From bfe01ae84586a1d25a443b450f6ce52bad13b10b Mon Sep 17 00:00:00 2001 From: Soothspider Date: Sat, 25 Nov 2023 16:15:28 -0800 Subject: [PATCH] Generating captions for last 3 streams. --- ...Resistance Low Noise Information Brief.vtt | 2624 ++++++++++++++ .../README.md | 5 + ...Resistance Low Noise Information Brief.vtt | 3062 +++++++++++++++++ .../README.md | 5 + ...Resistance Low Noise Information Brief.vtt | 1790 ++++++++++ .../README.md | 5 + 6 files changed, 7491 insertions(+) create mode 100755 twitch/1984857726 (2023-11-22) - OVID_ A Fine Line between Warning and Announcement --(22 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/1984857726 (2023-11-22) - OVID_ A Fine Line between Warning and Announcement --(22 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief.vtt create mode 100644 twitch/1984857726 (2023-11-22) - OVID_ A Fine Line between Warning and Announcement --(22 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/README.md create mode 100755 twitch/1985683350 (2023-11-23) - Thanks Pieter but LNPs are not Magic --(23 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/1985683350 (2023-11-23) - Thanks Pieter but LNPs are not Magic --(23 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief.vtt create mode 100644 twitch/1985683350 (2023-11-23) - Thanks Pieter but LNPs are not Magic --(23 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/README.md create mode 100755 twitch/1986525909 (2023-11-24) - Mr. Sparkle was ERASED in Germany --(24 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/1986525909 (2023-11-24) - Mr. Sparkle was ERASED in Germany --(24 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief.vtt create mode 100644 twitch/1986525909 (2023-11-24) - Mr. Sparkle was ERASED in Germany --(24 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/README.md diff --git a/twitch/1984857726 (2023-11-22) - OVID_ A Fine Line between Warning and Announcement --(22 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/1984857726 (2023-11-22) - OVID_ A Fine Line between Warning and Announcement --(22 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief.vtt b/twitch/1984857726 (2023-11-22) - OVID_ A Fine Line between Warning and Announcement --(22 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/1984857726 (2023-11-22) - OVID_ A Fine Line between Warning and Announcement --(22 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief.vtt new file mode 100755 index 0000000..9f9e0b8 --- /dev/null +++ b/twitch/1984857726 (2023-11-22) - OVID_ A Fine Line between Warning and Announcement --(22 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/1984857726 (2023-11-22) - OVID_ A Fine Line between Warning and Announcement --(22 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief.vtt @@ -0,0 +1,2624 @@ +WEBVTT + +00:30.000 --> 00:32.000 +. + +01:00.000 --> 01:02.000 +. + +01:30.000 --> 01:34.000 +. + +01:34.000 --> 01:38.000 +. + +01:38.000 --> 01:42.000 +. + +01:42.000 --> 01:46.000 +. + +01:46.000 --> 01:50.000 +. + +01:50.000 --> 01:54.000 +. + +01:54.000 --> 01:58.000 +. + +01:58.000 --> 02:02.000 +. + +02:02.000 --> 02:06.000 +. + +02:06.000 --> 02:10.000 +. + +02:10.000 --> 02:14.000 +. + +02:14.000 --> 02:18.000 +. + +02:18.000 --> 02:22.000 +. + +02:22.000 --> 02:26.000 +. + +02:26.000 --> 02:30.000 +. + +02:30.000 --> 02:34.000 +. + +02:34.000 --> 02:36.000 +. + +02:36.000 --> 02:38.000 +. . + +02:38.000 --> 02:42.000 +. + +02:42.000 --> 02:45.000 +. + +02:45.000 --> 02:49.000 +. . + +02:49.000 --> 02:54.000 +. . . + +02:54.000 --> 02:55.000 +. . + +02:55.000 --> 03:01.000 +He's going on French, British, Italian, Japanese television. + +03:01.000 --> 03:05.000 +People everywhere are starting to listen to him. + +03:05.000 --> 03:07.000 +It's embarrassing. + +03:25.000 --> 03:33.000 +I wasn't sure whether I was going to do it. + +03:33.000 --> 03:38.000 +No, there I am, I see it. + +03:38.000 --> 03:46.000 +It was not talking very loud or something. + +03:46.000 --> 03:51.000 +Or I had the music. + +03:51.000 --> 04:03.000 +Just give myself a little juice. + +04:03.000 --> 04:09.000 +I don't have my headphones on anymore. + +04:09.000 --> 04:12.000 +My name is Jonathan Cooley. + +04:12.000 --> 04:20.000 +I used to be a patch clam physiologist. + +04:20.000 --> 04:31.000 +The reason why we call this Giga ohm biological is because that describes the electrophysiological connection, the resistance of the connection between my electrode and a neuron. + +04:31.000 --> 04:36.000 +And it was a Giga ohm connection, which is both high resistance and low noise. + +04:36.000 --> 04:43.000 +And that's why we call this the Giga ohm biological, high resistance, low noise, information, brief. + +04:43.000 --> 04:46.000 +I'm just going to do the opening and we're ready to go. + +04:46.000 --> 04:49.000 +It should be a pretty quick show. I just got a little short video. + +04:49.000 --> 04:53.000 +We'll watch at one and a half speed as usual. + +05:13.000 --> 05:30.000 +Intramuscular injection of any combination itself. + +05:30.000 --> 05:33.000 +Intramuscular injection of any system itself. + +05:33.000 --> 05:35.000 +Transfection of the Giga. + +05:35.000 --> 05:36.000 +Primarily negative. + +05:36.000 --> 05:45.000 +Environments are not pattern integrity. + +05:45.000 --> 05:47.000 +My animations are running a little slow again. + +05:47.000 --> 05:48.000 +My music is low. + +05:48.000 --> 05:49.000 +High again. + +05:49.000 --> 05:54.000 +I'm just going to have to get my headphones back on or something here. + +05:54.000 --> 05:57.000 +I'm trying to figure it out dudes. + +05:57.000 --> 06:06.000 +I might just have to put my headphones back on. + +06:06.000 --> 06:09.000 +I'm not going to put my headphones back on, dang it. + +06:09.000 --> 06:16.000 +I'm going to try very hard not to put my headphones back on because I want to keep them off and let my ears breathe a little bit. + +06:16.000 --> 06:19.000 +I have them in all day to day and it's too much. + +06:19.000 --> 06:21.000 +It's too much, I tell you. + +06:21.000 --> 06:24.000 +Let me see if I can do this right. + +06:25.000 --> 06:26.000 +Good evening ladies and gentlemen. + +06:26.000 --> 06:27.000 +Welcome to the show. + +06:27.000 --> 06:29.000 +This is Giga Home Biological High Resistance. + +06:29.000 --> 06:33.000 +Low noise information brief brought to you by a biologist. + +06:33.000 --> 06:34.000 +Still can't hear me. + +06:34.000 --> 06:39.000 +I'm going to jack it up a little more and you're just going to have to hear also all the stuff in my throat. + +06:39.000 --> 06:41.000 +Turn it up just a little more. + +06:41.000 --> 06:44.000 +Every time I get closer of course it sounds fine. + +06:44.000 --> 06:49.000 +Then maybe I'll ding this once just to see where we're at. + +06:49.000 --> 06:55.000 +I don't know. + +06:55.000 --> 06:57.000 +That should be fine. + +06:57.000 --> 06:59.000 +Anyway, good to see you guys. + +06:59.000 --> 07:03.000 +Sorry that I'm not using my headphones as usual but I don't know. + +07:03.000 --> 07:11.000 +I'm trying to get out of the monitor thing but maybe I always have to do it as long as it's me and only me. + +07:11.000 --> 07:14.000 +I might have to do a monitor thing here. + +07:14.000 --> 07:16.000 +Let me get back to this guy. + +07:16.000 --> 07:18.000 +Let's see here. + +07:18.000 --> 07:27.000 +We have always been talking about this great Scooby-Doo, the illusion of consensus about a novel virus that killed millions of people. + +07:27.000 --> 07:29.000 +The millions more were saved from. + +07:29.000 --> 07:33.000 +The gain of function is likely the source of and that will definitely come again. + +07:33.000 --> 07:41.000 +I really think at this stage we can think of this as an orchestrated release of this narrative. + +07:41.000 --> 07:46.000 +A controlled operation as the truth or whatever the story is. + +07:46.000 --> 07:55.000 +The mythology that we're supposed to end up believing eventually becomes our conclusions that we solve this mystery. + +07:55.000 --> 08:10.000 +I think that's the reason why I like to use the Scooby-Doo so much and that's why I like to call it a faith because it really does feel like we're surrounded on all sides by all these different opinions but all these different opinions seem to agree on the central faith of everything to begin with. + +08:10.000 --> 08:18.000 +Of course we've been misled by the potential for pandemics and where it can be found. + +08:18.000 --> 08:30.000 +We've also been misled by how it can be created and the idea behind this misleading us about this took a really long time for us to understand. + +08:30.000 --> 08:51.000 +The gist of it is that it seems like they've been laying this worst case scenario from the very beginning on purpose and even in fact most likely you could even see eco-health alliance itself as an organization that was established with the intention of creating the worst case scenario narrative. + +08:51.000 --> 09:01.000 +And a sort of an intentional trail of malfeasance that they could then point to in the Scooby-Doo mystery. + +09:01.000 --> 09:09.000 +And I have almost no doubt at this stage that this aspect of the narrative we have nailed down pat. + +09:09.000 --> 09:13.000 +And that's why I think it's apt to call it a New World Order. + +09:13.000 --> 09:18.000 +It's apt to have the bats coming out of a cave there and kind of the reverse of the North Face logo. + +09:18.000 --> 09:40.000 +Because it is really what they have been planning for a very long time and we need to take a hold of this term much in the same way Tyrion Lannister suggested to Jon Snow that he had to own his identity and use it as his armor otherwise people would use it against him. + +09:40.000 --> 09:47.000 +We need to use this concept of a New World Order as a way of warning people that that's exactly what they are doing. + +09:47.000 --> 09:53.000 +And not only that but use this term as a way of warning them that this was a plan for a long time. + +09:53.000 --> 10:00.000 +At least that's the reason why I use it. So don't think that somehow I'm cryptically involved in this. + +10:00.000 --> 10:06.000 +I'm fighting it as much as you are for my kids and for theirs. + +10:07.000 --> 10:17.000 +So this illusion of consensus is what we need to break and I have been trying to sort of point out that there are some sort of key things that we have to think about. + +10:17.000 --> 10:29.000 +And one of them that I think we really do need to consider is the idea that there is very little difference between a warning and an announcement. + +10:29.000 --> 10:38.000 +And many times I've felt as though we have been led astrayed by certain people in this narrative. + +10:38.000 --> 10:48.000 +Led astray, distracted, we've become engrossed in certain discussions about intellectual property whose ideas are whose. + +10:48.000 --> 10:55.000 +And these things ended up to be a lot of fireworks in the sky but the real business was going on in the buildings below. + +10:56.000 --> 11:05.000 +And so we really want to be careful as we move forward because I really do think that there is a danger that there is some. + +11:05.000 --> 11:09.000 +We've been warned more often than we might be aware of. + +11:09.000 --> 11:19.000 +In fact, I think that there's one really interesting observation that was made first by my friend Matt Crawford. + +11:20.000 --> 11:27.000 +Then made by someone who I can't remember and I still couldn't remember after trying to think about it for a few days. + +11:27.000 --> 11:29.000 +And the third one was really me. + +11:29.000 --> 11:41.000 +And the observation that I made was that Dr. Robert Malone in the first part of the pandemic was calling it COVID, not COVID. + +11:42.000 --> 11:48.000 +And it dawned on me that COVID is actually Ovid. + +11:48.000 --> 12:01.000 +And Ovid is the way that my world literature teacher pronounced this guy Ovid's metamorphosis, this Greek epic or whatever. + +12:01.000 --> 12:10.000 +And so I thought what if I could find a world literature lecture on Ovid's metamorphosis and maybe they could tell us a little bit about what Ovid meant. + +12:11.000 --> 12:16.000 +And maybe it would have something to do with what's going on in the pandemic. + +12:16.000 --> 12:20.000 +So I found this world literature lecture on Ovid metamorphosis. + +12:20.000 --> 12:22.000 +And I don't want you to watch the whole thing. + +12:22.000 --> 12:36.000 +But I'm going to pick it up where my fellow long hair is talking about these original Gilgamesh Iliad and the Aeneid. + +12:36.000 --> 12:41.000 +And the idea that these are about a certain kind of structure in society. + +12:41.000 --> 12:45.000 +They have a certain general theme with a hero and all this other stuff. + +12:45.000 --> 13:02.000 +And so I'm picking him up here in the middle where he's discussing the kind of overarching themes that these three stories have in common and do not have in common with Ovid, which is over here under transformation and chaos, which he had already talked about earlier. + +13:02.000 --> 13:04.000 +But I don't want you to listen to the first. + +13:04.000 --> 13:06.000 +So let's see what we get out of this. + +13:06.000 --> 13:11.000 +So yes, so a very sort of patriarchal family structure, right? + +13:11.000 --> 13:15.000 +Piety, patriarchy. + +13:15.000 --> 13:16.000 +What else? + +13:16.000 --> 13:19.000 +Emperor should be worshiped as God. + +13:19.000 --> 13:21.000 +Okay, Emperor as God. + +13:21.000 --> 13:22.000 +Yep. + +13:22.000 --> 13:23.000 +Can you hear him? + +13:23.000 --> 13:24.000 +Okay. + +13:24.000 --> 13:25.000 +Place this under piety, right? + +13:29.000 --> 13:30.000 +Yes, here. + +13:31.000 --> 13:36.000 +Yeah, have a lot of kids within marriage, right? + +13:36.000 --> 13:39.000 +So kind of marital chastity. + +13:47.000 --> 13:55.000 +And above all, a good Roman does his or her duty, right? + +14:00.000 --> 14:07.000 +You're a citizen first and individual second, right? + +14:07.000 --> 14:15.000 +Rome, the idea of Rome matters more than your personal desires. + +14:15.000 --> 14:24.000 +So to what extent, given what you've read here, does Ovid seem to endorse any of these values? + +14:24.000 --> 14:27.000 +No, not so much. + +14:27.000 --> 14:32.000 +What seems to be going on here instead? + +14:32.000 --> 14:33.000 +Yes. + +14:33.000 --> 14:38.000 +We've got, yeah, constant rule breaking, right? + +14:38.000 --> 14:39.000 +Chaos. + +14:39.000 --> 14:42.000 +Yeah, this is a poem about chaos. + +14:42.000 --> 14:50.000 +And it's a poem that suggests that the natural human state is in fact chaos and that everything + +14:50.000 --> 14:57.000 +ultimately tends back to chaos. + +14:57.000 --> 15:01.000 +Order is always temporary and it's artificial. + +15:01.000 --> 15:10.000 +It has to be imposed by some God or kinder nature. + +15:10.000 --> 15:15.000 +As Ovid puts it, chaos is what's natural. + +15:21.000 --> 15:31.000 +Now, around the year eight CE, when he was just finishing up this poem, but parts of it + +15:31.000 --> 15:40.000 +are already circulated amongst various of Ovid's friends, Ovid was exiled. + +15:40.000 --> 15:47.000 +So the first part of this thing is, I forgot where I cut it off, so I wanted to just let it run. + +15:47.000 --> 15:53.000 +The first part of this commentary then is setting up the idea that the previous Roman + +15:53.000 --> 16:03.000 +epics were all about telling a story about a hero and stories about maintaining these sort of myths + +16:03.000 --> 16:06.000 +about the Roman society. + +16:06.000 --> 16:12.000 +Whereas Ovid's metamorphoses don't follow any of those rules and in fact start to turn things + +16:12.000 --> 16:19.000 +upside down and even... + +16:19.000 --> 16:21.000 +What has he done? + +16:21.000 --> 16:22.000 +I'll just let him say it. + +16:22.000 --> 16:24.000 +Yeah, he's putting things in order, right? + +16:24.000 --> 16:28.000 +He's imposing a shape on the universe. + +16:28.000 --> 16:32.000 +He's imposing a shape on reality. + +16:32.000 --> 16:35.000 +The matter was already there. + +16:35.000 --> 16:37.000 +He's just organizing it. + +16:37.000 --> 16:39.000 +So the creation really here is kind of misnamed. + +16:39.000 --> 16:46.000 +It's really like the great organization or the birth of order. + +16:46.000 --> 16:51.000 +So we start with chaos. + +16:51.000 --> 16:55.000 +Some God steps in and puts everything in order. + +16:55.000 --> 17:02.000 +So why is it then that so many things are able to change their shapes throughout this narrative? + +17:02.000 --> 17:05.000 +What is Ovid's setting up here? + +17:05.000 --> 17:13.000 +Why is the human form, the animal form, the plant form so unstable? + +17:13.000 --> 17:15.000 +What is the base unit of creation? + +17:15.000 --> 17:20.000 +In all of these stories there's transformations that occur between people and beast and beast + +17:20.000 --> 17:21.000 +and people. + +17:21.000 --> 17:28.000 +The thing that everything is ultimately made out of. + +17:28.000 --> 17:31.000 +What does? + +17:31.000 --> 17:34.000 +For Ovid. + +17:34.000 --> 17:37.000 +What's the thing that's there before anything else's? + +17:37.000 --> 17:46.000 +Yeah, everything's made out of chaos. + +17:46.000 --> 17:51.000 +This is why everything shifts and changes, right? + +17:51.000 --> 17:55.000 +This is why you can turn a human being into a cow. + +17:55.000 --> 17:58.000 +This is why you can turn a fleeing nymph into a tree, right? + +17:58.000 --> 18:03.000 +This is why a statue can be turned into a live woman. + +18:03.000 --> 18:06.000 +So what all forms of matter have in common, right? + +18:06.000 --> 18:09.000 +For Ovid, is that they're all inherently chaotic. + +18:09.000 --> 18:15.000 +And form and order and purpose are temporary. + +18:15.000 --> 18:20.000 +Now let's look at this in terms of what we talked about last week. + +18:20.000 --> 18:23.000 +What was Virgil trying to set up in the Aeneid? + +18:23.000 --> 18:27.000 +What was his basic purpose in writing the Aeneid? + +18:27.000 --> 18:30.000 +So did you kind of catch what I'm getting at there? + +18:30.000 --> 18:40.000 +That in a way the pronunciation of COVID as COVID may not have been a mistake. + +18:40.000 --> 18:42.000 +It may have been a hint. + +18:42.000 --> 18:48.000 +It may have some origins in the original meaning. + +18:48.000 --> 18:56.000 +But it's very interesting because if we just take a brief look at a video + +18:56.000 --> 19:06.000 +from the beginning of this year and I just want to use this video as a way of pointing + +19:06.000 --> 19:10.000 +out that there is a fine line between announcement and warning, right? + +19:10.000 --> 19:18.000 +These people can be telling us what's coming and saying, you know, we should fight it + +19:18.000 --> 19:24.000 +or they could be telling us what's coming so that these ideas are out there as they are + +19:24.000 --> 19:25.000 +implemented. + +19:25.000 --> 19:34.000 +And there is a very, very fine line, especially in the now ubiquitous term fifth generation + +19:34.000 --> 19:35.000 +warfare. + +19:35.000 --> 19:41.000 +It is a very fine line between announcement and warning, between a call to arms and a useless + +19:41.000 --> 19:46.000 +announcement that will not save you, but just make sure you understand what's going to happen + +19:46.000 --> 19:47.000 +to you. + +19:47.000 --> 19:54.000 +And I think I aptly describe these two guys and others as really giving us warnings. + +19:54.000 --> 19:59.000 +And I want to watch this video together with you to see if you think that there are people + +19:59.000 --> 20:02.000 +here who are announcing or are they warning. + +20:02.000 --> 20:06.000 +And we have to listen very carefully in order to know this answer. + +20:06.000 --> 20:09.000 +And maybe even when we listen carefully, we're not going to know the answer. + +20:09.000 --> 20:13.000 +But let's just see if we can pull something out of this one. + +20:13.000 --> 20:24.000 +So this is a strategy session, panel discussion, globalist wealth, or global health, with + +20:24.000 --> 20:32.560 +Assim Mahultra, Robert Malone, Meryl Nass, Jonathan Gilthrup, Sasha Latipova, and Michael + +20:32.560 --> 20:33.560 +Palmer. + +20:33.560 --> 20:39.680 +And I just want to, you know, it's not going to be real in a spectacular, but because the + +20:39.680 --> 20:42.920 +questions are rather panel discussion for session. + +20:43.920 --> 20:44.920 +But we'll just see where we get. + +20:44.920 --> 20:49.920 +Because on stage, and I think you all raised your concerns about crimes against humanity. + +20:49.920 --> 20:54.920 +We talked about corruption, bypassing rules and laws, infrastructure, biological weapons. + +20:54.920 --> 20:59.920 +So I think my first question to you will be, what's our way out of this? + +20:59.920 --> 21:01.920 +And I know you're all covering very different areas. + +21:01.920 --> 21:02.920 +What are the lessons learned? + +21:02.920 --> 21:05.920 +And how do we hold our government's authority accountable? + +21:05.920 --> 21:08.920 +I can start with you. + +21:08.920 --> 21:10.920 +It's a great question to start with. + +21:11.920 --> 21:13.920 +I think this will resonate with everybody. + +21:13.920 --> 21:17.920 +I think most of the people here, actually, in the speakers that have been on this journey, + +21:17.920 --> 21:23.920 +is I will talk from a broader conceptual strategy that I think about when I'm involved in these + +21:23.920 --> 21:29.920 +sorts of skirmishes, is based upon, first and foremost, is that I think everybody here is + +21:29.920 --> 21:33.920 +very much, are people that are very adherent to ethics and values, right? + +21:33.920 --> 21:36.920 +And I think that's something intrinsic in most human beings. + +21:36.920 --> 21:39.920 +I'm not maybe a cynical of some people in the sense that I think that even people like + +21:39.920 --> 21:42.920 +the likes of Bill Gates, etc, I think they are clouded in ignorance. + +21:42.920 --> 21:43.920 +I actually don't think they're malicious. + +21:43.920 --> 21:45.920 +I think they're ignorant. + +21:45.920 --> 21:47.920 +And I think that they engage in, you know, even for self-interested purposes, they ultimately + +21:47.920 --> 21:49.920 +are doing damage to people, and it will come back to them. + +21:49.920 --> 21:51.920 +Even if you look from the ignorance map point of view. + +21:51.920 --> 21:54.920 +But for me, it's about making the injustice visible. + +21:54.920 --> 21:56.920 +We have a gross injustice to people, and it will come back. + +21:56.920 --> 21:57.920 +I actually don't think they're malicious. + +21:57.920 --> 22:01.920 +I think they're ignorant, and I think that they engage in, you know, even for self-interested + +22:01.920 --> 22:03.920 +purposes, they're ultimately doing damage to people and it will come back to them. + +22:03.920 --> 22:05.920 +Even if you look from the ignorance map point of view. + +22:05.920 --> 22:08.920 +But for me, it's about making the injustice visible. + +22:08.920 --> 22:12.080 +have a gross injustice going on in the world right now. And it was, you know, who inspired + +22:12.080 --> 22:15.280 +me in this journey in one of my inspirations was Mahatma Gandhi. And he, you know, got + +22:15.280 --> 22:19.800 +essentially single-handedly took on the British Empire by non-violent resistance, right? + +22:19.800 --> 22:23.160 +It was adopted by Mandela, ultimately. It was adopted by Martin Luther King. And it's + +22:23.160 --> 22:27.200 +very, very powerful to do that. So the key is making the justice visible. Yes, one of + +22:27.200 --> 22:30.560 +our platforms where we would normally be able to make injustice visible, the mainstream + +22:30.560 --> 22:33.640 +media, has been more captured than ever, and that's been a challenge. But the social movement + +22:33.640 --> 22:37.160 +is growing, and I think we just have to just keep going on speaking the truth, looking + +22:37.240 --> 22:40.240 +after each other. And I actually think we're on the path. We are on that path to overcoming + +22:40.240 --> 22:44.960 +this corporate tyranny, if you like. Thank you, Seem. Anyone else? So I guess we already + +22:44.960 --> 22:49.480 +agree that that's absolutely absurd, that people like Bill Gates and the rest of them + +22:49.480 --> 22:55.680 +don't know what they're doing. That's, it's absolutely absurd. And we know that from other + +22:55.680 --> 23:00.560 +people that we've talked to who've been behind the scenes at these meetings, and we know that + +23:00.560 --> 23:04.120 +that's definitely not the case. So that's already strike one. + +23:04.120 --> 23:06.600 +Just wants to add to that, Tasha? + +23:06.600 --> 23:11.640 +Oh, my microphone. Well, so as far as how to hold the governments accountable, it's very, + +23:11.640 --> 23:16.360 +very difficult, as I have outlined here, at least in the US, they made an atrocity legal + +23:16.360 --> 23:19.840 +on paper. You can never legalize a crime, but they did, and they think that they're going + +23:19.840 --> 23:24.400 +to get away with it. And I think it's important to try any strategy that anybody wishes to + +23:24.400 --> 23:29.960 +try. And so go after the pharma manufacturers, go after your local health authorities, state + +23:29.960 --> 23:35.280 +authorities, try every strategy that you can think of or any lawyer can outline. Ultimately, + +23:35.280 --> 23:39.440 +my colleague, Catherine, has recommended the following overarching strategy, at least in + +23:39.440 --> 23:43.200 +the US. We have to force admissions like Pfizer did in court. We need to have them repeated + +23:43.200 --> 23:48.640 +over and over and over again so that everybody can hear them. Ultimately, we need to have + +23:48.640 --> 23:54.840 +US Department of Justice go to court on record stating two, either of two things. Either the + +23:54.840 --> 23:59.040 +genocide is an official US government policy, and nobody did anything wrong, or those were + +23:59.040 --> 24:01.040 +rogue actors and throw them under the bus. + +24:01.040 --> 24:06.720 +Thank you, Satcha. And I was just thinking about that great example with Rebel News, + +24:06.720 --> 24:09.680 +you know, and actually people I spoke to were solely about this during break, but actually + +24:09.680 --> 24:12.520 +people starting to take action and go after them in public, which is something we need + +24:12.520 --> 24:15.360 +to start doing as media as well, including myself and everyone else in this room who + +24:15.360 --> 24:18.040 +is media. Robert, do you want to continue? + +24:18.040 --> 24:23.760 +So first off, we have to keep speaking. In despite all of the arrayed forces against + +24:23.760 --> 24:30.240 +us that seek to silence us. We must keep speaking. As pointed out, we must avoid violence. + +24:30.240 --> 24:35.400 +We must use avoid the use of violent speech. Violence speech alone will be weaponized against + +24:35.400 --> 24:39.440 +us. It will be used as a justification for even harsher totalitarian measures against + +24:39.440 --> 24:45.840 +us. Unfortunately, let me phrase it this way. The Twitter files have, together with the + +24:45.840 --> 24:50.080 +two Attorney General's lawsuits, have clearly demonstrated that there is collusion from + +24:50.080 --> 24:53.880 +the lowest to the highest levels in the U.S. government to circumvent the U.S. Constitution + +24:53.880 --> 24:59.760 +in the form of the First Amendment. And I'm perplexed. I'm not aware of any remedy that + +24:59.760 --> 25:03.840 +we can use, even in the courts, to really overcome that. The only remedy structured in + +25:03.840 --> 25:09.720 +the United States, which for better or worse still serves as the organizational leadership + +25:09.720 --> 25:15.600 +hub for NATO and the Western world, is impeachment. Impeachment cannot happen under the current + +25:16.320 --> 25:20.320 +environment. There may be some possibility of impeaching, for instance, the Secretary + +25:20.320 --> 25:23.120 +for the Department of Homeland Security, better than that. There's nothing. Our only recourse + +25:23.120 --> 25:28.120 +is the courts, as was pointed out. And the courts are a little sketchy in the United + +25:28.120 --> 25:32.000 +States, even in the Supreme Court right now, in terms of there's a lot of division and + +25:32.000 --> 25:37.280 +tension within those. There are movements to fundamentally restructure the relationship + +25:37.280 --> 25:42.560 +between the legislator and what we call the administrative state. People may not appreciate + +25:42.560 --> 25:47.760 +here in Europe that the United States government is largely run by the senior executive service, + +25:47.760 --> 25:51.040 +which is a small cohort of a few thousand individuals that cannot be fired. They're + +25:51.040 --> 25:54.920 +completely immune from any executive action. And just like if any of you watch the old + +25:54.920 --> 26:00.040 +British sitcom Yes, Minister, it puts a happy face on a very ugly truth. These permanent + +26:00.040 --> 26:03.680 +employees run the government. And these permanent employees that run the government in the United + +26:03.680 --> 26:08.400 +States have created horizontal and vertical alliances with corporations and multinational + +26:08.480 --> 26:15.000 +organizations. It's just the way things are. I'm less angry about the short term. I'm + +26:15.000 --> 26:23.520 +of the opinion that we are now confronting an exemplar of what has been ongoing decades + +26:23.520 --> 26:29.440 +of planning for a centralized world government and calling it a government is a misnomer. + +26:29.440 --> 26:33.520 +It's a public-private partnership fusion that meets Mussolini's criteria. I'll just leave + +26:33.600 --> 26:38.400 +and it's unelected. It represents the largest corporations in the world and their financial + +26:38.400 --> 26:44.320 +interests. And it's uncountable. We're seeing it covered in the media or Davos in the winter + +26:44.320 --> 26:50.720 +and China in the summer. And I think that we are likely to be forced into a situation + +26:50.720 --> 26:57.040 +in which for many of us, we're forced to build new almost underground structures of + +26:57.040 --> 27:04.320 +affiliations and alliances and rebuild a different structure. I really don't – to + +27:04.320 --> 27:09.360 +be perfectly honest, the depth of the corruption that has been revealed is such that I don't + +27:09.360 --> 27:15.760 +see how those agencies can be rebuilt. And I don't see how we have the time and resources + +27:15.760 --> 27:19.840 +to build parallel agencies to a point that they'll be functional, that we could then + +27:19.840 --> 27:24.480 +eliminate the existing ones. I'm really quite dark in this and our only hope really truly + +27:24.480 --> 27:31.920 +is that all of you join us as we walk together and resist this. It will be a generational fight. + +27:32.960 --> 27:38.400 +And I think that personally, the only way to take it on is to focus on the children + +27:39.600 --> 27:46.000 +and proceed on that basis, recognizing that we have an opportunity, as Chris Longen points out, + +27:46.880 --> 27:52.240 +to fulfill the potential of humanity. And that may be the greatest gift of this moment in time, + +27:52.880 --> 27:57.200 +is to transcend the organizational structures and imperatives that we've lived under for + +27:57.200 --> 28:03.520 +thousands of years and move to a different way of organizing humankind in which we can fulfill + +28:03.520 --> 28:07.680 +our potential, but it's not going to be easy. No, definitely not. Thank you, Robert. + +28:08.640 --> 28:16.160 +Okay, so either genocide is a government policy or it's not, and then we should throw the people + +28:16.160 --> 28:23.200 +under the bus is what Sash a lot to Pova ended with. Violent speech, we have to be very careful + +28:23.200 --> 28:28.560 +of violent speech says Robert Malone, because Robert, Robert says that violent speech will be + +28:28.560 --> 28:34.000 +used against us. Is that announcement or in a warning? Is that something we can really avoid? + +28:34.000 --> 28:38.400 +Or is that something that we've been just told now? We should just expect this to occur? I think + +28:38.400 --> 28:44.640 +we should just expect this to occur. I think almost without a doubt, the plan is to police the + +28:44.720 --> 28:50.160 +internet in such a way that you'll have to use a digital ID in order to post anything. And so + +28:50.160 --> 28:55.920 +then if you post H speech, it will be tied to your digital ID, which in China might mean that you + +28:55.920 --> 29:01.440 +lose points in America, you might not for a few years, but that's that's the plan. In case you + +29:01.440 --> 29:08.320 +don't know, there's a digital ID and a digital euro in the works for the European Union, and + +29:08.320 --> 29:14.000 +they'll probably be ahead of us on that. But they're in Stockholm right now in this conference at the + +29:14.000 --> 29:19.360 +beginning of this year talking like this. So is this a warning or is it an announcement? + +29:20.560 --> 29:26.960 +Or are they going through talking at the EU to let all these EU citizens that are so excited about + +29:26.960 --> 29:32.400 +the dissident narrative, let them know that this is where they are that if they were real about this, + +29:32.400 --> 29:38.480 +they would be telling them that the EU is already there, that the EU Parliament is already out of + +29:38.480 --> 29:47.040 +their control. The EU Parliament is already has 10 and 20 year plans that include a huge + +29:47.040 --> 29:54.240 +decrease in flying in a huge reorganization of metropolitan areas. These are all real plans. + +29:54.240 --> 30:01.360 +The EU is not a joke. The EU is a real project that once it was ratified, they were lost. + +30:02.400 --> 30:07.680 +And so these people are over in the EU talking about America as if the EU is safe or something + +30:07.680 --> 30:15.520 +like that, when they are definitely not safe. The EU could flip this fascism on with the flip + +30:15.520 --> 30:21.840 +of a switch. The American government and the American infrastructure of society is not there yet. + +30:23.280 --> 30:28.480 +But I mean, Europeans are there in a snap. All of them have a passport already. All of them go + +30:28.480 --> 30:38.080 +on vacation already. All of them have a built-in understanding that they can move across countries. + +30:38.080 --> 30:43.120 +So as soon as a digital idea is needed, it'll just be required. And all of those people who are so + +30:43.120 --> 30:48.160 +used to moving between countries will gladly get a digital idea to move freely between countries. + +30:50.240 --> 30:55.120 +And there will be a convenience part to it, you know, faster through the airport, yada yada yada. + +30:56.000 --> 31:02.560 +And so is it a warning or an announcement? I don't know. I think it's pretty easy to see. + +31:03.520 --> 31:09.200 +The the senior executive service, as far as I can tell with everyone else that I've talked + +31:09.200 --> 31:16.880 +into government, no matter what Robert Malone actually is, this is a joke. The senior executive + +31:16.880 --> 31:23.360 +service is not a high-paid, are not high-paid executives. These are not people with a lot of + +31:23.360 --> 31:28.080 +power. They're not people with a lot of without with permanent contracts. That's not + +31:29.040 --> 31:34.080 +most of the senior executive service are are are short limited contracts. + +31:35.760 --> 31:40.000 +He says these are permanent employees that run the government. And as far as I can tell from + +31:40.000 --> 31:45.520 +everybody that I've talked to, this is absolutely positively not the case. Occasionally we have + +31:46.240 --> 31:52.960 +a chat member by the name of Janet Reno and and she can usually tell us things like that. + +31:54.240 --> 32:01.520 +Corporate plus government fascism, Davos in the winter and China in the summer, + +32:02.240 --> 32:07.360 +we need to build an underground structure. Sounds a lot like we can't take back America. + +32:08.480 --> 32:16.080 +We have to build an underground structure and and it's going to be a generational fight. Sounds + +32:16.080 --> 32:21.760 +a lot more like he's advocating for us to go underground than he is for advocating for us to + +32:21.760 --> 32:29.840 +organize and take back, which is I think a still a much more viable goal than building a + +32:30.560 --> 32:36.800 +parallel shadow infrastructure in America that is essentially a useful health care system, + +32:36.800 --> 32:40.800 +a useful educational system, a useful social infrastructure that's ridiculous. + +32:42.480 --> 32:45.920 +We're inside of a moving car right now. We're not going to just jump out. + +32:47.040 --> 32:50.960 +We're going to take the people in the driver's seat and we're going to knock them out and we're + +32:51.040 --> 32:54.000 +going to tie them up and we're going to put them in the back. That's what we're going to do + +32:54.800 --> 32:58.240 +and we're going to take control of the car. Somebody who knows how to drive is going to + +32:58.240 --> 33:03.760 +sit in the driver's seat slowly, slow the car down and we're going to figure this out. + +33:08.160 --> 33:16.000 +But underground structure I don't really like. Focus on the children and fulfill the potential + +33:16.000 --> 33:20.640 +of transforming our society. It sounds a lot like a lot of + +33:21.600 --> 33:25.280 +avid chaos. Covid chaos. + +33:28.320 --> 33:34.640 +Like they want to metamorphose our society and the first thing they need to do is create chaos + +33:34.640 --> 33:40.880 +upon which this metamorphosis can occur. Chaos where people starve and stuff like that. I wonder if + +33:40.880 --> 33:48.320 +that's what you're going to expect. I agree with what all the other speakers have said. + +33:49.120 --> 33:53.200 +It's not going to be easy. Guess what? We have a lousy society right now. You know our children + +33:53.200 --> 33:58.240 +have been taught all the wrong values and it's going to be okay. We have a lousy society right + +33:58.240 --> 34:01.760 +now she says. And we rebuild and figure out what kind of society we want. What do we want? + +34:02.720 --> 34:07.360 +This is avid right here. We have a lousy society right now. You know our children have been taught + +34:07.360 --> 34:13.280 +all the wrong values and it's going to be okay that it all comes apart and we can rebuild and + +34:13.280 --> 34:18.160 +figure out what kind of society we want. What do we want our two children taught? I won't go into + +34:18.160 --> 34:24.800 +all this woke business. Suffice to say I was a far left wing activist. Did she say that it's okay + +34:24.800 --> 34:29.280 +if it all comes apart? You know our children have been taught all the wrong values and it's going to + +34:29.280 --> 34:35.200 +be okay that it all comes apart and we can rebuild and figure out what kind of society we want. What + +34:35.280 --> 34:42.320 +do we want our children taught? I won't go into all this woke business. Suffice to say I was a + +34:42.320 --> 34:50.160 +far left wing activist for most of my life and I am no longer but I think it's inherent upon us + +34:50.160 --> 34:53.360 +to build the new structures. I think we don't know what the food supply is going to be like. + +34:53.360 --> 34:56.320 +Everybody should be gardening if you've got a place to do it. Some people are doing it on roofs. + +34:57.280 --> 35:01.120 +Learn how. There are a lot of people who are willing to help teach you. There's lots of videos and books. + +35:01.440 --> 35:06.800 +We have to learn if the pharmaceuticals are not available or we may not want them. You know what + +35:06.800 --> 35:10.480 +we have to learn more about the herbal medicines and the other alternative practices that are safer. + +35:11.440 --> 35:13.920 +So pharmaceuticals might not be available. + +35:16.400 --> 35:19.920 +That's another prediction apparently. Everything's going to fall apart. + +35:23.120 --> 35:28.000 +I am not as pessimistic about the agencies although I think that the people who have survived in + +35:28.000 --> 35:31.440 +the government agencies are yes men. There's no question about that at least in the United + +35:31.440 --> 35:36.640 +States. But some of them do have some regulatory knowledge. We do have rules in place that are + +35:36.640 --> 35:40.320 +not that bad. It's just that they're not following them. So I don't think we have to throw the + +35:40.320 --> 35:44.800 +whole structure away. What we need to do is get decent people at the top to revamp the agencies + +35:44.800 --> 35:49.760 +so that they do what they're supposed to do. Hey she said that. I think Robert Malone made a + +35:49.760 --> 35:54.160 +funny little eyeball there but she actually is saying something I really like there. That's + +35:54.240 --> 35:59.920 +really great, Meryl. Look at this little eyeball from from from from uh them do have some regulatory + +35:59.920 --> 36:03.920 +knowledge. We do have rules in place that are not that bad. It's just that they're not following + +36:03.920 --> 36:07.920 +them. So I don't think we have to throw the whole structure away. What we have to do is get decent + +36:07.920 --> 36:13.360 +people at the top to revamp. Pamela says the rules are bad and they probably are very terrible + +36:13.920 --> 36:18.960 +uh in addition to that they don't enforce them but I'm sure the rules are I'm not sure we need + +36:18.960 --> 36:23.680 +actually how can I say that the rules have to be bad because that's how they get away with this. + +36:23.680 --> 36:29.600 +They enforce the rules. They very strictly enforce the rules to the point of absurdity + +36:29.600 --> 36:35.440 +and those rules are up until you know if everybody votes then the rule is that there's an approval. + +36:36.320 --> 36:41.360 +So the rules are are very very bad. The rules don't require anything other than some people + +36:41.360 --> 36:48.320 +to say yes. So yes I agree with that. The CIA it's not that I meant CDC of course we definitely + +36:48.320 --> 36:54.640 +don't need the CIA. Did you catch that podium slip CDC and CIA? + +36:55.920 --> 37:00.800 +Maybe I should throw in the state department while we're at it but um you know I think again the NIH + +37:00.800 --> 37:07.840 +is a big waste. I'm sorry what? Maybe we should throw in the state party and slip CDC and + +37:07.840 --> 37:12.000 +CIA. Maybe I should throw in the state department while we're at it but um + +37:12.400 --> 37:19.680 +the state department interesting I've had a conversation or two about the state department + +37:19.680 --> 37:25.680 +and why they might be an interesting player in such an exercise. You know I think again the NIH + +37:25.680 --> 37:29.600 +is a big waste of money so is the National Science Foundation. There are all ways of giving money + +37:29.600 --> 37:35.120 +to cronies um in our country um but there's a lot of money there's a lot of resources in the world + +37:35.120 --> 37:39.520 +there's no reason for any of us to believe that the planet can or can't hold a certain number of + +37:39.520 --> 37:42.800 +people. We don't know how many it can hold because most of the resources are being stolen + +37:42.800 --> 37:47.600 +all the time and and we're polluting and destroying the commons and the resources we have + +37:47.600 --> 37:50.720 +and these are being done deliberately our governments are in cahoots with this. I mean why do we have + +37:50.720 --> 37:55.040 +these planes flying with chemtrails? We don't know what's in I mean we have some ideas about what + +37:55.040 --> 37:59.120 +is landing on the ground but why they're doing it um we have no idea I don't anyway + +37:59.760 --> 38:04.480 +who are allowing these things to happen and so if we got rid of all that crap that has been + +38:04.480 --> 38:11.840 +polluting our world mentally, physically, you know health-wise um we may not I'm pretty sure we + +38:11.840 --> 38:15.840 +won't have to worry about climate change. The whole nuclear war thing is you know it doesn't make + +38:15.840 --> 38:22.480 +sense to make. Is there anybody in the in the chat that can kind of confirm whether chemtrails is + +38:22.480 --> 38:28.080 +real or not? I mean I guess they occasionally spray stuff I'm sure they do but like it's not + +38:28.080 --> 38:36.560 +like some kind of global plan to darken the skies or to poison everybody or I just + +38:38.240 --> 38:44.080 +I've never been able to get my head around that other than it's a it's a elaborate story to get + +38:44.080 --> 38:51.440 +people to chase something that has many many other explanations and I can't believe she's + +38:52.240 --> 38:57.680 +I don't know they do hear in West yeah anyway I + +38:59.360 --> 39:04.800 +chemtrails are not nothing okay well I remain very skeptical of them I mean I'm not saying + +39:04.800 --> 39:09.760 +that there aren't planes that have been flown with stuff that they spray out of them what I am + +39:09.760 --> 39:17.840 +skeptical of is that every passenger aircraft that that flies is also equipped for this and so I'm not + +39:18.800 --> 39:25.280 +I'm not really sure how much of the phenomenon is actually a jet plane phenomenon and how much + +39:25.280 --> 39:30.960 +of the phenomenon is a spray phenomenon I do think it's possible that they would disguise + +39:30.960 --> 39:39.280 +and it's a very smart way to disguise the dispersal of of chemicals with a jet like that but it seems + +39:39.920 --> 39:47.920 +incredible to me that jets that are flying at 30,000 feet that are leaving a contrail + +39:48.960 --> 39:55.040 +are usefully dispersing a poison in such a way that could be either monitored, measured, + +39:55.040 --> 40:03.920 +touched whatever everyone on earth then is I think that's a that's the worst one let me just say + +40:03.920 --> 40:12.400 +it like this that's the worst conspiracy theory to open with it's the worst conspiracy theory to + +40:13.440 --> 40:20.400 +to put on the board unless all of your other chips are played and to bring that one up very + +40:20.400 --> 40:27.760 +specifically to me I mean there's so many other things you could say it's kind of like you know + +40:27.760 --> 40:35.280 +do you bring up 9-11 and building 7 or do you bring up 9-11 and the pentagon or are you + +40:35.280 --> 40:42.960 +being 9-11 and shanksville or do you just leave 9-11 for the second conversation and I'm afraid that + +40:44.080 --> 40:49.760 +chemtrails are a little bit like that but I'm totally open anybody that wants to fill me in + +40:49.760 --> 40:57.680 +with links and stories and and proof and and and some you know explanation I'm down with that + +40:57.680 --> 41:00.880 +the nuclear war that we haven't been talking about it for 40 years and all of a sudden they + +41:00.880 --> 41:05.200 +started talking about it again this past year simply because it's a mechanism by which fear + +41:05.200 --> 41:11.680 +can be induced in the population to move it towards a one-world government so I think some + +41:11.680 --> 41:18.320 +of the structures are going to fall apart some of them we're going to beat up and as we build + +41:18.400 --> 41:22.880 +structures that work for us you know organically things will improve and it's just you know as I + +41:22.880 --> 41:26.160 +said before how much pain will there be for how many people we've doubled the number of people who + +41:26.160 --> 41:31.200 +are at the edge of starvation in the world since the pandemic started so despite all of the you + +41:31.200 --> 41:34.960 +know pretty talk from the WHO they've increased the starving people by over a hundred million + +41:36.240 --> 41:39.760 +and we don't want to do that we don't want to let people down we want to encourage + +41:39.760 --> 41:42.560 +agriculture there have been so many different ways in which agriculture has been attacked + +41:43.120 --> 41:47.520 +including the restrictions on fertilizer and energy so we have to become aware of all these + +41:47.520 --> 41:51.040 +things and then stop them you know if somebody in the government is working against the people + +41:51.040 --> 41:56.320 +we have to get rid of them I know it's easy to say but once everybody starts figuring this stuff + +41:56.320 --> 42:01.040 +out it's going to happen quickly I previously said that the two main things that we use to try to + +42:01.040 --> 42:06.320 +get rid of this whatever it is great reset we're trying to talk to people get more people on our + +42:06.320 --> 42:10.880 +side and using legal means in the courts and we have not been particularly successful at either + +42:10.880 --> 42:15.120 +but I do believe it's a hundred monkey phenomenon and when I hear that 52 percent of Americans + +42:15.120 --> 42:18.480 +think their health care system is no good that's important you know when the Florida governor + +42:18.480 --> 42:21.760 +says we're going to do things differently that's important and one day everyone's going to flip + +42:21.760 --> 42:30.800 +and think oh I felt this way all along so I think we have to keep doing what we're doing + +42:30.800 --> 42:34.640 +there are going to be some countries in which the legal system has more angles where you can bring + +42:34.640 --> 42:37.760 +cases that are likely to win people have to explore that we have to figure out what the + +42:37.760 --> 42:42.240 +angles are and and go you know go for the throat basically we haven't been good at it but in the + +42:42.240 --> 42:46.960 +United States at least at Children's Health Defense the lawyers think that the courts follow + +42:46.960 --> 42:50.080 +what society believes when everyone was scared about the pandemic the courts would not rule in + +42:50.080 --> 42:53.440 +our favor even when the law was on our side but people feel like that's changing because the + +42:53.440 --> 42:58.160 +judges have figured out that the pandemic isn't much anymore so I think it will be until we get + +42:58.160 --> 43:05.040 +the next pandemic you know it's a new world and we just have to keep playing away thank you so + +43:05.040 --> 43:10.480 +much thank you Meryl hello thank you so much Meryl and just to add to what you said working + +43:10.480 --> 43:13.600 +within the United Nations for many years I also met you know it's not all bad because we have a + +43:13.600 --> 43:16.880 +lot of incredible people working inside the organizations and the governments with the the + +43:16.880 --> 43:20.320 +heart and the right places so it's good for us to have people on the inside and it's good so she + +43:20.320 --> 43:25.360 +worked at the UN and there's a lot of good people with their hearts in the right place working at + +43:25.360 --> 43:30.160 +the UN just like there are lots of people in their hearts in the right place working at the who + +43:34.960 --> 43:38.400 +for us to start influencing people on the inside too and talk to them because there are a lot of + +43:38.400 --> 43:40.720 +good people there who probably would be on our side if they knew what was going on + +43:42.240 --> 43:47.280 +Michael so maybe I can come back to the question of accountability more specifically + +43:48.080 --> 43:52.000 +so this has been a large-scale crime it is a large-scale ongoing crime and so we should treat it as + +43:52.000 --> 43:55.760 +such we need to allow enough time to deal with it for dealing with it and it was proposed that maybe + +43:55.760 --> 43:59.760 +we can solve it top down we can try that maybe we can indeed get some get some good people into + +43:59.760 --> 44:04.720 +leading positions and they would then be in a good position to clean up the system top to bottom + +44:04.720 --> 44:10.240 +on the other hand I think we need to also start bottom up um this conspiracy I'm + +44:10.240 --> 44:15.120 +an avowed conspiracy theorist today um so this conspiracy has been very large in scope and it + +44:15.120 --> 44:22.800 +reached it if Mark uh is still in there this is Michael Palmer this is the guy who wrote the book + +44:22.800 --> 44:28.720 +that's on the on the internet archive which questions the idea of whether a real nuclear bomb was + +44:28.800 --> 44:37.040 +used in Japan or whether it was a huge kiloton bomb with mustard gas and that book is available + +44:37.040 --> 44:45.200 +on the internet archive and that guy's name is Michael Palmer and he is a biochemist from Canada + +44:45.200 --> 44:53.280 +who's actually German and he's one of the coordinators leaders founders of the Doctors for COVID + +44:53.280 --> 44:59.840 +ethics the um one of the groups that I started following very early in the pandemic that split + +44:59.840 --> 45:05.440 +into two and so there was the doctors for COVID ethics and then there's medical doctors for COVID + +45:05.440 --> 45:11.840 +ethics international the one that Stephen Frost would that invites me regularly um this group uh + +45:11.840 --> 45:19.760 +Doctors for COVID ethics is actually a group of them wrote the book um about the dangers of the + +45:19.760 --> 45:26.320 +transfection that was circulated and published or not published by but circulated and publicized + +45:26.320 --> 45:33.600 +by CHD um I think there was at least one of our fellows science fellows helped write that a little + +45:33.600 --> 45:43.120 +bit um and so this is Michael Palmer anyway that this is the guy there were very many levels to the + +45:43.120 --> 45:47.360 +down to the local level I think we need to start with the smallest perpetrators and get them to + +45:47.360 --> 45:52.800 +fess up who made you do what you did or that you do it voluntarily so um then they have a chance + +45:55.840 --> 46:00.000 +yeah so just simply just simply as you would start addressing organized crime so you just work + +46:00.000 --> 46:03.200 +your way bottom up you start with these small ones who might actually have a residue of decency + +46:03.200 --> 46:09.040 +left until um may see the most benefit of uh not taking the fall but indeed just naming those + +46:09.040 --> 46:12.960 +who made them do it and then we just work our way up level by level and we simply need to not + +46:12.960 --> 46:17.360 +tie off it we just simply need to keep that up not tie off it and simply try to uh just + +46:17.360 --> 46:21.600 +reconcile prematurely with everybody I think um all and I don't think that that will work with + +46:21.600 --> 46:29.600 +all we do respect to Dr. Palmer because um you're talking about you're trying to find the liar + +46:31.760 --> 46:36.960 +so if you go from the bottom of the chain up you're just gonna find people that say yeah this + +46:36.960 --> 46:41.680 +person told me we had to do it well this lawyer told me we had to do it well my administrator told + +46:41.680 --> 46:47.200 +me we had to do it well my state's health secretary said we had to do it well the + +46:47.760 --> 46:52.400 +emergency act said we had to do it the CDC said we had to do it so where do you go then you're + +46:52.400 --> 46:57.840 +already at the top there is no accountability when everybody's found an emergency plan and + +46:57.840 --> 47:04.720 +there's no second guessing the chain of command which is how basically this was done across school + +47:04.720 --> 47:09.360 +districts across county governments across state governments and across the federal government + +47:09.360 --> 47:16.480 +so in a way this sounds like a great idea and Meryl was just clapping because she thought it + +47:16.480 --> 47:21.360 +was a great idea but I'm not really sure it makes much sense to do this when we're in reality who + +47:21.360 --> 47:31.040 +are looking for the people who will not reconsider the truth the people who are smart enough to know + +47:31.040 --> 47:37.760 +and therefore have to be lying and that's why I think the work that we have done in the past + +47:37.840 --> 47:44.960 +at GIGO and biological has been invaluable because we have looked back at previous work we've looked + +47:44.960 --> 47:51.360 +back at previous interviews we've looked back at track records of people and found that despite + +47:51.360 --> 47:58.160 +their claims of being some of the smartest people on the internet the intellectual dark web was + +47:58.160 --> 48:07.360 +surprisingly on pace for the slowest runners in the marathon despite claiming that they were world + +48:07.360 --> 48:14.160 +class runners world class readers they were surprisingly not ahead of the TV + +48:17.200 --> 48:23.360 +and surprisingly unwilling to listen to people like me people like Mike Eden people like + +48:23.360 --> 48:30.800 +Byron brittle people like actually Michael Palmer and so I find it curious that he's on the stage I + +48:30.880 --> 48:38.480 +think it's great that he's on the stage but he's on the stage with some people that + +48:42.640 --> 48:50.240 +for sure have not been what is the best word is they have not been questioning the faith + +48:51.520 --> 48:55.520 +they just simply have not been questioning the faith we've talked about this up here the whole + +48:55.520 --> 49:01.840 +time and no one has mentioned the protocols no one is questioning what happened everybody is + +49:01.840 --> 49:11.360 +looking forward not forward in in terms of like trying to get out of the cave but forward in in + +49:11.360 --> 49:18.720 +progression of the narrative and all of these speakers have accepted that we are progressing + +49:18.720 --> 49:24.560 +in the narrative there is no putting on the brakes and getting out of the car and rearranging things + +49:24.560 --> 49:28.160 +and putting other people in the driver's seat and then turning around and going the other way or + +49:28.160 --> 49:39.520 +back where we were or anything like that we there is no going back and so with quite a nice illusion + +49:39.520 --> 49:46.080 +of consensus we have been given a set of choices which I think our choices which aren't going to + +49:46.080 --> 49:53.840 +get us where we want to go if we don't try to take back the existing governance infrastructure + +49:53.840 --> 50:03.760 +and try to remember try to remember + +50:12.800 --> 50:18.080 +you can't really quite see it I guess but the reason why I was so excited to get this sign + +50:18.960 --> 50:25.200 +off of Craigslist was not just because it's got a Dutch beer but because it was the 19th whole + +50:25.200 --> 50:37.520 +sign at a golf course 2019 isn't that long ago the way that our our world was organized in 2019 + +50:37.600 --> 50:48.480 +was not crazy and the way that our our our culture was organized and say the year 2000 isn't that + +50:48.480 --> 50:57.120 +long ago and wasn't that crazy and so we are being told a story about how everything needs to change + +50:57.120 --> 51:02.720 +now we are being told a story about how there's coming chaos that we're going to run out of food + +51:02.720 --> 51:09.200 +that everything is going to have to fall apart that it's only a question of how much pain is + +51:09.200 --> 51:16.480 +there going to be the reality is is that if we really could use the internet in a way that + +51:16.480 --> 51:22.640 +benefited us if if algorithms were really really twisted in a way so that they were to benefit + +51:22.640 --> 51:29.040 +the common man we would be able to organize and our ideas would go viral in a matter of days + +51:29.200 --> 51:37.440 +if a structure was set up on the internet for us to adequately express our desires and our goals + +51:38.000 --> 51:46.480 +and organizing in a meaningful way as fellow citizens of earth we would progress very rapidly + +51:48.640 --> 51:55.440 +but the entire social infrastructure and all of the parts of it essentially are orchestrated + +51:55.440 --> 52:02.640 +in a way to govern us and these people I believe think that in order for us to make the radical + +52:02.640 --> 52:09.040 +change to a global governance system with a global digital ID and a global central bank digital + +52:09.040 --> 52:19.280 +currency system we need to have chaos we need to have chaos and so I'm afraid that that's what's + +52:19.280 --> 52:27.520 +coming I'm afraid that we are already sort of seeing the first hints of it and that the plan is + +52:27.520 --> 52:32.880 +is some kind of chaos I don't know what it what exactly it will be perpetrators need to be flushed + +52:32.880 --> 52:38.080 +out need to be held accountable in order to discourage anybody in the future from following the example + +52:38.080 --> 52:42.320 +because if we don't do this then we will for sure face the next fake pandemic or whatever it is the + +52:42.320 --> 52:46.960 +next fake emergency that will be used as a pretext to rob us of our freedoms our livelihoods and even + +52:46.960 --> 52:57.200 +our lives thank you can you hear me from yeah wow there's not much I can add to that really but + +52:58.080 --> 53:01.760 +I'd just like to make the point I think that it's very difficult to change other people I mean you + +53:01.760 --> 53:06.080 +can try but you'll waste a lot of energy doing that I think it's very important to take accountability + +53:06.080 --> 53:10.160 +for your own actions and change yourself and how you behave and then expect the same of other people + +53:10.160 --> 53:13.120 +I mean politicians for example I don't want to blame politicians because I think a lot of them are + +53:13.120 --> 53:17.120 +trying to do what they think is the right thing but we don't hold them accountable for the things + +53:17.120 --> 53:21.600 +they do and don't say as he mentioned that Hancock which is you know he's come under a lot of + +53:21.600 --> 53:26.240 +flat recently for some of the things he did under his time as health minister but he gets I'm a + +53:26.240 --> 53:29.840 +celebrity he get me out of here and earns a few hundred thousand pounds you know and people go + +53:29.840 --> 53:33.600 +and watch him on TV and say this is always in that Hancock's on there people should be you know + +53:33.600 --> 53:37.760 +writing letters herringing any little thing that you can do to try and switch this from a downward + +53:37.760 --> 53:42.240 +spiral to a spiral of growth is good both because you're doing something positive and also because + +53:42.240 --> 53:46.080 +you're not doing something negative so I don't I think everyone should try to do a little thing + +53:46.080 --> 53:49.760 +each day towards the the life that you would rather have for the planet rather than the one that we're + +53:49.760 --> 53:56.080 +going I don't think writing letters is going to do very much thank you thank you Jonathan also I + +53:56.080 --> 53:59.520 +forgot that we Michael has not been introduced so Michael would you just want to introduce yourself + +53:59.520 --> 54:03.440 +briefly so people know briefly I'm an empty by training from Germany I've been living in Canada + +54:03.440 --> 54:08.560 +for 20 years where I taught biochemistry for 20 years and in March 2022 I became the first and only + +54:08.560 --> 54:13.360 +10 year professor in Canada to be fired over his refusal to get vaccinated + +54:18.960 --> 54:24.080 +thank you so much Michael so I know you all have been subject of censorship so I wanted to + +54:24.080 --> 54:29.280 +know do you have any advice to us and others on how we can protect ourselves or you know I know I + +54:29.280 --> 54:32.880 +discussed this with some of you but some people also feel that we can use it to our advantage so + +54:33.440 --> 54:35.040 +so a little bit on that + +54:35.040 --> 54:43.600 +censorship again it comes back to that you know you have to go with thick skin when + +54:44.640 --> 54:48.080 +certainly when I've been involved in this space when you start getting attacked or censored + +54:48.080 --> 54:51.200 +then for me it means you're over the target and you're making progress but then you don't stop + +54:51.200 --> 54:54.880 +there you then highlight that censorship so for example I I was censored a number of times on + +54:54.880 --> 54:58.320 +Facebook and banned for several days on sharing things like you know masks are probably not that + +54:58.320 --> 55:03.600 +effective and citing some really important peer reviewed evidence and then I went on first of + +55:03.600 --> 55:07.520 +all the daily express did a story saying I was censored about the mask stuff and then I then + +55:07.520 --> 55:11.840 +referred to Mark Zuckerberg as being an enemy of democracy on GV News and made sure that was + +55:11.840 --> 55:14.480 +disseminated right so people because people feel that they're all being affected by it but once + +55:14.480 --> 55:18.240 +you get the truth out I think more people feel more courageous to deal with it so something + +55:18.240 --> 55:21.520 +interesting and just breaking to share with you I met him last week after this after the Times + +55:21.520 --> 55:24.400 +newspaper in the Guardian did sort of hatchet jobs on me grooming anti-vaxxer and all that kind of + +55:24.400 --> 55:29.040 +stuff the Sunday Times called me that they're doing an article tomorrow and the guy called me + +55:29.040 --> 55:32.480 +and he was very straight so I'm not going to lie to you here the editor has asked me to do a story + +55:32.560 --> 55:37.280 +on rise of the conspiracy theorists okay rise of the conspiracy theorists + +55:37.280 --> 55:40.160 +and but let's have a conversation so I spoke to him for about 40 minutes actually back and + +55:40.160 --> 55:43.680 +forth a lot to discuss a lot of what I discussed in my lecture and he just sent me this message + +55:43.680 --> 55:47.280 +I said how's the article going I was the first person they called clearly right they wanted to + +55:47.280 --> 55:51.920 +feature me as a conspiracy theorist hi Assim yes file the piece in the end I felt our discussion + +55:51.920 --> 55:57.360 +was too complex and nuanced to really include in the article the focus was more on conspiracy + +55:57.440 --> 56:00.560 +theories which I'm now not entirely sure is how I describe your position + +56:07.440 --> 56:09.680 +so apologies for that although you may ultimately prefer it + +56:10.800 --> 56:13.520 +so you know the point of making there is I know it's difficult and I know it's not + +56:13.520 --> 56:16.960 +easy and I've spoken to Robert I think in the States it's probably a bit more difficult because + +56:16.960 --> 56:21.200 +whatever you say things can get twisted and smeared and you get lied about but I still honestly believe + +56:21.200 --> 56:25.360 +that don't underestimate the power of your speech and the power of the truth but to convey that + +56:25.360 --> 56:29.920 +in a place of of compassion and if they go low you go high + +56:36.800 --> 56:41.440 +not sure yeah okay this one works yeah so I think to add on I had similar experiences actually with + +56:41.440 --> 56:45.680 +a very famous British documentary filmmaker who spent a whole day with my family but then + +56:45.680 --> 56:50.160 +couldn't use the footage for the same reason that the journalist just cited but but I wanted to + +56:50.160 --> 56:53.200 +say something else it's the good news there's a good news here is that no matter what they're + +56:53.200 --> 56:58.480 +trying to do smear misrepresent lie you have to realize that the truth is it's it's the most + +56:58.480 --> 57:03.520 +cost effective way to communicate it's the cheapest the easiest and they can spend billions on their + +57:03.520 --> 57:16.240 +propaganda machine but here we'll are right we win so propaganda again I think last night + +57:16.240 --> 57:20.640 +Elon Musk tweeted Scott Adam says he had a major side effect from his second booster shot + +57:20.640 --> 57:23.440 +felt like he was dying for several days hoping hopefully no permanent damage + +57:24.480 --> 57:27.520 +and his cousin who is young and in peak health had a serious case of myocarditis had to go to + +57:27.520 --> 57:32.640 +the hospital so this is written from one of the wealthiest men in the world um that that I don't + +57:32.640 --> 57:40.000 +know how many millions of followers he's got in his twitter account i feel so inferior you know that + +57:40.000 --> 57:48.560 +was a microaggression uh so it's wicked like I said there are no morals there's no boundaries + +57:48.560 --> 57:54.320 +they will say and do anything the propaganda technology is very sophisticated it's very advanced + +57:54.320 --> 57:59.520 +and if you think it doesn't hurt um to have um your name dragged through the mud again and again + +57:59.520 --> 58:05.760 +again to have people denying uh your own personal CV and achievements uh it's it's not nothing + +58:06.640 --> 58:10.800 +when Jill and I realized what we were up against which was not like anything I had encountered in + +58:10.800 --> 58:16.080 +any of the prior six or so pandemics or major outbreaks that I've involved in um we realized + +58:16.160 --> 58:20.400 +that we needed to find some other way to get information out uh and and there's all these + +58:20.400 --> 58:23.840 +traditional channels like rallies etc and what we do when we travel and we talk to groups like you + +58:23.840 --> 58:32.080 +which is great um we embraced uh new alternative media and uh this is not bragging the two of us + +58:32.080 --> 58:36.560 +just Jill and I writing with occasional guest authors that we're very grateful for now with our + +58:36.560 --> 58:40.320 +sub-stack we reach on a daily basis about the same audience that CNN prime time does + +58:41.120 --> 58:48.000 +with that's quite uh when I went on a sub-stack rumor has it that that's been seen over a hundred + +58:48.000 --> 58:53.680 +million times Joe Joe Rogan Joe Rogan is the is acknowledged by internal corporate media + +58:54.640 --> 58:59.360 +advisory and analysis groups um Joe Rogan is acknowledged to be the major threat to corporate + +58:59.360 --> 59:05.760 +media currently people people are are recognizing that um the information streams that they've + +59:05.840 --> 59:10.560 +relied on are heavily contaminated they are they are propaganda they are not reliable sources + +59:10.560 --> 59:14.400 +and particularly the young which of course over time becomes the majority of the population + +59:14.400 --> 59:18.800 +have gone to a new model that is more of a menu driven information stream a diverse + +59:18.800 --> 59:24.960 +decentralized information stream again decentralized is is I think how we fight their drive towards + +59:24.960 --> 59:30.720 +centralization but my big message to you is number one um yeah they're wicked and it hurts + +59:30.720 --> 59:34.720 +okay it's not trivial and the strategies to divide and conquer like the Mickey Willis clip that I + +59:34.720 --> 59:39.280 +put up I can tell you when that's being done to you it is no fun at all when you're having people + +59:39.280 --> 59:43.520 +that you thought were in the trenches with you shooting at you in addition to your opponents + +59:43.520 --> 59:49.280 +that is no fun at all um and it's you face when you're on the battle lines of dealing with this + +59:49.280 --> 59:54.480 +you face impossible decisions there are no good decisions when when you're encountering + +59:55.120 --> 01:00:00.320 +this type of targeted defamation um there are no good decisions it is a business model + +01:00:00.320 --> 01:00:04.800 +you need to understand that the the media ecosystem now is completely different from what it was + +01:00:04.800 --> 01:00:10.400 +in the last century and it's not only a CNN business model to defame attack and propagate + +01:00:10.400 --> 01:00:15.360 +fear that business model goes all the way down to the smallest broadcaster okay and they can + +01:00:15.360 --> 01:00:20.400 +they can generate clicks and revenue by attacking somebody who's more prominent and they do it is + +01:00:20.400 --> 01:00:25.600 +it is a model and it is extremely difficult there are no good decisions the only way that we're + +01:00:25.680 --> 01:00:29.520 +going to get through that is we have to make it clear that those kinds of behaviors are not + +01:00:29.520 --> 01:00:34.400 +acceptable I tried to give you an introduction there you go so he's already telling you he's + +01:00:34.400 --> 01:00:38.720 +advocating for censorship it I didn't think that he would do it but I felt it coming + +01:00:40.160 --> 01:00:46.160 +that's no different than Robert F Kennedy Jr. saying that anti-Semitic speech should be punished + +01:00:47.760 --> 01:00:54.800 +that these people are either really unaware of the words they're using or they really think + +01:00:54.800 --> 01:01:03.280 +we're dumb because that's not an American thing to say the right thing to do when people use + +01:01:04.320 --> 01:01:11.520 +when they when people are punching up to try and climb the ladder of a nonsense you know + +01:01:11.520 --> 01:01:18.960 +wild west media environment is to just keep working just keep telling the truth just keep + +01:01:18.960 --> 01:01:25.200 +sticking to your morals and this idea of all of this you know there's no good decisions well + +01:01:25.200 --> 01:01:28.960 +what decision did he make he made the decision to sue the brigands + +01:01:32.800 --> 01:01:35.040 +and the brigands have a book about bioweapons + +01:01:36.960 --> 01:01:44.160 +and that suit didn't go anywhere but it got both of them a lot of publicity and so two books + +01:01:44.160 --> 01:01:52.000 +about the narrative sold his only other real action that he's taken is to out some people + +01:01:52.000 --> 01:02:00.240 +about them being bad guys like stupiders and and Ruby somebody or other Dr. Ruby and + +01:02:02.000 --> 01:02:04.960 +who else is he after now and George Webb + +01:02:07.200 --> 01:02:13.120 +sharing all their links to all their channels all their previous work even George Webb's appearance + +01:02:13.120 --> 01:02:20.000 +on 60 minutes interestingly enough the guy that George Webb thinks is the smartest doctor + +01:02:20.000 --> 01:02:25.200 +the biggest doctor speak out hero of the pandemic is now other than Paul Catrell + +01:02:26.480 --> 01:02:32.560 +who at least on two separate occasions was the host of Robert Malone on a podcast one of the first + +01:02:32.560 --> 01:02:39.920 +to ever do it in 2021 and certainly one of the lowest ranking podcasters as he would so aptly + +01:02:39.920 --> 01:02:46.800 +describe it here from the highest like Joe Rogan down to the lowest like like Paul Catrell + +01:02:47.920 --> 01:02:52.400 +who Robert Malone graced with his presence in the middle of 2021 + +01:02:56.400 --> 01:03:02.640 +I feel like this is a I feel like this is a lot more of an announcement than a warning + +01:03:03.520 --> 01:03:09.520 +I don't feel like we're giving given any useful direction here I don't think I've heard + +01:03:10.320 --> 01:03:18.640 +in any of this discussion that the fresh air is coming from over there or the light from the + +01:03:18.640 --> 01:03:28.320 +Sun is that way I haven't heard any of that I've heard a lot about inevitability I've heard a lot + +01:03:28.320 --> 01:03:36.400 +about the coming pain and the coming inevitable changes and the way that we might do it is just + +01:03:36.400 --> 01:03:41.120 +you know make our own parallel system because the whole thing is going to come falling apart + +01:03:41.120 --> 01:03:49.280 +crashing to the ground anyway I hear an announcement not a warning and to the tools and technologies + +01:03:49.280 --> 01:03:57.360 +of fifth generation warfare but I want to make it clear we cannot assimilate their ethics we cannot + +01:03:57.360 --> 01:04:04.000 +normalize lying we cannot accept the logic that if they've done it to us we can do it to them I + +01:04:04.000 --> 01:04:08.720 +firmly firmly reject that okay now keep in mind how magical this is because if you + +01:04:10.240 --> 01:04:16.720 +he's also said this several times where he said that you can't get give get trust unless you give + +01:04:16.720 --> 01:04:23.760 +trust and we shouldn't divide we should we should be uniting as ways of sort of tempering critique + +01:04:23.760 --> 01:04:27.680 +of himself and here I really feel like it's a very + +01:04:30.240 --> 01:04:42.160 +it's a very malevolent magic trick to to complain about lying to identify lying as a problem + +01:04:43.280 --> 01:04:52.000 +when at the heart of your behavior is lying and I don't I don't want to sit here and accuse people + +01:04:52.560 --> 01:04:56.560 +and I don't want to say it exactly that I have + +01:04:59.840 --> 01:05:04.320 +his story has changed so much from the beginning of the pandemic to the end of the pandemic the + +01:05:04.320 --> 01:05:11.120 +details have changed so much since he came out on the Brett Weinstein podcast in June of 21 until now + +01:05:13.840 --> 01:05:21.040 +that for me he has not been forthright from the beginning to the end he hasn't been forthright + +01:05:21.040 --> 01:05:27.840 +about his activities in 2020 up until 2021 he hasn't been forthright about his activities + +01:05:27.840 --> 01:05:32.960 +before the pandemic he hasn't been forthright about his understanding of the things that have + +01:05:32.960 --> 01:05:38.560 +gone on and that is evident because again he spent an awful lot of time podcasting + +01:05:40.240 --> 01:05:46.480 +which means we've got a lot of recordings of him we've got a lot of of diatribes by him and + +01:05:46.480 --> 01:05:53.280 +there's not an incredible evidence there's not incredible evidence of congruity between these + +01:05:53.280 --> 01:05:59.600 +various stories the stories change a lot you can just follow one character in his story like Michael + +01:05:59.600 --> 01:06:05.920 +Callahan for example and just go back to the beginning and find out what the story was from + +01:06:05.920 --> 01:06:11.600 +Robert's own mouth and then find a few more examples of him telling the story of Michael Callahan and + +01:06:11.600 --> 01:06:19.280 +look at how it changes now if you do that with each part of his narrative each part of his story + +01:06:19.920 --> 01:06:25.360 +and you look for evidence of really what their position is it actually depends on who's holding + +01:06:25.360 --> 01:06:31.280 +the microphone who's sitting in the audience and what day it is on the calendar + +01:06:34.000 --> 01:06:40.080 +and that's how I've drawn the conclusion that I'm I'm pretty sure that he's not being + +01:06:40.960 --> 01:06:47.760 +forthright about things all the time and so I don't know why but it's not to our benefit + +01:06:49.840 --> 01:06:54.400 +and these really do feel like warnings these really do feel like there's nothing you can do + +01:06:54.400 --> 01:07:00.480 +about it and this is what's coming if we accept that logic we become them okay we have to hold + +01:07:00.480 --> 01:07:07.520 +ourselves to higher standard so that's what what I tried to give you in my talk was to empower you + +01:07:08.240 --> 01:07:14.960 +to fight in this new media space but it is not easy and and it is a the terrain is constantly + +01:07:14.960 --> 01:07:21.360 +shifting and the only way that I think you and your children are going to persevere in this is + +01:07:21.360 --> 01:07:26.640 +you have to triangulate truth you know I've worked with a lot of CIA folks CIA are trained + +01:07:26.640 --> 01:07:31.360 +liars we are surrounded by trained propaganda slayers and it is very difficult to fair it out + +01:07:31.360 --> 01:07:37.120 +what truth there's there's a lot of strategies they use to confuse and your only weapon really + +01:07:37.520 --> 01:07:42.640 +is to keep your mind clear and sharp triangulate truth and think for yourself and join us in the + +01:07:42.640 --> 01:07:52.960 +battle please and so I just want you to imagine the possibility that if you were a CIA agent you + +01:07:52.960 --> 01:07:59.360 +would say exactly that that if you were an NSA agent you would say exactly that if you were a + +01:07:59.360 --> 01:08:06.240 +DoD agent or whatever agent of MI6 or whatever whoever's orchestrating this + +01:08:08.480 --> 01:08:14.560 +would say exactly that that those people are liars and therefore the transitive property or the + +01:08:15.200 --> 01:08:21.040 +that's not the transitive property but the the flip side of that is is that obviously he's telling + +01:08:21.040 --> 01:08:29.600 +the truth that's the magic trick that gets pulled there and you don't have this consistent + +01:08:29.600 --> 01:08:34.240 +behavior over three years you don't have this consistent behavior over two years so the only + +01:08:34.240 --> 01:08:40.640 +reason why you are or this audience would believe that he's telling the truth is because of that + +01:08:40.640 --> 01:08:54.800 +linguistic trick since the pandemic started I personally have learned something that has been + +01:08:54.800 --> 01:08:59.760 +invaluable to me it helps me almost on a daily basis and that is connecting to my intuition + +01:09:01.520 --> 01:09:02.640 +I've learned to listen to it + +01:09:02.640 --> 01:09:13.360 +and I really recommend that you try it if you haven't try to you know see what is your what is + +01:09:13.360 --> 01:09:17.680 +coming up you know what is coming into your mind or your body what makes your body tense or gives + +01:09:17.680 --> 01:09:24.400 +you you know I mean I have a really good take on people I know whether someone is a bullshitter + +01:09:24.400 --> 01:09:28.960 +from almost the first moment I see them and who is straight and all the rest you know and I mean + +01:09:29.040 --> 01:09:33.360 +I've just picked one winner after another since this pandemic started and the more you connect to + +01:09:33.360 --> 01:09:38.800 +that the sort of stronger gets the more information comes in somehow and that is what's helped me do + +01:09:38.800 --> 01:09:43.600 +my work all along I wouldn't be here without it whether it might be grace it might be God it + +01:09:43.600 --> 01:09:49.200 +might be the universe doesn't matter there are forces here that are here to help us yes thank you + +01:09:52.160 --> 01:09:57.520 +yes um that was a weird that was a weird story or information comes in somehow that was a weird + +01:09:57.520 --> 01:10:01.040 +statement and that is what's helped me do my work all along I wouldn't be here without it + +01:10:02.080 --> 01:10:06.480 +whether it might be grace it might be God it might be the universe doesn't matter there are forces + +01:10:06.480 --> 01:10:09.520 +here that are here to help us yes thank you + +01:10:12.480 --> 01:10:17.520 +yes um censorship seems to be a failing business model I mean we have seen twitter fail and they + +01:10:17.520 --> 01:10:21.360 +have been forced simply by people voting with their feet to remove much of that censorship I + +01:10:21.360 --> 01:10:24.400 +guess we'll have to see wait and see how far that goes whether twitter will actually would have + +01:10:24.400 --> 01:10:28.480 +become fully truly transparent and open to everybody but I think we saw a clear case of + +01:10:28.480 --> 01:10:33.760 +business failure due to censorship and I mean whether or not we can rebuild all of society's + +01:10:33.760 --> 01:10:36.640 +institutions maybe we cannot but on the other hand in the media this seems to be simple enough + +01:10:36.640 --> 01:10:40.320 +I mean with the internet everybody who can write and think think and write can actually have their + +01:10:40.320 --> 01:10:44.640 +own subject for example or some other blog or on website it would be successful simply + +01:10:44.640 --> 01:10:49.840 +if they manage to produce convincing content so as long as we can hold on to the internet as + +01:10:49.840 --> 01:10:54.320 +such the entire internet being freely accessible and free from censorship I think in the long term + +01:10:54.320 --> 01:10:59.760 +I think people overcome censorship thank you that is true I think to a certain extent if the + +01:10:59.760 --> 01:11:07.440 +if things like peer tube and soapbox and and federated distributed networks can be built + +01:11:08.800 --> 01:11:14.800 +and my server links to all other trusted servers and yada yada yada I think that's a great idea + +01:11:15.360 --> 01:11:20.400 +but there's a certain threshold that's going to need to be reached and they're going to the + +01:11:20.400 --> 01:11:24.640 +corporations that now control those spaces are going to do everything that they can to make + +01:11:24.640 --> 01:11:29.200 +that not happen they're going to pass laws to make it hard for that to happen they're going to make + +01:11:29.200 --> 01:11:35.920 +laws about censorship that will make it hard for maybe even illegal to have a decentralized + +01:11:35.920 --> 01:11:43.200 +network like that that can't be policed or allows these kinds of illicit materials to circulate + +01:11:44.080 --> 01:11:50.640 +or angry messaging violent messaging will be a way for them to regulate or even + +01:11:52.080 --> 01:12:00.800 +ban these unregulated federated spaces so I think in a way you're really hearing a warning + +01:12:00.800 --> 01:12:05.760 +and an announcement here at the same time it's an announcement that this is what's going to happen + +01:12:05.760 --> 01:12:10.800 +that this is where we're going I don't really hear a bad guy in Michael Palmer but I do hear + +01:12:10.800 --> 01:12:17.280 +somebody who who sees what's coming and uh I just don't think he understands that + +01:12:17.840 --> 01:12:22.480 +that the team that he's playing for right here is probably much more about announcing than they + +01:12:22.480 --> 01:12:25.760 +are about warning even though I think Michael Palmer is still on the warning team + +01:12:30.720 --> 01:12:36.480 +uh message to self never go after something with your gut feeling unless it's intuition you know + +01:12:36.480 --> 01:12:39.520 +quite often you you pull up a tweet or you see oh look at that you know because it confirms to + +01:12:39.520 --> 01:12:42.560 +what you would like to believe you forward it immediately to 30 people and then suddenly + +01:12:42.560 --> 01:12:48.320 +realize it was fake news and anything that ends in ism is bad because it's an ideology and life + +01:12:48.320 --> 01:12:51.920 +just doesn't work like that we life will never be perfect it's always going to be a balance of + +01:12:51.920 --> 01:12:56.960 +factors leading to some particular outcome so if anyone's preaching ism to you don't listen or + +01:12:56.960 --> 01:13:00.960 +challenge them I would say because I think we've been social media has an amazing effect on society + +01:13:00.960 --> 01:13:04.800 +it's polarizing us into two groups and we'll fight in those two groups or more and also that + +01:13:04.800 --> 01:13:08.320 +the authorities have real-time feedback on the things they're dropping into this information + +01:13:08.320 --> 01:13:11.440 +space how people are reacting to that so we're a little bit like uh predators in + +01:13:11.440 --> 01:13:17.200 +in the headlight and we need to be smarter than that so yeah thank you pray and pray in the + +01:13:17.200 --> 01:13:21.440 +headlights wouldn't want it would be not predators in the headlights I like that that's not a bad + +01:13:21.440 --> 01:13:27.600 +statement follow the dualism and anything anything anything anything I preferred actually Nick Hudson + +01:13:27.600 --> 01:13:33.440 +statement though that really the way to see through this scam is that when they say it's a global + +01:13:33.440 --> 01:13:37.600 +problem or a global crisis that needs a global solution you know they're full of bull + +01:13:38.960 --> 01:13:46.000 +and so we should be thinking of it that way the isms are are obviously distractions the isms are + +01:13:46.960 --> 01:13:52.880 +are are something that just are ridiculous but I think a more + +01:13:54.320 --> 01:13:58.320 +bulletproof rubric is one where when we're told that it's a global crisis + +01:13:59.200 --> 01:14:03.200 +or a global problem that needs a global solution we're done we're not in that + +01:14:03.920 --> 01:14:10.400 +so thank you Jonathan we're gonna have to round up but as I always do when I interview people I + +01:14:10.400 --> 01:14:13.760 +want to end it on a positive note so I was thinking that maybe all of you because we just entered + +01:14:13.760 --> 01:14:19.600 +2023 could give us a short short short short short short inspiring uh message or quote for 2023 + +01:14:20.480 --> 01:14:21.600 +uh mike for a seam + +01:14:26.240 --> 01:14:30.640 +um you'll make the best friends you've ever had you get in this battle with us + +01:14:31.600 --> 01:14:32.240 +yes + +01:14:36.000 --> 01:14:39.920 +maybe someone else can go ahead I would say that I mean we've been driven into new networks now + +01:14:39.920 --> 01:14:43.200 +people that we'd never appreciated that we would have interacted with before this happened + +01:14:43.200 --> 01:14:45.920 +and that's an entirely positive thing because now you work with people that live on the other + +01:14:45.920 --> 01:14:54.160 +side of the world that you never met before amazing well I can only agree with my two predecessors + +01:14:54.160 --> 01:14:58.400 +thank you it's it's indeed the best people I've ever met in my life just during the last two years + +01:15:00.960 --> 01:15:09.440 +um what I see is when people wake up they're often overwhelmed by a sense of hopelessness and + +01:15:09.440 --> 01:15:14.240 +helplessness when they encounter what has transpired over the last three years and the message I'm + +01:15:14.240 --> 01:15:19.840 +trying so hard this quarter to push out is that we don't have to be victims we don't have to be + +01:15:19.840 --> 01:15:25.440 +hopeless and helpless we can all be empowered we can all be engaged we can all help to move this + +01:15:25.440 --> 01:15:30.160 +forward towards the future that we would rather have for our children and it begins with each + +01:15:30.160 --> 01:15:34.320 +one of you committing to being a warrior and not being a victim whether you're vaccine + +01:15:34.320 --> 01:15:39.040 +damaged psychologically damaged lost your job you do not have to be a victim don't let them + +01:15:39.040 --> 01:15:39.680 +victimize you + +01:15:44.400 --> 01:15:49.040 +yes I think I have the you know similar message my main message is you while you heard about warfare + +01:15:49.040 --> 01:15:52.880 +and bio weapons and things like that being deployed here the message is you should not be afraid + +01:15:52.880 --> 01:15:56.800 +there's nothing to be afraid of because once you know who the enemy is and what really is going on + +01:15:56.800 --> 01:16:02.160 +then you can act accordingly you can be confident and empowered to act accordingly there's no longer + +01:16:02.160 --> 01:16:06.880 +this invisible mutating you know BS coming from the department of defense you just know that it's + +01:16:06.880 --> 01:16:12.000 +BS and you can you know you can you can you can formulate a coherent strategy so my message for + +01:16:12.000 --> 01:16:13.200 +2023 be not afraid + +01:16:17.440 --> 01:16:21.920 +so my late father was one of my my greatest inspirations and just to give you an idea of his + +01:16:21.920 --> 01:16:24.400 +character the mayor of Manchester when he died said he was one of the kindest souls to ever walk + +01:16:24.480 --> 01:16:27.680 +the earth and I think that's probably true I'll be biased and say that um but this is I'm just + +01:16:27.680 --> 01:16:30.080 +gonna finish with actually I think very relevant to everything we've been saying today and I gave + +01:16:30.080 --> 01:16:34.080 +this is eulogy the he was well known amongst his friends and on twitter for sharing lessons for + +01:16:34.080 --> 01:16:37.840 +life he was very very philosophical and very wise my religion is humanity there is no need for + +01:16:37.840 --> 01:16:42.240 +mosques synagogues or temples no need for complicated philosophy our own brain our own heart is our + +01:16:42.240 --> 01:16:46.560 +is our temple the philosophy is kindness doing good to others and he gave his top these are very + +01:16:46.560 --> 01:16:51.120 +briefly his top 10 or finished with his top 10 personal tips completely I think is relevant + +01:16:51.200 --> 01:16:54.800 +everything we've been discussing today enjoy the climb and don't just focus on the end goal + +01:16:54.800 --> 01:16:58.000 +live in the moment and take something special from each day do not worry if someone does + +01:16:58.000 --> 01:17:03.040 +you harm as they've only harmed themselves live as you wish to be seen again by improper methods + +01:17:03.040 --> 01:17:06.640 +is no gain at all always do the right thing as this will give you the peace and tranquility + +01:17:06.640 --> 01:17:10.720 +that we all seek lament not if you are manipulated or used because discovering such is a moment of + +01:17:10.720 --> 01:17:16.000 +freedom do not harbor anger or resentment as it only harms you and lastly last but not least + +01:17:16.000 --> 01:17:18.480 +a small group of loyal friends can bring you all the happiness you desire + +01:17:23.440 --> 01:17:28.080 +thank you thank you all so and then I just wanted to end with my favorite quote which is + +01:17:28.080 --> 01:17:31.840 +be the change you want to see in the world so thank you so much to all of you for all the + +01:17:31.840 --> 01:17:36.240 +incredible things that you're doing for humanity and you know I'm myself looking forward to + +01:17:36.240 --> 01:17:39.040 +working with all of you in 2023 and make this world a better place + +01:17:39.520 --> 01:17:41.520 +thank you + +01:17:42.960 --> 01:17:50.400 +ladies and gentlemen we can't have a good accounting of where the mystery virus came from unless + +01:17:50.400 --> 01:17:56.480 +we do the math and that math is something that people don't want to do we've got to force them + +01:17:56.480 --> 01:18:01.680 +to do that math over and over again and we've got to keep telling this story over and over again + +01:18:01.680 --> 01:18:06.720 +this wasn't that great of a show tonight but at least we were together at least I saw you tonight + +01:18:06.800 --> 01:18:11.440 +at least I exercised the throat a little bit and I didn't break the street hopefully tomorrow + +01:18:11.440 --> 01:18:19.280 +will be a little bit better tomorrow's throwback Thursday but I think throwback Thursday well + +01:18:19.280 --> 01:18:24.000 +I don't know I don't know what I'm gonna do tomorrow but sometime this weekend I'm gonna take a look + +01:18:24.000 --> 01:18:32.240 +at the Matt Crawford rounding the earth that went on yesterday because it was a a wonderful show + +01:18:32.240 --> 01:18:40.160 +of admissions and and backpedaling and antics and hilarity + +01:18:42.320 --> 01:18:48.080 +I hadn't seen those guys in almost like two months and so I kind of thought that they had + +01:18:48.640 --> 01:18:53.680 +moved on to the mathematics of ancient Judaism and stuff like that but apparently + +01:18:54.320 --> 01:18:58.800 +they're still pretty fired up about the biology that we were teaching for the last three years + +01:18:58.880 --> 01:19:06.320 +so that was really flattering and it was funny and confusing and sad but it was nice because they + +01:19:06.320 --> 01:19:11.760 +clarified for me anyway they clarified the kind of stuff that they don't understand they clarified + +01:19:11.760 --> 01:19:17.280 +the stuff that they think they understand but you know our way over their skis on and then it also + +01:19:17.280 --> 01:19:26.480 +really clarified the kind of narrative that they're really attempting to tell because one of the + +01:19:26.480 --> 01:19:32.880 +things that was most extraordinary and I'll just leave it at this is that as they argued with Matt + +01:19:34.080 --> 01:19:43.200 +consistently about the idea that this protein in the SARS-CoV-2 virus had a 20 amino acid sequence + +01:19:43.200 --> 01:19:51.040 +that was capable of causing prion disease and that a single prion protein is enough to cause + +01:19:51.040 --> 01:19:58.800 +prion disease and yet somehow or another the virus leaked it's spread around the world for + +01:19:58.800 --> 01:20:05.600 +three years we've tracked it through millions of people and there's still not really a noticeable + +01:20:05.600 --> 01:20:14.080 +signal in prion disease and humans nowhere anywhere and then to top it off we've actually + +01:20:14.720 --> 01:20:22.160 +transfected over a billion people with the same protein albeit with a different codon optimized + +01:20:22.160 --> 01:20:29.600 +sequence I find it really curious that that was really one of the main messages of that + +01:20:30.400 --> 01:20:36.080 +live stream except for of course that they admitted freely that everything's clones it's all clones + +01:20:36.080 --> 01:20:42.080 +it's all clones said Rixie and McCarran after a year and a half of calling me an idiot for talking + +01:20:42.160 --> 01:20:47.360 +about clones and then McCarran said it was all exosomes and the proteins that are the excess + +01:20:47.360 --> 01:20:54.880 +number of proteins that are produced and the exosomes actually matter so in my mind you know + +01:20:54.880 --> 01:21:02.000 +they carried the football over the over the foot over the end zone for me twice sat down on it + +01:21:02.000 --> 01:21:07.760 +and gave me a safety so it's four to nothing and I didn't even get on the football field yet so as + +01:21:07.760 --> 01:21:12.320 +far as I'm concerned I'm going to wait until they kick me a field goal or score me a touchdown + +01:21:12.880 --> 01:21:18.720 +before I even bothered to put my pads on this has been giga ohm biological it's a high resistance + +01:21:18.720 --> 01:21:24.400 +low noise information brief brought to you by a biologist our consistent message and I will say + +01:21:24.400 --> 01:21:30.720 +that very very proudly our consistent message over the last year or so has been that we don't + +01:21:30.720 --> 01:21:34.800 +really know what happens but we definitely know that they're trying to eliminate the control group + +01:21:34.800 --> 01:21:40.560 +by any means necessary because intramuscular injection of any combination of substances with + +01:21:40.560 --> 01:21:46.240 +the intent of augmenting the immune system is dumb and they know it. Transfection in healthy + +01:21:46.240 --> 01:21:51.920 +humans is criminally negligent and they know it and most importantly viruses are not pattern + +01:21:51.920 --> 01:21:56.960 +integrity and they also know that so I am going to be a broken record for a while I am going to be + +01:21:56.960 --> 01:22:01.040 +saying this an awful lot and if you're joining me on a regular basis then you're going to hear + +01:22:01.120 --> 01:22:06.480 +it an awful lot thanks I don't know what to say I'll see you guys again tomorrow it is thanks + +01:22:06.480 --> 01:22:11.120 +giving but I'll be doing a show because we're just having a little meal in the house with + +01:22:12.720 --> 01:22:17.600 +my wife is a wonderful cook my kids are wonderful kids and so I'm going to be spending most of + +01:22:17.600 --> 01:22:22.000 +the time trying to keep the kids busy while they stay out of the way of my wonderful cook and + +01:22:22.000 --> 01:22:25.920 +then we're going to enjoy that meal we're going to play some games we're going to watch a movie or + +01:22:25.920 --> 01:22:30.560 +something like that and then later on I'll come down here and and pump out a stream from the back + +01:22:30.560 --> 01:22:35.280 +of the garage so anyway thanks for joining me and I'll see you tomorrow + +01:24:00.560 --> 01:24:02.640 +you + diff --git a/twitch/1984857726 (2023-11-22) - OVID_ A Fine Line between Warning and Announcement --(22 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/README.md b/twitch/1984857726 (2023-11-22) - OVID_ A Fine Line between Warning and Announcement --(22 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/README.md new file mode 100644 index 0000000..a847207 --- /dev/null +++ b/twitch/1984857726 (2023-11-22) - OVID_ A Fine Line between Warning and Announcement --(22 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/README.md @@ -0,0 +1,5 @@ +# OVID: A Fine Line between Warning and Announcement --(22 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief + +## Streams +- - https://twitch.tv/videos/1984857726 + diff --git a/twitch/1985683350 (2023-11-23) - Thanks Pieter but LNPs are not Magic --(23 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/1985683350 (2023-11-23) - Thanks Pieter but LNPs are not Magic --(23 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief.vtt b/twitch/1985683350 (2023-11-23) - Thanks Pieter but LNPs are not Magic --(23 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/1985683350 (2023-11-23) - Thanks Pieter but LNPs are not Magic --(23 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief.vtt new file mode 100755 index 0000000..fa5002e --- /dev/null +++ b/twitch/1985683350 (2023-11-23) - Thanks Pieter but LNPs are not Magic --(23 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/1985683350 (2023-11-23) - Thanks Pieter but LNPs are not Magic --(23 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief.vtt @@ -0,0 +1,3062 @@ +WEBVTT + +00:00.000 --> 00:13.920 +testing one two I said 10 22 10 29 I don't think that worked out quite how I + +00:13.920 --> 00:21.980 +wanted to but we're gonna manage to make it work you can find me at giggle + +00:21.980 --> 00:28.900 +and biological.com you can also go to the soapbox link that you can find there + +00:28.900 --> 00:34.180 +which is also at giggle ohm.bio happy thanks giving everybody happy thanks + +00:34.180 --> 00:40.920 +giving Pamela Watcherby tense oral strain there's a click there that you can do + +00:40.920 --> 00:45.580 +to watch the show you can also download the stream deck starting next week we're + +00:45.580 --> 00:51.900 +gonna have the stream deck up I hope every time I do a stream at least every + +00:51.900 --> 00:56.860 +week stream and that means that you can start subscribing again if you'd like + +00:56.860 --> 01:01.420 +to get something like an email and a PDF of the show beforehand it might only + +01:01.420 --> 01:06.340 +be for Fridays or Wednesdays or whatever day we're gonna make it but + +01:06.340 --> 01:10.860 +someday at some point we're gonna start that PDF stuff again because these + +01:10.860 --> 01:15.260 +slides have started to become good enough that I think they're shareable + +01:15.260 --> 01:21.060 +and useful for people to start to really push these ideas out they haven't been + +01:21.060 --> 01:26.140 +there in a long time and so I think it's really nice for this to happen + +01:26.140 --> 01:31.220 +it is a little lonely in this crazy brainwashed world I'll tell you what it's + +01:31.220 --> 01:35.860 +very lonely my wife feels very lonely + +01:38.020 --> 01:47.140 +it's yeah it's tough thanks for coming tonight guys I didn't tweet it I didn't + +01:47.140 --> 01:51.260 +share it I didn't do anything I didn't have time it's Thanksgiving I just wanted + +01:51.260 --> 01:57.780 +to get a stream out there and keep the streak alive and keep the keep the + +01:57.780 --> 02:03.220 +sea warm keep the rig warm + +02:08.300 --> 02:15.220 +I yelled at the basketball team the other night my throat is still a little sore + +02:21.260 --> 02:43.980 +you schedule for 60 minutes next is going on French British Italian Japanese + +02:43.980 --> 02:51.060 +television people everywhere are starting to listen to him it's embarrassing yeah + +02:51.060 --> 02:55.060 +I'm gonna have to start with some more I'm gonna have to start with some more + +02:55.060 --> 03:01.820 +inspirational some more inspirational stuff in the beginning again I used to + +03:01.820 --> 03:06.740 +put a lot of work a lot more work into that beginning section of video so I + +03:06.740 --> 03:10.260 +just didn't think anybody was watching them but that one was a really good one + +03:10.260 --> 03:14.140 +keep in your arms straight + +03:40.260 --> 04:02.620 +so you know the drill you can look me up on PubMed and the name of the channel + +04:02.620 --> 04:06.980 +is derived from the resistance of the recordings that I used to make giga home + +04:06.980 --> 04:13.420 +resistance high-resistance low-noise information brief let's get this thing + +04:13.420 --> 04:15.860 +started + +04:36.980 --> 04:46.500 +I feel like my computer slowed down there for a minute hopefully you guys + +04:46.500 --> 04:56.620 +didn't lose anything yes happy Thanksgiving everybody good to see + +04:56.620 --> 05:02.380 +everyone here it's like we lost a few viewers see I told you I told you something + +05:02.380 --> 05:08.100 +poopy's going on they don't like it our information and our message is + +05:08.100 --> 05:13.060 +getting too sharp they don't like it at all + +05:32.420 --> 05:38.220 +yes yes truth bombs at dinner that's an understatement I bet at some of these + +05:38.220 --> 05:42.200 +places that we've been today thank you very much for joining me this is + +05:42.200 --> 05:45.900 +giga home biological a high-resistance low-noise information brief brought to + +05:45.900 --> 05:50.260 +you by a biologist if there's anything wrong with the timing or anything like + +05:50.260 --> 05:56.060 +that give me a shout out we are still here fighting against the same sort of + +05:56.060 --> 06:02.860 +nonsense you know the illusion of consensus the Scooby-Doo created by these + +06:02.860 --> 06:08.940 +people on social media I'm starting to really see what happened I know that + +06:08.940 --> 06:13.220 +there was this TV stuff and this stuff in Congress and whatever but I'm starting + +06:13.220 --> 06:19.300 +to understand how these people are all linked and it has a lot to do with these + +06:19.300 --> 06:24.780 +new social media and new communication platforms that came online during the + +06:24.820 --> 06:31.100 +pandemic and there's more than one there's actually about five or six and we can + +06:31.100 --> 06:35.380 +start to look back at when that was all happening when we were all scrambling + +06:35.380 --> 06:41.740 +during this during this censorship time in 2020 oh my goodness I can see it + +06:41.740 --> 06:47.380 +also clearly now I'm really excited as we break through some of this stuff on the + +06:47.380 --> 06:55.820 +18th and 19th of November in Bucharest Romania there was a COVID conference and + +06:55.820 --> 07:00.380 +some of our friends were at this COVID conference I'm gonna go over here + +07:00.380 --> 07:08.660 +pull myself down here and see if we can use my mouse to he has so just the + +07:08.660 --> 07:14.060 +prominent ones for now I'll pop my head down for a second Robert Malone was + +07:14.100 --> 07:19.000 +there Nick Hudson was there Brett Weinstein was there you can see this + +07:19.000 --> 07:24.740 +arrow right yeah and Denny Rancor was there among others which is kind of cool + +07:24.740 --> 07:31.620 +because as you know there is this there is this you know consensus that we're + +07:31.620 --> 07:34.460 +trying to battle against something and all of us are trying to work together + +07:34.460 --> 07:41.700 +towards some amorphous goal like health freedom or something like that and there + +07:41.740 --> 07:45.840 +is this faith in a novel virus this faith that millions of people were + +07:45.840 --> 07:50.500 +killed by it this faith that millions more were saved from it this faith that + +07:50.500 --> 07:55.280 +gain a function is real and possibly the source of it and therefore a virus will + +07:55.280 --> 08:00.420 +come again and this story is basically not been questioned by most of the + +08:00.420 --> 08:07.300 +people that we have been trying to look to for leadership in this in this fight + +08:07.300 --> 08:15.700 +to return to you know pre-2019 Western civilization which clearly we're never + +08:15.700 --> 08:19.780 +going to do the build back better the new normal this was all for real to make + +08:19.780 --> 08:27.180 +sure that we never thought we could have that back again and so in some ways it + +08:27.180 --> 08:35.980 +would be it should be somewhat curious if we can't find any leader on this + +08:36.020 --> 08:40.900 +playing board that doesn't want to say just simply well why don't we just go + +08:40.900 --> 08:44.500 +back to the way we were doing it about four years ago and start there and then + +08:44.500 --> 08:49.540 +we can repeat we can we can fix that but first of all we got to go back to that + +08:49.540 --> 08:57.340 +and everybody that through that out needs to be held to account + +08:57.340 --> 09:02.260 +everybody that just went against all those rules whence against all those + +09:02.300 --> 09:07.460 +norms went against all those expectations those people need to be held to + +09:07.460 --> 09:11.260 +account but that doesn't seem there doesn't seem to be anyone who's + +09:11.260 --> 09:17.220 +interested in that particular path and in fact yesterday I wanted to point that + +09:17.220 --> 09:21.500 +out and so that was one of the reasons why we went through that that video from + +09:21.500 --> 09:26.700 +Stockholm earlier this year so some more people were there that that definitely + +09:26.700 --> 09:31.180 +as far as I know aren't questioning the narrative that I really like Byron + +09:31.180 --> 09:36.660 +Bridal a lot and he's a great guy but he is not questioning there being a + +09:36.660 --> 09:41.860 +novel virus that spread around that's spreading still Jessica Rose hasn't + +09:41.860 --> 09:48.220 +questioned that even though she has done a selfie with Denny Rancor she has an + +09:48.220 --> 09:53.180 +acknowledge that that one of the main findings of Denny's data is that there's + +09:53.180 --> 09:59.900 +no evidence of spread of a novel deadly pathogen Harvey Reich is also another + +09:59.980 --> 10:08.260 +guy who I've talked to before and not on my show live but on a stream with with + +10:08.460 --> 10:12.780 +oh I'm not gonna remember her name and shoot that's really annoying Kathy + +10:12.780 --> 10:17.500 +something I believe I apologize for that if you're watching but it's a one of + +10:17.500 --> 10:21.740 +these private zoom calls so Harvey Reich is another guy who's not questioning + +10:21.740 --> 10:26.100 +the narrative there's Ryan Cole I'm not sure how much he's questioning the + +10:26.100 --> 10:30.300 +spread of a novel virus but I don't think that he's really there yet he's + +10:30.300 --> 10:35.300 +certainly not there yet with regard to promoting Denny Rancor's data and what + +10:35.300 --> 10:41.100 +Denny Rancor's data tends to you know it seems to show here's Jill Glasspool + +10:41.100 --> 10:46.540 +Malone and Meryl Nast you know that those two are also probably not pushing + +10:46.540 --> 10:53.380 +that narrative and then again what Brett Weinstein Nick and Robert and Denny + +10:53.380 --> 11:00.260 +Rancor so even if Denny Rancor is there and he presents to all these people and + +11:00.260 --> 11:06.580 +Robert Malone tweets it out he tweets out that 17 million people were killed + +11:06.580 --> 11:13.540 +by the vaccine and that he's never seen such shocking accounting of the 17 + +11:13.540 --> 11:17.700 +million people around the world estimated to be killed by the vaccine but he's + +11:17.700 --> 11:22.180 +not at all shocked by the conclusion that there's no evidence of spread that + +11:22.180 --> 11:26.900 +the spread respected even borders of counties in the United States it has + +11:26.900 --> 11:35.420 +correlated much much better to to poverty and mental illness and income than it + +11:35.420 --> 11:46.460 +is to to like proximity of the previous cases or proximity of of of large + +11:46.540 --> 11:51.620 +incidences or events of all cause mortality I'm getting really good at + +11:51.620 --> 11:55.340 +not saying um when I'm doing these things but it's sometimes I have to pause + +11:55.340 --> 12:03.700 +for a second there um anyway and then I said okay this is all because these + +12:03.700 --> 12:08.540 +people have participated in this in this illusion of consensus and I don't know + +12:08.540 --> 12:12.700 +to what extent they were aware of this illusion before the start of the + +12:12.700 --> 12:16.140 +pandemic but most of them have to be aware of the illusion now because most of + +12:16.140 --> 12:21.180 +them have heard my my discussion of it our discussion of it over these + +12:21.180 --> 12:26.220 +this past year or so and most of them know what our contention is and they + +12:26.220 --> 12:29.340 +don't have a real meaningful argument because the only people that have + +12:29.340 --> 12:32.460 +tried to meaningfully argue with me are now blocking me on Twitter and no + +12:32.460 --> 12:37.340 +longer discussing it all and that's because again it really feels very very + +12:37.340 --> 12:43.980 +positive that that these these people are all involved in + +12:44.060 --> 12:48.300 +making sure that the worst case scenario of a pandemic caused by a gain of + +12:48.300 --> 12:52.940 +function virus is never out of your possibility space even if you don't + +12:52.940 --> 12:57.020 +believe that's what happened this time they need you to believe that that's + +12:57.020 --> 13:01.580 +what gonna happen next time or could happen next time or or eventually will + +13:01.580 --> 13:07.740 +happen they need you to believe that maybe in the + +13:07.740 --> 13:11.980 +same way that they needed us when we were children to really believe that + +13:11.980 --> 13:17.100 +the Russians had nine thousand warheads and we had six thousand warheads + +13:17.100 --> 13:22.300 +and they were on a on a hair trigger well two hair keys + +13:22.300 --> 13:27.900 +so i i don't you know i i have a hard time understanding + +13:27.900 --> 13:32.140 +anymore what history really is given the fact of all of things that i've + +13:32.140 --> 13:36.300 +learned over the last three years about how willing and able + +13:36.300 --> 13:42.380 +this apparatus is to govern us with lies in mythology + +13:42.380 --> 13:46.700 +and so i think that this illusion of consensus really needs to be inspected + +13:46.700 --> 13:51.020 +for this mythology and i suspect that we're going to find that it mostly is + +13:51.020 --> 13:54.060 +and that's why i think you need to think of this as a card game + +13:54.060 --> 13:59.500 +a card game with a rig deck a card game with a rig deck that a dealer is trying + +13:59.500 --> 14:03.260 +to steal your money so when you get the cards in order for you to have any + +14:03.260 --> 14:07.420 +meaningful chance of gambling with success + +14:07.420 --> 14:12.300 +you have to play knowing that the dealer is trying to get you + +14:12.300 --> 14:17.580 +to make a mistake so what would that mistake be + +14:17.580 --> 14:20.940 +how would they how would they communicate to those + +14:20.940 --> 14:25.260 +inside the game versus those outside the game + +14:25.260 --> 14:29.660 +what kinds of clues would there be that there's a game being played + +14:29.660 --> 14:34.300 +i think one of the clues that that Matt Crawford + +14:34.300 --> 14:38.540 +of rounding the earth pointed out about two years ago was this + +14:38.540 --> 14:43.580 +possibility that this covid is actually ovid + +14:43.580 --> 14:50.140 +ovid being this famous greek set of stories + +14:50.140 --> 14:55.820 +about various metamorphosis a lot of them are kind of like punishments or + +14:55.820 --> 15:00.140 +or or gods being vindictive but the point + +15:00.140 --> 15:04.860 +only being uh in this thing that this is a time of + +15:04.860 --> 15:08.700 +transformation and some of the the themes + +15:08.700 --> 15:14.220 +of ovid's metamorphosis in relation to the the fall of rome + +15:14.220 --> 15:21.100 +and the theme of let's say order being imposed on a world + +15:21.100 --> 15:25.660 +founded on chaos or based from or or growing from chaos + +15:25.660 --> 15:33.180 +an order is imposed on that and so in this story + +15:33.180 --> 15:39.580 +in this idea of covid it could be that in order to transform us into a new + +15:39.580 --> 15:43.260 +global government in order to transform us into a new global + +15:43.260 --> 15:47.740 +governance structure based on on digital currencies and digital + +15:47.740 --> 15:51.980 +IDs and no more national borders that mean anything + +15:51.980 --> 15:57.180 +they need to have a chaos they need to start from a chaos they can't + +15:57.180 --> 16:01.740 +have all of this order and then rearrange it + +16:01.740 --> 16:06.460 +or hope to usefully disassemble it at least that's what they think + +16:06.460 --> 16:10.460 +that's what they they think that's how how maybe that is how people have been + +16:10.460 --> 16:15.820 +governed through chaos and then imposed order + +16:15.820 --> 16:19.340 +and if that's the case then it does seem as though the people that are + +16:19.340 --> 16:25.340 +governing the globe that want to shift us to this new paradigm + +16:25.340 --> 16:30.300 +understand it as a necessity for us to go through some kind of chaos + +16:30.300 --> 16:34.540 +in order for this societal metamorphosis to take place + +16:34.540 --> 16:38.060 +and so i'm starting to make this argument that there's a fine line between an + +16:38.060 --> 16:41.980 +announcement and a warning and i want you to start to + +16:41.980 --> 16:46.860 +think about what people say on our side about where we're going and how we + +16:46.860 --> 16:51.260 +avoid going there and whether or not it's an + +16:51.260 --> 16:54.300 +announcement or a warning whether it's an announcement or a + +16:54.300 --> 16:58.060 +suggestion whether it's an alternative or + +16:58.060 --> 17:03.500 +an inevitability because i think it's very important it doesn't only have to be + +17:03.500 --> 17:07.500 +a guy like carol adebach the health guy from germany + +17:07.500 --> 17:12.140 +or jorston talking about these kinds of things and then for us to know that + +17:12.140 --> 17:17.020 +oh this is not really a warning or a complaint this is an announcement + +17:17.020 --> 17:23.340 +when when jorston says that we really need to crack down on misinformation + +17:23.340 --> 17:27.980 +and the press needs to do their job we understand that fully + +17:27.980 --> 17:31.820 +that they mean to crack down on misinformation they want us to beg for + +17:31.820 --> 17:36.460 +that but then when we hear robert melone say that he's been + +17:36.460 --> 17:41.100 +harassed on on the internet and it's not fun and you wouldn't like it and we've + +17:41.100 --> 17:47.020 +got to stop using violent speech or they're going to use it against us + +17:47.020 --> 17:52.060 +is that an warning or an announcement if somebody says we need to build new + +17:52.060 --> 17:56.300 +underground systems but doesn't ever advocate for us to take back the system + +17:56.300 --> 18:01.340 +that we have and and remodel it retake it back and use it + +18:01.340 --> 18:05.100 +the way it's supposed to be restore our republic no he says we need to build new + +18:05.100 --> 18:09.900 +underground systems it's not very different than what + +18:09.900 --> 18:15.740 +happened when we got censored back in 2020 and everybody ran to gab + +18:15.740 --> 18:18.700 +and to telegram + +18:21.180 --> 18:25.340 +and everybody went on signal and had all these secret groups where they chatted + +18:25.340 --> 18:29.500 +about i don't know + +18:29.980 --> 18:35.820 +well everything and everybody went to discord + +18:35.820 --> 18:39.580 +and how hard was it for these non-encrypted apps to + +18:39.580 --> 18:45.660 +actually be like honey traps for us in a way all the people that + +18:45.660 --> 18:51.020 +wanted to march around and be efficient you know or not efficient but uh + +18:51.020 --> 18:55.180 +evasive of the of the system they went away + +18:55.180 --> 19:02.460 +they went on gab they went on telegram i'm on signal now + +19:03.020 --> 19:09.100 +curiously who led us to gab who led us to telegram who led us to signal + +19:09.100 --> 19:13.820 +who led us to discord who led us to sub-stack + +19:18.220 --> 19:22.140 +if you hear somebody up on stage say we have a lousy society our children have + +19:22.140 --> 19:25.420 +been taught all the wrong values it's going to be okay that it all comes + +19:25.420 --> 19:30.380 +apart is that really a announcement + +19:30.540 --> 19:33.180 +a warning + +19:33.660 --> 19:37.020 +is that inevitability + +19:42.140 --> 19:47.340 +is that somebody trying to help us or is that somebody just trying to keep us + +19:47.340 --> 19:54.220 +walking down or riding numbly down this neon hallway + +19:54.220 --> 20:00.620 +covered in lies is that somebody who's pretending to be a part of the + +20:00.620 --> 20:05.740 +group of mimes stopping this drain it's a really important analogy + +20:05.740 --> 20:11.580 +try to imagine fooling a young group a group of young kids + +20:11.580 --> 20:16.620 +and try to see that this guy all by himself with his little chalk dish + +20:16.620 --> 20:25.340 +he can't fool a group of kids but if you got a bunch of crossfit athletes + +20:25.420 --> 20:28.700 +and then you fitted them with a bunch of uh + +20:28.700 --> 20:33.500 +machines that made a lot of noise with wheels and sparks + +20:33.500 --> 20:36.700 +i guarantee you you could fool a bunch of kids you might even be able to fool + +20:36.700 --> 20:43.260 +a bunch of teenagers and the more people that you lined up on the train with more + +20:43.260 --> 20:49.260 +elaborate props and a more elaborate coordinated effort + +20:49.260 --> 20:54.780 +the more people you could fool the more inspection + +20:54.780 --> 21:00.300 +they would pass the more the more scrutiny they could withstand + +21:00.300 --> 21:03.020 +in their act + +21:03.340 --> 21:07.180 +if you made it really complicated + +21:07.180 --> 21:11.660 +if you made it with smoke and heat so that people couldn't get very close to the + +21:11.660 --> 21:14.780 +train as these people stopped it + +21:14.780 --> 21:21.580 +if you made it really loud so that people were afraid to get near it + +21:21.580 --> 21:25.100 +the point that i'm trying to make is is that during the pandemic that's what + +21:25.100 --> 21:28.860 +all of these stories did to us + +21:28.860 --> 21:34.460 +they made it seem like there was nothing to guess or or wonder about + +21:34.460 --> 21:38.620 +these people were doing the best that they could to stop a national security + +21:38.620 --> 21:44.220 +priority a national security threat of never-before-seen proportions + +21:44.220 --> 21:48.940 +and potential the potential to kill a billion people and we don't have any + +21:48.940 --> 21:52.540 +treatment we don't know what will work + +21:52.540 --> 21:56.140 +the best we can do is hope that these people can put out enough pcr's and + +21:56.140 --> 22:00.540 +lateral flow tests so that we can at least keep track of when we're sick asymptomatically + +22:00.540 --> 22:09.260 +and so many people on social media seem to agree about this + +22:09.260 --> 22:13.420 +so many people on social media are arguing whether or not hydroxychloroquine or + +22:13.420 --> 22:17.580 +ivermectin are crazy or not + +22:17.580 --> 22:22.460 +and ivermectin and hydroxychloroquine did not save anyone from a ventilator did + +22:22.460 --> 22:26.380 +not save anyone from rendezivir did not save + +22:26.380 --> 22:29.900 +anyone from an opioid death + +22:32.220 --> 22:36.540 +financial incentives to declare covid didn't save anyone from the covid + +22:36.540 --> 22:39.100 +protocols it actually put more people on them + +22:43.100 --> 22:47.660 +sending people back with to elderly care homes with pneumonia + +22:47.660 --> 22:53.500 +and viral pneumonia without antibiotics didn't save anyone + +22:53.500 --> 22:59.340 +the dismissal of immunology 101 in october of 2020 + +22:59.340 --> 23:03.820 +by a whole list of leaders including wollinski + +23:03.820 --> 23:09.420 +as in we don't know if our immunity will be good enough it could be like aids + +23:09.420 --> 23:14.780 +where we build antibodies and that's actually a sign of disease not a sign of + +23:14.780 --> 23:18.620 +immunity did you know that do you remember that + +23:18.620 --> 23:23.260 +giant contradiction thanks for reminding me of that pamela or + +23:23.260 --> 23:27.820 +pointing it out even the value of nutrition in + +23:27.820 --> 23:33.660 +america was dismissed a place where almost every grown + +23:33.660 --> 23:37.900 +adult has been malnourished for at least a decade + +23:37.900 --> 23:42.940 +and many children grow up malnourished over + +23:42.940 --> 23:50.620 +carbon carbohydrate over sugared over medicated over immunized + +23:56.060 --> 24:01.260 +they have been doing this train pulling and pushing act for three years + +24:01.260 --> 24:06.780 +and public health the public health apparatus would like to govern the + +24:06.780 --> 24:09.900 +world with this act + +24:10.540 --> 24:17.180 +public health apparatus needed to convert this pattern + +24:17.180 --> 24:25.020 +into something that they could declare was a pandemic of a novel virus + +24:27.100 --> 24:30.460 +and in order to convert this very distinct + +24:30.460 --> 24:35.740 +and reliable pattern this very distinct reliable pattern + +24:35.740 --> 24:40.300 +in pneumonia deaths into this very indistinct + +24:40.300 --> 24:45.340 +and novel pattern of pneumonia deaths it required protocols not a novel + +24:45.340 --> 24:47.740 +virus + +24:48.540 --> 24:52.780 +it required novel protocols like do not resuscitate people if they're having a + +24:52.780 --> 24:56.140 +heart attack at home or a stroke let them die + +24:56.140 --> 25:00.620 +don't bring them back to the hospital pronounce them dead + +25:00.620 --> 25:03.740 +if you do bring them into the hospital make sure you ventilate in my extra + +25:03.740 --> 25:08.780 +high pressure to make sure that the virus doesn't come out + +25:08.780 --> 25:12.780 +antibiotics don't work on viral pneumonia dumbass + +25:12.780 --> 25:16.700 +and steroids don't either + +25:17.900 --> 25:23.180 +remdesivir works though it's pretty good we should try it on everybody + +25:23.740 --> 25:28.700 +and opioid deaths well those people are just covid deaths + +25:28.700 --> 25:33.340 +we don't even need to talk about them i mean who who even cares about those + +25:33.340 --> 25:37.420 +people isn't it a waste to even use Narcan on them like + +25:37.420 --> 25:43.180 +they're just i wonder what people in san francisco would say + +25:43.180 --> 25:48.380 +death certificate fraud how far should this list go how much longer how much + +25:48.380 --> 25:51.980 +many more things can we think about they need to go on there + +25:51.980 --> 25:55.820 +the reason why i want this to happen is because i need you to see + +25:55.820 --> 25:59.340 +because i need you to see what because i need you to see + +25:59.340 --> 26:01.980 +what that was an echo there because i had that open + +26:01.980 --> 26:05.740 +yikes that was scary i need you to see that these people + +26:05.740 --> 26:15.740 +have really fooled us now this video is a video from one month ago + +26:15.740 --> 26:19.340 +by a professor + +26:19.340 --> 26:23.020 +of carny g melon and today i'll be talking mostly + +26:23.020 --> 26:26.460 +let me get my head out of the way for a second so i can rewind this + +26:26.460 --> 26:29.660 +and make sure it's all set up correctly + +26:29.660 --> 26:35.420 +1.5 so this is a video of + +26:36.140 --> 26:40.620 +a professor from carny g melon university so that's that's in pittsburgh + +26:40.620 --> 26:47.020 +and she gave this talk one month ago as part of a + +26:47.020 --> 26:52.300 +honoring peter colas series of lectures so it's about our ln + +26:52.300 --> 26:56.140 +lnp for r and a delivery which i thought already got the nobel prize + +26:56.140 --> 27:03.980 +which is usually when something has had you know like a decade of impact + +27:03.980 --> 27:07.900 +and so she's going to give a lecture about this but i want you to listen + +27:07.900 --> 27:10.940 +very carefully to the assumptions that she makes + +27:10.940 --> 27:17.340 +and the assumptions are are monumental + +27:17.340 --> 27:22.620 +she's going to say what we said at giga ohm biological they were going to do + +27:22.620 --> 27:29.020 +we said that in 2021 when everybody was all hot and bothered about the + +27:29.020 --> 27:31.260 +spiky spike being toxic + +27:35.820 --> 27:41.260 +we said it that they were going to blame the vaccine + +27:41.260 --> 27:44.620 +and it not working right because they chose the wrong protein or they're + +27:44.620 --> 27:47.340 +going to make some other excuse and otherwise + +27:47.340 --> 27:52.300 +otherwise we just proved that r and a and + +27:52.300 --> 27:56.140 +transfection in general works great in humans + +27:56.140 --> 28:00.460 +now this is a woman who just gave a talk a month ago and basically + +28:00.460 --> 28:07.100 +she's going to lead off with that in an extraordinarily aggressive way + +28:07.100 --> 28:10.380 +r and a's here to stay + +28:13.420 --> 28:16.700 +so today i wanted to speak with you about some of the work that we've been + +28:16.700 --> 28:20.540 +doing developing lipid nanoparticles for targets outside of the liver + +28:20.540 --> 28:23.740 +and i specifically wanted to focus on some of our data regarding delivery to + +28:23.740 --> 28:26.380 +the pancreas i'm not really sure i just want to + +28:26.380 --> 28:31.180 +talk to Moderna for a second modified r and a is not biological messenger r and a + +28:31.180 --> 28:34.380 +i'm not really sure why you're making that point because + +28:34.380 --> 28:40.460 +we understand that that coat we we recognize that codon optimization + +28:40.460 --> 28:45.580 +has certain implications and effects we've recognized that the chemical + +28:45.580 --> 28:50.860 +alterations have certain effects and we're calling it r and a + +28:50.860 --> 28:55.260 +are calling it transfections so you keep saying that but + +28:55.260 --> 29:00.220 +i've we've all acknowledged that this is modified r and a + +29:00.220 --> 29:05.820 +if we call it m r and a or r and a it doesn't really matter it's synthetic + +29:05.820 --> 29:11.260 +r and a so i mean you're you're making a semantic argument that doesn't + +29:11.260 --> 29:14.540 +it doesn't really matter if you listen to her talk and you assume that this is + +29:14.540 --> 29:18.300 +all synthetics then then it's really about what they + +29:18.300 --> 29:21.500 +can and can't do with them that is the point + +29:21.500 --> 29:25.740 +they can't control where they go and when they say that they inject you in the + +29:25.740 --> 29:29.180 +muscle to augment your immune system it's just + +29:29.180 --> 29:33.500 +absolutely absurd and that's that's what she's going to talk about here with + +29:33.500 --> 29:36.940 +cartoons so just a little bit about my lab in + +29:36.940 --> 29:39.180 +general and dr khalis had mentioned this in the introduction + +29:39.180 --> 29:41.900 +we work in a couple of different areas of drug delivery + +29:41.900 --> 29:46.380 +so we focus on oral delivery of protein medication so drugs like insulin that + +29:46.380 --> 29:49.740 +currently have to be injected and trying to find ways of delivering them + +29:49.740 --> 29:53.580 +in more patient-friendly forms so that might involve oral delivery for + +29:53.580 --> 29:55.660 +proteins the problem with proteins is that they're + +29:55.660 --> 29:58.700 +digested by our gastrointestinal tracts and so we're very interested in + +29:58.700 --> 30:01.260 +studying the transport of these large molecules across the + +30:01.260 --> 30:05.420 +gastrointestinal tract to facilitate these more patient-friendly means of + +30:05.420 --> 30:09.740 +delivering proteins. More recently my lab has taken interest in + +30:09.820 --> 30:12.780 +women's and infant health. I had my first pregnancy at this point about seven + +30:12.780 --> 30:15.100 +years ago and then another one shortly before the + +30:15.100 --> 30:17.100 +pandemic happened and there's nothing like firsthand + +30:17.100 --> 30:21.100 +experience to realize that the state of maternal medicine is rather poor + +30:21.100 --> 30:23.660 +and there are a lot of things that we can do to try to improve our + +30:23.660 --> 30:26.700 +understanding of transport processes during pregnancy + +30:26.700 --> 30:31.660 +to try to create medications that are safe that do not cross into the infant. + +30:31.660 --> 30:35.580 +And then finally the subject of today's lecture is in this area of RNA delivery + +30:35.580 --> 30:38.780 +where I've been working now on lipid nanoparticles for over 15 years + +30:38.860 --> 30:41.820 +and it's just been wonderful to see how far this field has come since I first + +30:41.820 --> 30:45.420 +started. My lab is especially interested in how manipulating the chemistry + +30:45.420 --> 30:47.820 +of these particles which are quite complex chemically. + +30:47.820 --> 30:50.700 +How those manipulations can affect their functionality in vivo + +30:50.700 --> 30:54.380 +both in terms of bio distribution where they're working well immunogenicity + +30:54.380 --> 30:57.580 +and toxicity. So I'll speak a bit more about that today. + +30:57.580 --> 31:01.100 +So as pretty much all of you probably know at this point these RNA therapies + +31:01.100 --> 31:05.420 +have gone from niche to mainstream so the first FDA approval of a lipid + +31:05.420 --> 31:09.180 +nanoparticle formulation and the first FDA approval of an RNA drug + +31:09.180 --> 31:14.140 +was back in 2018 by Al nylon and they developed this medication for a rare + +31:14.140 --> 31:17.260 +type of liver disease and this was wonderful and it brought to + +31:17.260 --> 31:21.260 +fruition decades of research on liposomal and lipid nanoparticle type + +31:21.260 --> 31:24.700 +materials but even then we still had a very small + +31:24.700 --> 31:27.820 +population of people who were benefiting from this type of technology + +31:27.820 --> 31:30.940 +and people were quite cautious about you know using these types of + +31:30.940 --> 31:34.620 +medications for larger patient populations. So then we had this awful + +31:34.620 --> 31:37.740 +occasion to need to put these materials to the test + +31:37.740 --> 31:41.500 +and I think all of us in the delivery field were absolutely delighted to see + +31:41.500 --> 31:44.780 +how well these materials and how well RNA therapies can work + +31:44.780 --> 31:46.940 +in you know huge. Was there ever a + +31:46.940 --> 31:51.500 +humanity or is this a stupid picture like what did they ever have this + +31:51.500 --> 31:55.980 +actually available or it was always the it was always Pfizer right + +31:55.980 --> 32:01.340 +it never came out with that I think this is BS right here + +32:01.820 --> 32:05.740 +anyway this is the statement that I'm trying to make + +32:05.740 --> 32:11.260 +this is you guys can all see it for what it is this is absolutely absurd + +32:11.260 --> 32:16.780 +the idea is very clear this was always the plan + +32:16.780 --> 32:21.100 +there was always going to be the plan it was always going to be + +32:21.100 --> 32:25.100 +throw the adenavirus under the bus so that we can point to the adenavirus + +32:25.100 --> 32:28.380 +as well obviously we took it off the market because + +32:28.380 --> 32:35.500 +it was causing clots and the mRNA doesn't cause clots. + +32:35.500 --> 32:40.140 +I mean duh the mRNA causes myocarditis but that goes away + +32:40.140 --> 32:44.940 +myocarditis is fine it only kills 50% of the people that + +32:44.940 --> 32:50.540 +they get it. It's it's really sad it's really sad + +32:50.540 --> 32:54.220 +because we said this we said it was going to happen two years ago we said + +32:54.220 --> 33:00.060 +they were going to do this and not one single person + +33:00.060 --> 33:05.420 +in that narrative control panel ever even bothered to think out loud that + +33:05.420 --> 33:09.100 +thought never mind actually speak the words or write a + +33:09.100 --> 33:16.620 +sub stack about it nobody and for two or three years + +33:16.620 --> 33:19.420 +almost three years really now that where we are + +33:19.420 --> 33:23.900 +it's almost three years oh my gosh it's going to be 2024 + +33:23.900 --> 33:27.980 +we have been saying that they are going to blame + +33:27.980 --> 33:33.740 +some mistake in the methodology some mistake in the choice of protein some + +33:33.740 --> 33:37.580 +epitope they should have taken out + +33:38.860 --> 33:42.860 +and then they moved on to impurities then they moved on to + +33:42.860 --> 33:48.700 +process one versus process two and double stranded DNA and this sv40 + +33:48.700 --> 33:55.500 +enhancer and promoter it's always been the same story + +33:55.500 --> 34:00.620 +these things work great but there were some problems with the rollout yeah sure + +34:00.620 --> 34:04.620 +but it was a rush job when we make these things like + +34:04.620 --> 34:09.900 +fine brewed beer this stuff is amaze balls + +34:12.620 --> 34:16.860 +that's the story that's the sales pitch that's the tv narrative that's what + +34:16.860 --> 34:21.020 +skilled tv watchers believe right now that's where we are at + +34:21.020 --> 34:26.780 +Thanksgiving 2023 just where i said we would be + +34:30.940 --> 34:32.220 +i'm not thankful for that + +34:36.540 --> 34:39.980 +which numbers of people and so now with this evidence and hundreds of millions of + +34:39.980 --> 34:43.180 +people at this technology works well this is really going to open the floodgates + +34:43.180 --> 34:47.340 +to all sorts of new therapies not just in vaccines but in protein replacement + +34:47.340 --> 34:52.060 +gene editing and otherwise so think about how naive that is think about + +34:52.060 --> 34:56.380 +how naive that is that she thinks that those two are equivalent because we + +34:56.380 --> 35:02.700 +used it for vaccination successfully even if even if + +35:02.700 --> 35:05.260 +even if + +35:06.620 --> 35:11.980 +replacing proteins hasn't worked + +35:13.260 --> 35:18.060 +curing cancer rarely works with mRNA + +35:22.540 --> 35:26.300 +putting these things in certain places doesn't work + +35:28.380 --> 35:33.340 +when you change their chemistry and they go places it's a fraction of it right + +35:35.180 --> 35:38.220 +these people would be very excited if they changed the lipid + +35:39.100 --> 35:45.180 +the lipid nanoparticle chemical composition and you went from 50 percent of it in the + +35:45.180 --> 35:51.180 +liver and 50 percent of it in the ovaries to 80 percent of it in the liver and 30 percent + +35:51.180 --> 35:56.380 +in the ovaries that would be a phd project that would be a very significant result + +35:57.100 --> 36:00.460 +that would allow them to stand in front of years of lecture halls + +36:01.100 --> 36:06.860 +saying that these results suggest that in a few years we can have really precisely targeting + +36:07.020 --> 36:11.980 +lipid nanoparticles based on the chemical alterations of and the properties that + +36:11.980 --> 36:16.060 +that emerge from those alterations blah blah blah blah blah blah + +36:18.460 --> 36:22.940 +and so let's listen to this lady explain what she plans to do and explain the + +36:23.500 --> 36:26.780 +sort of hand waving that she does look at this terrible cartoon already + +36:28.700 --> 36:31.340 +a protein is just a ball that comes from a comb + +36:32.300 --> 36:36.940 +I mean so for any trainees in the audience who are a little bit less familiar with this + +36:36.940 --> 36:40.060 +I wanted to just go through some of the basic molecular biology that + +36:40.060 --> 36:44.380 +underpins all this RNA work that we're doing so this is the central dogma of molecular biology + +36:44.380 --> 36:48.700 +that tells us that our permanent blueprint the DNA inside of ourselves this is transcribed + +36:48.700 --> 36:53.500 +into a temporary copy called messenger RNA which is then translated in the cell cytoplasm + +36:53.500 --> 36:59.500 +into proteins and so those arrows don't mean anything understanding the DNA polymerase + +36:59.500 --> 37:03.420 +doesn't mean anything like how it's copied understanding the RNA polymerase + +37:04.380 --> 37:08.060 +don't worry about that that's just an arrow understanding ribosomes + +37:08.940 --> 37:12.860 +mRNA protein that's just an arrow who cares about those things + +37:15.340 --> 37:19.500 +and now she's going to say that proteins are everything proteins are the motor as well + +37:20.620 --> 37:28.220 +ribosomes are RNA ribosomes are made of RNA and proteins in combination so it's a little + +37:29.500 --> 37:35.580 +hand wavy to say that proteins do everything when the most important thing the most important + +37:35.580 --> 37:39.100 +nanomachine that we almost know nothing about is the ribosome + +37:42.140 --> 37:47.260 +but that's okay you know just just keep us asking the wrong questions keep us focused + +37:47.260 --> 37:53.340 +on the wrong things instead of the arrows we'll focus on those funny shapes in blue + +37:54.300 --> 37:59.100 +genes are the doers in our body and because they're the molecules responsible for all function + +37:59.100 --> 38:04.860 +many diseases are caused by misregulated proteins so either the protein is non-functional + +38:04.860 --> 38:09.660 +either we have too much of a particular protein or too little and so to treat so a protein is + +38:09.660 --> 38:13.820 +non-functional we have too much we have too little it has nothing to do with the tertiary + +38:13.820 --> 38:19.740 +structure of the protein or the tertiary chemical alterations of it that's extraordinary and again + +38:20.620 --> 38:26.860 +you could say that this is being imprecise but she's talking to a really educated audience you + +38:26.860 --> 38:33.740 +would think that you'd want to hit this pretty pretty on the money you think you'd want to be + +38:33.740 --> 38:39.020 +with be pretty sharp with your biology but we're not we're not sharp right now this is one month + +38:39.020 --> 38:44.620 +ago ladies and gentlemen please we really need to manipulate protein expression such that it goes + +38:44.700 --> 38:49.820 +back to what it's supposed to be so that first FDA approved drug it contained short interfering + +38:49.820 --> 38:55.340 +RNA and it's short because it's about 21 base pairs in length as opposed to RNA mRNA which can + +38:55.340 --> 38:59.900 +be thousands long and it interferes with protein production so you can design this so it would + +38:59.900 --> 39:05.020 +be specific for a target gene of interest and then you can have reductions in that protein expression + +39:05.660 --> 39:12.140 +now i'm a little gonna object to the way that this is drawn because it looks like to me + +39:12.700 --> 39:20.620 +her si RNA is drawn as double-stranded but actually i think correct me if i'm wrong smart people in + +39:20.620 --> 39:28.140 +the audience but i think RNA is single-stranded and when you put small interfering RNAs in there + +39:28.140 --> 39:36.140 +they bind to the endogenous RNA and make a double-stranded RNA and that's why they get degraded + +39:36.460 --> 39:41.740 +because double-stranded RNA ain't allowed in our cells + +39:45.020 --> 39:47.900 +you see again it's just kind of imprecision you know like + +39:50.300 --> 39:55.900 +it's just kind of imprecise and it's annoying because these people get paid a crap ton of tax payer + +39:55.980 --> 40:05.260 +money to teach children to apprentice young biologists into this + +40:06.940 --> 40:07.980 +into this endeavor + +40:11.580 --> 40:16.300 +if we want to upregulate protein expression instead of downregulate that's where messenger RNA comes + +40:16.300 --> 40:22.380 +in and so we can design mRNA's that can for example give us more of a particular gene of or protein + +40:22.380 --> 40:27.020 +of interest and in the case of the vaccines it's just super cool we can ask our bodies to + +40:27.020 --> 40:31.180 +generate proteins that our bodies would never normally make so in this case it's generating + +40:31.180 --> 40:36.780 +the spike protein which is not native to mammalian cells so very powerful technology + +40:36.780 --> 40:42.300 +i wanted to speak very briefly on our news this week that the noble prize was given for the mRNA + +40:42.300 --> 40:48.380 +biology that underpinned the covid-19 vaccines so RNA therapeutics really require two parts + +40:48.460 --> 40:53.340 +so one is functional mRNA that once it goes inside the cell it can produce the protein of interest + +40:53.340 --> 40:57.260 +effectively and then the other is the delivery system which i think hasn't gotten quite as + +40:57.260 --> 41:01.900 +much press as the RNA itself but is equally important so today i'll be talking about the delivery + +41:01.900 --> 41:07.500 +system and the noble prize had to do with this mRNA biology so here are the two people who have + +41:07.500 --> 41:12.060 +just been awarded so koriko and weissmann who originally did the work at the university of + +41:12.060 --> 41:16.940 +pennsylvania in philadelphia so they um i like to just tell people they're both really terrific + +41:16.940 --> 41:22.620 +people i think they could be on a sitcom together or something the two videos that we watched of them + +41:22.620 --> 41:32.700 +i mean they were lovable people i mean definitely but in a you're not a nobel prize-winning kind + +41:32.700 --> 41:37.980 +of lovable way i think i think we don't always have um you know sometimes famous scientists aren't + +41:37.980 --> 41:43.420 +the best models of of collaboration it's been my privilege to collaborate with drew over the years + +41:43.500 --> 41:48.700 +when i was getting started in the mRNA field it was back in 2017 and RNA is quite expensive + +41:48.700 --> 41:53.500 +if you purchase it and i was giving a seminar at pen and drew was a stranger to me and we had a + +41:53.500 --> 41:59.500 +meeting and he offered to make me whatever mRNA i wanted and send it to me and people didn't believe + +41:59.500 --> 42:03.100 +too much in RNA therapies at that time there was still a lot of hesitation so i was taken aback + +42:03.100 --> 42:07.020 +and confused why a stranger would offer to help me in this way given the expense so it took me a + +42:07.020 --> 42:10.940 +couple of years to actually approach him and then when i did he was true to his work and he's provided + +42:10.940 --> 42:15.980 +me with with RNA since that time and has otherwise been a great collaborator i've also met + +42:15.980 --> 42:20.060 +katie koriko briefly and she's given me some nice advice so just such a pleasure to see good + +42:20.060 --> 42:26.460 +people um reward it for for their work so um in terms of what they did they discovered that + +42:26.460 --> 42:31.980 +base modifications of RNA are needed for protein translation and mammals so here is the molecule + +42:31.980 --> 42:38.140 +uridine which is one of those canonical nucleic acids that are present in RNA and the problem + +42:38.140 --> 42:43.180 +when we make RNA typically with these molecules such as uridine is that our cells recognize them + +42:43.180 --> 42:49.500 +as foreign and that's because our cells make RNA to incorporate some base modifications so if it + +42:49.500 --> 42:54.220 +sees RNA without base modifications it mounts a bit of an immune response that shuts down protein + +42:54.220 --> 42:58.860 +production so that's part of why nobody thought RNA therapies would become a reality because + +42:58.860 --> 43:03.580 +when we made RNA in lab and introduced it it just would not make protein so what they found was that + +43:03.580 --> 43:09.740 +they could make modifications to these different nucleobases and so here's um one version of this + +43:09.740 --> 43:14.140 +this is um n1 methyl pseudo uridine the ones that are used in the vaccines are just called + +43:14.140 --> 43:19.420 +pseudo uridine so i don't think this is i'm sorry i had to i had to put something in my ear and + +43:19.420 --> 43:24.460 +clean it from my i'm wearing my headphones again tonight i don't think this is right and i hope i + +43:24.460 --> 43:32.060 +don't so i don't care if i do it's it's thanksgiving and i'm streaming i i think that this is absolute + +43:32.140 --> 43:38.380 +nonsense i don't think that base modifications are necessary for protein translation in mammals i + +43:38.380 --> 43:43.820 +think they're necessary for sustained protein translation in mammals for them to get a signal + +43:43.820 --> 43:53.020 +that they can point to and say look it works but if you put non uh methyl pseudo uridine + +43:53.820 --> 43:57.500 +RNA in your lipid nanoparticle you'll get very transient expression + +43:58.460 --> 44:08.860 +very transient expression absolutely but that that's not quite right what they what this is is + +44:10.460 --> 44:18.620 +what this is is somebody who is i think over their skis saying what they've been told is right + +44:19.740 --> 44:25.420 +they probably practiced this talk and somebody said it's fine but essentially she's not saying + +44:25.500 --> 44:33.580 +this correctly i i really don't think so i know that we have base alterations in our RNA + +44:34.860 --> 44:43.340 +and they are used presumably for RNA regulation but for purposes of a + +44:43.340 --> 44:53.900 +transfection tool that's true for purposes of how RNA functions endogenously in your cells + +44:54.620 --> 45:02.460 +that's true to an extent because actually again the transient nature of RNA being degraded quickly + +45:02.460 --> 45:08.060 +in your cells is how protein expression is regulated at least as far as we guess + +45:08.780 --> 45:15.260 +and that's why small interfering RNAs that are complementary to your own + +45:15.980 --> 45:21.500 +mRNAs and circulation are an interesting way to interfere with protein expression + +45:23.020 --> 45:27.020 +somebody put in the chat that they're double stranded RNAs i'm going to look it up i'm not sure + +45:27.660 --> 45:30.940 +i think the mechanism is how i've described it though um + +45:31.500 --> 45:37.980 +um and so i think this is a bit of a hand-waving exercise to say that this is how it works but + +45:37.980 --> 45:45.100 +she's specifically talking about transfection not about about translation of proteins and + +45:45.100 --> 45:49.820 +endogenous proteins so we have these modifications and the cells are more willing to recognize these + +45:49.820 --> 45:54.620 +externally introduced RNAs as self and then they are willing to produce that protein so all the + +45:54.620 --> 45:59.420 +work that i'm showing you today is made with RNA that's been base modified so that it works well + +45:59.580 --> 46:07.580 +so that it works well see so so that it works well in its transfection excuse me so to go back to + +46:07.580 --> 46:12.940 +the delivery vehicle part of the equation RNA is large it's on the order of a hundred thousand + +46:12.940 --> 46:17.180 +grams per mole it's negatively charged and so it doesn't readily cross negatively charged cell + +46:17.180 --> 46:21.340 +membranes and if you were to inject it into the bloodstream it would be both degraded and + +46:21.340 --> 46:25.260 +negatively charged on the order of a hundred thousand delivery vehicle part of the equation + +46:25.260 --> 46:30.460 +RNA is large it's on the order of a hundred thousand grams per mole it's negatively charged + +46:30.460 --> 46:34.060 +and so it doesn't readily cross negatively i get to go back a little bit further and + +46:34.060 --> 46:37.900 +previous of delivery barrier it's been base modified so that it works well + +46:39.100 --> 46:45.100 +so in terms of delivery barriers excuse me so to go back to the delivery vehicle part of the + +46:45.100 --> 46:50.780 +equation RNA is large it's on the order of a hundred thousand grams per mole it's negatively + +46:50.780 --> 46:54.940 +charged and so it doesn't readily cross negatively charged cell membranes and if you were to + +46:55.020 --> 46:59.500 +inject it into the bloodstream it would be both degraded and quickly cleared from our system so + +46:59.500 --> 47:04.220 +we need a vehicle that's going to package it up and protect it and take it to the cells of interest + +47:04.220 --> 47:11.020 +wow so that's to me we've got to hear that for what she says it is right you got to hear it for + +47:11.020 --> 47:16.620 +what she says because that assumption is wrong listen carefully you inject it into the bloodstream + +47:16.620 --> 47:21.740 +it would be both degraded and quickly cleared from our system so if you injected it into the + +47:21.740 --> 47:27.180 +bloodstream it would be degraded and very quickly cleared did she mean that without lip + +47:27.180 --> 47:32.700 +and nanoparticle i think that must be what she means right because + +47:34.060 --> 47:38.780 +wow that that must be just naked RNA but we need a vehicle that's going to package it + +47:38.780 --> 47:44.860 +yeah okay and take it to the cells of interest so this diagram depicts a couple of barriers that + +47:44.860 --> 47:49.100 +it needs to overcome if we were to do IV injection so once it's injected into the bloodstream it + +47:49.100 --> 47:53.580 +needs to avoid clearance by macrophages once it exits the bloodstream it needs to + +47:53.580 --> 47:57.980 +it needs to avoid clearance by macrophages it also needs to avoid + +47:58.940 --> 48:06.940 +transfecting endothelial cells and avoid transfecting blood cells and as it goes through + +48:06.940 --> 48:13.260 +capillaries that will be more and more difficult because the then that's where this is all going + +48:13.260 --> 48:16.140 +to occur right that's where this size scale comes into play + +48:19.180 --> 48:23.740 +it's not going to happen in the big vessels it's going to happen in the capillaries and capillaries + +48:23.740 --> 48:34.460 +that this this size scale is wrong this cartoon is wrong and avoiding the transfection of endothelial + +48:34.460 --> 48:42.460 +cells is much harder than one might think diffuse through the tissue of the organ that you want to + +48:42.460 --> 48:47.020 +target it then needs to be up taken into the cell of interest and this happens through a + +48:47.020 --> 48:50.940 +process called endocytosis where the cell membrane reaches up and around that particle + +48:50.940 --> 48:55.100 +and it brings it inside and so at this point the nanoparticle is in this Waldorf compartment + +48:55.740 --> 48:58.780 +and the cell keeps it there because it's not sure what it is and it looks and says this is + +48:58.780 --> 49:05.340 +something I want to see that the the whole anytime a biologist anthropomorphizes the + +49:05.340 --> 49:14.060 +operations of a cell and I don't even know I don't think you can ever do that and if you do + +49:14.060 --> 49:21.260 +it you need to be very very careful in this case it's ridiculous it's held in an endosome until + +49:21.260 --> 49:25.660 +it does the cell decides what to do with it because it's not sure what it is + +49:26.940 --> 49:32.700 +are you kidding this is a chemical covered in other chemicals + +49:33.260 --> 49:36.220 +the hell is she talking about + +49:39.180 --> 49:43.900 +and typically a lipid nanoparticle is not on its wish list so the endosome begins to acidify + +49:43.900 --> 49:47.820 +and would otherwise degrade these lipid nanoparticles so part of the design of the chemistry behind + +49:47.820 --> 49:51.980 +these particles is that they need to mediate this process of endosomal escape and that's one of + +49:51.980 --> 49:56.380 +the most difficult parts of this process so once the RNA is into the cell cytoplasm that's when + +49:56.380 --> 49:59.980 +it can interface with the protein translational machinery and make our protein of interest + +50:00.460 --> 50:06.300 +so years ago we asked if we could develop a potent and degradable RNA delivery system + +50:06.300 --> 50:10.700 +potent for obvious reasons and degradable because many of these therapeutics will need to be + +50:10.700 --> 50:18.220 +repeat dose I mean seriously jittery and maker jason all of these arrows are pretty magical + +50:18.220 --> 50:22.860 +all of these arrows are pretty magical this arrows very magical this arrow what is this + +50:22.860 --> 50:28.860 +like is this an an electron going down from two different energy levels what the hell is this + +50:30.540 --> 50:36.540 +I mean did they take and are they trying to convert a photosynthesis diagram into a + +50:41.900 --> 50:48.860 +I mean even this is silly this part you know like okay now we have RNA I guess but it's + +50:48.860 --> 50:55.180 +double stranded or something what is this you know I don't I don't I don't I don't know what to say + +50:56.140 --> 51:01.100 +I don't know how to overcome this I mean could I get her to come to + +51:01.820 --> 51:06.620 +giga ohm biological and let me give her an hour lecture like this but then say completely + +51:06.620 --> 51:17.820 +the opposite what would she do it's shocking isn't it it's just shocking this B arrow this + +51:17.820 --> 51:23.580 +C arrow what is that the part of the design of the chemistry behind these particles is that they + +51:23.660 --> 51:27.100 +need to mediate this process of endosomal escape and that's one of the most difficult + +51:27.100 --> 51:31.500 +parts of this process so once the RNA is into the cell cytoplasm that's when it can interface + +51:31.500 --> 51:36.140 +with the protein translational machinery and make our protein of interest see if you can say all + +51:36.140 --> 51:41.100 +those words together that's when it can interface with the protein the cells protein machinery or + +51:41.100 --> 51:48.140 +whatever I mean that that doesn't make you a commander of this knowledge it doesn't make you + +51:48.140 --> 51:53.260 +understanding the way that this complex system manifests it's just a joke + +51:55.900 --> 52:02.060 +she was anthropomorphizing the cell as holding the liposome in an endosome because it didn't + +52:02.060 --> 52:08.940 +know what it was and it wasn't sure what to do with it that was her explanation for these other PhDs + +52:09.260 --> 52:17.500 +so years ago we asked if we could develop a potent and degradable RNA delivery system + +52:17.500 --> 52:21.980 +potent for obvious reasons and degradable because many of these therapeutics will need to be + +52:21.980 --> 52:26.860 +repeat dosed we will not necessarily create a cure but a treatment and we don't want this material + +52:26.860 --> 52:32.620 +building up over time so the materials that we work with in my lab they're lipid-like materials + +52:32.620 --> 52:37.180 +we call them lipidoids and they're a variation of the cationic lipids that have been used for + +52:37.260 --> 52:41.340 +decades at this point for different types of nucleic acid delivery first a lot of the work + +52:41.340 --> 52:45.820 +was done in the DNA delivery field so here's one of these cationic lipids if you were to put it + +52:45.820 --> 52:50.940 +into aqueous medium you would find that they would assemble into these liposomal structures + +52:50.940 --> 52:57.660 +where we have the hydrophilic head group on the outside of the aqueous media and then we would + +52:57.660 --> 53:02.460 +have these hydrophobic tails on the inside and you can load then hydrophilic drugs into the interior + +53:03.020 --> 53:07.420 +so we wanted to make something like this to hold on to our RNA and we also wanted to + +53:07.420 --> 53:11.260 +generate materials where we could look at a lot of different chemistries and try to understand + +53:11.260 --> 53:17.420 +I want you to see how how extraordinary it is that she talks as though we wanted to do we wanted to + +53:17.420 --> 53:24.700 +do we wanted to do like it's something you know it's almost like saying you know I wanted to put + +53:24.700 --> 53:31.180 +together a bunch of pages and I'm gonna call it a book and I really wanted to make a book so it was + +53:31.180 --> 53:34.860 +my idea to bunch a bunch of pages together and then bind them at the back + +53:36.780 --> 53:45.660 +she's talking about a a technology that she started her talk by saying that it had gone from + +53:45.660 --> 53:54.060 +niche to mainstream so what does she need to explain it for what's so special about hers + +53:55.020 --> 54:01.580 +and why does she need to explain it on this level she's giving a talk with Peter Coles in the + +54:01.580 --> 54:09.260 +background it's extraordinary I find this extraordinary it is the lack of + +54:13.180 --> 54:19.820 +appropriate audience I mean it's it's just oh it drives me crazy this is what used to drive me + +54:20.220 --> 54:29.660 +crazy about about neuroscience you could have a room full of people talking about supposedly + +54:29.660 --> 54:34.940 +about the highest level of discussion about our understanding of how micro circuits in the brain + +54:34.940 --> 54:39.500 +work and you could have somebody in the back room raise their hand and say I don't I don't + +54:40.140 --> 54:43.420 +could you briefly explain what a G protein coupled receptor is + +54:43.980 --> 54:51.340 +and you might have been talking about a type of receptor that is a G protein coupled receptor + +54:54.780 --> 54:59.980 +and you may have even given an introduction that was reasonable about G protein coupled + +54:59.980 --> 55:04.380 +receptors and this person would still have the audacity to raise their hand and ask that question + +55:07.180 --> 55:08.380 +only in biology + +55:09.100 --> 55:10.620 +you + +55:10.620 --> 55:15.580 +couldn't go into a physics lecture and say hey can you briefly explain to me what you mean by that + +55:17.900 --> 55:25.100 +I'm not sure I get it you couldn't go into an organic chemistry lab or lecture and say you know + +55:25.100 --> 55:30.460 +can you briefly explain to me what that category of molecule is I'm not really familiar with that + +55:31.180 --> 55:38.860 +but for some reason in biology everybody any any poser that wants to can go and join a lab + +55:38.860 --> 55:41.340 +and do a PhD project and there you go + +55:45.580 --> 55:51.340 +you did some programming as a PhD student and now you're up now you're going to do a postdoc in biology + +55:53.180 --> 55:56.940 +and since you did some T cell stuff I guess you're an immunologist now + +56:00.540 --> 56:05.020 +oh you put some silt bubbles and some RNA together and you followed the recipe + +56:05.740 --> 56:10.780 +and then you followed another recipe successfully and after following six recipes successfully that + +56:10.780 --> 56:15.340 +you basically adapted from other people's recipes you're a biologist now + +56:18.860 --> 56:24.540 +and the depth of your understanding of the concepts that you purport to wield is terrifying + +56:25.420 --> 56:29.980 +the chemistry of these lipidoids would affect their functionality and try to derive structure + +56:29.980 --> 56:33.900 +functional relationships from that so we use a high throughput type of chemistry called Michael + +56:33.900 --> 56:38.940 +addition in which we take an alkalamine so we need some combination and say primary means a + +56:38.940 --> 56:43.580 +secondary means and we would react them with alkal acrylate tails here it's an easy reaction + +56:43.580 --> 56:46.940 +you put the two together in a scintillation vial there's no solvent you can mix them for a + +56:46.940 --> 56:50.780 +couple of days at high temperature and out the other side comes something that's not too dissimilar + +56:50.860 --> 56:55.900 +from this cationic lipid up here so we can vary the chemistry of both this amine and the tail + +56:55.900 --> 57:00.620 +to generate large numbers of materials the degradability comes in from the use of these + +57:00.620 --> 57:06.060 +acrylate materials with which result in an ester in the final form of these lipids and those esters + +57:06.060 --> 57:12.540 +degrade under physiological conditions so these lipids are ionizable meaning that under reduced + +57:12.540 --> 57:17.660 +pH conditions as we form these particles they are going to have this nice electrostatic interaction + +57:17.660 --> 57:21.980 +with the negatively charged RNA which will help to catalyze the formation of these particles + +57:22.700 --> 57:27.580 +so the particles are made through a nanoprecipitation process in which we need rapid mixing + +57:28.540 --> 57:33.820 +so we have a rapid mixing of two streams to form our nanoparticles one of which is going to be + +57:33.820 --> 57:39.020 +RNA that's in a saline solution and then i do have to say that microfluidics is really cool + +57:39.020 --> 57:44.380 +they can do a lot of really cool things with microfluidic devices we have a variety of lipids + +57:44.460 --> 57:48.700 +that are dissolved in ethanol and they are rapidly mixed you can use microfluidic devices + +57:48.700 --> 57:52.620 +t-mixers and you can also use pipettes which are relatively straightforward + +57:52.620 --> 57:55.820 +pipettes are not appropriate for scale up or anything like that but they work well in the + +57:55.820 --> 58:00.140 +lab when you don't have a lot of money for microfluidic systems so you mix these two streams together + +58:00.620 --> 58:05.580 +and you get materials that you know you have you have lipids both on the exterior of the + +58:05.580 --> 58:09.100 +particle like we had with liposomes but you also have lipids throughout the material + +58:09.100 --> 58:13.740 +so in terms of the ingredients in these particles they include the ionizable lipid or lipidoid that + +58:13.740 --> 58:18.300 +i just told you about this tends to be where a lot of the IP is in the lipid nanoparticle space + +58:18.300 --> 58:22.860 +many labs or companies attempt to create their own chemistry and intellectual property with + +58:22.860 --> 58:27.340 +these synthetic materials they also contain helper lipids so these are often phospholipids that + +58:27.340 --> 58:31.180 +naturally occur in our cell membrane they can help with stability of the particles and also + +58:31.180 --> 58:35.660 +their ability to help with endosomal escape we have a lot of cholesterol in these particles + +58:35.660 --> 58:40.220 +which adds stability and prevents the particles from falling apart very similar to the way we + +58:40.300 --> 58:43.900 +have a lot of cholesterol in our cell membranes we would all be piles of boo if it were not for + +58:43.900 --> 58:49.580 +our cholesterol in our particles would be too then we have our polyethylene glycol lipid so the lipid + +58:49.580 --> 58:53.420 +anchor here will insert on the inside of the particle and then we have polyethylene glycol + +58:53.420 --> 58:57.740 +which is a hydrophilic polymer which decorates the outside of the particle it can quench that + +58:57.740 --> 59:02.700 +nanoparticle formation process so help us obtain particles of a nice size it can also improve + +59:02.700 --> 59:06.460 +stability and decrease the amount of unwanted immune cell uptake that we get + +59:07.900 --> 59:12.700 +unwanted immune cell uptake i thought you wanted immune cell uptake + +59:14.700 --> 59:18.940 +or maybe not for their maybe they're maybe they're not trying to do vaccines maybe they're trying + +59:18.940 --> 59:23.340 +to do something else so over the years we've made and screened thousands of these ionizable lipidoids + +59:23.340 --> 59:27.900 +for RNA delivery and we found a number that we really like and we've used them for numerous + +59:27.900 --> 59:31.980 +applications so here's one of our favorite lipidoids that we use in my lab + +59:31.980 --> 59:35.500 +it's a four-tailed lipidoid it has a couple of these nitrogen groups which help it + +59:35.500 --> 59:40.620 +protonate in the endosome and endosome doing endosomal escape we have our esters here for + +59:40.620 --> 59:44.220 +degradability and then these materials are interesting because they have these branch + +59:44.220 --> 59:49.260 +tails and the branch tails seem to change the structure of these lipids so that they can + +59:49.260 --> 59:54.540 +interface with endosomal membranes differently and aid that fusion and escape process so this + +59:54.540 --> 59:58.940 +is a great lipid and so the work i'm going to show you today all of it involves this ionizable lipid + +59:59.820 --> 01:00:04.140 +so standard nanoparticles where the state of the field is at this point is that we can achieve + +01:00:04.140 --> 01:00:08.780 +delivery to a couple of locations so the liver has been the easiest location i don't want to say + +01:00:08.780 --> 01:00:13.420 +it's easy but it's been the easiest because when you inject particles the liver is the organ that + +01:00:13.420 --> 01:00:18.380 +will naturally clear them from the bloodstream and so if it doesn't clear them from the bloodstream + +01:00:18.380 --> 01:00:23.580 +then those particles go elsewhere they go to any place they want to go they go to endothelial + +01:00:23.580 --> 01:00:29.260 +cells they go to the ovary they go to the testes they go to your brain they can go anywhere they + +01:00:29.260 --> 01:00:37.740 +want to if if you have perforated endothelial barriers so this concept that it can be + +01:00:37.740 --> 01:00:45.180 +it can be remain in the muscle and look how they label it immune cells and muscle now i'm sorry i'm + +01:00:45.180 --> 01:00:51.660 +not trying to be a creep here but the immune system isn't really organized to protect the + +01:00:51.660 --> 01:00:58.540 +interior of your deltoid there may be some resident immune cells there there may be a lymph + +01:00:58.540 --> 01:01:07.340 +vessel that runs through there the immune system is present but the immune system is + +01:01:07.340 --> 01:01:12.620 +oriented around barriers there is no question about it and barriers with the outside world + +01:01:12.620 --> 01:01:17.340 +there is a barrier with the outside world that runs through your body there's a barrier with + +01:01:17.340 --> 01:01:22.860 +the outside world that is in your lungs and there's a barrier in the outside world on the + +01:01:22.860 --> 01:01:31.820 +outside of your body and all three of these barriers are manned are our outward facing + +01:01:31.820 --> 01:01:38.140 +epithelial barriers epithelial cells are necessarily dividing barriers + +01:01:38.300 --> 01:01:48.860 +and the immune system is organized around them and so this assumption that she makes that we + +01:01:48.860 --> 01:01:56.460 +can inject it in in a muscle and it stays there and it's expresses protein and the immune system + +01:01:56.460 --> 01:02:03.980 +comes and it's not sure what to do but eventually it decides that what what the intention of this + +01:02:04.060 --> 01:02:09.420 +protein is is to make me make immune to a memory to it or something like this whenever they would + +01:02:09.420 --> 01:02:15.580 +talk through it and that first FDA approved product was to treat a liver condition and it's a to treat + +01:02:15.580 --> 01:02:20.940 +a liver condition because that's where the lipid nanoparticles go necessarily because the liver + +01:02:20.940 --> 01:02:27.420 +cleans your blood not because they're chemically altered to go to the liver but because that's + +01:02:27.420 --> 01:02:31.900 +where the majority of them go all of them don't go there + +01:02:35.020 --> 01:02:40.060 +the ones that don't transfect something else first get pulled out in the liver + +01:02:42.620 --> 01:02:46.060 +much of the transfection occurs at the liver + +01:02:49.260 --> 01:02:54.700 +and in fact it's very likely that when you get injected with an mRNA in your muscle and it leaks + +01:02:54.700 --> 01:03:03.020 +out the transfection occurs in the liver the transfection occurs in the capillaries of the heart + +01:03:03.020 --> 01:03:06.940 +the capillaries of the lungs maybe the capillaries of your skin + +01:03:08.380 --> 01:03:13.340 +I think we've seen it many many times where it's the capillaries of the skin where we get a massive + +01:03:13.340 --> 01:03:21.980 +transfection and therefore a massive inflammation a massive neutrophil attack on the endothelial cells + +01:03:21.980 --> 01:03:28.700 +we've seen this all around the world we've seen what happens we know this is what's going on + +01:03:28.700 --> 01:03:38.940 +there's no other biological alternative and these people know even as she disingenuously describes + +01:03:39.580 --> 01:03:48.540 +the nature of targeting the liver they called them liver targeting lipid nanoparticles because + +01:03:48.540 --> 01:03:52.060 +the liver pulls them out and the majority of them showed up there + +01:03:59.180 --> 01:04:02.540 +I mean I just hope you can see how disingenuous that is + +01:04:07.180 --> 01:04:08.460 +I just hope you can see it + +01:04:09.340 --> 01:04:11.340 +oops + +01:04:13.260 --> 01:04:18.300 +we also are capable of vaccination so delivery to the immune cells and the muscle cells within + +01:04:18.300 --> 01:04:22.780 +the muscle tissue to mount the immune response that we need but the question really is is we're + +01:04:22.780 --> 01:04:28.220 +thinking about the future of RNA therapies is how we will deliver these materials beyond the liver + +01:04:28.220 --> 01:04:32.620 +so as you can imagine most of the diseases in the body are outside of the liver and there are + +01:04:32.620 --> 01:04:36.860 +many different places we'd like to go so my lab works on delivering these materials to a couple + +01:04:36.940 --> 01:04:41.020 +of these particular organs and today I'll be talking mostly about our ability to deliver to + +01:04:41.020 --> 01:04:47.580 +the pancreas so for this work we're going to be focusing on swapping out the helper lipids + +01:04:47.580 --> 01:04:52.540 +in these particles and looking at how the influence of helper lipid charge in particular + +01:04:52.540 --> 01:04:57.660 +can direct these particles to different cell types so there have been a couple of people who + +01:04:57.660 --> 01:05:03.100 +have reported the influence of charge on the delivery process so Dan Seagard's lab was one + +01:05:03.100 --> 01:05:07.660 +of the first to show that changing the charge either cationic or negative compared to some of + +01:05:07.660 --> 01:05:12.540 +the neutral helper lipids can shift delivery from the liver to either the spleen or the lungs + +01:05:12.540 --> 01:05:18.860 +and we found something similar in our lab so in this case I'm showing you so DOPE is the standard + +01:05:18.860 --> 01:05:23.340 +phospholipid that we use in my lab it carries a net neutral charge and you can see if we look at + +01:05:23.340 --> 01:05:27.900 +organ distribution of protein expression so that's the blue and purple signal here you can see that + +01:05:27.900 --> 01:05:32.380 +we have expression in the liver and a bit in the spleen it's more it's more in the liver than the + +01:05:32.380 --> 01:05:36.380 +spleen just because the liver is larger so here's the quantified signal where we're looking at + +01:05:36.380 --> 01:05:41.580 +luminescence expression which is a model protein that we were trying to create so here we have + +01:05:41.580 --> 01:05:46.700 +mostly liver and a little bit in the spleen and then if we change our helper lipid to DOPS + +01:05:46.700 --> 01:05:50.860 +which is a negatively charged lipid you can see now that we have improved delivery in the spleen + +01:05:50.860 --> 01:05:55.580 +some shifts there whereas if we include a positively charged helper lipid now we have a + +01:05:55.580 --> 01:06:00.380 +significant shift shifts to the lung tissue so this is just evidence that the charge of these + +01:06:00.460 --> 01:06:05.420 +materials can be quite influential and this is just one of the the molecules out of four types of + +01:06:05.420 --> 01:06:10.780 +lipids that are present in these particles so we wanted to know if we could use a similar approach + +01:06:10.780 --> 01:06:15.740 +in our delivery to the pancreas so we're going to manipulate two parameters to try to get good + +01:06:15.740 --> 01:06:20.460 +delivery to the pancreas one is that chemistry so specifically the helper lipid and its charge + +01:06:20.460 --> 01:06:24.620 +and the other is the route of administration so you can imagine that depending on where you are + +01:06:24.620 --> 01:06:28.860 +injecting materials into the body you're going to go different places so we are going to swap out + +01:06:28.940 --> 01:06:34.540 +some of the typical IV injections for interperitoneal injections which is into the cavity that holds + +01:06:34.540 --> 01:06:39.660 +the liver and the pancreas and some other organs so for all of our experiments here that i'm going + +01:06:39.660 --> 01:06:45.500 +to show you today we're looking at the expression so interperitoneal would be like to lift the skin + +01:06:45.500 --> 01:06:53.660 +of your of your gut area and then poke through the skin but not poke into an organ and then squirt + +01:06:53.740 --> 01:06:59.580 +it in there it's like the space if you were to cut open the skin of your belly and open it up to + +01:06:59.580 --> 01:07:05.420 +see your intestines and then squirt it under there that that's the interperitoneal if you do that on + +01:07:05.420 --> 01:07:12.620 +a mouse or or a dog he would just pick up the skin of the belly and then put it into the triangle of + +01:07:12.620 --> 01:07:18.860 +skin that you have there and then you'd be in the space and you'd inject it in of a model protein + +01:07:18.860 --> 01:07:23.900 +so firefly vociferase and we're able to visualize protein expression if we have good delivery so + +01:07:23.900 --> 01:07:29.260 +our mRNA encodes firefly vociferase we'll put that into our particles we will deliver them into + +01:07:29.260 --> 01:07:34.300 +mice and then a few hours later we'll be able to take out their organs and to image them for + +01:07:34.300 --> 01:07:39.660 +luminescence so they take them out a few hours later you don't know where it goes after that you + +01:07:39.660 --> 01:07:44.300 +don't know if where it was is where it's going to stay you don't know anything that's the whole + +01:07:44.380 --> 01:07:51.020 +point of all of these experiments with mice is that there's necessarily an end point you're + +01:07:51.020 --> 01:07:57.580 +not going to cover all time lengths you're not going to cover all and then you're going to draw big + +01:07:57.580 --> 01:08:06.540 +conclusions and so imagine the extraordinary hubris that's going on here okay we already know + +01:08:06.540 --> 01:08:11.180 +they're safe because we tested them on three billion people so if they don't go everywhere we want + +01:08:11.260 --> 01:08:14.940 +them to all the time it doesn't matter because we know they're safe + +01:08:18.460 --> 01:08:22.780 +expressing proteins in the wrong place and the body doesn't cause any harm at all because we + +01:08:22.780 --> 01:08:27.980 +know they're safe from the vaccines don't you see otherwise we would know from the five billion + +01:08:27.980 --> 01:08:37.180 +shots that we rolled out don't you see we can target the liver because that's where they all go when + +01:08:37.660 --> 01:08:45.260 +you put them in as Mark said it's like a smart ball that when no matter which way you throw it + +01:08:45.260 --> 01:08:52.220 +it goes right back to the ground no matter what you inject in your body and into your blood it + +01:08:52.220 --> 01:09:00.940 +goes to your liver wow that's pretty brilliant you are so smart expression so here what i'm showing + +01:09:00.940 --> 01:09:05.420 +you first is if we take some of our favorite particles and we deliver them IV and this is + +01:09:05.420 --> 01:09:09.260 +with a neutral helper lipid and you can see as i showed you before that most of our expression + +01:09:09.260 --> 01:09:14.860 +is in the liver what my postdoc found when she quantified this was a very small amount of + +01:09:14.860 --> 01:09:19.900 +expression in the pancreas so note this is a exponential scale here so 10 to the 7th versus + +01:09:19.900 --> 01:09:24.140 +you know a couple of orders of magnitude more in the liver but she noticed there was a little + +01:09:24.140 --> 01:09:28.060 +something and she wondered if she could turn that little something into something more substantial + +01:09:28.060 --> 01:09:31.660 +so the first thought was okay let's change our route of administration and let's deliver + +01:09:31.660 --> 01:09:36.540 +these same particles intreparitinial injection and you can see here that we do have some shifts + +01:09:36.540 --> 01:09:40.780 +away from the liver and into the pancreas and if we quantify this here you can see the pancreas + +01:09:40.780 --> 01:09:45.500 +expression has jumped up in order of magnitude and we do see some reductions in the amount of liver + +01:09:46.140 --> 01:09:52.060 +i say give this woman a NIH grant i say payer for five more years right i mean that's + +01:09:52.060 --> 01:09:58.140 +hugely significant holy p-values Batman expression that we have and the overall efficacy is a bit + +01:09:58.140 --> 01:10:01.900 +lower this total bar is a bit lower but if our goal is to deliver to the pancreas that's not a + +01:10:01.900 --> 01:10:07.340 +problem so then she wondered about the charge of that helper lipid so here again are her data with + +01:10:07.340 --> 01:10:12.700 +the overall net neutral helper lipid which when she delivers it IP we have quite a bit in the + +01:10:12.700 --> 01:10:18.060 +pancreas then if she swaps this out for a negatively charged helper lipid we don't really see significant + +01:10:18.060 --> 01:10:21.660 +changes there there's certainly not more in the pancreas if anything there's a little less and + +01:10:21.660 --> 01:10:26.300 +then if she uses a positive helper lipid instead you can see something interesting happens so we + +01:10:26.300 --> 01:10:29.980 +we have the same amount of expression in the pancreas but what we've done is is to almost + +01:10:30.700 --> 01:10:34.380 +you know not completely but we've significantly reduced the amount of expression in the liver + +01:10:34.380 --> 01:10:39.260 +so where the hell does it go does she think it disappears it's degraded + +01:10:40.300 --> 01:10:45.340 +or is it in the endothelial cells or is it in the ovaries or is it in the brain + +01:10:46.780 --> 01:10:52.300 +there's only four organs listed here there's only four places they're looking + +01:10:56.940 --> 01:11:03.180 +and so this is really nice because ultimately if we want to do things in the pancreas you usually + +01:11:03.180 --> 01:11:06.620 +don't also want to manipulate protein expression in the liver so it's nice if we can do something + +01:11:06.620 --> 01:11:12.380 +more targeted so just to summarize what we've been able to do with these two different manipulations + +01:11:12.380 --> 01:11:17.260 +if we have IV injection of our neutral helper lipid we have less than 1% of signal in the pancreas + +01:11:17.260 --> 01:11:22.300 +if we change that to IP administration now we have 15% in the pancreas and if we then swap that + +01:11:22.300 --> 01:11:25.900 +neutral helper lipid out for something that's positively charged now we flip the ratio of + +01:11:25.900 --> 01:11:31.660 +pancreas to liver and we have about 60% and the rest we don't know what happens to who cares + +01:11:31.660 --> 01:11:37.340 +because you know we gave five billion shots to people and they're all fine so obviously it can't + +01:11:37.340 --> 01:11:47.260 +hurt holy balls i can't believe it so our next question was where in the pancreas was this + +01:11:47.260 --> 01:11:52.300 +expression occurring and what my postdoc found was that interestingly it's occurring in the + +01:11:52.300 --> 01:11:57.020 +eyelet cells so the eyelet cells are not a whole lot of the total tissue i forgot what it is but + +01:11:57.020 --> 01:12:01.900 +it's less than 10% of total pancreas tissue are these eyelets which contain both alpha and beta + +01:12:01.900 --> 01:12:08.540 +cells and so what she's trying to transfect the pancreas and it has two basic cell types and + +01:12:08.540 --> 01:12:19.100 +she's not even sure what the ratio is like i'm not an expert in the pancreas i'm not trying to + +01:12:19.100 --> 01:12:25.340 +transfect i'm not i'm not asking for grant money for the pancreas but if you don't know that ratio + +01:12:25.340 --> 01:12:29.180 +off the top of your head and you are supervising a postdoc doing a + +01:12:33.660 --> 01:12:38.060 +showing you here is some staining of luciferase expression so these are our control mice + +01:12:38.700 --> 01:12:42.380 +which have not received lipid nanoparticles and you can see that they don't have any brown + +01:12:42.380 --> 01:12:46.540 +signal which would correspond to luciferase expression and now this is the treated sample + +01:12:46.620 --> 01:12:51.420 +and you can see that the eyelets are expressing a lot of this luciferase there's also some + +01:12:51.420 --> 01:12:57.500 +outside here in the asinar tissue as well and if we quantify how important these beta cells are + +01:12:57.500 --> 01:13:01.980 +for protein expression we see that they are predominantly responsible for the protein + +01:13:01.980 --> 01:13:06.460 +expression so here if we look at wild type mice we have a certain amount of protein expression + +01:13:06.460 --> 01:13:11.020 +around 10 to the eighth and then if you treat these mice with stz which is a molecule that + +01:13:11.020 --> 01:13:15.820 +will deplete beta cells in the body you can see that we have about an order of magnitude reduction + +01:13:15.820 --> 01:13:19.740 +in the signal that we have in the animal suggesting that most of the protein expression + +01:13:19.740 --> 01:13:26.460 +is occurring in these beta cells so how on earth is this happening how are we transmitting these + +01:13:26.460 --> 01:13:30.540 +eyelets it's it would be very strange if the particles were penetrating the outer capsule + +01:13:30.540 --> 01:13:34.620 +of the pancreas my collaborator who's a pancreatic surgeon says you know that's quite unlikely + +01:13:34.620 --> 01:13:40.220 +so we wanted to understand more about how this was happening and what my postdoc did first is + +01:13:40.220 --> 01:13:45.020 +she looked at the bio distribution of these particles in the peritoneal cavity so she used + +01:13:45.500 --> 01:13:50.860 +fluorescently labeled mRNA so it was labeled with a red dye and she isolated different cell types + +01:13:50.860 --> 01:13:55.980 +so B cells T cells and macrophages and she looked at where these particles were accumulating and + +01:13:55.980 --> 01:14:00.700 +what she found was that they did not enter T cells but they were entering B cells and macrophages + +01:14:00.700 --> 01:14:03.980 +so this is not complete delivery we're not looking at protein expression here we're looking at + +01:14:03.980 --> 01:14:09.260 +which cells took up these particles so since both B cells and macrophages took up the particles + +01:14:09.260 --> 01:14:13.900 +she then asked if either one of these were involved in the process so here is an efficacy experiment + +01:14:13.900 --> 01:14:18.940 +in which she has wild-type mice and she compared the expression of luciferase here in our wild-type + +01:14:18.940 --> 01:14:24.220 +mice to mice in which those B cells have been depleted and what we see is no difference in + +01:14:24.220 --> 01:14:28.460 +expression so this suggests that the B cells are taking up the particles but they're not producing + +01:14:28.460 --> 01:14:34.940 +protein however we see something do you understand what she's testing here she she's testing whether + +01:14:34.940 --> 01:14:45.260 +the B cells the take-up protein are responsible for the signal that she saw on the spleen the liver + +01:14:45.260 --> 01:14:52.300 +or the lung or the pancreas and so she's depleting lymphocytes + +01:14:54.700 --> 01:14:57.740 +to show that there's no change in fluorescence + +01:14:57.900 --> 01:15:09.260 +to demonstrate that the fluorescence that she sees in her target organs is fluorescence that's + +01:15:09.260 --> 01:15:15.580 +not caused by these immune cells but it's caused by a transfection of those cells in those tissues + +01:15:17.740 --> 01:15:23.740 +now + +01:15:24.140 --> 01:15:28.940 +I just don't know what to say about this + +01:15:30.860 --> 01:15:35.420 +I don't know what it means I don't know what she's showing I don't know why she would call this + +01:15:35.420 --> 01:15:40.860 +an experiment that would answer that question but that's what she said that's what she explained + +01:15:46.620 --> 01:15:50.780 +and she's saying that if you deplete the macrophages that you get decreased + +01:15:51.020 --> 01:15:57.260 +efficacy of transfection decreased + +01:16:01.260 --> 01:16:03.900 +in different with the macrophages in the peritoneal cavity + +01:16:03.900 --> 01:16:08.780 +when we use a molecule that depletes these macrophages we see about an order of magnitude + +01:16:08.780 --> 01:16:12.620 +reduction in the expression that we're getting suggesting that macrophages are very important + +01:16:12.620 --> 01:16:19.580 +for this delivery process and as we dug a little bit deeper we wondered how macrophages were involved + +01:16:19.660 --> 01:16:24.140 +so there is some literature showing the process of or the concept of horizontal gene transfer + +01:16:24.140 --> 01:16:27.260 +by which cells in our body the macrophages in particular + +01:16:27.260 --> 01:16:35.020 +holy shit holy shit do you hear this what she does is she transfects the macrophages + +01:16:35.020 --> 01:16:39.740 +and the macrophages produce exosomes and she's calling them extracellular vesicles + +01:16:39.740 --> 01:16:44.140 +they are exosomes filled with that mRNA that they just got squirted with + +01:16:44.860 --> 01:16:55.580 +and those exosomes are then causing the transfection are you hearing this this is not facilitation + +01:17:03.580 --> 01:17:07.340 +I'm really I'm really I'm wow I don't even know what to say + +01:17:07.340 --> 01:17:11.740 +the type of communication to other cells that are nearby and we wondered if these extracellular + +01:17:11.820 --> 01:17:16.220 +vesicles might have some kind of role in this process so we did a rather complex experiment + +01:17:16.220 --> 01:17:19.500 +I'm going to try to walk you through it so again we have particles that are expressing + +01:17:19.500 --> 01:17:24.300 +our luciferase we're containing our luciferase mRNA we're going to inject them + +01:17:24.300 --> 01:17:29.980 +interparitoneally into mouse number one and then after a little bit of time goes past we're going + +01:17:29.980 --> 01:17:34.620 +to do a peritoneal wash so that's where you introduce some saline into the interparitoneal cavity + +01:17:34.620 --> 01:17:38.460 +and then you pull it out and it's going to contain the immune cells that are in that IP space + +01:17:39.180 --> 01:17:43.980 +so we'll take that wash and we'll put them into a cell culture dish and then we are going to + +01:17:43.980 --> 01:17:48.620 +allow these cells to produce extracellular vesicles which will bud off of them into the media + +01:17:48.620 --> 01:17:54.460 +and then we will collect them okay so now we have these EVs from the immune cells that are in mouse + +01:17:54.460 --> 01:17:59.660 +number one why are they calling them EVs when they're exosomes they're extracellular vesicles + +01:17:59.660 --> 01:18:06.460 +they are exosomes number one that have been treated with lmp's we take these EVs and we inject those + +01:18:06.540 --> 01:18:10.780 +interparitoneally into mouse number two so this mouse has not seen any lipid nanoparticles + +01:18:10.780 --> 01:18:15.340 +it's just seen these extracellular vesicles and then we do imaging to look at this luciferase + +01:18:15.340 --> 01:18:20.220 +expression and the results we found are quite interesting so we see that these EV treated mice + +01:18:20.220 --> 01:18:25.020 +so those are mouse or mice number two they do not have statistically significant differences + +01:18:25.020 --> 01:18:29.660 +in delivery compared to our lipid nanoparticle treated mice although the averages here are a bit + +01:18:29.660 --> 01:18:35.100 +we might have you know the averages about two times that of these EV treated mice so it's really + +01:18:35.100 --> 01:18:39.020 +very interesting that these EVs seem to be responsible for at least part of the delivery + +01:18:39.020 --> 01:18:43.500 +that we're seeing to the pancreas and as next steps we're going to try to figure out how exactly + +01:18:43.500 --> 01:18:48.700 +that's happening and why so finally I'll just share a little bit of safety data I always like to say + +01:18:48.700 --> 01:18:53.580 +when it comes to looking at immune responses and the toxicity there are lots of different ways + +01:18:53.580 --> 01:18:57.980 +that toxicity can happen and we've looked at only a subset of those measures and so more testing + +01:18:57.980 --> 01:19:03.340 +as well in this case we've looked at after our injections of these particles we look at some + +01:19:03.340 --> 01:19:07.740 +innate cytokines that can be expressed and we don't want to see significant differences there + +01:19:07.740 --> 01:19:12.460 +for the most part and certainly not elevation of these inflammatory cytokines then we also + +01:19:12.460 --> 01:19:17.020 +looked at antibody expression for IgG and IgM and we don't see any significance there + +01:19:17.020 --> 01:19:24.700 +after injection either what IgM and IgG antibodies would you be looking for what epitopes did you + +01:19:24.700 --> 01:19:32.940 +look for just serum IgG changes or what do you expect to see a serum IgG change + +01:19:32.940 --> 01:19:38.620 +that's a specific or was this specific for an epitope that's weird what a weird statement + +01:19:38.620 --> 01:19:45.260 +what a weird wow we also did some histology of all of these pertinent organs and compared to + +01:19:45.260 --> 01:19:50.220 +I mean then what does it mean like I don't understand does it activate the immune system then or not + +01:19:50.220 --> 01:19:57.740 +because how I guess it doesn't it only does it when they want it to they're so good at this + +01:19:57.740 --> 01:20:03.580 +wow it's impressive we also did some histology of all of these pertinent organs and compared to + +01:20:03.580 --> 01:20:08.940 +our PBS controls we don't see significant differences in the tissue or infiltration of + +01:20:08.940 --> 01:20:13.500 +immune cells so encouraging for now but as I said there's always more work so they were able to do + +01:20:13.500 --> 01:20:21.020 +histological inspection of the pancreas liver spleen heart kidney and lungs for immune + +01:20:21.660 --> 01:20:28.060 +infiltration and let's just think about this a second let's just think where are we here I'm + +01:20:28.060 --> 01:20:39.420 +going to look at the time the time is 33 19 okay so let's look let's just play shall we play a little + +01:20:39.500 --> 01:20:47.340 +bit of play where is that diagram where is that diagram well back here farther I guess + +01:20:48.540 --> 01:20:55.900 +where's the diagram there was a diagram where she told us the pro this the the the + +01:20:57.180 --> 01:21:00.940 +where she told us the actual experiment and how long was it going to take right here okay + +01:21:02.220 --> 01:21:03.020 +let's go back + +01:21:03.020 --> 01:21:13.660 +I want to go back because I want to hear how long they left the mice before they went looking for + +01:21:13.660 --> 01:21:25.580 +problems come on you demon don't mess with me demon come on later we'll be able to take out + +01:21:25.580 --> 01:21:30.700 +their organs and to image them for mice codes firefly with sipperase we'll put that into our + +01:21:30.700 --> 01:21:35.980 +particles we will deliver them into mice and then a few hours later we'll be able to take out + +01:21:35.980 --> 01:21:42.860 +their organs and to image them for luminescence expression so here what I'm showing you first a + +01:21:42.860 --> 01:21:52.140 +few hours later a few hours later that can't be when they did it for this one at 33 no way no way + +01:21:52.460 --> 01:21:59.100 +no way that can't be but you know that is it's the same + +01:22:02.140 --> 01:22:03.420 +they waited like an hour + +01:22:04.860 --> 01:22:10.220 +it's EV treated mice so it's really very interesting that these EVs seem to be responsible for at least + +01:22:10.220 --> 01:22:14.220 +part of the delivery that we're seeing to the pancreas and as next steps we're going to try + +01:22:14.220 --> 01:22:19.420 +to figure out how exactly that's happening and why so finally I'll just share a little bit of safety + +01:22:19.420 --> 01:22:23.980 +data I always like to say when it comes to looking at immune responses and and then of course we + +01:22:23.980 --> 01:22:29.420 +reviewed the safety data toxicity can happen and then of course we reviewed the safety data + +01:22:29.420 --> 01:22:34.380 +more testing is always needed in this case we've looked at after our injections of these particles + +01:22:34.380 --> 01:22:39.100 +we look at some innate cytokines that can be expressed and we don't want to see significant + +01:22:39.100 --> 01:22:43.900 +differences there for the most part and certainly not elevation of these inflammatory cytokines + +01:22:43.900 --> 01:22:48.540 +then we also looked at antibody expression for IgG and IgM and we don't see any significance + +01:22:48.540 --> 01:22:53.660 +there after injection either we also did some histology of all of these pertinent organs + +01:22:53.660 --> 01:22:58.380 +boy I'd like to know how long this was before they did it see significant differences in + +01:22:58.380 --> 01:23:04.060 +the tissue or infiltration of immune cells so after how many days there's always more work to be done + +01:23:05.020 --> 01:23:09.500 +so in summary what I've shown you today is that we can take our favorite ionizable lipid + +01:23:09.500 --> 01:23:14.780 +and we can formulate particles in which we tune both the helper lipid charge and the route of + +01:23:14.780 --> 01:23:21.020 +administration to deliver RNA to the pancreas and it seems that the eyelets are where most + +01:23:21.020 --> 01:23:26.700 +but it was mostly the the adjustment of where you injected it it had very little to do with + +01:23:26.700 --> 01:23:31.820 +what you did to the lipid did you notice that when you injected into the blood it didn't really + +01:23:31.820 --> 01:23:35.580 +change very much of where it went it was when you injected it into peritonealia and + +01:23:35.900 --> 01:23:44.780 +this is they didn't show it they didn't it's like this is so typical for an + +01:23:44.780 --> 01:23:51.660 +academy vision to say that these results are something because my p-values say it's something + +01:23:54.300 --> 01:24:00.060 +it's just unbelievable protein expression is happening and then we see that peritoneal + +01:24:00.060 --> 01:24:04.300 +macrophages are doing something very interesting to help in this process perhaps by engaging in + +01:24:04.300 --> 01:24:10.540 +this horizontal gene transfer mediated perhaps by engaging in horizontal gene transfer but the + +01:24:10.540 --> 01:24:17.420 +only thing they have as evidence that macrophages do something are this one figure + +01:24:21.980 --> 01:24:29.900 +this figure is not proof the difference between these six animals and these six + +01:24:29.900 --> 01:24:36.220 +animals right here is the proof that macrophages do something like horizontal gene transfer + +01:24:38.140 --> 01:24:43.980 +you understand that right this whole story with cartoons about macrophages + +01:24:45.420 --> 01:24:46.300 +at the end here + +01:24:46.700 --> 01:24:54.140 +the do something this cartoon hello it's me what what a horse no + +01:24:58.860 --> 01:25:06.540 +it's just unbelievable how how far this has gone how unbelievable it's it's it's totally harmless + +01:25:08.700 --> 01:25:10.460 +if you're doing experiments about + +01:25:10.700 --> 01:25:17.340 +soil microbes and just trying to figure out how that whole ecosystem works and you're never going + +01:25:17.340 --> 01:25:22.780 +to do any you know genetic manipulation and you're just measuring stuff and whatever that's great + +01:25:23.980 --> 01:25:29.100 +or if you work somewhere on some remote island on some interesting tuber + +01:25:31.660 --> 01:25:36.940 +but if you're making medical therapeutics if you're making biologics if you're making + +01:25:36.940 --> 01:25:41.820 +things that you intend to save the world with you better be freaking more complicated and more + +01:25:42.460 --> 01:25:44.460 +more humble in your biology than this + +01:25:47.580 --> 01:25:52.540 +you better have more command over the details than this you better get the details better than this + +01:25:55.340 --> 01:26:03.180 +this is terrible this is somebody with a very long narrow sliver of expertise + +01:26:03.180 --> 01:26:11.900 +a very long sliver of expertise that extends right to the edge of understanding of how + +01:26:11.900 --> 01:26:20.300 +lipid nanoparticles can be targeted to specific tissues but not nearly broad enough to understand + +01:26:20.300 --> 01:26:29.020 +how dumb a question it is if she had this kind of an understanding of biology she might understand + +01:26:29.020 --> 01:26:34.060 +how kind of ridiculous it is what she's trying to do if she had this broad of an understanding of + +01:26:34.060 --> 01:26:43.820 +biology she would not even be in this field a guy like me would have never found himself + +01:26:43.820 --> 01:26:47.260 +in this lab because this lab is even worse than + +01:26:49.500 --> 01:26:57.500 +wow someday i'm going to do like a a week on patch clamp physiology so that we can talk about + +01:26:57.980 --> 01:27:02.140 +what we can and can't do with it and more importantly we can talk about what we did with + +01:27:02.700 --> 01:27:10.060 +the mice before we did patch clamp experiments and how the in vivo manipulations of the behavior + +01:27:10.060 --> 01:27:18.780 +of the animal were read out in the the micro circuit i think i heard one member of the clown + +01:27:18.780 --> 01:27:25.420 +show talking the other day about how i might not know anything about anything because i've only + +01:27:25.500 --> 01:27:33.660 +ever worked in vitro and under a microscope a good majority of my work is under a microscope + +01:27:33.660 --> 01:27:38.860 +a good majority of my work in pitzburg was in a condor a confocal microscope a good majority of + +01:27:38.860 --> 01:27:45.420 +my work in trolenheim was and in the Netherlands was with live animals that were manipulated before + +01:27:45.420 --> 01:27:52.780 +the recordings were made either molecularly or behaviorally or both + +01:27:52.940 --> 01:27:59.820 +so i've got plenty of in vitro and in vivo experience and more importantly i've got that + +01:27:59.820 --> 01:28:09.740 +nice combination but you know it's these kind of limp-risted attacks that are happening all the + +01:28:09.740 --> 01:28:17.020 +time now and we're just not going to look backwards we're not going to look backwards in the cave + +01:28:17.100 --> 01:28:20.380 +we're not going to listen to the people saying hey wait for us + +01:28:23.500 --> 01:28:32.140 +we're out our flashlights are out pointed out we are climbing out we are actually probably + +01:28:32.140 --> 01:28:39.500 +outside of the hole helping other people out we're not climbing back in the cave + +01:28:39.580 --> 01:28:48.220 +let's see if there's any more for her let's see any more for her perhaps by engaging in this + +01:28:48.220 --> 01:28:53.980 +horizontal gene transfer mediated by extracellular vesicles so with that i'd like to thank all of + +01:28:53.980 --> 01:28:57.740 +the members of my group and particularly the people who were the most hands-on with this work + +01:28:57.740 --> 01:29:02.380 +so sam lakresti was the postdoc who looked at some of our initial charged helper-lifted work + +01:29:02.380 --> 01:29:06.060 +in the spleen and lungs and then the bulk of the work i showed you today was performed by + +01:29:06.060 --> 01:29:11.420 +jillian melamed who so this is jillian and this is sam and then our collaborator george + +01:29:11.420 --> 01:29:14.940 +get us who's at the university of pitzburg he's been a huge help he's a pancreatic surgeon and was + +01:29:14.940 --> 01:29:19.820 +able to assist us with some of our experiments um so uh then i'll just mention that i had the + +01:29:19.820 --> 01:29:24.700 +privilege of giving a ted talk a couple of years ago so if any of you want to see a lay version of + +01:29:24.700 --> 01:29:29.100 +some of what i've described here you can find that they're called fatballs for the purposes of + +01:29:29.100 --> 01:29:35.420 +uh psychom to lay audiences and then oh my gosh for the purposes of science communication they call + +01:29:35.420 --> 01:29:43.020 +them fatballs we almost should really look that that thing up right i i almost have to look at that + +01:29:43.020 --> 01:29:51.580 +that talk up um because you know it's going to be even worse than this um anyway uh who's the funders + +01:29:52.300 --> 01:29:58.220 +oh DARPA that's nice oh that's sweet isn't that nice then i age in DARPA good good good i mean + +01:29:58.300 --> 01:30:06.700 +what else you know what else what else could it be what else could it be it could only be that + +01:30:09.260 --> 01:30:14.140 +ladies and gentlemen sometime in 2019 they started telling us a story about a lab leak + +01:30:14.140 --> 01:30:19.500 +bat cave zoanosis maybe it came from a bat cave maybe it come from a laboratory maybe it came from + +01:30:19.500 --> 01:30:24.140 +the stitching done in the laboratory maybe they took it to the market after they sold animals + +01:30:24.140 --> 01:30:30.220 +there it doesn't matter this multi-colored rainbow of RNA covered the world the last three + +01:30:30.220 --> 01:30:35.740 +years and there is an illusion of consensus about this that the EUA and lockdowns were a bad idea + +01:30:36.460 --> 01:30:41.340 +but millions of people were killed by this novel virus and millions more were saved from it + +01:30:41.900 --> 01:30:46.220 +we should focus on regulating gain of function viruses because that's almost certainly where this + +01:30:46.220 --> 01:30:55.020 +came from and this faith in the fidelity of PCR and in the the lack of relevance of the + +01:30:55.020 --> 01:31:03.260 +protocols this is what we need to dismiss because the faith is a lie it was a conflated background + +01:31:03.260 --> 01:31:14.460 +signal or conflated background signals as my uh my my the clown car behind me said you know it's + +01:31:14.460 --> 01:31:21.900 +all clones now it wasn't all clones a year ago but it's all clones now the only real debate is + +01:31:21.900 --> 01:31:29.420 +whether clones spread or not which of course we've known that that's then the debate all along + +01:31:29.420 --> 01:31:33.180 +but these children are just catching up ladies and gentlemen so we're not going to look back + +01:31:33.180 --> 01:31:35.980 +we're not going to worry about it we're going to keep our arms straight we're going to keep + +01:31:35.980 --> 01:31:41.500 +our flashlights pointed forward and we are going to keep helping people find the way out + +01:31:44.540 --> 01:31:48.460 +because we are at a time point where our kids could end up enslaved + +01:31:50.060 --> 01:31:55.820 +and the way out is not to bug out the way out is not to get a cabin in the woods and don't look + +01:31:55.900 --> 01:32:03.900 +back or sign up for for Elon Musk satellite internet why would we do that + +01:32:06.940 --> 01:32:11.420 +I mean I almost feel like I have to start putting my money where my mouth is why would I do that when + +01:32:11.420 --> 01:32:19.500 +I could just take over Pittsburgh when everybody in Pittsburgh knows this immunology why would I + +01:32:19.580 --> 01:32:26.620 +have to leave when everybody at your church knows this immunology why would we need to leave + +01:32:28.860 --> 01:32:33.580 +when everybody knows this biology why would we need to leave + +01:32:38.140 --> 01:32:43.580 +making an underground network of bad of good guys is not going to solve the problem + +01:32:43.580 --> 01:32:51.340 +burning down the whole system is not going to solve the problem it's not fine if this whole + +01:32:51.340 --> 01:32:58.780 +thing falls apart because our kids were taught bad morals it's time for the adults to put their + +01:32:58.780 --> 01:33:05.420 +pants on and do the work that they should have been doing for the last 20 years it's time for + +01:33:05.420 --> 01:33:12.620 +people like you and me in our 50s to start doing the things that we should have been doing that our + +01:33:12.620 --> 01:33:16.380 +parents should have been doing but didn't do because we left it to Mitch McConnell + +01:33:17.660 --> 01:33:21.580 +and we left it to Nancy Pelosi and we left it to Joe Biden + +01:33:25.820 --> 01:33:32.380 +my dad could be president right now if he wanted to for the last 40 years but he certainly could have + +01:33:32.380 --> 01:33:38.940 +been a senator he certainly could have been a representative and he certainly would have had + +01:33:38.940 --> 01:33:41.260 +a hell of a lot better than some of the people that we've had + +01:33:43.660 --> 01:33:47.900 +it's a little weird talking from that way from Wisconsin because we did have Russ Feingold when + +01:33:47.900 --> 01:33:52.220 +I was a kid and when my dad would have been a senator and so that would have been a ridiculous + +01:33:52.220 --> 01:33:56.620 +person to run against because Russ Feingold was the last good guy we've had in Wisconsin + +01:33:58.540 --> 01:34:03.580 +I don't know about the the the young guy though he's pretty good Gallagher seems like a good guy + +01:34:03.580 --> 01:34:07.500 +stop all transfections and healthy humans please ladies and gentlemen because they are trying to + +01:34:07.500 --> 01:34:12.460 +eliminate the control group by any means necessary I don't know if this was a very good stream or + +01:34:12.460 --> 01:34:19.180 +not but I thought it was really important to show you how how far the assumptions have gone this is + +01:34:19.180 --> 01:34:27.420 +totally gone from niche to mainstream and that niche to mainstream is a lie because intramuscular + +01:34:27.420 --> 01:34:31.820 +injection of any combination of substances with the intent of augmenting the immune system is dumb + +01:34:32.380 --> 01:34:38.940 +and specifically transfection in healthy humans is criminally negligent viruses are not pattern + +01:34:38.940 --> 01:34:46.220 +integrity neither are exosomes neither are extracellular vesicles neither are lipid nanoparticles + +01:34:46.220 --> 01:34:52.780 +filled with mRNA none of them are patterned integrity and they all basically behave roughly the same + +01:34:54.380 --> 01:34:59.260 +let's just start to get this once you start to get this we're gonna get them we're gonna get them + +01:34:59.260 --> 01:35:03.500 +we're gonna win I assure you the book's not even out yet + +01:35:06.220 --> 01:35:09.340 +I know I sound like a broken record but man oh man + +01:35:11.100 --> 01:35:12.620 +holy p-values Batman + +01:35:13.260 --> 01:35:15.260 +hmm + +01:35:18.700 --> 01:35:21.020 +thanks guys I'll see you again tomorrow + +01:35:21.020 --> 01:35:24.460 +it's friday gotta keep working + +01:35:42.620 --> 01:35:44.620 +you + +01:36:04.300 --> 01:36:09.820 +are you from Wisconsin I'm from cadat up by Chippewa Falls good to see you thanks for joining + +01:36:09.820 --> 01:36:12.460 +see you tomorrow + diff --git a/twitch/1985683350 (2023-11-23) - Thanks Pieter but LNPs are not Magic --(23 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/README.md b/twitch/1985683350 (2023-11-23) - Thanks Pieter but LNPs are not Magic --(23 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/README.md new file mode 100644 index 0000000..c37cfb4 --- /dev/null +++ b/twitch/1985683350 (2023-11-23) - Thanks Pieter but LNPs are not Magic --(23 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/README.md @@ -0,0 +1,5 @@ +# Thanks Pieter but LNPs are not Magic --(23 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief + +## Streams +- - https://twitch.tv/videos/1985683350 + diff --git a/twitch/1986525909 (2023-11-24) - Mr. Sparkle was ERASED in Germany --(24 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/1986525909 (2023-11-24) - Mr. Sparkle was ERASED in Germany --(24 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief.vtt b/twitch/1986525909 (2023-11-24) - Mr. Sparkle was ERASED in Germany --(24 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/1986525909 (2023-11-24) - Mr. Sparkle was ERASED in Germany --(24 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief.vtt new file mode 100755 index 0000000..3ed0936 --- /dev/null +++ b/twitch/1986525909 (2023-11-24) - Mr. Sparkle was ERASED in Germany --(24 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/1986525909 (2023-11-24) - Mr. Sparkle was ERASED in Germany --(24 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief.vtt @@ -0,0 +1,1790 @@ +WEBVTT + +00:00.000 --> 00:02.000 +. + +00:30.000 --> 00:32.000 +. + +00:32.000 --> 00:37.000 +. + +00:37.000 --> 00:40.000 +. + +00:40.000 --> 00:43.000 +. + +00:43.000 --> 00:45.000 +. + +00:45.000 --> 00:48.280 +Good evening everybody welcome to Giga Home Biological. + +00:48.280 --> 00:51.380 +You can find me at gigaombiological.com or Gigaome.cia. + +00:51.380 --> 00:56.220 +All of this stuff is on the same website. + +00:56.220 --> 01:02.300 +able to download the stream deck every Friday. It used to be free. It used to come by email. + +01:02.300 --> 01:08.460 +It's going to start again. The broadcast schedule is usually pretty up to date, although it's + +01:08.460 --> 01:13.100 +going to be hard for me to promise any given start time, although I will try very hard. + +01:13.100 --> 01:19.020 +At the email link, you can also find a voicemail that you can call in. Leave a question. I leave + +01:19.020 --> 01:24.300 +a comment. You can also subscribe there if you'd like to become part of this officially. + +01:26.300 --> 01:30.940 +Thanks very much, guys, for being here. Good to see all of you here again. And yeah, + +01:31.740 --> 01:37.740 +happy Thanksgiving weekend. Let's keep this thing going. + +01:49.020 --> 02:19.020 +Bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, + +02:19.020 --> 02:49.020 +Bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, bye, good, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go, go + +02:49.020 --> 02:54.020 +his many, many pages on many, many people. + +02:54.420 --> 02:56.100 +Don't be afraid to do it. + +02:56.100 --> 02:57.260 +If you're bored, it's a great place. + +02:57.260 --> 02:58.100 +It's getting place. + +02:58.100 --> 02:59.980 +Sixteen minutes next. + +02:59.980 --> 03:03.340 +He's going on French, British, Italian, + +03:03.340 --> 03:04.900 +Japanese television. + +03:06.100 --> 03:08.140 +People everywhere are starting to listen to him. + +03:09.500 --> 03:10.420 +It's embarrassing. + +03:10.420 --> 03:13.880 +But not again. + +03:40.420 --> 04:10.420 +Oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh + +04:10.420 --> 04:40.420 +oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, Oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh, oh + +04:40.420 --> 04:48.100 +my ears in today so I won't have this too bad. No it's not a replay. I'm here. Whoa and I'm not + +04:48.100 --> 05:00.580 +pushing the buttons. Happy Friday Diva song. Happy Friday. Happy Friday it is indeed the faith + +05:00.580 --> 05:06.020 +in the novel virus is still there and the faith is still alive. We've got to get this message out + +05:06.020 --> 05:11.780 +ladies and gentlemen good to see you Idaho garden girl. I just saw a recent little documentary + +05:11.780 --> 05:18.420 +about how Idaho people don't want anymore. Idahoans that's pretty cute. I can imagine that that's + +05:18.420 --> 05:30.980 +the case. It feels like that in Pittsburgh too actually. Don't forget what these people are + +05:30.980 --> 05:35.780 +defending is this faith in a novel virus. This is what we've got to dispel over the holidays if we + +05:35.780 --> 05:40.180 +can for even one person. We've got to bring them to the light. We've got to get them out of the cave + +05:40.180 --> 05:52.260 +ladies and gentlemen. Thanks for joining me. Oh now see that every once in a while the timing + +05:52.260 --> 05:58.820 +is right. Every once in a while the timing is right. Good evening ladies and gentlemen welcome + +05:58.820 --> 06:03.140 +to the show. This is King of home biological high resistance low noise information brief brought + +06:03.140 --> 06:08.500 +to you by a biologist in the back of his garage in Pittsburgh Pennsylvania. It is the 24th of + +06:08.500 --> 06:18.100 +November 2023 and we are still battling against this this illusion of consensus about a dangerous + +06:18.100 --> 06:23.860 +novel virus. We are still battling this mystery we got tricked into solving about whether or not + +06:23.860 --> 06:30.900 +they were covering up a lab leak and who was responsible for it and this slow role of a narrative + +06:30.900 --> 06:36.900 +to make us believe that we actually figured out what happened and it indeed was a pandemic. + +06:38.020 --> 06:44.740 +This is the trick that they played on us. And not everybody was participating willingly. + +06:45.380 --> 06:55.460 +I went along with it for a very long time 2020. I was mostly bamboozled. 2021 still not quite there + +06:55.460 --> 06:59.940 +yet seeing the whole picture for what it was still thinking there was something to figure out. + +07:01.860 --> 07:07.540 +And so I participated as much as many others did. I just want to switch over to this really quick + +07:07.540 --> 07:13.860 +because I think it's an interesting thing to cut about. I didn't point out all the people yesterday + +07:13.860 --> 07:19.220 +because I wasn't so good at it. So I'm going to transform the picture now and try to point out + +07:19.220 --> 07:25.060 +some of these people that I think are really important. First of all the people that we have + +07:25.140 --> 07:30.900 +up on our diagram already Robert Malone, Nick Hudson, Brett Weinstein, and Denny Rancor. + +07:31.860 --> 07:35.220 +I don't think I need to explain to you why their colors are different because + +07:35.940 --> 07:41.620 +I have some suspicions that Brett Weinstein is an entirely on our team. I also have these + +07:41.620 --> 07:46.900 +sneaky suspicion that Robert Malone is an entirely on our team. Does that mean that they're bad guys? + +07:46.900 --> 07:53.700 +Not necessarily. It could just mean for any number of reasons they've chosen to work for the large + +07:53.700 --> 08:01.380 +weaponized piles of money that in reality control our societies. And we have to be pretty honest + +08:01.380 --> 08:06.260 +about it using pretty broad terms but we can, I think we can think about it this way, that there + +08:06.260 --> 08:12.740 +are weaponized piles of money, piles of money that are large enough so that they can effectively be + +08:12.740 --> 08:21.220 +used to control people, even set up a combination of different social media apps that can be used + +08:21.220 --> 08:28.820 +to control people. Even use those apps to amplify people artificially to make it seem like certain + +08:28.820 --> 08:37.700 +people are rising to the top and then use those people to limit the spectrum of debate, create a + +08:37.700 --> 08:44.740 +very lively debate within that spectrum and make sure that the real presuppositions that are being + +08:44.740 --> 08:51.620 +used to govern the people are never questioned. And so think very carefully about why it would be + +08:51.620 --> 08:57.460 +that Steven Hatfield would be standing right there in the middle of that old picture. + +09:00.260 --> 09:02.900 +What in the world is that guy doing there? + +09:05.620 --> 09:13.060 +Harvard professor Harvey Reich, not really much to say about the dangerous novel virus + +09:13.060 --> 09:18.740 +and millions of people died. The last time I talked to him, he said he had had his second case + +09:18.740 --> 09:24.500 +of COVID, I believe, and it was really, really bad despite the fact that he had had all the shots + +09:24.500 --> 09:31.620 +that he was supposed to have and was using hydroxychloroquine. And so basically everything that he thought he + +09:31.620 --> 09:37.460 +understood about whatever this is, apparently he doesn't understand it. But that's okay. + +09:37.460 --> 09:50.260 +There's Jill, Robert's wife, there's Meryl Nasse, long-time friend of the movement and + +09:50.260 --> 10:01.220 +a long-time activist on behalf of the older anthrax vaccines was when she first came on the scene + +10:01.300 --> 10:06.580 +speaking out against their deployment in the in the military. + +10:09.380 --> 10:15.700 +So it's a really, really curious photo, especially with this guy right there in the middle. He is a + +10:15.700 --> 10:24.180 +very strange fella. I don't exactly understand his role, but I can guarantee you that he is not + +10:24.180 --> 10:30.420 +just some property owner with a wood shop in his garage who would just as soon have everybody + +10:30.420 --> 10:35.780 +leave him alone so that he can make cabinets. I guarantee you that that's not the case. + +10:36.500 --> 10:42.180 +He is in Romania for a reason. I don't know what it is, but every one of these people is there + +10:42.820 --> 10:49.540 +for a reason. That's Byron Brittle, a very good guy, I believe. The guy that actually was breaking + +10:49.540 --> 10:57.700 +the the story of the distribution of the RNA or sorry, I apologize, the lipid nanoparticle + +10:57.700 --> 11:03.540 +from the Japanese data. And it was around that time, actually, that Robert Malone came out on + +11:03.540 --> 11:09.460 +Brett Weinstein's podcast. I don't know exactly the timing there, but about the same time they + +11:09.460 --> 11:15.540 +were burning Byron Brittle. I hope I'm not saying that wrong. I think it's Brittle, not Brittle. But + +11:15.540 --> 11:21.780 +anyway, that's when Robert Malone started to become prominent. So it's an interesting + +11:22.580 --> 11:35.540 +wall of people, especially in this social media space of Twitter, GAB, getter, telegram, signal, + +11:36.260 --> 11:43.220 +discord, locals. All of these people tend to kind of operate on that level, except for those + +11:43.220 --> 11:49.700 +that are more mainstream and can still do it on YouTube. And many, many, many of these people + +11:49.780 --> 11:54.660 +are capable of, you know, they have staff and whatever that are capable of number one, + +11:55.860 --> 12:03.540 +populating a channel of shorts, number two, populating multiple channels on multiple platforms. + +12:04.500 --> 12:09.700 +So there's a lot of things that these people all share in common with regard to how their message + +12:09.700 --> 12:16.820 +gets out there and how it is perceived to be amplified or censored and how they use that story + +12:16.820 --> 12:21.140 +to say that, you know, you have to pay attention to me. Most of the time you have to pay attention + +12:21.140 --> 12:27.540 +to them because they were censored and because they say they suffered so much from it. And if + +12:27.540 --> 12:32.980 +you look around this circle, you can actually see quite a few people whose whose primary shtick + +12:32.980 --> 12:39.780 +is that Stephen Kersch claims to be the number one misinformation spreader. Brett Weinstein + +12:39.780 --> 12:44.660 +claims to have lost over half of his family's income when his YouTube channel was demonetized + +12:44.660 --> 12:51.460 +because he put Robert Malone on who was is risking a whole lifetime career of of money and lives a + +12:51.460 --> 12:59.380 +very meager life on a horse farm. All of these people have the same sort of kind of story here. I + +12:59.380 --> 13:07.620 +mean, if you think about it, not necessarily all being censored, but all having some kind of reason + +13:08.580 --> 13:14.260 +to speak out. But then none of these people are are streaming from a garage that they rent. + +13:17.060 --> 13:21.540 +None of these people can claim to have been fired from a medical school because they spoke out + +13:21.540 --> 13:27.540 +against testing and they spoke out against taking temperature at the door and they spoke out against + +13:27.540 --> 13:34.020 +transfection. None of them can say that. There are people like that in the world. There are lots of + +13:34.100 --> 13:40.180 +people like that in the world that gave up their career. They burnt their they lost their lifelong + +13:40.180 --> 13:47.700 +business because they stood up for something. But for whatever reason, none of those people + +13:47.700 --> 13:52.500 +seem to have risen to the cream of the crop in terms of the the dissident narrative and in + +13:52.500 --> 13:58.660 +terms of the people that seem to get to travel from the United States to Romania and from the + +13:58.740 --> 14:05.940 +United States to Sweden and from the United States to Brussels, from the United States to Italy and + +14:05.940 --> 14:14.740 +from the United States to San Juan and from the mainland United States to Hawaii. I mean, + +14:14.740 --> 14:21.620 +this this same group of people plus or minus has been a lot of places over the last three years. + +14:21.940 --> 14:29.860 +And none of them are streaming from their garage. None of them have lost everything. None of them + +14:29.860 --> 14:37.540 +have. I mean, you can lose everything and not lose everything, right? And then you can lose + +14:37.540 --> 14:43.540 +everything. Like if you have Brett Weinstein says that he lost everything in 2017 despite the fact + +14:43.540 --> 14:48.340 +that he got a half a million dollar settlement. I'm not really sure that's being completely + +14:49.300 --> 14:54.900 +genuine. If if you say that you lost everything when your YouTube channel got demonetized, but + +14:54.900 --> 15:00.740 +you replaced it with a whole host of other income that got even better and you sold a book + +15:01.700 --> 15:06.340 +at the end, I mean, I don't know if you really lost everything + +15:08.980 --> 15:14.020 +or did getting your YouTube channel sell twice as many books as would have sold if you didn't get + +15:14.260 --> 15:22.100 +you know what I mean? I'm not really sure this math is being done as as genuinely as it could be. + +15:24.260 --> 15:28.340 +And again, it has to do with protecting this narrative. That's the bottom line. Anybody + +15:28.340 --> 15:34.660 +who's not explaining it at this point is being disingenuous, including the people who met + +15:34.660 --> 15:41.140 +Denny Rancor in person in Romania, then came back and still haven't tweeted that Denny Rancor's + +15:41.140 --> 15:49.140 +data shows that there's no spread. None of them have tweeted it. Robert Malone has very + +15:49.140 --> 15:54.740 +conspicuously tweeted twice at least and done one sub stack, which is just the transcript of + +15:54.740 --> 16:04.340 +Denny's talk and titled it 17 million people dead from the shot. So unless you read Denny's + +16:04.340 --> 16:10.260 +transcript, which I guess most people aren't going to do because Robert puts out so many + +16:10.340 --> 16:18.020 +sub stack articles, but unless you read it and you read that one line, you're actually not + +16:18.020 --> 16:23.380 +going to read it. It's not going to really hit you like it should hit you because he's got other + +16:23.380 --> 16:28.900 +papers, not just this one. That's about the shot, but he's got other papers that show that there's + +16:28.900 --> 16:37.460 +no evidence of spread across counties in America. And so that's just, I mean, you know, they talk + +16:37.460 --> 16:42.740 +to each other in person. They questioned each other. There's no doubt in my mind you've had, + +16:42.740 --> 16:50.580 +you've seen Denny on our on our stream. If he took a selfie with Jessica Rose and Jessica Rose + +16:50.580 --> 16:57.300 +saw his talk and she had any questions, he would have answered them. So she's aware that not only + +16:57.940 --> 17:03.140 +does it show that millions of people perhaps have been killed by the shot, but it definitely + +17:03.140 --> 17:06.340 +more importantly shows that there was no real evidence of spread. + +17:08.980 --> 17:14.820 +And that should that should be on everybody's top priority list. I know it's on a mixed priority + +17:14.820 --> 17:23.940 +list. He was there. But somehow the impression that was left on everybody at that place is not + +17:23.940 --> 17:29.540 +strong enough for any of those prominent people in that picture to have tweeted anything about + +17:29.540 --> 17:37.780 +there being no spread. Nobody did. And that should tell you all you need to know. + +17:39.380 --> 17:44.580 +So why was Denny there? Well, it's to me. I'm sorry, but it's the same reason why I've been + +17:44.580 --> 17:49.300 +invited to places, I'm afraid. It's to make you feel like you're making progress. It's make to + +17:49.300 --> 17:57.300 +make you feel like people are hearing you. If they flew Denny Rancor into the Senate + +17:58.180 --> 18:04.580 +or flew him into the parliament and and wherever it is in Canada, is it in Toronto? I don't know where it is. + +18:09.140 --> 18:10.980 +But they're not they flew him to Romania. + +18:14.020 --> 18:18.500 +I just don't I don't buy it. I don't think we're moving fast enough. I think we're being held back + +18:18.500 --> 18:23.300 +by the same mythology. I think we're being held back because this mythology is not being questioned. + +18:24.020 --> 18:27.940 +This illusion of consensus about a worst case scenario is not being questioned at all. + +18:29.060 --> 18:33.780 +And nobody wants us to. Nobody will is allowed to question it. Otherwise, everybody would be + +18:33.780 --> 18:42.500 +pouncing on this. It's very conspicuous that this is the border of the new world order. We are seeing + +18:42.500 --> 18:49.700 +the bricks. We just ran into the wall here. And if nothing progresses from this point on when + +18:49.780 --> 18:55.540 +they've all met him in person, when they've all seen his talk. And if all we're going to get out + +18:55.540 --> 19:00.660 +of Robert Malone is that wow, 15 million, I mean, 17 million people have been killed by the RNA. + +19:01.940 --> 19:05.860 +If that's all we're going to get out of it, we're not going to get a whole sub stack about how + +19:05.860 --> 19:08.740 +striking it is that there's no evidence of spread. + +19:13.940 --> 19:17.780 +That's pretty biologically striking. Is it not? Is that not remarkable? + +19:19.700 --> 19:32.820 +I mean, I would love it if if mathematicians and statisticians would ask Denny for the data + +19:32.820 --> 19:38.180 +and then go and verify it and people would put in the due diligence to prove him wrong. + +19:39.460 --> 19:40.820 +To find a different signal. + +19:43.940 --> 19:47.860 +You know, maybe we could put somebody on it. Maybe somebody like Steve Kirsch could put somebody + +19:47.860 --> 19:52.260 +on it. Pair him up with with Denny and make sure that we're not screwing this up. But you + +19:52.260 --> 19:57.780 +know, Denny's already publishing with a guy at Harvard. What more do you want? By the way, + +19:57.780 --> 20:04.900 +single strand or small interfering RNAs indeed double stranded. I can explain it a little bit + +20:04.900 --> 20:12.660 +now and I understand it a little bit better. But apparently, there is a protein complex that gets + +20:13.300 --> 20:20.020 +formed with small interfering RNAs that allows the double stranded RNA to unfold and one side + +20:20.020 --> 20:26.820 +stays in this complex and one side is then able to interact with complementary RNAs and + +20:29.780 --> 20:35.860 +that's how it gets down regulates the the RNA that it's so it is this it is the mechanism that I + +20:35.860 --> 20:44.820 +described but I was wrong and the lady did have the correct cartoon for the double stranded RNA + +20:44.820 --> 20:51.780 +as being the small inhibitory RNA. My bad. I never claimed to be a high level molecular + +20:51.780 --> 20:56.820 +biologist. I hope you realize that. I've taught myself all the molecular molecular biology I know + +20:56.820 --> 21:01.860 +and everything that I knew before the start of the pandemic was because I needed to do in a specific + +21:01.940 --> 21:09.540 +experiment and there's a fine line between announcement and warning and that's really + +21:09.540 --> 21:12.820 +something that I want you to think about a lot as we move forward in this card game. + +21:15.540 --> 21:20.020 +We have a lousy society. Our children have been taught all the wrong values and it's going to be + +21:20.020 --> 21:25.140 +okay that it all comes apart. It's not something that that's not a giga ohm biological message + +21:25.300 --> 21:32.180 +and anybody that tells you that it's okay if America falls apart is not being truthful. + +21:33.060 --> 21:42.900 +It's not okay and in fact that may be the only way that we can save the future for our children + +21:42.900 --> 21:51.860 +is to save what's left of the American republic and rebuild it. Not to allow chaos to develop + +21:51.940 --> 21:56.180 +not to allow a full societal breakdown which is not okay + +21:58.740 --> 22:03.380 +and yet there seems to be a message system happening right now on our side that says you + +22:03.380 --> 22:07.460 +know get your bug out bag ready make sure you're ready to load your car up and drive out of the + +22:07.460 --> 22:11.060 +city make sure you got enough guns for the zombie apocalypse. + +22:14.660 --> 22:19.780 +What if we just didn't have a zombie apocalypse? What if we just took over our school boards? What + +22:19.780 --> 22:25.540 +if we just made our neighborhoods the place that we want it to be? What if we just + +22:26.740 --> 22:32.100 +taught this biology to everybody in the United States or enough people in the United States so + +22:32.100 --> 22:39.700 +that we could avoid this calamity? Don't be lured into we're going to just let this happen. + +22:39.700 --> 22:45.300 +It's just that I think the public needs to be informed we need to be told the benefits versus + +22:45.380 --> 22:50.500 +the risk. We need to know what we're facing. Well the darker side of a polio vaccine and what + +22:50.500 --> 22:55.780 +nobody knows is that Jonas Salk has pointed out that in the last 10 years in this country + +22:55.780 --> 23:00.980 +two-thirds of all the cases of polio have been vaccinated. How many days is this on top and + +23:02.020 --> 23:06.260 +there's nothing I can do about this sound it's an extremely old video but what we're talking + +23:06.260 --> 23:13.700 +about here is 1985 on the Donahue show that's on television they're discussing whether or not + +23:13.700 --> 23:16.020 +people are being injured by the polio vaccine. + +23:21.220 --> 23:27.060 +Would you not interrupt me for a second? I know that doctors are used to interrupting patients + +23:27.060 --> 23:39.700 +but not another doctor. I think but let's get he does make a point that we should also say + +23:39.700 --> 23:46.500 +Sabin is live and the live vaccine in Salk is inactive as we say in the laboratory aren't + +23:47.060 --> 23:54.260 +how many was it they asked? Well how many people know that the European epidemic of polio there + +23:54.260 --> 23:59.860 +were about 20 or 30 cases in this country now of course the American doctors will argue that the + +23:59.860 --> 24:08.340 +reason why polio disappeared in this country was because of the vaccine but then why did it disappear + +24:08.420 --> 24:15.220 +in Europe in the 1940s and the 1950s without mass vaccination and I doesn't occur in the third world + +24:15.220 --> 24:19.540 +where only 10% of the people have never been immunized against polio or anything else. So in + +24:19.540 --> 24:24.500 +other words we may be fighting a tiger that died. That's quite correct. Ask the people in Great + +24:24.500 --> 24:32.020 +Britain. Ask the people in Japan who are all over. Back here. Gentlemen if you please I've got + +24:32.100 --> 24:39.060 +probably the smartest audience we've ever had. I have a question how long a delayed action + +24:39.060 --> 24:41.620 +if any would you connect this with like MS? + +24:44.500 --> 24:50.740 +MS a possibility. Would multiple sclerosis be one of the possible results? As a matter of fact + +24:50.740 --> 24:55.540 +there's a new publication that just came out from John Hoffman the closest associate of Tony + +24:56.500 --> 25:03.780 +that gives the references linking MS in later life to the early introduction of live virus + +25:03.780 --> 25:10.020 +vaccines like measles and like some of the others in the live viruses. Now at the present time + +25:10.020 --> 25:18.260 +I would recommend that anybody who has MS or amiotrophic lateral sclerosis or any of those + +25:18.260 --> 25:23.940 +degenerative neurologic conditions of later life carefully review their vaccine histories. + +25:23.940 --> 25:28.820 +I would also like to comment to that because in connection with my case I've been doing some + +25:28.820 --> 25:32.900 +research. Let me tell them once again Ms. Gundy that you're a Guillain-Barre victim + +25:33.700 --> 25:38.580 +contracted following the following year receipt of the swine flu vaccination. + +25:38.580 --> 25:43.540 +Yes and I am in the process of writing a book about my experience and in the process I've done + +25:43.540 --> 25:49.220 +considerable research and from what I have learned it looks as if immunizations frequently caught + +25:49.220 --> 25:54.740 +out of immune diseases not only on the race syndrome but lupus, rheumatoid arthritis, + +25:54.740 --> 25:58.580 +multiple sclerosis and other types of things. Now I have no data at this point. + +25:58.580 --> 26:03.540 +We should also say that there's a good deal of evidence suggesting that multiple sclerosis may + +26:03.540 --> 26:08.660 +be the result of a distemper in an animal that the victim received during childhood. + +26:10.180 --> 26:15.460 +None of this is absolutely nailed to the wall but that's the problem with this. How's + +26:15.460 --> 26:21.540 +what's a mother to do with all of these balls in the air and nobody really certain. + +26:21.540 --> 26:27.540 +I would just like to also comment that we had 46 million people vaccinated at the swine flu shot + +26:27.540 --> 26:32.020 +and I have written to Ralph Nader's organization. I have written to some of the other organizations + +26:32.020 --> 26:38.260 +claim to get them to do a survey, a long-going survey to see if these vaccinations do cause + +26:38.260 --> 26:42.980 +all the immune diseases or not the reactions are. I can't even get a response because I'm not a + +26:42.980 --> 26:47.060 +doctor. I have no clout. I'm a nobody. Mrs. Graham, why were you shaking your head? + +26:47.060 --> 26:51.460 +Well, it is known with that vaccine. It's a law vaccine. They are not interested in the + +26:51.460 --> 26:55.940 +adverse reactions. As a matter of fact, if I may, I'd like to invite anyone to write to me if they'd + +26:55.940 --> 26:59.700 +have an adverse reaction. I'd like to help the government because they don't want to know but + +26:59.700 --> 27:04.020 +I would like to know. I am a mother of three children and I have been informed and I've read + +27:04.020 --> 27:08.980 +up on these things and I chose not to vaccinate my children but when they get to school, why is + +27:09.060 --> 27:12.660 +it that I have to fight for my rights as a mother and a choice I can make? + +27:12.660 --> 27:17.140 +Just quickly, we're along but that's a very important question. Here are the states + +27:18.260 --> 27:25.060 +in which you either have the totally free decision about whether or not to vaccinate or there's, + +27:25.060 --> 27:30.180 +we're calling them loophole states, states where they're not going to send your child to + +27:30.820 --> 27:37.860 +solitary if you don't have a scar. All right, California, not all children must be immunized + +27:37.860 --> 27:42.340 +in these states. Some require religious reasons. Some places there is a bureaucratic + +27:42.340 --> 27:48.580 +find this Colorado, Toronto, Vermont, Washington. You see that this is Phil Donahue in 1985. What + +27:48.580 --> 27:57.380 +happens one year later? The vaccine act is passed and the discussion is ended and you will never + +27:57.380 --> 28:04.260 +have a state or federal court case about it because again, the vaccine act established this thing + +28:04.260 --> 28:09.700 +where there's a court with a special master that's not even really a court. + +28:13.620 --> 28:19.380 +And the crazy thing is my new friend Ralph Hazelhurst is actually one of the guys whose kid is in the + +28:19.380 --> 28:27.300 +one of the original autism omnibus cases is one of the lawyers at CHD + +28:27.700 --> 28:38.180 +been fighting for years. Just running around in circles with these people saying that nobody's + +28:38.180 --> 28:42.420 +ever been injured. Nobody gets injured. The people that have been injured have been compensated. + +28:44.180 --> 28:51.860 +We've got nothing to complain about. There's nothing to see here. 1985 + +28:52.180 --> 29:01.220 +All you college kids out there who are too young to know, too young to be aware of this, + +29:01.220 --> 29:08.500 +you have to understand that this history is there. It's still barely findable, but it's there. + +29:10.740 --> 29:14.180 +And this is the history you need to understand. This is where it started. + +29:14.500 --> 29:17.780 +It hasn't always been this way. + +29:20.420 --> 29:25.300 +People didn't always lie. America wasn't always about fake until you make it. + +29:27.220 --> 29:36.260 +America actually used to be about being honest and working hard to get where you needed to go + +29:37.460 --> 29:40.260 +to achieve your goals if that's the way you want to phrase it. + +29:40.740 --> 29:46.420 +We need to get back there, ladies and gentlemen, and don't let them tell you that we can't. + +29:48.020 --> 29:50.180 +Don't let them tell you that we can't. + +29:53.060 --> 30:02.980 +Even in the process of trying to remember how it used to be, we will improve ourselves infinitely. + +30:04.820 --> 30:09.700 +If we let these people keep leading us by our nose, we're going to be stuck in this trap forever. + +30:10.820 --> 30:21.460 +Anyone who fortunately took the vaccine is a much higher risk for blood clots. + +30:22.260 --> 30:28.740 +So there's over the counter substance called enacetylcysteine, or NAC. + +30:29.620 --> 30:33.700 +And it's a powerful substance that prevents blood clots, + +30:34.660 --> 30:37.700 +inhibited sulfide bonds, whatever, but it prevents blood clots. + +30:38.900 --> 30:42.900 +It's also it makes glutathione, which is a very powerful antioxidant. + +30:43.540 --> 30:49.460 +And when human cells are attacked, they get what's called oxidative stress. + +30:49.460 --> 30:53.780 +So it's like an extra layer of protection against assault. + +30:54.820 --> 30:59.540 +So that's for people that have been vaccinated or at high risk for the blood clots. + +31:00.260 --> 31:02.420 +Then I recommend a zinc ionophore. + +31:02.980 --> 31:07.460 +In other words, if you get enough zinc into your cell, you'll be protected from single-stranded RNA + +31:07.460 --> 31:10.100 +viruses. What are single-stranded RNA viruses? + +31:10.740 --> 31:16.740 +All the strains of COVID, I'm going to say to you, call the strains of COVID. + +31:16.740 --> 31:20.660 +I don't care which variant is, all variants are treated the same way by me. + +31:22.420 --> 31:25.140 +It also inhibits influenza virus. + +31:25.140 --> 31:31.300 +I'm sure the pharmaceutical industry is very happy that I'm + +31:33.140 --> 31:38.180 +basically disseminating information that the flu shot is no longer + +31:39.540 --> 31:43.060 +really necessary at best. It works around 38% a year. + +31:43.060 --> 31:49.060 +And even with the flu shot from 2015 to 2020, each year we had 40 million cases + +31:49.060 --> 31:52.740 +of the flu in America and around 40,000 dead, half of which were kids. + +31:53.700 --> 31:58.020 +So the influenza shot and the treatment approaches that we have aren't very good. + +31:59.220 --> 31:59.940 +No, they're not. + +31:59.940 --> 32:01.060 +That's trusted zinc. + +32:02.900 --> 32:06.180 +Yeah, but you need to get zinc in the right place, but you need a zinc ionophore. + +32:07.540 --> 32:09.460 +And those are the over-the-counter options. + +32:10.340 --> 32:15.620 +You have a corsetin, q-u-e-r-c-e-t-i-n, + +32:16.180 --> 32:20.180 +so biflavinoid derivative of onions and apple peels. + +32:22.580 --> 32:23.620 +Go to the counter. + +32:23.620 --> 32:26.820 +And then there's another one called EGCG, which is even more powerful. + +32:27.380 --> 32:29.540 +EGCG is a green tea extract. + +32:30.740 --> 32:34.660 +The point is there's peer-reviewed papers on the NIH that all document + +32:34.660 --> 32:37.620 +that these substances are very powerful zinc ionophores. + +32:38.660 --> 32:39.700 +Then obviously you need zinc. + +32:41.860 --> 32:44.260 +Vitamin D3 is absolutely essential. + +32:45.220 --> 32:47.700 +And you should have levels between 15 and 70. + +32:48.420 --> 32:54.980 +Because all the data shows, every few papers that people have high normal levels of vitamin D, + +32:55.940 --> 32:59.460 +they're virtually assured not to get admitted in the intensive care use. + +32:59.460 --> 33:04.340 +Otherwise your immune response is upregulated, it's very robust, + +33:04.340 --> 33:09.620 +and it protects you and helps you overcome any infection or most infections. + +33:10.340 --> 33:15.860 +And vitamin C. Vitamin C is an important cofactor in many processes. + +33:15.860 --> 33:16.980 +It's a three-year immune system. + +33:17.700 --> 33:22.820 +And so those substances, which are all available over the counter, + +33:23.700 --> 33:28.340 +they're affordable, should be within grasp of every single entity. + +33:31.460 --> 33:38.020 +And so of course we know how that message was elevated and how quickly that went viral + +33:38.020 --> 33:42.580 +on the internet and how quickly everybody around the world had high respect for + +33:43.460 --> 33:49.940 +Dr. Zebzalenko and his insight into how all single-stranded RNA viruses could potentially be + +33:50.820 --> 33:51.860 +fortified against. + +33:52.740 --> 33:56.820 +I know that we saw this on the front page of most magazines and newspapers, + +33:57.620 --> 33:59.140 +and some even had a fold out. + +34:01.140 --> 34:04.420 +Now in a real world, in a real good world, in a real, + +34:05.220 --> 34:09.780 +if that really is what was necessary, and that was really the answer, + +34:09.780 --> 34:13.780 +because it was an RNA virus spreading around the world, that knowledge + +34:15.700 --> 34:17.300 +should have gone somewhere, but it didn't. + +34:18.180 --> 34:19.540 +Maybe it got where it needed to go. + +34:22.820 --> 34:26.020 +But I'll tell you what got where it needed to go actually. + +34:26.020 --> 34:27.380 +I think we're in the middle of it. + +34:27.380 --> 34:34.260 +Excuse me, is you can find this on Ube Alshner's + +34:35.540 --> 34:40.740 +substack and on his Twitter. + +34:42.340 --> 34:49.540 +There was a second corona supposium put on by the alternative for Germany party. + +34:50.260 --> 34:55.620 +And if you're not familiar with the AFD, that is the party that Christine + +34:56.580 --> 35:01.220 +Anderson is a part of, a quite prominent spokesman, + +35:01.220 --> 35:07.620 +a spokeswoman in the European Parliament and a very outspoken person about certain things + +35:07.620 --> 35:11.700 +with regard to the pandemic and lockdowns and this kind of thing. + +35:14.260 --> 35:16.820 +It was a five hour or so symposium. + +35:16.820 --> 35:18.500 +The link is here. + +35:18.500 --> 35:20.340 +I can probably, I think we're in the middle of it. + +35:20.340 --> 35:22.100 +I can probably give that to you. + +35:22.180 --> 35:27.700 +I'm going to go back here and maybe I have it, maybe I have it here. + +35:29.460 --> 35:33.060 +So this, this movie is pretty long, + +35:35.140 --> 35:40.020 +but you can grab that link and then it's at three hours and 28 minutes that Michael + +35:40.020 --> 35:41.060 +Yeden has mentioned. + +35:41.780 --> 35:45.300 +And so I'm going to play this video first so I can kind of remind you of the kind of + +35:45.300 --> 35:46.900 +things that Michael Yeden says. + +35:46.900 --> 35:51.460 +And then hopefully I'm just queuing you up right now, 86 people in the chat. + +35:51.460 --> 35:57.220 +If anybody speaks German, go get your Q-tips and clean your ears or go get your earbuds + +35:57.220 --> 36:01.860 +and put them on because after this, I'm going to play a couple clips from that, + +36:02.820 --> 36:07.540 +that section where I think we can glean some information about what was said + +36:08.260 --> 36:12.340 +with regard to Mike and then what was said at the edit. + +36:13.780 --> 36:17.860 +And Sukhred Bhakti actually says something that I've included in here and I hope we can + +36:17.860 --> 36:18.660 +watch it together. + +36:19.140 --> 36:20.340 +And then I'm going to go to bed. + +36:20.820 --> 36:23.460 +So let's listen, see if we can get this to go. + +36:25.380 --> 36:27.860 +I think we're in the middle of an ongoing crime. + +36:27.860 --> 36:29.860 +I've no idea how long it's going to last. + +36:29.860 --> 36:34.740 +I think it's, I'm convinced that it will be the biggest crime in history. + +36:34.740 --> 36:39.460 +It's global, it has the intent of control, removing everybody's freedom. + +36:39.460 --> 36:44.020 +And I personally think we'll involve killing further millions, if not billions of people. + +36:44.020 --> 36:48.020 +That makes it a pretty big competitor for the title, World's Crime and History. + +36:48.020 --> 36:49.300 +It is long plans. + +36:49.940 --> 36:54.340 +I went boy with the details, but I've definitely come across information that shows that the + +36:54.340 --> 37:02.100 +components of the deceit that they've used, PCR, exaggerated PCR testing, the use of fear-based + +37:02.100 --> 37:07.780 +messaging through the media, this stuff's been rehearsed by militaries and the people we might + +37:07.780 --> 37:12.180 +think of as the spooks for at least 25 years and possibly longer. + +37:12.180 --> 37:14.340 +So it's long plan, very serious. + +37:14.420 --> 37:16.580 +Here's the thing why I'm calling you to arm. + +37:16.580 --> 37:19.700 +It's not going to return to the old normal. + +37:19.700 --> 37:21.380 +One, that's never their intention. + +37:21.940 --> 37:25.220 +So it's not going to happen passively because it's not, there isn't an actual + +37:25.220 --> 37:26.500 +phenomenon that's going to wear off. + +37:26.500 --> 37:28.820 +They're not going to allow it to return to normal. + +37:28.820 --> 37:35.220 +So if you comply with this tyranny, it will end with the loss of your liberty and probably your + +37:35.220 --> 37:41.380 +life. The supply chains that move materials, raw materials and finished goods around the world + +37:41.460 --> 37:44.100 +are being sawn through on a global scale. + +37:44.100 --> 37:47.540 +You only got to look at where the shipping is, where it should be and where it actually is. + +37:48.020 --> 37:54.500 +And, terrifyingly, the same is happening to food production, worldwide food and fertiliser production. + +37:54.500 --> 37:55.460 +It's in the wrong place. + +37:55.460 --> 37:56.180 +It's deliberate. + +37:56.180 --> 38:02.420 +They're smashing the means of manufacturing enough calories to keep 7.8 billion people alive. + +38:03.220 --> 38:05.220 +And, you know, where do you think that's going to end? + +38:05.220 --> 38:11.060 +Well, the answer is mass starvation or a global migration. + +38:11.060 --> 38:16.420 +That's what's going to happen if you and everybody else choose to do nothing at all. + +38:17.540 --> 38:20.740 +Also, economic instruction, we can see happening around us. + +38:20.740 --> 38:26.260 +Interest rates will rise on the back of huge debts that will just cause mass bankruptcies, + +38:26.260 --> 38:29.700 +rolling, recessions, depressions, things like that. + +38:29.700 --> 38:34.340 +And I would also imagine loss of confidence in the very thing called money. + +38:34.340 --> 38:37.460 +So any savings you've got, I think they'll just vanish. + +38:37.460 --> 38:40.180 +Literally, people will just say, I no longer trust sterling. + +38:40.180 --> 38:41.540 +I don't want to accept it. + +38:41.540 --> 38:43.860 +And so all your savings are worth nothing. + +38:43.860 --> 38:46.420 +So if you wait, I believe it will be too late. + +38:46.420 --> 38:51.380 +I think you already know that I'm broadly telling you something that's closer to the + +38:51.380 --> 38:53.380 +reality than what government's telling me. + +38:53.380 --> 39:00.020 +But I believe that we can head off the worst crimes in history by actively withdrawing our + +39:00.020 --> 39:06.500 +consent and definitely not accepting these digital ID for any reason, any reason. + +39:06.500 --> 39:09.060 +If you accept it, they will sweep over us. + +39:10.020 --> 39:13.860 +And so just in the last few words, I implore you to get involved, + +39:13.860 --> 39:18.100 +to use some of what I and others are saying to you, be brave actually. + +39:18.100 --> 39:20.180 +You have to be brave now and risk embarrassment. + +39:21.300 --> 39:26.500 +So let's presume that he basically said the same thing at this thing, right? + +39:26.500 --> 39:27.540 +We can presume that. + +39:28.500 --> 39:33.620 +So the first thing that I will point out is that this guy got introduced. + +39:34.100 --> 39:37.540 +I'm going to put the video forward in a second because the clip is too long. + +39:37.540 --> 39:38.260 +There's a suit. + +39:38.260 --> 39:39.540 +Can you see my arrow? + +39:39.540 --> 39:41.220 +Succard Bockty sitting right here. + +39:42.420 --> 39:47.540 +And this guy is speaking, who I think is Dr. Hawkert's here that's listed. + +39:48.500 --> 39:52.260 +And then right here, it says DY, but that's actually Michael Eden. + +39:53.220 --> 39:54.180 +And you can see it here. + +39:54.180 --> 39:55.780 +It says Dr. Mike Eden. + +39:55.780 --> 39:58.340 +So this is Dr. Mike Eden, DY. + +39:58.340 --> 40:00.660 +So he's waiting on zoom and he's going to speak. + +40:00.740 --> 40:05.300 +But when we go forward to this three minutes here, and then we watch it from here, + +40:05.300 --> 40:06.820 +I'm going to search from the beginning. + +40:11.620 --> 40:15.380 +See, so he's going to introduce him Dr. Michael Eden, + +40:15.380 --> 40:18.500 +is to show us how it is. + +40:18.500 --> 40:22.900 +There's a secret to Professor Hawkert. + +40:23.260 --> 40:46.000 +I'll start now where he's going to come from from this + +40:46.000 --> 40:47.420 +good keeps going. + +40:49.180 --> 40:51.940 +And then there's a cut last month prescription. + +40:51.940 --> 40:58.900 +international and interdisciplinary and now some other people are speaking. So there was no + +40:58.900 --> 41:09.860 +my own and so now I'm gonna go back again and I'm gonna try and find more. I just wanted to make + +41:09.860 --> 41:35.940 +sure that he was actually saying it, but he is, we've confirmed it multiple ways. So this is not + +41:35.940 --> 41:41.380 +my work. This is actually Uve's work. So don't don't think that I've done this. This is a German + +41:41.380 --> 41:47.860 +friend of mine. Long story about how he met, but he's one of the real freedom fighters over there. + +41:47.860 --> 41:56.900 +And yeah, it's he's become a very fast friend of mine. And so this has really worried me a lot. + +41:57.620 --> 42:03.060 +I'm really happy that he brought it to my attention. I think everybody that has any + +42:03.060 --> 42:10.260 +possibility of acting on behalf of this, because think about this. I want you to see it very + +42:10.260 --> 42:20.180 +carefully. Christine Anderson's party put on a corona symposium at which Michael Yeadon spoke + +42:20.180 --> 42:27.300 +and then their archive of it doesn't have the Michael Yeadon speech in it. That would be like + +42:27.300 --> 42:36.100 +Donald Trump's party. Donald Trump throws a coronavirus party and then everybody that speaks + +42:36.100 --> 42:43.860 +and then you know, I don't know who do you want it to be? Michael Yeadon speaks and they edited it out. + +42:46.500 --> 42:53.780 +Would that be okay with you? If Donald Trump did that, would it be okay with you in the Netherlands? + +42:53.780 --> 43:00.420 +If Wilders did that, the Netherlands just elected a guy who thinks that Gaza should be a parking lot. + +43:01.860 --> 43:08.420 +The Netherlands just elected a guy who is ultra right, but also totally in photographs with + +43:09.060 --> 43:11.300 +WEF people and with Bill Gates. + +43:11.300 --> 43:25.220 +It is absolutely shocking that the skilled TV watchers are lemming themselves off the cliff + +43:25.220 --> 43:31.940 +right now and we must wake them up because their the state is not playing around anymore. + +43:31.940 --> 43:34.580 +Germany's not even faking it. They're not even pretending. + +43:34.980 --> 43:41.060 +Their own right-wing parties are controlled. + +43:44.900 --> 43:50.500 +I'm going to have Uve on my show in the next week or so and we're going to talk all about Germany + +43:50.500 --> 43:54.500 +and about well, we need to talk about a lot of things. + +43:59.060 --> 44:03.700 +But this is unacceptable, but this is where we are. Germany is not playing. + +44:04.820 --> 44:09.460 +But what's strange about it is is that remember that Sucred Bakhti was also under threat of + +44:10.340 --> 44:13.220 +jail or something. He was accused of trees and I thought. + +44:15.460 --> 44:20.420 +But now here he is at this far right party, far right party in Germany. + +44:23.060 --> 44:28.340 +Did you know that there was a real far right party in Germany that the German government tried to ban? + +44:29.220 --> 44:32.420 +And then the Supreme Court of Germany said no, we're not going to ban it. + +44:32.500 --> 44:36.660 +Well, why aren't you going to ban it? Well, because you already have it infiltrated to the highest levels. + +44:38.580 --> 44:44.820 +So why would we ban a party that's actually run by the government? That's in court documents in Germany. + +44:46.180 --> 44:51.780 +Here we are a decade later and they seem to more or less be doing it the same way but with more sophistication. + +44:54.420 --> 44:58.980 +But think about how important it is that they threw a party for the dissidents. + +44:58.980 --> 45:05.060 +They had five hours of lectures and of all the lectures that they decided to edit out. Let's not have mics in there. + +45:07.700 --> 45:09.700 +Wouldn't want mics in there. + +45:11.620 --> 45:14.580 +Where he likely said what he said in that previous video. + +45:16.340 --> 45:21.060 +Which is as Tony said in the chat, it's pretty big downer when he's so bang on the money. + +45:24.260 --> 45:26.900 +Because withdrawing our consent is a big move. + +45:27.860 --> 45:31.940 +And the first few people who do it are going to feel really alone. + +45:34.740 --> 45:36.340 +Maybe for a really long time. + +45:38.420 --> 45:41.540 +But we've got to do it, ladies and gentlemen. I think we've got to start doing it. + +45:41.540 --> 45:44.180 +We've got to find ways for us to start doing it. + +45:47.620 --> 45:50.980 +So listen, what does he say here? + +45:56.900 --> 45:57.700 +Yeah. + +46:01.620 --> 46:07.060 +It's, it's hard, decent, tight, spontan, fuhoiter, + +46:08.020 --> 46:09.780 +eing about it for four guests then. + +46:11.940 --> 46:21.140 +That's why I can't understand German. But I swear he just said that this was not planned. + +46:21.140 --> 46:25.700 +I swear he said it. + +46:27.780 --> 46:30.580 +Did he not say it? Did anybody hear it? + +46:32.100 --> 46:37.140 +He said that it's not planned. He said it was a spontaneous something something, but it was not planned. + +46:37.140 --> 46:37.780 +It's planned. + +46:46.340 --> 46:46.740 +Hurry up. + +46:46.740 --> 46:47.540 +Would you hear it? + +46:48.260 --> 46:48.660 +Listen. + +46:52.260 --> 46:56.740 +It's hard, decent, tight, spontan, fuhoiter, + +46:57.620 --> 46:59.380 +eing about it for four guests then. + +47:01.540 --> 47:02.900 +That's why I can't understand. + +47:02.900 --> 47:03.540 +Did you hear it? + +47:03.940 --> 47:07.140 +This one needs to be planned. + +47:07.140 --> 47:16.980 +And I understand that Dutch and German are not the same language, so I could be a retard, + +47:16.980 --> 47:20.100 +but I'm telling you, I'm sorry, Jackie, I could be an idiot. + +47:21.300 --> 47:26.260 +But this sure sounds like he's saying this was spontaneous, this was not planned. + +47:26.260 --> 47:27.620 +It's not done yet. + +47:32.660 --> 47:39.780 +It's hard, decent, tight, spontan, fuhoiter, eing about it for four guests then. + +47:41.940 --> 47:43.140 +The sponger needs to be planned. + +47:46.340 --> 47:51.220 +So they probably took him out because he said that and probably + +47:52.180 --> 47:53.700 +the secret doesn't mind. + +47:57.540 --> 48:01.700 +The guy who oh my gosh, I can't even believe I I want to say this, + +48:02.500 --> 48:04.500 +but do you see what I where we're going here? + +48:04.500 --> 48:06.180 +Do you see how scary it is? + +48:06.740 --> 48:08.580 +Who's going to say it if I don't say it? + +48:10.260 --> 48:13.620 +Who else is going to dare look at this and just add this up? + +48:17.300 --> 48:18.820 +Who's going to do it? + +48:18.820 --> 48:22.100 +I'm dividing everybody now, secret's a hero. + +48:22.100 --> 48:25.220 +Yes, secret is a hero, absolutely. + +48:31.460 --> 48:34.340 +But why don't we put it all the way to the goal line? + +48:35.780 --> 48:38.740 +Does he really believe that this wasn't planned? + +48:41.460 --> 48:42.660 +I guess it's possible. + +48:44.420 --> 48:46.820 +I guess it's possible that it wasn't planned. + +48:49.060 --> 49:00.660 +But then why does it hurt to have that idea out there? + +49:03.620 --> 49:12.740 +Wouldn't a spontaneous disaster be different from a planned event + +49:13.460 --> 49:16.900 +and stand the scrutiny that a planned event wouldn't? + +49:19.060 --> 49:24.180 +Are we so afraid of a narrative that's untrue that we can't talk about it? + +49:26.740 --> 49:29.620 +I thought that's what we were fighting about for the first two years. + +49:33.380 --> 49:35.060 +It's not like he's just nobody. + +49:36.420 --> 49:37.300 +He's Mike Eden. + +49:38.500 --> 49:40.500 +He's been speaking out as long as anyone. + +49:41.860 --> 49:44.180 +I find this to be a problem. + +49:45.220 --> 49:46.660 +I don't know who the problem is. + +49:46.740 --> 49:49.140 +It could be that the party is the problem. + +49:49.140 --> 49:52.340 +And we don't even know the name of the people who decided to take that out. + +49:53.780 --> 49:55.620 +Maybe Sukhid Bhakti complained. + +49:55.620 --> 49:56.500 +Maybe he was mad. + +49:56.500 --> 49:58.180 +Maybe he was never even consulted. + +49:58.180 --> 49:59.940 +And once he finds out, he'll say something. + +49:59.940 --> 50:03.140 +I don't know, but I hope that's for sure. + +50:04.900 --> 50:09.220 +Because if this just fizzles out into the wind and nobody says anything to anyone + +50:09.220 --> 50:13.460 +and nobody asks Christine Anderson, what the hell's going on with the AFD party? + +50:16.660 --> 50:20.260 +Wouldn't this be a wonderful time for Christine Anderson to come forward and say, + +50:20.260 --> 50:25.220 +hey, somebody in my party took down Mike Eden's video. + +50:26.740 --> 50:30.900 +All Mike Eden says is that they're going to do digital ID and digital currencies in + +50:30.900 --> 50:31.940 +order to control us. + +50:32.980 --> 50:35.380 +Is Christine Anderson afraid to say that? + +50:37.620 --> 50:41.460 +Because if she's worried about our freedom, she should be a hell of a lot more worried about that + +50:41.460 --> 50:42.500 +than the WHO. + +50:42.500 --> 50:47.060 +Holy balls. + +50:47.060 --> 50:50.500 +This is some serious, serious stuff here, ladies and gentlemen. + +50:50.500 --> 50:52.340 +This is absolutely serious. + +50:53.220 --> 50:54.740 +Red alert, serious. + +50:54.740 --> 50:55.940 +I don't have that one anywhere. + +50:56.900 --> 50:57.860 +I need a red alert. + +51:01.060 --> 51:04.900 +Whole ladies and gentlemen, this train pulling and pushing exercise has been going + +51:04.900 --> 51:06.180 +along for a while. + +51:06.180 --> 51:10.420 +And they fooled us because they all did it together in coordinated action. + +51:10.420 --> 51:14.340 +They pretended that they were doing something useful to augment a natural + +51:14.340 --> 51:17.380 +phenomenon, a conflated background signal. + +51:17.380 --> 51:21.540 +They all participated in this theater at some point, wittingly or unwittingly. + +51:21.540 --> 51:23.460 +And now they're still participating in it. + +51:25.300 --> 51:30.180 +Making these stories last longer and longer and people keep asking this question when they + +51:30.180 --> 51:32.420 +should be asking, is there evidence of spread? + +51:37.460 --> 51:39.220 +Is this evidence of spread? + +51:40.020 --> 51:42.100 +Is this evidence of a novel virus? + +51:44.180 --> 51:46.580 +It's not because the math isn't done. + +51:46.580 --> 51:50.260 +You've got to subtract all the people that you didn't resuscitate because you were afraid to + +51:50.260 --> 51:52.660 +bring them into the hospital in New York City. + +51:52.660 --> 51:55.460 +You got to separate all the subtract all the people that you've + +51:55.460 --> 51:58.340 +ventilated with extra pressure so that the virus wouldn't get out. + +52:00.980 --> 52:07.220 +You got to all the people that you sent back to old folks homes without antibiotics and steroids. + +52:08.020 --> 52:13.940 +All the people that you put on Remdesivir in the hospitals over 2020 and 2021 and 2022. + +52:13.940 --> 52:19.940 +And oh my gosh, can you believe it's still 2023 and almost 2024. + +52:19.940 --> 52:24.100 +Hopioi deaths, ladies and gentlemen, are just continuing to rise. + +52:24.100 --> 52:25.380 +Nobody cares. + +52:27.940 --> 52:29.780 +And the accounting is really great, right? + +52:29.780 --> 52:36.020 +Because the death certificate fraud is wide and crazy and there is a financial reason to do it. + +52:37.940 --> 52:44.340 +They lied to us about this with a consensus and the consensus still exists. + +52:45.380 --> 52:46.740 +It's not gone. + +52:46.740 --> 52:47.620 +It's there. + +52:47.620 --> 52:49.300 +It was there in Romania. + +52:49.300 --> 52:51.940 +In that picture, the consensus was there. + +52:51.940 --> 52:53.380 +That there was a novel virus. + +52:53.380 --> 52:58.660 +Even if there was a new star of the show named Denny Rancor, + +52:58.660 --> 53:04.980 +the faith in the novel virus escaped Romania unscathed, unchallenged. + +53:08.020 --> 53:13.700 +And that faith is a lie because that has to be a conflated background signal. + +53:13.700 --> 53:14.500 +It has to be. + +53:15.220 --> 53:23.140 +It is the only possible biological explanation that does not involve further human intervention + +53:23.140 --> 53:27.220 +and malfeasance on top of a conflated background signal. + +53:30.260 --> 53:36.100 +In other words, I am also certain that if you subtract whatever man-made nonsense + +53:36.260 --> 53:38.820 +was added to that conflated background signal, + +53:38.820 --> 53:41.700 +the conflated background signal is still pretty dominant. + +53:46.180 --> 53:51.380 +I think they're doing this because they need to invert our children's sovereignty to permission + +53:51.380 --> 53:55.140 +so that they can start to require that all of their data is collected. + +53:56.180 --> 53:57.140 +They don't need everybody. + +53:57.140 --> 54:00.020 +They just need most of us and they don't need us. + +54:00.020 --> 54:01.140 +They need our children. + +54:01.140 --> 54:01.940 +We're too old. + +54:03.460 --> 54:05.220 +They need our DNA from the start. + +54:05.220 --> 54:06.980 +They need our medical data from the start. + +54:06.980 --> 54:08.340 +The more they can get, the better. + +54:09.860 --> 54:12.660 +Who knows where they're going to store it or how they're going to store it long enough + +54:12.660 --> 54:14.180 +until they can feed it into their AI. + +54:14.180 --> 54:16.340 +But I'm sure they got lots of plans on how to do it. + +54:16.340 --> 54:16.740 +It's great. + +54:16.740 --> 54:18.580 +It's probably just an infrastructure problem. + +54:20.100 --> 54:23.940 +Please stop all transfections in humans because they are trying to eliminate the control group + +54:23.940 --> 54:25.140 +by any means necessary. + +54:25.140 --> 54:27.940 +Share Mr. Sparkles videos wherever you find them. + +54:28.580 --> 54:30.980 +The more you know, the better will be. + +54:31.860 --> 54:35.300 +Intramuscular injection of any combination of substances + +54:35.300 --> 54:38.100 +with the intent of augmenting the immune system is dumb. + +54:38.100 --> 54:45.140 +Transfection in healthy animals is criminally negligent and viruses are not patterned in tegrities. + +54:48.100 --> 54:51.300 +I am going to sound like a broken record with regard to these statements, + +54:51.300 --> 54:54.820 +ladies and gentlemen, because these are the core message of giga-ol biological + +54:54.820 --> 54:58.500 +a high-resistance low-noise information brief brought to you by a biologist. + +54:59.060 --> 55:03.060 +Thank you very much for joining me and I will see you again tomorrow because + +55:03.060 --> 55:06.660 +tomorrow is another day and we do it every day here at Gigo and Biological. + +55:07.460 --> 55:13.140 +The independent bright web, the interdisciplinary bright web, the invisible bright web. + +55:13.140 --> 55:21.940 +We're here now and add some people every week and every month and until we have something + +55:21.940 --> 55:31.060 +that encounter the governance mythology and its various means of deployment. + +55:32.260 --> 55:36.340 +The mythology is being deployed and we have to work against it. + +55:36.340 --> 55:38.420 +That's what the independent bright web is going to be. + +55:39.460 --> 55:40.420 +Maybe it'll catch on. + +55:40.420 --> 55:40.820 +I don't know. + +55:42.180 --> 55:42.900 +I hope it does. + +55:44.660 --> 55:45.700 +See you guys again tomorrow. + +55:46.340 --> 55:51.780 +Have a good night. + +56:22.820 --> 56:25.940 +Thanks ladies and gentlemen again. + +56:25.940 --> 56:29.060 +I will see you tomorrow as Streak will stay alive. + +56:29.060 --> 56:30.180 +I can promise you that. + +56:30.180 --> 56:34.100 +I feel great and thank you very much for joining me. + diff --git a/twitch/1986525909 (2023-11-24) - Mr. Sparkle was ERASED in Germany --(24 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/README.md b/twitch/1986525909 (2023-11-24) - Mr. Sparkle was ERASED in Germany --(24 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/README.md new file mode 100644 index 0000000..0c145b0 --- /dev/null +++ b/twitch/1986525909 (2023-11-24) - Mr. Sparkle was ERASED in Germany --(24 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief/README.md @@ -0,0 +1,5 @@ +# Mr. Sparkle was ERASED in Germany --(24 Nov 2023)-- Gigaohm Biological High Resistance Low Noise Information Brief + +## Streams +- - https://twitch.tv/videos/1986525909 +