:25.800 so the ribosome is clearly the most unique and special structure in the cell it has seven major 50:25.800 --> 50:31.480 RNA chains including three messenger three tRNA chains and one messenger RNA it has 47 different 50:31.480 --> 50:36.760 proteins going into the structure in one newly synthesized protein chain the size is several 50:36.760 --> 50:40.920 million dolphins so this is the heart of all biology we would not have cells we would not have 50:40.920 --> 50:45.480 life without this working and this is the machine that converts the linear dna code 50:46.520 --> 50:52.200 into proteins and the process with doing this what did he just say i mean think about how he said it 50:52.200 --> 50:56.920 so from there's a several million dolphins so this is the heart of all biology we would not have 50:56.920 --> 51:02.360 cells we would not have life without this working this is the heart of biology they don't have a 51:02.360 --> 51:07.480 clue how it works they've been telling you for years the heart of biology is dna it's the tape 51:08.280 --> 51:13.880 the tape that goes into the machine it's not the tape that goes into the machine at all 51:17.400 --> 51:25.160 it's the machine or the machines they don't know how the dna copying machine works they don't know 51:25.160 --> 51:30.360 how the RNA polymerase works they don't know how reverse transcriptase works they don't know how 51:30.360 --> 51:35.640 a ribosome works they can tell you they know but they don't 51:41.480 --> 51:43.160 do you see what we're dealing with here 51:46.040 --> 51:48.200 they can talk out of both sides of their mouths 51:51.000 --> 51:56.600 these people know that they haven't made progress just like peter teal told you in that video in 51:57.160 --> 52:04.200 2019 they know that the progress is stalling out that yeah we can sequence things faster we can 52:04.200 --> 52:14.120 sequence more things in less time we can identify cracks in the neck of the violin faster we can 52:14.120 --> 52:19.240 find them easier we have technology to locate hairline cracks that we're hard to see before 52:19.960 --> 52:24.360 does that mean that we understand how the violin makes music no we don't 52:26.120 --> 52:34.200 no we don't and these kinds of observations are being misconstrued as understanding they're not 52:34.200 --> 52:44.600 understanding please see it this is the biology the big picture biology we need to teach to our kids 52:45.400 --> 52:49.400 we are being misled by a bunch of people who have been misled 52:51.160 --> 52:53.640 who are too naive or too smart to see out of it 52:59.880 --> 53:06.200 and this is the machine that converts the linear dna code into proteins and the process with doing 53:06.200 --> 53:11.640 this RNA synthesis from RNA is called transcription and protein synthesis is called translation 53:12.600 --> 53:17.160 so if these processes were highly reliable life would be very different and perhaps not need the 53:17.160 --> 53:21.160 same kind of information driven system if you were building a factory to build automobiles 53:21.160 --> 53:25.720 that worked the way the ribosome did you would be out of business very quickly a significant 53:25.720 --> 53:30.120 fraction of all the proteins synthesized get degraded shortly after synthesis because they 53:30.120 --> 53:34.920 formed the wrong confirmations they aggregate in the cell or cause another problem so as 53:34.920 --> 53:39.400 transfer RNA brings in the final amino acid to a growing peptide chain coming out of the ribosome 53:39.400 --> 53:43.080 the next step is truly one of the most remarkable and that's the protein folding 53:43.080 --> 53:48.360 so the number of protein confirmations if you have 100 amino acids is only a word of 2 to the 100th 53:48.360 --> 53:55.400 power 2 to the 100th power if you have 100 amino acids so tell me again how we understand that 53:55.400 --> 54:02.440 preons can cause other proteins to misfold how does that work exactly why do we believe that 54:02.440 --> 54:10.440 that seems like a good idea like that makes sense proteins that have countless configurations 54:10.440 --> 54:17.560 that are complex electrostatic magnets with three dimensional shapes inside of a polar solvent 54:17.560 --> 54:26.760 called water and yet somehow or another despite that absolutely irreducible complexity this old 54:26.760 --> 54:30.360 man is still trying to tell us that we basically have a grip on how all that works 54:32.120 --> 54:42.120 or is he or is he listen the next step is truly one of the most remarkable 54:42.120 --> 54:46.600 and that's the protein folding so one of the most remarkable that we still don't understand but 54:46.600 --> 54:53.080 google tells us we do it's too bad that google fold can't explain the simple mechanisms by which 54:53.160 --> 54:59.400 proteins go into prion states or go into amyloidosis and cause other proteins to do it 55:01.960 --> 55:07.240 if the way that a protein folds is dependent on its sequence then how can a prion protein 55:07.880 --> 55:12.200 influence another protein without the right sequence to fold into that protein 55:14.040 --> 55:18.520 how come we don't talk about any of this stuff in the prion literature we just talk about in very 55:18.520 --> 55:32.120 grand terms he's telling you that proteins misfold all the time that if you started a car 55:32.120 --> 55:38.840 manufacturing plant that made cars as well as a ribosome does that you'd go out of business 55:39.960 --> 55:46.200 think about how extraordinary what he's saying is that must mean that there's a lot of misfolded 55:46.280 --> 55:50.600 protein in every cell that we have that must mean that misfolded protein must be dealt with pretty 55:50.600 --> 55:56.680 effectively but how do they know that it's a misfolded protein after it gets translated from 55:56.680 --> 56:03.800 DNA to RNA to protein who's checking what what mechanism is checking to see if that protein has 56:03.800 --> 56:10.600 all the right amino acids do they line it up against a standard i thought these things were 56:10.600 --> 56:16.440 just molecules with no mind yet somehow or another you're just going to keep hand waving 56:16.440 --> 56:20.440 over and over this happens and then that happens and then this happens and then they do this and 56:20.440 --> 56:25.800 then they do this and the most amazing thing is despite all of these errors and terrible folding 56:25.800 --> 56:32.520 and and the last transfer RNA being wrong the body is able to get rid of those proteins very 56:32.520 --> 56:37.080 quickly if they're folded wrong or if they're translated wrong because there's all these magic 56:37.080 --> 56:49.000 mechanisms that do it he is trying to make you believe that protein misfolding is a very normal 56:49.000 --> 56:54.760 thing it happens all the time it's something we have to deal with and can be pathogenic if it goes 56:54.760 --> 57:05.880 wrong is it true that's the question you have to ask yourself is it a natural process or is it 57:05.880 --> 57:11.800 something that happens after a long exposure to a toxin repeated exposure to chronic inflammation 57:12.840 --> 57:17.800 other insults to the brain or tissues which go through this protein misfolding process 57:17.800 --> 57:27.000 electromagnetic radiation or other damaging sources of biodamaged nobody talks about any of 57:27.000 --> 57:33.480 that stuff here and the reason why is because they are oversimplifying your understanding of 57:33.480 --> 57:38.280 what is irreducible complexity in biology the number of protein confirmations if you have 100 57:38.280 --> 57:43.560 amino acids is on the order of two to the 100th power it would take about 10 to the 10th years 57:43.560 --> 57:49.080 that for you to even try all those if you can try one a second so wait i thought that google 57:49.080 --> 57:54.360 already has a algorithm that figured it all out and can do it for any protein do you see where we are 57:55.720 --> 58:02.840 did we figure that out in like 10 years just hardcore number crunching but built into this 58:02.920 --> 58:06.520 linear code of the amino acid based on the linear genetic code these processes 58:07.080 --> 58:12.840 happened very quickly so here's a movie that spreads out that six microseconds 58:13.400 --> 58:19.320 slightly longer to show you a folding of a small protein so this is the end folded structure 58:19.320 --> 58:24.040 so you'll see it starts with a linear protein and over six microseconds it goes through all 58:24.040 --> 58:29.880 these different confirmations to try and get to the final fold so somehow the linear code limits 58:29.880 --> 58:33.000 the number of folds it can take but it tries a number of different ones and if it gets them 58:33.000 --> 58:39.720 wrong the protein has to be degraded very quickly or it will cause problems so imagine all the 58:39.720 --> 58:43.880 selection that went into this because the protein structure actually determines its rate of folding 58:43.880 --> 58:50.040 as well as the final structure in fact the end terminal amino acid determines how fast a protein 58:50.040 --> 58:56.920 is degraded this is now called the the end rule pathway for protein degradation for example if 58:57.000 --> 59:01.640 you had a amino acid a lysine and arginine or tryptophane as an interminal on a protein beta 59:01.640 --> 59:07.400 galactosidase it results in a protein with a half-life of 120 seconds in E. coli or 180 seconds in 59:07.400 --> 59:11.080 eukaryotic cell yeast whereas you have three different amino acids a serine of valine or 59:11.080 --> 59:16.760 methionine you get a half-life of over 10 hours in bacteria over 30 hours in yeast but these are 59:16.760 --> 59:22.360 still relatively short times a bacteria will sell in an hour will have to remake half of all its 59:22.360 --> 59:29.720 proteins we make things at almost similar rate but because of this instability and the random 59:29.720 --> 59:34.920 folding and misfolding of proteins protein aggregation is a key problem so we have to constantly synthesize 59:34.920 --> 59:40.360 new proteins and if they fold wrong you have to get rid of them or they clog up the cell this I 59:40.360 --> 59:45.640 think it's absolutely extraordinary that he's spending so much time talking about protein 59:45.720 --> 59:47.720 misfolding I can't even believe it 59:50.600 --> 59:56.360 he is emphasizing this for like four minutes already that the ribosome isn't very good 59:56.360 --> 01:00:02.280 even though it's the most beautiful thing and it is it is the secret to life it's not very 01:00:02.280 --> 01:00:08.680 good machine it makes errors all the time and this protein misfolding has to be is a source of 01:00:08.680 --> 01:00:16.280 danger like what is he talking about here how can we replace our gut epithelial cells every 01:00:16.280 --> 01:00:25.080 three to five days if protein misfolding in RNA and ribosomes is so shitty how the hell would that work 01:00:28.920 --> 01:00:33.320 I'm sorry but I feel like what I see here is exactly what I thought I would see here 01:00:34.040 --> 01:00:39.800 I'm going to find as we look back on these scientists talking about the human genome project talking 01:00:39.800 --> 01:00:46.600 about sequencing talking about the idea of DNA to RNA to protein are going we're going to find 01:00:46.600 --> 01:00:51.960 out that we missed it but they were emphasizing protein misfolding for a lot longer than we thought 01:00:53.560 --> 01:00:57.960 and not because they have a plethora of evidence about how devastating this is or how important it 01:00:57.960 --> 01:01:04.920 is to understand but because they knew it was going to increase in the future and they needed to be 01:01:04.920 --> 01:01:13.720 sure that we had a naturally occurring mechanism cartoon in our head already when it started to 01:01:13.720 --> 01:01:22.200 become more and more apparent more and more part of our daily lives Alzheimer's cannot be a toxin 01:01:22.840 --> 01:01:28.840 or will be angry it cannot be poisoning or will be angry it cannot be something in the water 01:01:28.840 --> 01:01:34.920 or will be angry it cannot be electromagnetic radiation or cell phone towers or anything or 01:01:34.920 --> 01:01:40.120 we will be angry it has to be a natural thing that just happens to some old people when they get 01:01:40.120 --> 01:01:50.280 unlucky or they use too many aluminum pans this guy is laying down a narrative of protein 01:01:50.280 --> 01:02:00.840 misfolding that is absolutely ridiculous because they have no absolutely none zero zip evidence 01:02:00.840 --> 01:02:06.040 for how it is that if the ribosome is making so many mistakes how in the world do we compensate 01:02:06.040 --> 01:02:11.400 for all that wasted energy all that was wasted raw materials that get assembled into something 01:02:11.400 --> 01:02:17.000 that just needs to be broken down again how in the world can we take this seriously 01:02:21.160 --> 01:02:28.600 when our endothelial cells are replaced weekly our epithelial cells in our gut are replaced 01:02:28.600 --> 01:02:35.000 weekly how can we possibly take this guy seriously how much wasted energy is he actually describing 01:02:35.000 --> 01:02:43.320 as part of the perfect symphony of life i hear mythology being laid here folks same way as if 01:02:43.320 --> 01:02:48.920 you stop taking out the trash in a city and this is definitely not doubling everything comes to a 01:02:48.920 --> 01:02:53.640 halt so cells work the same way you have to degrade the proteins you have to pump the trash 01:02:53.640 --> 01:02:59.160 out of the cell it can be toxic very quickly there's a number of diseases known to most of you 01:02:59.960 --> 01:03:03.880 that are misfolding or aggregation diseases and Alzheimer's disease and macao disease are 01:03:03.880 --> 01:03:10.280 examples of accumulation of toxic protein aggregates but recently a new drug came out to deal with 01:03:10.280 --> 01:03:14.120 cystic fibrosis and it's quite interesting people thought the mutations in cystic fibrosis 01:03:14.120 --> 01:03:19.560 just yielded in a less functioning chloride ion channel that affected the cell's ability 01:03:19.560 --> 01:03:24.440 to survive properly it turns out the single mutation that's the major mutation cystic fibrosis 01:03:24.440 --> 01:03:29.240 actually blocks the protein from disassociating with its chaperonin and never gets to the cell 01:03:29.240 --> 01:03:33.480 surface so simple changes a single letter change in the genetic code in this case doesn't allow 01:03:33.480 --> 01:03:40.200 it to fold properly and get associated so lots of diseases are turning out to be problems from 01:03:40.280 --> 01:03:47.240 protein folding but it's weird right so it doesn't fold properly but the RNA gets translated by the 01:03:47.240 --> 01:03:52.120 ribosome and the system doesn't recognize it as being folded incorrectly so alchemy doesn't get 01:03:52.120 --> 01:04:00.760 degraded so there's mechanisms that he talks about then not talk about then ignores then says 01:04:00.760 --> 01:04:08.200 are there then says aren't there the incongruencies come every other sentence because he's describing 01:04:08.200 --> 01:04:13.800 something with certainty of which he has no actual certainty about and he knows it 01:04:15.480 --> 01:04:20.280 and these incongruencies are there because the story of what they understand is incongruent 01:04:20.280 --> 01:04:26.200 they don't understand it they're still shooting in the dark and pretending they got this all under 01:04:26.200 --> 01:04:30.760 control so you and I don't ask any questions and so that the government keeps funding them 01:04:31.240 --> 01:04:41.560 these are the exact charlatans that peter teal was warning us about where the hyper specialization 01:04:41.560 --> 01:04:49.800 allows people to lie and to exaggerate the politicization of science allows people encourages people to 01:04:49.800 --> 01:04:55.000 lie and exaggerate that's what you see here a man who's done it his whole career 01:04:55.800 --> 01:05:06.040 because he's been encouraged to do it by people like David Baltimore and Stanley Plotkin 01:05:07.800 --> 01:05:18.280 and all the other people like Robert Gallo and Murray Gardner and everybody else who has 01:05:18.280 --> 01:05:24.040 a vested interest in no one actually understanding the biology at the molecular level 01:05:25.160 --> 01:05:29.080 so that the biosecurity state can have an imperative to control us forever 01:05:30.600 --> 01:05:35.320 and more importantly so that they can invert the sovereignty that we feel over our own bodies 01:05:35.320 --> 01:05:40.680 and that of our children so that guys like Craig Venter can finally have the genetic data that 01:05:40.680 --> 01:05:47.720 they have already told us many decades ago they need that Mark Lander told us already a decade ago 01:05:47.800 --> 01:05:53.480 that we would need without all the genomes we need all of them we're not going to have a chance 01:05:53.480 --> 01:06:00.680 of figuring this out that's what the human genome project's final answer was that they got to the 01:06:00.680 --> 01:06:05.560 meeting they went to the the secret room in the Department of Energy and they said well we've 01:06:05.560 --> 01:06:13.480 got the restriction enzyme maps but they are so a specific that we can barely even see patterns 01:06:13.480 --> 01:06:19.640 between people that are closely related so I think the only choice for us is to have as many 01:06:19.640 --> 01:06:26.280 genomes as possible we need all the sequences we need them all and so China being partnered 01:06:26.280 --> 01:06:30.360 with that with that whole movement just said okay well we'll start collecting ours we're 01:06:30.360 --> 01:06:38.520 going to do it right now meanwhile we with our inertia in our system still have this thing called 01:06:38.600 --> 01:06:45.880 privacy and and all that other stuff and and so we couldn't convert we couldn't just start 01:06:45.880 --> 01:06:52.040 collecting all the data from all our kids and so instead what we did was we had people like Craig 01:06:52.040 --> 01:06:59.640 Venter and and people like like James Giordano and others brief secret meetings and tell people 01:06:59.640 --> 01:07:03.400 that look China is already collecting all this data and they might even be collecting it on us 01:07:03.400 --> 01:07:07.320 too and in the meantime we're not doing anything and at some point in time they're going to have 01:07:07.320 --> 01:07:12.440 enough data to make very big progress in cracking the pattern integrity that is the genome and how 01:07:12.440 --> 01:07:19.080 it's translated into people or animals or viruses or bacteria and so we don't do what they are doing 01:07:19.080 --> 01:07:27.160 we will be behind forever and so their plan was well we'll create a pandemic and we'll 01:07:27.160 --> 01:07:33.800 invert the sovereignty that people currently have in our system to permission we might have 01:07:33.800 --> 01:07:38.200 to do it gradually over a couple executions of it but that's what we'll do and in the end we'll 01:07:38.200 --> 01:07:42.760 collect the data that we need just like the Chinese are collecting the data that they need and that's 01:07:43.320 --> 01:07:50.120 what people like Craig Venter say at the back rooms of TED Talks and at at food conferences after 01:07:50.120 --> 01:07:55.400 the main audience leaves and they have meetings with the directors and the people that coordinate 01:07:55.400 --> 01:08:01.320 these things that's what they talk about that's what Peter Thiel and his friends at the top of 01:08:01.320 --> 01:08:05.640 these weaponized piles of money are talking about when they talk about us and how they're 01:08:05.640 --> 01:08:11.240 going to use us we are data and if we're not going to give up our data and then you can die at 55 01:08:14.040 --> 01:08:19.640 am I pessimistic yeah I kind of am because it's starting to become obvious to me that this has 01:08:19.640 --> 01:08:26.680 been going on for a very very long time and I like everybody else was a victim of it since a child 01:08:27.400 --> 01:08:31.480 based on this genetic code so I'm trying to leave you with a notion that life is a process of 01:08:31.480 --> 01:08:37.880 dynamic renewal we're all shedding about 500 million uskin cells every day that dust that 01:08:37.880 --> 01:08:43.000 accumulates in your home that that's you so you shed your entire outer layer skin every two to 01:08:43.000 --> 01:08:47.960 four weeks you have five times 10 to the 11 blood cells that die every day if you're not 01:08:47.960 --> 01:08:53.400 constantly synthesizing new cells you're in trouble and can you see how easy it would be to get rid 01:08:53.480 --> 01:08:59.400 of virally replicating cells that we're replicating a an RNA they weren't supposed to replicate if 01:08:59.400 --> 01:09:03.880 that's what happens in a viral infection do you see how easy it would be if there's such high turnover 01:09:03.880 --> 01:09:11.080 at these barriers give me a break ladies and gentlemen well and this surprised me the most 01:09:11.080 --> 01:09:16.280 I'm looking at this about half of all our cells die during normal organ development so everything 01:09:16.280 --> 01:09:20.680 is constantly turning over and changing looking at cancer cells the half-life of human proteins 01:09:20.760 --> 01:09:25.960 was between 45 minutes think about all this turnover of proteins and of cells and of tissues but 01:09:26.600 --> 01:09:31.400 all this extremely erroneous protein production that he just described five minutes ago 01:09:32.840 --> 01:09:37.240 it just doesn't all jive together it doesn't make sense unless he's trying to lay down 01:09:37.880 --> 01:09:45.480 a narrative about how protein misfolding can be caused catastrophic disease states unless he's 01:09:45.480 --> 01:09:52.680 actually trying to convince people of this extremely rare possibility there's no reason for 01:09:52.680 --> 01:10:00.680 him to talk about the extreme infidelity of of RNA translation by ribosomes and pretend that 01:10:00.680 --> 01:10:06.440 there that so many errors in folding are made that that you know we get one out of every what four 01:10:06.440 --> 01:10:11.080 proteins are good then or what what's his what's the ratio there because the way that he talks about 01:10:11.080 --> 01:10:17.160 it it sounds like it's a really crappy thing as he said if you built a car factory out of ribosomes 01:10:17.160 --> 01:10:21.720 you'd go out of business because they don't make cars very well what in the world is he talking 01:10:21.720 --> 01:10:27.240 about then if we have such high turnover how do we succeed in getting all that height millions of 01:10:27.240 --> 01:10:33.400 cells are being produced with perfect proteins apparently and despite that they're also making 01:10:33.400 --> 01:10:38.280 on top of that a bunch of shitty proteins that waste all that energy waste all that ribosomal 01:10:38.760 --> 01:10:46.680 uh uh sort of translation time and also waste all that degradation machinery think about how many 01:10:46.680 --> 01:10:52.440 proteins that we eat digest into amino acids and then reassemble into garbage that we then 01:10:52.440 --> 01:11:01.320 have to digest again according to this guy it's spectacular that's in 22 hours if you take the 01:11:01.320 --> 01:11:07.240 DNA out of the cells the cells die uh so this is a key part of things that we were looking into 01:11:07.240 --> 01:11:12.040 going forward now as you know all life is cellular and the cellular theory is that you can only get 01:11:12.040 --> 01:11:17.400 life from pre-existing cells and people attributed all kinds of special parameters to these cells 01:11:17.400 --> 01:11:23.560 over time this is what an artist version view of what a cell cytoplasm might be it's actually 01:11:23.560 --> 01:11:27.800 quite a crowded place it's relatively viscous it's not this empty bag with a few proteins 01:11:27.800 --> 01:11:32.840 floating around in it and it's a very unique environment so you know why isn't he talking 01:11:32.840 --> 01:11:38.440 about the aspect that it's in water and at that scale water is a polar solvent with his 01:11:38.440 --> 01:11:47.880 definite shape and so with a simple computer model you can you can show that water can arrange 01:11:47.880 --> 01:11:55.720 very well in a compact matrix where the positive and negative dipoles of the of the molecules are 01:11:55.720 --> 01:12:02.040 lined up in a pattern that's almost a crystal lattice and thinking about how proteins behave 01:12:02.040 --> 01:12:08.200 inside of that highly organized water lattice is crucial to understanding how these things 01:12:08.200 --> 01:12:14.200 would come together in this three-dimensional space that is the cytoplasm of the cell instead 01:12:14.200 --> 01:12:19.400 he's talking about the proteins without the context in which they are found he's talking 01:12:19.400 --> 01:12:24.040 about the proteins without talking about how they are actually electrostatic three-dimensional 01:12:24.040 --> 01:12:31.960 shapes that at those size scales have great forces of repulsion great forces of hydrophobicity 01:12:31.960 --> 01:12:45.880 and what's the opposite of hydrophobicity hydrophilic behavior so we really need to understand how 01:12:45.880 --> 01:12:53.400 many of these really almost infinite variables are being edited out of this reductionist model 01:12:53.400 --> 01:12:58.520 of the cell your cytoplasm when he says a pretty crowded place with lots of proteins and stuff 01:12:58.520 --> 01:13:04.360 that are all floating around in a very highly organized polar solvent of water 01:13:05.480 --> 01:13:11.320 which is again what Luke Montagnier was working on as he died when he passed away he was working 01:13:11.320 --> 01:13:22.120 on what happens when water is occupied by biomolecules is it possible that biological molecules 01:13:22.840 --> 01:13:29.240 have a property where they cause the water around them to organize now i want you to think about this 01:13:29.240 --> 01:13:34.920 because this is again one of those things where the real data and the real ideas have been put 01:13:34.920 --> 01:13:39.720 out there and just you've been distracted by people who have said that you can freeze water and capture 01:13:39.720 --> 01:13:46.120 the emotion in it like in a picture of a wedding ring or some nonsense like that those kinds of 01:13:46.120 --> 01:13:53.160 water memory bullshit stories are out there because Luke Montagnier was onto something 01:13:54.040 --> 01:13:57.640 onto something that physicists and chemists have known about for a long time 01:13:58.600 --> 01:14:02.360 has something to do with the the surface tension of water and what happens 01:14:02.360 --> 01:14:07.720 at this where water becomes at a surface but it's how the water molecules are able to organize 01:14:07.720 --> 01:14:12.840 relative to one another and change their properties the way that that you can move through them 01:14:13.720 --> 01:14:19.880 and Luke Montagnier was onto the idea that if you had a DNA molecule and a DNA molecule could have 01:14:20.520 --> 01:14:29.400 the propensity to organize the water molecules around it you can imagine a scenario where a 01:14:29.400 --> 01:14:37.000 a DNA molecule could cause a crystal lattice to form around it in the polar solvent of water 01:14:37.640 --> 01:14:43.800 and because of the way that water organizes itself that that shadow in the water could be more than 01:14:47.400 --> 01:14:51.080 spun it could exist for longer than the molecules present 01:14:53.000 --> 01:15:02.520 and curiously in my humble opinion this would have to play a crucial role in any pathogenic 01:15:03.480 --> 01:15:11.480 infectiousness of a prion protein because in between each protein is going to be a water layer 01:15:12.520 --> 01:15:19.480 or layers and so in order to understand how a prion protein can cause a non-prion protein to 01:15:19.480 --> 01:15:25.240 become a prion protein we need to understand how these two electrostatic shapes complex shapes 01:15:25.240 --> 01:15:30.520 can come together in the polar solvent of water and then produce essentially the same structure 01:15:30.520 --> 01:15:40.760 function that's the model that we have been given that's the model that we're we're we're 01:15:40.760 --> 01:15:46.440 going to try to understand over the coming days and weeks and when we do as we approach that 01:15:47.400 --> 01:15:52.840 model and we see how people have have tested and tried to verify you're going to find that nobody 01:15:52.840 --> 01:15:58.040 nobody did anything that everybody just keeps making the assumptions that this guy's making 01:15:58.120 --> 01:16:03.480 which is that ribosomes make a lot of errors and that sometimes those errors are catastrophic I guess 01:16:05.480 --> 01:16:09.080 but if you listen to Craig describe and it sure seems like there should be a lot more 01:16:09.080 --> 01:16:15.720 misfolded proteins than than we seem to be aware of and we sure waste a lot of energy on it then 01:16:15.720 --> 01:16:20.440 the proteins are actually in solid phase now a key tentative chemistry that's developed 01:16:20.440 --> 01:16:26.840 is the notion of synthesis as proof this perhaps dates back to 1828 when Francis Waller first 01:16:26.840 --> 01:16:31.880 synthesized urea now this is herald is the end of vitalism because the thought that you could 01:16:31.880 --> 01:16:38.440 only get organic molecules from living entities and so a great amount of attention was given to this 01:16:38.440 --> 01:16:43.160 but now there's tens of thousands of papers published that either have proof by synthesis as 01:16:43.160 --> 01:16:48.600 the starting point or key point of the title we decided to take the same approach of dealing 01:16:48.600 --> 01:16:53.880 with DNA and dealing with life back in 1995 when we sequenced the first genome we actually did a 01:16:53.960 --> 01:16:58.840 second one that year looking for the cell with a smallest genome and we chose microplasmid genitalium 01:16:58.840 --> 01:17:04.440 it has 482 protein coding genes and 43 RNA genes we ask simple questions how many of these genes 01:17:04.440 --> 01:17:08.760 are essential for life but what's the smallest number of cells needed for a cellular machinery 01:17:09.320 --> 01:17:15.160 and ultimately to answer these questions could we design and construct a minimal DNA genome 01:17:15.160 --> 01:17:18.920 of the cell as soon as we went down that route we had new questions would chemistry even allow us 01:17:18.920 --> 01:17:23.160 to synthesize a bacterial chromosome and if we could would we just have a large piece of DNA 01:17:23.160 --> 01:17:28.200 or could we actually boot it up on the cell like a new chemical piece of software we decided to 01:17:28.200 --> 01:17:34.440 start where DNA history started with phi X 174 we chose it as a test synthesis i still think that 01:17:34.440 --> 01:17:38.760 he is again casting an enchantment here what he uses that you know see if we can boot it up 01:17:44.280 --> 01:17:46.440 if you had a machine 01:17:46.760 --> 01:17:52.760 that could take a book 01:17:55.480 --> 01:17:56.920 and turn it into a movie 01:17:58.840 --> 01:18:04.760 just coming up with an analogy off the cuff here if you had a had a machine that could turn a book 01:18:04.760 --> 01:18:15.560 into a movie and i told you that the words were turned into images and sometimes those images 01:18:15.640 --> 01:18:18.040 come out wrong but most of the time they come out right 01:18:20.440 --> 01:18:26.280 and i can make a copy of the book and i can put it into the machine and it will make the same 01:18:26.280 --> 01:18:33.240 movie that i copied the book that i copied would make do we understand the machine 01:18:36.920 --> 01:18:42.280 because i believe that's the kind of bamboozlement that's happening here we're being made to believe 01:18:45.720 --> 01:18:53.320 that we have a machine that can take a book that's the tape right this is a Turing machine 01:18:53.320 --> 01:18:57.800 it can take a tape and it can read the tape and it can make a copy of itself 01:19:02.920 --> 01:19:09.480 and so if we copy the tape and put the tape through in the machine do we understand how the 01:19:09.480 --> 01:19:15.000 machine works then the answer is no no matter how many ways we make a copy of the tape 01:19:15.000 --> 01:19:20.200 or a partial copy of the tape or we put the tape in a different machine and it still works 01:19:20.200 --> 01:19:26.040 we still don't understand how the machine works and the machine is life it's a big 01:19:26.040 --> 01:19:31.000 ship in a bottle variable that we keep calling it nothing because we can't penetrate it 01:19:33.480 --> 01:19:38.440 we can ting the bottle at all different sides and stuff like that but we can't explain how that 01:19:38.440 --> 01:19:41.640 ship got assembled in there how it was done or who did it and why 01:19:45.560 --> 01:19:51.880 and so make no mistake about it he's not describing a fidelity of understanding he's 01:19:51.880 --> 01:19:58.200 actually describing a lack of understanding a horrible lack of understanding this because 01:19:58.200 --> 01:20:03.880 you can make very few changes on the genetic code of phi x without destroying viral particles 01:20:03.880 --> 01:20:07.880 so Clyde Hutchinson who helped sequence phi x ham smith and i developed a series of new techniques 01:20:08.280 --> 01:20:12.280 to correct the errors that take place when you synthesize DNA but the machines that make DNA 01:20:12.280 --> 01:20:15.880 are not very accurate and the longer the piece of DNA you make the more errors so we had to find 01:20:15.880 --> 01:20:20.680 ways to correct errors we corrected the errors and had this 5 000 letter piece of DNA we injected 01:20:20.680 --> 01:20:25.320 into e coli and this is the actual photo of what happened the e coli recognized this synthetic 01:20:25.320 --> 01:20:29.720 piece of DNA as normal DNA and the proteins being robots to started reading this piece of genetic 01:20:29.720 --> 01:20:33.560 code because that's what their program to do they made what the DNA told them to do is to make viral 01:20:33.560 --> 01:20:37.640 proteins the virus self-assembled and it showed us gratitude by killing the cells which is how 01:20:37.640 --> 01:20:42.600 we defective we get these clear spots on the cell so the virus self-assembled is another one of 01:20:42.600 --> 01:20:48.680 those very large mythologies that completely discounts the possibility like i've said before 01:20:48.680 --> 01:20:55.400 and i'm going to say it again you can't make a cuckoo clock make toast you cannot hijack the 01:20:55.400 --> 01:21:03.240 machinery of a cell and make it do something that it already doesn't do so cells already produce 01:21:03.240 --> 01:21:14.200 exosomes which are are lipoprotein coated vesicles that have receptor agonists on the outside or 01:21:14.200 --> 01:21:18.200 targeting proteins on the outside and they have a genetic signal on the inside 01:21:20.440 --> 01:21:25.640 and i believe that all tissues likely communicate this way signal to the immune system this way 01:21:25.640 --> 01:21:31.400 and communicate their state of homeostasis with the rest of the body in this way and if there are 01:21:31.480 --> 01:21:37.160 RNAs which are capable of hijacking this machinery they don't hijack this machinery to make 01:21:37.720 --> 01:21:44.840 the cells do something they don't already do they make the cells produce exosomes that contain their 01:21:44.840 --> 01:21:57.080 sequence and so he is explaining something again laying down a mythology that precludes any other 01:21:57.080 --> 01:22:03.320 interpretation of their limited data set a virus is replicating because and making copies 01:22:03.320 --> 01:22:09.240 of itself and hijacking the bacterial machinery because we put the DNA in there and then stuff came 01:22:09.240 --> 01:22:16.600 out that couldn't be a natural process that's already there all the time that your that your 01:22:16.600 --> 01:22:23.960 experimental transfection is harnessing it couldn't possibly be that it has to be evidence of pathogens 01:22:24.040 --> 01:22:32.120 and evidence of the fidelity of these RNA pathogens that's that it's it's another illusion it's 01:22:32.120 --> 01:22:38.040 crazy how succinctly it's being done so we call this a situation where the software is building 01:22:38.040 --> 01:22:42.520 its own hardware all we did was put a piece of DNA software in the cell and we got out a protein 01:22:42.520 --> 01:22:49.800 virus with a nucleic acid a core you could call it was not to make viruses you could call it an 01:22:49.800 --> 01:22:54.360 exosome but if they called it an exosome then they would let you know that it's a natural process 01:22:54.360 --> 01:22:59.240 that it's a process that already exists inside of the cell so it's not surprising 01:23:01.480 --> 01:23:05.560 that we can put a transfection in a cell and that a cell will produce 01:23:06.840 --> 01:23:12.600 vesicles that contain the contents of that production it's not unusual because it happens 01:23:12.600 --> 01:23:16.360 this we wanted to make something substantially larger we wanted to make an entire chromosome 01:23:16.520 --> 01:23:20.600 of a living cell but we thought if we could make viral size chromosomes accurately maybe we could 01:23:20.600 --> 01:23:24.520 make a hundred or so of those and find a way to put those together so that's what we did we sent 01:23:24.520 --> 01:23:30.120 out set out to sequence these pieces that we made these small pieces we sequenced them verify them 01:23:30.120 --> 01:23:35.000 and put them together and it looks like a soccer or basketball playoff so we put four pieces together 01:23:35.000 --> 01:23:39.320 and we had pieces now that were 24,000 letters long we would draw these up sequence them in 01:23:39.320 --> 01:23:43.400 assemble those together to get pieces that were 72,000 we would do this again it was very 01:23:43.480 --> 01:23:47.960 what in the hell are you hearing here except for the assembly of recombinant clones 01:23:49.720 --> 01:23:55.000 i thought that that Ralph Barrick invented the no-seum technique where you use restriction enzymes 01:23:55.000 --> 01:24:04.360 to stitch things together oh no he didn't invent that oh i see craig venter says craig venter says 01:24:04.360 --> 01:24:10.600 that we had restriction enzymes back before 1973 and that we were making recombinant DNA clones 01:24:10.600 --> 01:24:16.680 back in the 70s isn't that strange because i thought i was told by all these people in the 01:24:16.680 --> 01:24:22.200 magic show that it was Ralph Barrick's no-seum technique and the things that he shared with the 01:24:22.200 --> 01:24:29.000 with the Chinese that was so scary are you telling me that we've had restriction enzymes and been able 01:24:29.000 --> 01:24:37.400 to make and assemble clones just like he recited already since the 70s and 80s wow what does that 01:24:37.400 --> 01:24:45.080 mean for Ralph Barrick as a bad guy i guess he's not really a bad guy anymore 01:24:47.000 --> 01:24:53.400 can you see this the guy Kevin McCurnan trying to tell me that i didn't have anything to stand 01:24:53.400 --> 01:24:59.000 on i didn't know what i was talking about kevin McCurnan knows this history he was working for 01:24:59.000 --> 01:25:06.600 the department of energy and mit and the whitehead institute in this very project he knows the 01:25:06.680 --> 01:25:13.320 limitations of those restriction enzyme maps he knows that they need countless more human 01:25:13.320 --> 01:25:17.880 genomes to have any clue about what actually is working and how these are organized 01:25:21.160 --> 01:25:25.320 as kevin McCurnan ever said that it actually all comes down to understanding the ribosome 01:25:31.400 --> 01:25:35.000 i'm going to play that back because this is really important pieces we sequence them verify 01:25:35.480 --> 01:25:40.120 and put them together and it looks like a soccer or a basketball playoff so we put four pieces 01:25:40.120 --> 01:25:44.760 together and we had pieces now that were 24,000 letters long we would draw the 24,000 letters 01:25:44.760 --> 01:25:53.240 long the coronavirus genome is 30,000 bases at most you need to freaking hear this you need to 01:25:53.240 --> 01:26:00.680 hear it right now this molecular biology was not invented by Ralph Barrick this molecular 01:26:00.680 --> 01:26:04.760 biology was not invented by Ralph Barrick no matter how many people insist it was 01:26:06.040 --> 01:26:12.680 i have been saying it since bobby asked me to figure it out in 2022 that they were telling a 01:26:12.680 --> 01:26:18.120 story about Ralph Barrick inventing this stuff because these are old school techniques that go 01:26:18.120 --> 01:26:24.440 back to the very basics of molecular biology back before 1973 01:26:24.440 --> 01:26:32.280 we are being misled ladies and gentlemen we are knee deep in it 01:26:34.920 --> 01:26:39.480 leaves up sequence them and assemble those together to get pieces that were 72,000 01:26:39.480 --> 01:26:42.120 we would do this again it's very laborious let's talk about a year and a half to do 01:26:42.920 --> 01:26:51.560 and we got pieces 144,000 letters in length this was 144,000 base pairs in length 01:26:55.400 --> 01:26:59.480 don't tell me for one second that we couldn't have made this don't tell me for one second 01:26:59.480 --> 01:27:04.280 that we couldn't made enough of it to put all over the place so that the pcr's would be positive 01:27:04.280 --> 01:27:10.440 and the sequencing reactions would be exactly what we wanted them to be so that all molecular 01:27:10.440 --> 01:27:18.040 biology could be distorted into this very obvious planted phylogenetic tree where nobody pays 01:27:18.040 --> 01:27:23.080 attention to anything they paid attention to in 2020 like fear and cleavage sites or hiv inserts 01:27:23.560 --> 01:27:28.520 or staphylococcan and tangerine toxin B homologies none of those things that were 01:27:28.520 --> 01:27:33.480 screamed about in 2020 were tracked at all despite the fact that we can sequence it 15 01:27:33.480 --> 01:27:34.920 million times in four years 01:27:38.440 --> 01:27:44.600 and we're supposed to believe that eco-health alliance a guy like like Peter Dasek and a guy 01:27:44.600 --> 01:27:50.120 like like Ralph Barrick are responsible for what just happened here instead of the weaponized 01:27:50.120 --> 01:27:57.320 piles of money that are currently trying to permanently have a hold on our our habits 01:27:59.480 --> 01:28:07.880 and and our our intuition about reality decades of lying ladies and gentlemen decades of lying 01:28:07.880 --> 01:28:14.440 about protein misfolding decades of lying about about DNA to RNA to protein decades of lying about 01:28:14.440 --> 01:28:20.600 how we understand it decades of lying about how close we are to understanding all these 01:28:20.600 --> 01:28:27.640 nano machines including the most beautiful important one key to all life on earth target of antibiotics 01:28:27.640 --> 01:28:32.920 the ribosome beyond the largest piece that ever been synthesized to 30,000 letters 01:28:33.560 --> 01:28:38.840 and at this time E. coli didn't like these large pieces of synthetic DNA in them so we 01:28:38.920 --> 01:28:44.520 switched to yeast I found out last night this is a city that loves beer that comes from this 01:28:44.520 --> 01:28:50.440 same brewer's yeast a beer and bread but aside from fermentation this little cell has remarkable 01:28:50.440 --> 01:28:55.400 properties of assembling DNA so all we had to do was put the four synthetic quarter molecules into 01:28:55.400 --> 01:29:00.520 yeast with a small synthetic yeast centromere and yeast automatically assembled these pieces 01:29:00.520 --> 01:29:05.480 together so that gave us the first synthetic bacterial chromosome and this is what we published 01:29:05.560 --> 01:29:12.280 in 2008 this was the largest chemical structure of a defined a structure ever assembled we continued 01:29:12.280 --> 01:29:16.760 to work on DNA synthesis and a somebody started out a young postdoc Dan Gibson came up with a 01:29:16.760 --> 01:29:22.680 substantial breakthrough instead of the hours the days to years he found out that by putting 01:29:22.680 --> 01:29:27.160 three enzymes together with all the DNA fragments in one pot at 50 degrees centigrade for a little 01:29:27.160 --> 01:29:33.080 while it would automatically assemble these pieces so it went from a year or so down to an hour 01:29:33.080 --> 01:29:36.520 and there's a breakthrough for a number of reasons most importantly it allows us now to 01:29:36.520 --> 01:29:41.240 automate these processes so having a simple one step method allows us to go from the digital 01:29:41.240 --> 01:29:46.280 code in the computer to the analog code of DNA in a robotic fashion see it's weird that he's not 01:29:46.280 --> 01:29:51.160 mentioning Ralph Barrick with all these technologies I really thought that he was responsible for like 01:29:51.160 --> 01:29:56.520 half of all the molecular biology techniques that were used in the world but it turns out 01:29:56.520 --> 01:30:01.400 that what he did was take proven molecular biology techniques that were developed in the 01:30:01.400 --> 01:30:06.840 70s 80s and 90s and applied them to coronaviruses that were really only discovered and became 01:30:06.840 --> 01:30:21.240 tractable in 2006 and 7 and 8 the pandemic narrative is is falling apart like wet tissue paper 01:30:22.280 --> 01:30:26.600 and this is being scaled up substantially we proved this initially by in just one step 01:30:26.680 --> 01:30:31.560 synthesizing the mouse mitochondria genome so I had two teams working one on the chemistry 01:30:31.560 --> 01:30:35.320 and one on the biology and it turns out the biology ended up being more difficult than the chemistry 01:30:35.320 --> 01:30:39.880 so how do you boot up a synthetic chromosome in a cell this took us a substantial time 01:30:39.880 --> 01:30:43.960 at the workout and this paper that we published in 2007 I think is one of the most important 01:30:43.960 --> 01:30:48.840 for understanding how cells work and what the future of this field brings so this is where we 01:30:48.840 --> 01:30:53.480 describe genome transplantation in simply by changing the genetic code the chromosome in one 01:30:53.480 --> 01:30:59.160 cell swapping it out for another we converted one species into another because it's so important 01:30:59.160 --> 01:31:02.600 to the theme of what we're doing I'm going to walk you through this a little bit and by the way 01:31:02.600 --> 01:31:06.680 these are two of the scientists that led this at Carol Luckteague was the one with a breakthrough 01:31:06.680 --> 01:31:12.200 John Glass and there was a large team working with them so we initially did this by isolating 01:31:12.200 --> 01:31:18.600 the chromosome from a cell called in my coides and chromosomes are enshrouded with proteins 01:31:18.600 --> 01:31:21.880 which is why there was confusion for so many years whether proteins are DNA with the genetic 01:31:22.760 --> 01:31:27.560 material we simply did what Avery did we treated the DNA with the proteolytic enzymes removing all 01:31:27.560 --> 01:31:31.800 the proteins because if we're making a synthetic chromosome we need to know can naked DNA work 01:31:31.800 --> 01:31:35.320 on its own or there are going to be some special proteins needed for transplantation 01:31:35.320 --> 01:31:38.680 we added a couple of cassettes to it one so we could select for it and another so it turns 01:31:38.680 --> 01:31:44.520 cells bright blue if it got activated and we found a way to get these genome into a recipient cell 01:31:44.520 --> 01:31:49.080 a cell m cap or colon which is about the same distance apart genetically from my coides as we are 01:31:49.080 --> 01:31:53.160 from mice so relatively close on the order 10 percent are more different 01:31:53.160 --> 01:31:55.240 but let me show you what happened we have this very sophisticated movie 01:31:56.360 --> 01:32:02.120 so we inserted the n-microious chromosome into the recipient cell and just as with the phiaxis 01:32:02.120 --> 01:32:06.920 soon as we put this DNA into the cell the protein robots started producing mRNA started producing 01:32:06.920 --> 01:32:11.240 proteins some of the early proteins were the restriction enzymes that ham smith discovered 01:32:11.240 --> 01:32:16.360 in 1970 they recognized the initial chromosome in the cell as foreign DNA and shoot it up 01:32:17.240 --> 01:32:22.360 so now we have the body and all the proteins in one species and the genetic software of another 01:32:22.360 --> 01:32:27.160 so what happened in a very short period of time we had these bright blue cells when we 01:32:27.160 --> 01:32:31.880 interrogated the cells they had only the transplanted genome but more importantly when we sequenced 01:32:31.880 --> 01:32:36.440 the proteins in these cells there wasn't a single protein or other molecule from the original 01:32:36.440 --> 01:32:42.200 species every protein in the cell came from the new DNA that we inserted into the cell life 01:32:42.840 --> 01:32:47.400 is based on DNA software we're a DNA now did you listen because I didn't hear that the cells divided 01:32:48.760 --> 01:32:55.720 what I heard was that he transfected the cells the DNA was translated there were enzymes that 01:32:55.720 --> 01:33:03.800 were present that degraded the other genome and by the time it had transfected the whole dish 01:33:03.800 --> 01:33:10.760 then they had blue cells that were not expressing their own proteins but the ones that they were 01:33:10.760 --> 01:33:16.360 transfected with that's not that I'm sorry but I'll look up the paper later but that's not 01:33:16.920 --> 01:33:22.760 artificial life that's not reprogramming a cell that's just transfection or transformation 01:33:22.760 --> 01:33:32.280 of a of a bacteria and again I'm arguing that I think Craig Venter like Peter Thiel suggested 01:33:32.280 --> 01:33:38.040 has a vested interest in lying and exaggerating about the significance of these these experiments 01:33:38.040 --> 01:33:43.400 with the idea of making sure that he stays an expert in his hyper specialized field that he 01:33:43.400 --> 01:33:48.440 keeps getting all of the the funding and that nobody questions his actual progress and the 01:33:48.440 --> 01:33:55.400 significance of it and nobody will right because these people all need us to believe that it's 01:33:55.400 --> 01:34:00.920 just a matter of time you might as well go limp where we are about to to solve all of these problems 01:34:01.640 --> 01:34:07.080 a software system you change the DNA software you change the species it's a remarkably simple 01:34:07.160 --> 01:34:12.520 concept remarkably complex in its execution now we had a problem that some of you may have 01:34:12.520 --> 01:34:17.080 picked up on or have read about we were assembling the bacterial chromosome in a eukaryotic cell 01:34:17.800 --> 01:34:21.320 so we're going to take the synthetic genome and do the transplantations we had to find a way to 01:34:21.320 --> 01:34:25.880 get the genome out of yeast that transplanted back into a bacteria and we developed a whole new way 01:34:25.880 --> 01:34:30.280 just to grow bacterial chromosomes in yeast as eukaryotic chromosomes and it was remarkably 01:34:30.280 --> 01:34:35.400 simple in the end all we do is add a very small synthetic centromere from yeast to the bacterial 01:34:35.400 --> 01:34:38.600 chromosome and all of a sudden it turns into a eukaryotic chromosome the centromere is when 01:34:38.600 --> 01:34:42.360 you look at pictures of chromosomes it's that little piece in the middle of the y for example 01:34:42.360 --> 01:34:46.680 so now we can stably grow bacterial chromosomes in yeast so we had the situation where we had 01:34:46.680 --> 01:34:50.040 the emicoidy's chromosome in the eukaryotic cell we could try isolating it and doing the 01:34:50.040 --> 01:34:55.000 transplantation the trouble is it didn't work and this little problem took us two and a half years 01:34:55.000 --> 01:34:59.480 to solve of why it didn't work and it turns out when we initially did the transplantations taking 01:34:59.480 --> 01:35:04.520 the chromosome out of the emicoidy cell that DNA had been methylated and that's how cells 01:35:04.520 --> 01:35:11.640 protect their own DNA from interloping species so we proved this by isolating the six methylases 01:35:11.640 --> 01:35:15.720 and methylating the DNA when we took it out of yeast if we methylated the DNA we could then do 01:35:15.720 --> 01:35:21.080 the transplantation we proved this ultimately by in the recipient cell removing the restriction 01:35:21.080 --> 01:35:25.640 enzymes and in that case we can just put a naked unmetallated DNA because there's nothing to 01:35:25.640 --> 01:35:30.120 destroy the DNA in the cell so we're at this point now where we thought we had solved all the problems 01:35:30.920 --> 01:35:35.240 we could create these new bacterial strains from the bacterial genomes cloned in yeast 01:35:35.240 --> 01:35:38.280 and we had this nice cycle we could work our way around the circle we could add a center 01:35:38.280 --> 01:35:42.840 mirror to the bacterial chromosome and turn it into a eukaryotic chromosome the advantages for 01:35:42.840 --> 01:35:46.440 those of you who work with bacteria most bacteria do not have genetic systems which is why most 01:35:46.440 --> 01:35:50.520 scientists don't work with them as soon as you put that bacterial genome in yeast we have the 01:35:50.520 --> 01:35:54.680 complete repertoire of genetic tools in yeast such as homologous recombination so we can make 01:35:54.680 --> 01:35:59.160 rapid changes in the genome isolate the chromosome methylated if necessary and do a transplantation 01:35:59.160 --> 01:36:04.280 to create a highly modified cell so at this stage we decided to synthesize the mycoides genome 01:36:04.280 --> 01:36:07.800 with all these new synthesis techniques Dan Gibson took this on almost single-handedly 01:36:08.360 --> 01:36:13.240 if 1.1 million base pairs we started with pieces that were 1,000 letters long we put 10 of those 01:36:13.240 --> 01:36:16.680 together to make pieces that were 10,000 letters long we put 10 of those together to make pieces 01:36:16.680 --> 01:36:22.040 now that are 100,000 letters long and we had these 11 100,000 base pair pieces we put them in yeast 01:36:22.040 --> 01:36:26.600 yeast assembled the DNA we knew how to transplant it out of yeast we did the transplantation and it 01:36:26.680 --> 01:36:31.720 didn't work so those of you are software engineers that software engineers have debugging software 01:36:31.720 --> 01:36:35.560 to tell them where the problem is in their code so we had to develop the biological version of 01:36:35.560 --> 01:36:39.720 debugging software which was basically substituting natural pieces of DNA for the synthetic ones 01:36:39.720 --> 01:36:44.280 until we could find out what was wrong we found out we could have 10 of the 11 synthetic pieces 01:36:44.280 --> 01:36:49.480 and the last piece I had to be native DNA to get a living cell now what I do think Robert 01:36:50.680 --> 01:36:56.040 Ralph Barrick did contribute is what he's talking about now which is idea of coming up with the 01:36:56.040 --> 01:37:05.560 minimum coronavirus genome to get exosomes to be produced and so Ralph Barrick used very 01:37:05.560 --> 01:37:12.200 standard restriction enzyme ligation techniques to create synthetic DNA versions of RNA viruses 01:37:13.320 --> 01:37:18.440 but more importantly because the RNA virology that they had at that time was very sketchy and 01:37:18.440 --> 01:37:24.120 only could find the RNA to pet an RNA polymerase or this protein or that protein but not the whole 01:37:24.120 --> 01:37:31.560 genome one of the contributions that Ralph Barrick made was that here are the 01:37:32.200 --> 01:37:37.800 minimum number of proteins that you need and so if you find a spike protein in the wild that you 01:37:37.800 --> 01:37:43.800 want to test you can add that spike protein to all of these now why is that important ladies and 01:37:43.800 --> 01:37:50.600 gentlemen please let's go back to the frontier why is that important because in a viral replicating 01:37:50.600 --> 01:37:57.560 cell according to their cartoon by far and away the most abundant RNA present is the spike protein 01:37:57.560 --> 01:38:04.120 by several orders of magnitude perhaps hundreds of thousands of more spike protein sub genomic 01:38:04.120 --> 01:38:13.320 RNAs than any other transcript including the end protein and definitely including the probably 01:38:13.400 --> 01:38:23.160 protein of 1a1 or rf1a in other words if you were to do a PCR test in a bat and you were looking for 01:38:23.160 --> 01:38:29.160 novel coronaviruses their strategy was to look for the most conserved gene which was the RNA 01:38:29.160 --> 01:38:35.160 dependent RNA polymerase and the most abundant one which was the spike protein and they look 01:38:35.160 --> 01:38:40.360 for a conserved region of the spike protein because as you know spike proteins are highly 01:38:40.360 --> 01:38:45.480 homologous because they have this conformational change that allows membranes to come together 01:38:45.480 --> 01:38:53.160 we use a very similar protein in our in our developing embryo yada yada yada so our immune 01:38:53.160 --> 01:39:00.920 system looks for that commonality that conserved hydrophobic damage associated molecular pattern 01:39:03.160 --> 01:39:08.280 and so my point is is that they looked for those two signals if they found them then Ralph Barrick 01:39:08.440 --> 01:39:13.720 had a whole set of genes that you could just put in with that spike protein and now you could make 01:39:13.720 --> 01:39:23.640 a synthetic clone of a purported novel coronavirus if you just found the sub genomic RNA of the 01:39:23.640 --> 01:39:30.120 spike protein that's how it was done from 2005 until very very recently ladies and gentlemen 01:39:31.400 --> 01:39:36.680 exactly as he's describing it where you come up with a minimum set of genes 01:39:36.760 --> 01:39:42.280 and by substituting natural ones in until it grows or until it works you can eliminate 01:39:43.480 --> 01:39:47.800 the genes you don't need find the genes that you do need and now you have a minimum set 01:39:49.640 --> 01:39:54.680 and that's what Ralph Barrick did he didn't invent no serum technologies what he did 01:39:54.680 --> 01:40:01.880 was identified the minimum set of genes that would be necessary for an RNA to cause reproduction 01:40:01.880 --> 01:40:08.680 of itself and packaging into exosomes not something that the cell doesn't normally do not hijacking 01:40:08.680 --> 01:40:14.680 the cell and reprogramming it to make viruses for the first time in its existence but to hijack 01:40:14.680 --> 01:40:21.080 the already existing exosomal production machinery to reproduce package and send out the RNA 01:40:22.600 --> 01:40:28.680 and I think that Ralph Barrick and these coronavirus people found the minimum set of genes proteins 01:40:28.680 --> 01:40:33.880 it's necessary to get that phenomenon to happen and they are telling you that that's a pathogen 01:40:33.880 --> 01:40:40.200 that does it when in reality they are hijacking the synthetic machinery of a cell to try and 01:40:40.200 --> 01:40:48.120 understand how the hell it works absolutely no different than the illusion created by this 01:40:48.120 --> 01:40:53.640 guy claiming to try to create synthetic life I really think we're on to this 01:40:53.720 --> 01:40:58.040 re-sequenced it and found one letter wrong and an essential gene made the difference between life 01:40:58.040 --> 01:41:02.200 and no life so it was in the DNA gene which is important for starting the whole process of binding 01:41:02.200 --> 01:41:08.360 to DNA we corrected that error so one out of 1.1 million we corrected that error and we got the first 01:41:08.360 --> 01:41:14.520 actual synthetic cell from the genome transplants one of the ways that we knew this was a synthetic 01:41:14.520 --> 01:41:20.360 cell we watermarked the DNA so we could always tell our synthetic species from any naturally occurring 01:41:21.240 --> 01:41:26.840 one this was reported in early 2010 and science published it shortly thereafter 01:41:27.480 --> 01:41:31.880 the watermarks we watermarked the first genome that we did just using the single letter amino acid 01:41:31.880 --> 01:41:37.240 code and we were accused of not having much of an imagination so for this new genome we went a 01:41:37.240 --> 01:41:42.120 little bit further and I added three quotations from the literature but first we developed a 01:41:42.120 --> 01:41:45.560 whole new code where we could write the english language complete with numbers and punctuation 01:41:45.560 --> 01:41:49.560 in DNA code and it's quite interesting we set the paper to science for review and one of the 01:41:49.560 --> 01:41:53.080 reviewers sent back the review written in DNA code much to the frustration of the 01:41:53.080 --> 01:41:57.720 science editor who could not do separate but the reviewers DNA code was based on the ASCII code 01:41:58.680 --> 01:42:03.080 and with biology that creates a problem because you can get long stretches without a stock code 01:42:03.080 --> 01:42:06.920 on so we developed this new code that puts in very frequent stock code ons because the last thing 01:42:06.920 --> 01:42:10.440 you want to do is put in a quote from James Joyce and have it turn into a new toxin that kills 01:42:10.440 --> 01:42:17.640 the cell or kills you you didn't know poetry could do that I guess so we built in the names of the 01:42:17.720 --> 01:42:22.520 46 scientists that contributed to this and also there was a message with a URL so being the first 01:42:22.520 --> 01:42:25.880 species to have a computer as a parent we thought it was appropriate it should have its own web 01:42:25.880 --> 01:42:30.120 address built into the genome and as people solve this code they would send an email to the web 01:42:30.120 --> 01:42:36.840 address written in the genome and once numerous people solved it we made this available and let 01:42:36.840 --> 01:42:40.680 me just I know what this is hard to read the three quotes are the first one and probably the most 01:42:40.680 --> 01:42:45.400 important one to Ireland is James Joyce the live to air to fall the triumph to recreate life out 01:42:45.480 --> 01:42:50.280 of life somehow that seemed highly appropriate the second is from Oppenheimer's biography American 01:42:50.280 --> 01:42:55.080 Prometheus see things not as they are but as they might be in the third from Richard Fineman what 01:42:55.080 --> 01:43:01.640 I cannot build I cannot understand everybody thought it was very cool until a few months after this 01:43:01.640 --> 01:43:08.200 appeared we got a letter from James Joyce estate attorney saying did you seek permission to use 01:43:08.200 --> 01:43:13.960 this quotation and in the US at least there's fair use laws allow you to quote up to a paragraph 01:43:13.960 --> 01:43:18.440 without seeking permission so we sort of dismissed that one then James Joyce was dead we didn't know 01:43:18.440 --> 01:43:23.080 how to ask him anyway and then we started getting an email trail from a Caltech scientist saying 01:43:23.080 --> 01:43:26.840 we'd misquoted Richard Fineman but if you look on the internet this is the quotation that you find 01:43:26.840 --> 01:43:31.080 everywhere and we argued back this is what we found and this was what was in his biography 01:43:31.080 --> 01:43:34.840 instead of proof his point he sent a picture of Fineman's blackboard with the original quotation 01:43:35.720 --> 01:43:42.520 and what it was what I cannot create I do not understand what I cannot create I do not understand 01:43:42.520 --> 01:43:51.720 and so rather than that being a a sort of a cardinal teaching of sacred biology which it should be 01:43:52.920 --> 01:43:55.880 you can't create it so you don't understand it we can try 01:43:57.880 --> 01:44:05.640 but what he's arguing of course is is that because he claims to have created it he understands it 01:44:06.200 --> 01:44:12.360 that's what he's arguing here that's the arrogance that he's putting out here in a very 01:44:12.360 --> 01:44:19.720 indirect way it is ugly it is an ugly arrogance make sure you see it 01:44:22.280 --> 01:44:26.200 I think it's actually a much better quotation and we've gone back to correct the DNA code 01:44:26.200 --> 01:44:33.080 so that Fineman can rest much more peacefully so we can actually go much further now there's 01:44:33.080 --> 01:44:38.840 an exciting paper that includes out of Stanford that includes John Glass from my institute using 01:44:38.840 --> 01:44:43.240 our work on the micro plasma cell to do the first complete mathematical modeling of a cell 01:44:43.960 --> 01:44:46.920 now I was going to show you the movie of their mathematical model but it has so many different 01:44:46.920 --> 01:44:50.280 components it would take about 20 minutes to show but this is coming out in cell I think 01:44:50.280 --> 01:44:54.520 next week it is going to be an exciting change so we can go from the digital code to the genetic 01:44:54.520 --> 01:45:00.360 code and now modeling the entire function of the cell in a computer going to complete a digital 01:45:00.360 --> 01:45:05.160 circle we're going further now we're using computer software to design new DNA software 01:45:05.160 --> 01:45:12.120 to create a new cells and this is an important part of what I'll be talking about on a Saturday 01:45:12.120 --> 01:45:17.480 evening now in conclusion I hope it's starting to become clear if it wasn't already that all 01:45:17.480 --> 01:45:24.280 living cells that we know of on this planet are DNA driven DNA software driven biological machines 01:45:24.280 --> 01:45:29.480 comprised of hundreds to thousands of proteins and these are protein robots coded for by the DNA 01:45:30.440 --> 01:45:35.400 these protein robots carry out these very precise functions and developed by billions of years of 01:45:35.400 --> 01:45:39.240 evolution you make a change in the DNA code it makes a change in the protein code that can 01:45:39.240 --> 01:45:42.280 affect whether the protein is functional or not it can affect whether the cell lives or not 01:45:42.280 --> 01:45:48.520 billions of years of evolution that he's not at all concerned about screwing up billions of 01:45:48.520 --> 01:45:54.040 years of evolution that he's not at all worried about his lack of understanding of to go ahead 01:45:54.600 --> 01:45:59.320 and start thinking that everything is a nail it can affect the rate that the protein folds how 01:45:59.320 --> 01:46:04.200 fast it is degraded this is all programming built into life that controls the three-dimensional 01:46:04.200 --> 01:46:11.160 structure so this is dynamic regulation and explains most of what Darwin described as Darwinian 01:46:11.160 --> 01:46:16.440 evolution by making a copy of the DNA software the cell can self-replicate making another copy 01:46:16.440 --> 01:46:21.800 of itself as Schrodinger described all these processes require energy and from all the genome 01:46:21.800 --> 01:46:26.920 two sequences a range of mechanisms that cell cells can provide energy as you know if we eat 01:46:26.920 --> 01:46:31.400 sugar that's one way to do it and with simple metabolism it's been well worked out pathways for 01:46:31.400 --> 01:46:35.960 decades how we extract the energy contained in the sugar molecule converting it into cellular 01:46:35.960 --> 01:46:40.040 energy that can drive all these different processes in 1996 we sequenced the genome of 01:46:40.040 --> 01:46:44.120 methanococcus genacia the first archaea and the first autotrof that means it makes everything 01:46:44.120 --> 01:46:49.080 from life from inorganic substances and it makes its energy by converting co2 into nothing it also 01:46:49.080 --> 01:46:54.280 uses the carbon and co2 to make all its proteins in lipids all these processes are coded for in 01:46:54.360 --> 01:47:00.280 the DNA we've shown now using synthetic genomes when you put new DNA software into the cell the 01:47:00.280 --> 01:47:04.600 protein robots read it immediately start producing the proteins coded for changing the cellular 01:47:04.600 --> 01:47:09.560 phenotype and when you change the DNA software you change the species this is all consistent with 01:47:09.560 --> 01:47:14.360 Schrodinger's code script and organisms astonishing gift of concentrating a stream of order on itself 01:47:15.320 --> 01:47:19.000 Schrodinger citing the second law of thermodynamics the entropy principle the natural 01:47:19.000 --> 01:47:22.920 tendency of things to go over into disorder describe the notion of order based on order 01:47:22.920 --> 01:47:26.200 we get the order from the genetic code we get the order from its interpretation into 01:47:27.960 --> 01:47:32.600 we can digitize life and regenerate life from the digital world and just as the ribosome can 01:47:32.600 --> 01:47:38.120 convert the analog message and mRNA into a protein robot it's becoming standard now in the world 01:47:38.120 --> 01:47:45.000 of science to convert digital code into proteins viruses and now cells scientists send digital 01:47:45.000 --> 01:47:49.160 code to each other instead of sending genes or proteins and there's several companies around 01:47:49.160 --> 01:47:54.440 the world that make their living by synthesizing genes for scientific labs it's faster and cheaper 01:47:54.440 --> 01:48:00.440 to synthesize a gene than is the clonet or even get it by federal express an example of this 01:48:00.440 --> 01:48:06.040 digital biological conversion is we've been working on new ways to make vaccines using synthetic DNA 01:48:06.040 --> 01:48:10.040 and we progress this process very efficiently and now working with barda in the u.s. government 01:48:10.040 --> 01:48:15.000 and novartis barda sends us an email containing a test pandemic flu sequence and we have less 01:48:15.000 --> 01:48:20.760 than 24 hours to convert that digital code into a virus we now have that process under 12 hours 01:48:20.760 --> 01:48:25.960 we get that to novartis and they're ready to scale up production for vaccines now we're in the process 01:48:25.960 --> 01:48:32.520 of building a much smaller simpler what i call digital conversion device so my digital biological 01:48:32.520 --> 01:48:37.000 converter is going to work somewhat like the telephone where it takes digital waves and converts 01:48:37.000 --> 01:48:41.560 it into sound waves so you can hear it only will have a small box that you could attach to a computer 01:48:42.200 --> 01:48:48.600 to in fact receive a digital wave and convert it into a protein perhaps a vaccine or even a cell 01:48:49.240 --> 01:48:55.800 so think about in a future flu pandemic we could this sounds a lot like that that thing that David 01:48:55.800 --> 01:49:00.840 Hone talked about where you got a arm band on one side that reads the pathogen and arm band on the 01:49:00.840 --> 01:49:06.200 other side that makes the vaccine and injects it in you is he not talking about exactly the same 01:49:06.200 --> 01:49:10.520 thing am i a am i a crazy person here barda and novartis 01:49:12.200 --> 01:49:16.200 we distribute a new vaccine in seconds around the world because this is biology now moving 01:49:16.200 --> 01:49:22.520 at the speed of light perhaps even through each individual home oh no this wasn't a plan there's 01:49:22.520 --> 01:49:27.480 no way that this was a plan how could you possibly believe it's a plan if it was a plan they would 01:49:27.480 --> 01:49:34.040 have been talking about what they were going to do for years already uh all life is derived 01:49:34.040 --> 01:49:39.080 currently from other cellular life but i think it's just a short matter of time before someone 01:49:39.080 --> 01:49:44.120 discovers the right chemical cocktail of enzymes ribosomes lipids together with the synthetic genome 01:49:44.120 --> 01:49:49.080 to just to create a simple boot up system to get cells without a prior cellular history 01:49:49.720 --> 01:49:54.200 wow that's amazing i'm sure it's you know only a matter of time before we are curing childhood 01:49:54.200 --> 01:49:59.400 diseases with retroviruses in every childhood her every uh children's hospital in america i'm 01:49:59.400 --> 01:50:04.200 sure it's not very long before the futurist dream of being able to look at your kid and 01:50:04.200 --> 01:50:08.920 pick all the phenotypes you want and dial up the intelligence and musical creativity 01:50:08.920 --> 01:50:13.240 will be as simple as calling craig ventors uh company and saying sequence me 01:50:15.640 --> 01:50:18.520 so let's look at the tremendous progress in this last seven years and shorteners 01:50:18.520 --> 01:50:23.080 lecture on this campus and try to imagine things 70 years from now uh jim watson still with us 01:50:23.080 --> 01:50:28.600 whether he'll be with us 70 years from now is an open question try to imagine 70 years from now 01:50:28.600 --> 01:50:36.360 is exactly the bamboozlement and mythology they want you to do by imagining a future that he just 01:50:36.360 --> 01:50:42.440 brainwashed you into believing in or imagining you are accepting the model of reality that is in 01:50:42.440 --> 01:50:49.880 that imaginary model in that imaginary image that model is what he just got through describing 01:50:49.880 --> 01:50:58.280 which is that we are the summation of chemistry and physics there's nothing else 01:50:59.160 --> 01:51:02.760 protein machines mindlessly do what they're told 01:51:04.520 --> 01:51:08.200 and we are nothing more than a Turing machine that reads a tape 01:51:10.360 --> 01:51:16.280 that's what craig vetner that's what all the people at the human genome project that's what 01:51:16.280 --> 01:51:21.800 all the people that want to enslave your grandchildren want you to believe about your biology 01:51:22.440 --> 01:51:28.120 about your children's biology and about the flawed nature of every child that's born 01:51:29.720 --> 01:51:35.160 when in reality it's exact inversion of the truth children are born perfect 01:51:36.680 --> 01:51:42.840 and even if they're born imperfect it is a perfect imperfect that cannot be augmented 01:51:43.400 --> 01:51:50.360 through any rudimentary understanding that we think we have of this pattern integrity 01:51:51.560 --> 01:51:53.880 it can't it simply cannot 01:51:55.480 --> 01:52:00.120 but certainly some of you will be here in 70 years so in the year 2082 what will be happening 01:52:00.760 --> 01:52:06.440 well we just saw my friend Elon Musk launch a private space flight to go up to the space station 01:52:06.440 --> 01:52:10.520 certainly within 70 years we will have colonized the moon and Mars there's several working on trying 01:52:10.520 --> 01:52:15.640 to do that so just like new life forms for food in 70 years we're going to be on Mars you see 01:52:15.640 --> 01:52:21.000 where we're going here and I mean Robert Malone thought within 10 years we would be curing childhood 01:52:21.000 --> 01:52:26.360 diseases with retroviruses and we're at least 30 years off on that if not 40 01:52:28.360 --> 01:52:34.200 WTF ladies and gentlemen how can we take these people seriously when they've been doing exactly 01:52:34.200 --> 01:52:40.040 what Peter Teal said they've been doing which is lying and exaggerating because of the hyperspecialization 01:52:40.040 --> 01:52:47.080 completely allows it and because we're producing so much knowledge i.e. noise 01:52:48.440 --> 01:52:54.440 with this endless reiterative falsification of hypotheses driven by preparean thinking 01:52:57.080 --> 01:53:02.680 and every one of these people knows it Peter Teal knows it Elon Musk knows it 01:53:03.320 --> 01:53:07.480 the Weinstein's probably know it because they've probably had it explained to them by their father 01:53:07.560 --> 01:53:08.280 by these guys 01:53:12.280 --> 01:53:16.120 it's an elaborate hoax ladies and gentlemen the quicker that we can teach it to our kids the quicker 01:53:16.120 --> 01:53:22.840 that we break free energy production new medicines perhaps a vaccine could be sent from earth to 01:53:22.840 --> 01:53:28.600 Mars at the speed of light taking somewhere between 4.3 and 21 minutes to get their depending on the 01:53:28.600 --> 01:53:33.560 distance between earth and Mars the digital and biological worlds are now becoming interchangeable 01:53:34.280 --> 01:53:39.160 perhaps more importantly and i'll speak to this again on on Saturday evening synthetic life 01:53:39.160 --> 01:53:43.000 is going to be the tool that allows us to understand the diversity of life on this planet 01:53:43.000 --> 01:53:47.160 and hopefully enable new industries to produce food fuel clean water and medicine 01:53:48.040 --> 01:53:53.000 as we add a billion people to the planet over the next 12 years and every 12 years of following 01:53:53.000 --> 01:53:57.400 that as we'll hear in a few minutes and you heard in the introduction Schrodinger's life 01:53:57.400 --> 01:54:02.520 helps to stimulate the Jim Watson and Francis Crick over 60 years ago to help kick off this new 01:54:02.520 --> 01:54:08.520 era of the DNA world with their discovery of the double helix one can only hope that this new 01:54:08.520 --> 01:54:13.400 frontier of synthetic life will have a similar impact on the future thank you very much 01:54:21.720 --> 01:54:27.640 yeah go back and sit down there sir ladies and gentlemen this has been giga ohm biological 01:54:27.640 --> 01:54:33.240 it is a high resistance low noise information brief brought to you by a biologist make no 01:54:33.240 --> 01:54:39.160 mistake about it ladies and gentlemen why is it doing that dang it i clicked on that slide like 01:54:39.160 --> 01:54:48.440 three times now click click current slide there we go so we are in a trap right now ladies and 01:54:48.440 --> 01:54:54.200 gentlemen we are in a trap and we are being trapped in this new world order where all of these things 01:54:54.200 --> 01:54:59.560 that peter vetner said are about to come true all of this virology is real all this pandemic 01:54:59.560 --> 01:55:05.480 potential is real and if we allow this mythology to be passed on to our children our children will 01:55:05.480 --> 01:55:13.800 be enslaved by these machines by these softwares and by these apps not by the ai to come but by the 01:55:13.800 --> 01:55:22.120 algorithms currently deployed and by the liars currently lying ladies and gentlemen please stop 01:55:22.200 --> 01:55:26.920 all transfections in humans because they are trying to eliminate the control group by any means 01:55:26.920 --> 01:55:34.520 necessary intramuscular injection of any combination of substances with the intent of augmenting the 01:55:34.520 --> 01:55:40.440 immune system is dumb transfection is criminally negligent and viruses are not pattern integrity 01:55:40.440 --> 01:55:44.600 so thanks very much for joining me i will see you again tomorrow i have an interview with 01:55:44.600 --> 01:55:50.760 thomas binder and we are trying to decide whether we want to do 12 o'clock or i rather one o'clock 01:55:50.840 --> 01:55:54.760 and have two hours and i think that's what we're going to do right now it's scheduled for two 01:55:55.320 --> 01:56:00.520 but don't be surprised if it starts at one or if it's scheduled for one don't be surprised if it 01:56:00.520 --> 01:56:05.720 starts at twelve because i'm going to try and get two hours with thomas instead of one so 01:56:05.720 --> 01:56:09.880 he's offered an earlier hour i'm going to take it and then i'll change the schedule when i have 01:56:09.880 --> 01:56:14.280 confirmation i'll see you tomorrow for thomas binder it's going to be a great discussion one of my 01:56:14.280 --> 01:56:20.680 favorite people on the interwebs with regard to the pandemic and speaking truth to this power 01:56:21.720 --> 01:56:26.680 i'm really excited about that you can find me at giggleonbiological.com don't underestimate how 01:56:26.680 --> 01:56:32.200 much we are sacrificing for this it might look like this is a very rich production but it's a 01:56:32.200 --> 01:56:38.840 couple of free cameras got a couple of craigslist hardware devices and an old mac that's what we're 01:56:38.840 --> 01:56:45.480 doing this with and my family is absolutely positively living off of this stream so 01:56:45.480 --> 01:56:49.160 if you can see that i've got about a hundred and ten subscribers that's about a thousand 01:56:49.160 --> 01:56:54.840 dollars a month we have two thousand four hundred dollars a month in rent because we rent from 01:56:54.840 --> 01:57:01.800 a weaponized pile of money that's starting to take over the residential property in in 01:57:01.880 --> 01:57:07.560 pittsburgh so i'm i'm asking for help i'm begging for help i need everybody's help and if you are 01:57:07.560 --> 01:57:14.520 already helping then share if you are already helping then share and if you can't help please 01:57:14.520 --> 01:57:19.800 share that's about all i can say because that's what we need we need millions of viewers thousand 01:57:19.800 --> 01:57:25.320 subscribers and we can actually win i'm convinced of it thank you very much for joining me and i'll 01:57:25.320 --> 01:57:32.920 see you again soon tomorrow for sure intellectual bright web we'll be back tomorrow for sure thanks 01:57:55.960 --> 01:57:57.960 you 01:58:13.320 --> 01:58:19.960 i would be very up for meeting anyone in northern corner of western pennsylvania for a picnic 01:58:19.960 --> 01:58:25.000 on the eighth of april if you want to organize that with me you got to email me directly i'm not 01:58:25.080 --> 01:58:30.200 gonna tell everybody in the world where my little family's gonna go but i would be happy to have 01:58:30.200 --> 01:58:36.520 anybody who wants to join me it is the eighth it is i think two monday's from now um we won't 01:58:36.520 --> 01:58:42.040 have a chance to see this again without a big travel expense so hopefully we're gonna get clear 01:58:42.040 --> 01:58:47.640 weather um my boss at the university of pittsburgh actually didn't let me go see the one at the 01:58:47.640 --> 01:58:53.960 beginning of the pandemic and uh we got in a big fight about it actually uh i wanted to go camping 01:58:53.960 --> 01:58:58.920 in tevisi and see it and he wouldn't allow me to do it so this this is one i'm not gonna miss i 01:58:58.920 --> 01:59:04.040 just hope that i hope that we have cloudless day on that day okay see you later guys thank you 01:59:04.040 --> 01:59:06.760 i'll see you tomorrow 01:59:23.960 --> 01:59:26.280 you