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+WEBVTT
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+You
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+You
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+01:00.000 --> 01:02.000
+You
+
+01:30.000 --> 01:32.000
+You
+
+02:00.000 --> 02:02.000
+I
+
+02:17.580 --> 02:23.280
+Think truth is good for kids. We're so busy lying. We don't even recognize the truth no more in this society
+
+02:23.680 --> 02:27.960
+We want everybody to feel good. That's not that's not the way life is
+
+02:30.720 --> 02:39.440
+Let's check that right now. How is this sound that we lined up or not?
+
+02:40.240 --> 02:44.240
+Talk to me goose if we're not lined up. We'll just start again
+
+02:47.200 --> 02:50.840
+All good Arthur says good step says good we're out
+
+02:50.840 --> 03:00.640
+This episode is sponsored by mink. That's moo plus link
+
+03:04.720 --> 03:11.440
+This my point is that if if we were able to just like we're trying to get everybody to take the vaccine
+
+03:11.440 --> 03:17.640
+If we had put that into getting everybody to take hypermectin and fluvoxamine for for a month
+
+03:17.960 --> 03:21.880
+If we and if we could accomplish that then COVID would be wiped out
+
+03:21.880 --> 03:28.320
+We could do it and actually any municipality that could regulate its borders could clear the disease if it could accomplish that
+
+03:28.320 --> 03:30.320
+I believe
+
+03:30.680 --> 03:34.980
+But you can tell if someone's you know you can sort of feel it and people
+
+03:36.320 --> 03:41.240
+And I have lied I'm sure I don't want a lot. You know, I don't think I'm a liar
+
+03:41.240 --> 03:43.240
+I try not to be a liar. I don't want to be a liar
+
+03:43.760 --> 03:46.600
+It's like really important not to be a liar
+
+03:47.640 --> 03:49.640
+You
+
+04:17.640 --> 04:19.640
+You
+
+04:47.640 --> 04:54.600
+Three people with thyroid cancer sounds not good
+
+04:55.600 --> 05:01.000
+It's not the kind of correlation we want to be having here, but I'm afraid this is the kind of truth
+
+05:01.960 --> 05:06.360
+This is the only kind of truth that will save us people need to start having
+
+05:08.280 --> 05:10.280
+Feeling pain
+
+05:10.320 --> 05:11.720
+Somehow
+
+05:11.720 --> 05:16.840
+If enough placebos were rolled out, we're always gonna have problems
+
+05:17.640 --> 05:22.240
+So crazy like yeah, it's it's not good. This is so crazy
+
+05:23.920 --> 05:25.920
+Nervous like what in the world man
+
+05:25.920 --> 05:27.920
+Oh
+
+05:43.760 --> 05:47.360
+Well, thank you very much for 35 people being here at
+
+05:47.360 --> 05:49.360
+1313
+
+05:50.920 --> 05:56.240
+Another weekday it is Monday again. We are still working on dispelling the enchantment
+
+05:59.560 --> 06:02.920
+For the first time you might be a skilled TV watcher
+
+06:02.920 --> 06:10.120
+But I suspect most of the people who are here already are are at the top of this wave where we are staying focused on the biology
+
+06:10.120 --> 06:13.920
+We aren't taking the bait on television and social media. We are loving our neighbors
+
+06:14.000 --> 06:16.000
+As
+
+06:16.000 --> 06:21.000
+You know the way this works is if people spread this around the new biology finds
+
+06:21.600 --> 06:26.000
+people each week and that's how we grow our roots are at
+
+06:26.640 --> 06:33.840
+Gigalombiological.com and also giga home.bio as well as screen dot giga home.bio where you can see it live and afterwards
+
+06:34.560 --> 06:38.480
+And it's all provided by us here at giga home biological
+
+06:39.640 --> 06:42.120
+We are completely supported by
+
+06:44.000 --> 06:46.000
+Hello, well, hello
+
+06:47.520 --> 06:57.080
+We are completely supported by viewers and viewers only there are a couple people who are responsible for having funded more than more than a year of our work
+
+06:57.840 --> 07:04.320
+People like Greg James and Rodney Mullen and a few other people have donated very significant amounts of money to keep this
+
+07:08.400 --> 07:13.800
+And it's the start of something really cool like an independent bright web that I think actually maybe
+
+07:13.920 --> 07:15.280
+Jimmy Gore
+
+07:15.280 --> 07:17.280
+Could in theory be a part of
+
+07:19.120 --> 07:26.480
+I don't know if you're aware of why I was not on air last night, but my wife and I this this lovely person photographed
+
+07:27.080 --> 07:30.680
+There 20 years ago. That's us 20 years ago
+
+07:31.800 --> 07:33.800
+In the Brookfield Zoo
+
+07:33.800 --> 07:38.920
+I have a friend who may still be a keeper there. I have to admit that I'm out of touch with him now
+
+07:39.760 --> 07:45.960
+But at the time he was the only keeper in the world who would free swim with walruses during training
+
+07:46.880 --> 07:52.400
+Keep in mind that that animal right there is about a thousand pounds and so if you have a thousand pound
+
+07:53.480 --> 07:57.480
+Aquatic golden retriever bump into you between you and the wall
+
+07:57.480 --> 08:02.160
+It can be a very dangerous position to be in there's lots of funny stories that he told us
+
+08:02.560 --> 08:07.360
+That's why we got to make that photograph. We got to hold a penguin that day
+
+08:07.360 --> 08:09.840
+I got attacked by octopus that day
+
+08:09.840 --> 08:11.040
+I got to
+
+08:11.040 --> 08:17.320
+Pet a dolphin in the middle of a dolphin show and like all the kids are like who the hell is this guy that gets to pet a dolphin?
+
+08:17.840 --> 08:22.520
+It was a really cool day and one of the things we got to do look at all those people in the window back there
+
+08:23.240 --> 08:25.240
+Thinking what in the hell are those people doing?
+
+08:25.800 --> 08:31.640
+Getting to play with that walrus and then there's another walrus over there that keeper's got to keep that one busy while
+
+08:31.640 --> 08:33.640
+This one was over here posing with us
+
+08:34.640 --> 08:41.280
+Anyway, this is gigo and biological a high-resistance low-noise information brief brought to you by a biologist that biologist is me
+
+08:41.920 --> 08:46.760
+Jonathan Cooley United non-compliance is something we all need to start trying to understand
+
+08:46.760 --> 08:53.400
+What does it really mean in the context of of our current scenario where there isn't too much to obviously?
+
+08:54.080 --> 08:59.640
+Not comply with but in reality, there's a lot you can you can not comply with there's a lot
+
+09:00.120 --> 09:06.080
+Going on at your school that you cannot comply with there's a lot going on at the barbecues and at at
+
+09:07.400 --> 09:10.240
+basketball games that you cannot comply with and
+
+09:11.600 --> 09:17.840
+Yeah, this is gigo and biological the safest way to get biology in your head. It is the 22nd of April
+
+09:18.920 --> 09:20.920
+2024
+
+09:20.920 --> 09:22.920
+2024 how is that even possible?
+
+09:22.960 --> 09:29.580
+We have been here for a while still fighting this conscious and intelligent manipulation of the organized habits and opinions of the
+
+09:29.640 --> 09:35.760
+masses which is how they got us to accept this pandemic as real and all the consequences of it
+
+09:36.200 --> 09:43.960
+Being a result of you know, nobody's nobody's got anybody. Nobody's got any bad intentions. It's just how it happened
+
+09:44.520 --> 09:50.040
+And that's how they got us to discard the principle of informed consent
+
+09:52.320 --> 09:57.200
+Hello, my name is Jonathan Cooley. This is gigo and biological coming to you live from Pittsburgh, Pennsylvania
+
+09:57.200 --> 09:59.200
+We
+
+10:00.240 --> 10:02.240
+Have a hypothesis that in
+
+10:03.040 --> 10:10.720
+2020 a number of mass casualty events were staged around the world and used and misconstrued as evidence of impending doom
+
+10:11.240 --> 10:17.640
+That a novel virus had just started to spread around the world. New York City was one of the key illusions
+
+10:17.640 --> 10:23.560
+That was used as a sort of seating event where here if you can see my little tiny arrow there
+
+10:24.560 --> 10:32.080
+That little slope right there was used to extrapolate that we were at the at the doorstep of impending doom and
+
+10:32.600 --> 10:33.760
+they
+
+10:33.760 --> 10:42.840
+Told this story using non-specific PCR tests that were actually rolled out on a very hot background and this hot background resulted in what
+
+10:43.000 --> 10:45.000
+effectively was
+
+10:45.000 --> 10:48.720
+The idea that wow we're finding it everywhere. We're finding it everywhere
+
+10:48.800 --> 10:53.560
+in fact, wherever you look for it you found it because it was always there in the background a combination of
+
+10:53.960 --> 10:56.720
+Always there in the background in non-specific tests
+
+10:57.360 --> 11:03.160
+This enabled a larger percentage of all-cause mortality than ever before to be converted to a
+
+11:03.720 --> 11:09.120
+National security threat in the form of not influenza, but a novel virus for which we were all
+
+11:09.880 --> 11:11.880
+vulnerable and that story
+
+11:11.880 --> 11:18.160
+That one particular line a novel virus for which we were all vulnerable with an unknown set of
+
+11:18.440 --> 11:26.120
+Consequences for an unknown number of people was the mythology that allowed them to justify everything up and to and including the
+
+11:26.480 --> 11:30.520
+Transfection the coercion of transfection the coercion of accepting
+
+11:30.880 --> 11:32.880
+Transfection as a countermeasure
+
+11:33.000 --> 11:40.280
+to this potential impending doom and I do think it's very possible that if they felt it was necessary in
+
+11:40.640 --> 11:45.840
+Order to bamboozle academic science as a whole around the world. It is possible very easy
+
+11:46.480 --> 11:54.920
+to seed PCR positivity in the form of a spike protein and end protein or an entire genome using DNA or RNA
+
+11:55.200 --> 12:01.920
+Combinations there of recombinant technologies used to produce mass quantities of a signal that then would be misconstrued as
+
+12:02.880 --> 12:04.680
+spread and
+
+12:04.680 --> 12:07.320
+Because the goal is a total inversion of our
+
+12:08.040 --> 12:13.560
+National sovereignty and also our individual sovereignty or sovereignty over our children that complete conversion
+
+12:14.120 --> 12:18.080
+To us as experimental animals who are given permission to do things
+
+12:19.280 --> 12:21.280
+Since that's the goal
+
+12:21.800 --> 12:29.640
+Then a spectacular commitment to this lie is is what's required and it shouldn't be surprising to many of us
+
+12:29.640 --> 12:34.200
+But it will be surprising to people joining the stream for the first time that we are actually
+
+12:35.440 --> 12:42.600
+Working under the the hypothesis that that everyone is coordinated in their lying spectacularly committed to the lie
+
+12:43.200 --> 12:49.400
+Because it is a national security situation. They understand that there will be dire consequences because
+
+12:52.120 --> 12:58.720
+Interfering with or obstructing a national security operation would have very dire consequences
+
+13:00.240 --> 13:05.080
+And of course we're all humans right and so as these people rushed into the fire in
+
+13:05.400 --> 13:11.440
+2020 many of them ended up being co-opted by this national security event giving given two choices
+
+13:11.440 --> 13:13.120
+You can either help us
+
+13:13.120 --> 13:16.200
+Make sure that people take the worst-case scenario seriously
+
+13:16.200 --> 13:24.040
+You can either help us and make sure that people comply with our edicts and our rules until we're ready for the next shift
+
+13:24.040 --> 13:26.460
+Or we can give that job to somebody else
+
+13:27.800 --> 13:34.160
+And so it's very likely that people like Peter McCullough and Pierre Corey and many other people were read in
+
+13:34.480 --> 13:41.040
+To the situation in so far as they needed to know and given a set of talking points that they were
+
+13:42.240 --> 13:46.080
+Required to stick to in order to make sure that they didn't encroach on
+
+13:46.440 --> 13:51.080
+The operation that was going on in the background that was this national security thing
+
+13:52.240 --> 13:54.600
+And I think once you start to see it this way
+
+13:54.680 --> 14:00.960
+You can actually forgive a lot of these people for making two hundred and thirty thousand dollars a year as the head of a
+
+14:01.440 --> 14:08.800
+doctor group or you can forgive them for for selling a book about Ivermectin and nothing else or a book about
+
+14:09.360 --> 14:11.360
+Lab leak and nothing else
+
+14:14.400 --> 14:19.880
+Before I do the the the study hall today with Judy Mikovitz's video from
+
+14:20.880 --> 14:27.600
+2018 did I say 2008 in the description I did it should be 2018 so I'm gonna fix that
+
+14:28.120 --> 14:29.880
+I'll do that post
+
+14:29.880 --> 14:31.880
+But I wanted to make a couple
+
+14:32.200 --> 14:37.440
+Mentions of some things that are going on in my world that I thought would be worth mentioning
+
+14:37.440 --> 14:40.120
+The first thing is is that I've been making subtle
+
+14:40.680 --> 14:42.680
+Remarks about my friend at the gym
+
+14:43.680 --> 14:49.680
+As you may well be aware if you're a viewer here my boys and I have joined a basketball workout gym
+
+14:50.800 --> 14:57.480
+so that they can work on their basketball and then if I get their membership then I get one kind of a free because I'm just a dad and
+
+14:57.840 --> 15:02.960
+So I've been shooting around very consistently for the last 50 odd days or so
+
+15:02.960 --> 15:07.040
+I think I've missed three days in the last 50 shooting around jumping rope this kind of thing
+
+15:07.440 --> 15:12.560
+Getting in shape and I've been making friends with the guys that work there. There aren't that many guys that work there actually
+
+15:12.560 --> 15:14.560
+It's really crazy. I got two stories for you
+
+15:14.800 --> 15:21.320
+The first one is is that one of the guys that works there actually coaches high school where my kids go and my son will start next year
+
+15:21.320 --> 15:25.680
+and it turns out that that dude played in the game where
+
+15:26.160 --> 15:33.040
+Chris Weber like called the timeout and and played for North Carolina and like won a national championship and was a pro
+
+15:33.560 --> 15:36.840
+For 16 years in Europe, which doesn't even make sense to me
+
+15:38.320 --> 15:44.240
+And so this guy is now one of the managers there and gives you know shooting coaching lessons
+
+15:44.240 --> 15:49.040
+And and is the high school coach at this high school that we're currently in that township up
+
+15:49.040 --> 15:50.120
+So it's really exciting
+
+15:50.120 --> 15:53.360
+House have found out that he might not be there anymore, which would kind of suck
+
+15:53.360 --> 15:56.800
+But he's a nice guy. He invited me to work out with him and his friends
+
+15:57.520 --> 16:00.400
+Downtown Pittsburgh during the week, which is also very flattering
+
+16:00.400 --> 16:02.880
+I don't know if I'm gonna be able to swing that but it sounds really cool
+
+16:03.120 --> 16:10.520
+And then the other guy working there the older guy actually has been a coach at more than 10 division one schools in his career
+
+16:10.520 --> 16:15.600
+And as he characterized himself, there's probably nobody that spent more time in a gym than me
+
+16:16.880 --> 16:18.880
+Really really nice guy
+
+16:18.880 --> 16:20.560
+White hair
+
+16:20.560 --> 16:23.960
+Short white hair, you know old white dude from somewhere. I don't know where
+
+16:24.760 --> 16:28.200
+Real humble helps everybody gives a little lessons to kids
+
+16:28.200 --> 16:32.480
+But also just you know when he comes walks past my kids and they're working out
+
+16:32.480 --> 16:38.080
+He'll knock the ball out of their hand and tell them to protect the ball or he'll try to block their shot real sweet old guy
+
+16:39.320 --> 16:45.000
+And last week I had to help him carry a ladder because he had to get to one of the the screens
+
+16:45.000 --> 16:50.280
+That's above the shooting machines and it was a long heavy fiberglass ladder that opened up like this
+
+16:50.280 --> 16:55.200
+So it's pretty heavy and me and another kid carried it for him because he couldn't even carry it with his one arm
+
+16:55.200 --> 16:59.040
+And he last week he told me that he'd gotten a shingles shot and this week
+
+16:59.680 --> 17:06.040
+Yesterday I was at the gym and and that gentleman was there again and when I was talking to him. He was he was like this
+
+17:08.120 --> 17:13.080
+And I was like dude what's up with your neck and he said oh man, I know I
+
+17:14.040 --> 17:15.600
+Don't know
+
+17:15.600 --> 17:18.800
+And he was kind of hesitant. He says, you know, I'm not an anti-vaxxer
+
+17:19.480 --> 17:23.440
+But I think last week I told you that I got a single shingles shot remember
+
+17:23.920 --> 17:27.440
+I had to I had you help me carry that ladder. I said I definitely remember man
+
+17:27.840 --> 17:32.760
+And he said well, it's gotten worse like I don't know I don't like I said
+
+17:32.760 --> 17:36.040
+I'm not an anti-vaxxer, but it happened like immediately after the shot
+
+17:36.040 --> 17:41.120
+I had this pain in my arm and it goes all the way up the back of my head and in my neck and
+
+17:41.680 --> 17:43.680
+I'm thinking right away
+
+17:43.680 --> 17:50.400
+Ossipital neuropathy. I'm thinking right away isn't that what people get from shingles like holy shit. So
+
+17:51.160 --> 17:53.840
+It's it's extraordinary because
+
+17:54.400 --> 18:01.600
+He's he's making apologies. He's telling his doctor this the doctor says nah, it's a stiff neck and gets him a chiropractor
+
+18:03.320 --> 18:05.840
+recommends a chiropractor for this guy
+
+18:06.000 --> 18:11.840
+He can't sleep he hasn't slept in three nights because when he lays down the pain is so unbearable and
+
+18:12.480 --> 18:14.480
+I was I couldn't really
+
+18:15.360 --> 18:17.800
+Process it all because I don't know what to say to him
+
+18:17.800 --> 18:24.960
+You know because he's already airing on the side of caution that I might not understand that he's he's not an anti-vaxxer
+
+18:24.960 --> 18:30.520
+But you know this can happen and he had to really walk on those eggshells afraid that I might be like, oh, you know
+
+18:31.680 --> 18:38.360
+Of course I talked to him and told him who I was and what I had done and where I'd been as briefly as I could and
+
+18:39.360 --> 18:42.600
+Now I don't have anything else really to say to him. What can I say to him?
+
+18:42.600 --> 18:46.760
+He took a he didn't take shingrix. He took the other one, which is recombinant
+
+18:47.120 --> 18:50.240
+It's recombinant virus, you know, it's weakened somehow
+
+18:50.240 --> 18:52.840
+I don't know they got rid of some jeans or something. I have no idea
+
+18:52.840 --> 18:57.040
+I haven't looked into it yet, but it's just terrible because he's got neuropathy now
+
+18:57.040 --> 19:02.480
+And I know I'm not a doctor, but I know that neuropathy is not something you can just take vitamin C4
+
+19:04.160 --> 19:05.720
+And so it terrifies me
+
+19:05.720 --> 19:08.880
+I don't know if I'm gonna see that guy today when I go to the gym with my kids
+
+19:08.880 --> 19:10.880
+I don't know if I'm gonna see him next month and
+
+19:11.840 --> 19:16.880
+And will this ever go away from or is it gonna be a devastating thing that ruins this guy's life forever
+
+19:17.120 --> 19:19.800
+He says to me at some point in the conversation
+
+19:19.800 --> 19:22.440
+No, I never have reactions when I get these vaccines
+
+19:22.440 --> 19:24.480
+And then I'm thinking holy shit
+
+19:24.480 --> 19:32.200
+How many vaccines are they telling you to take when you go on the CDC website the CDC recommends everybody over 50 to take two shots of the singles
+
+19:32.280 --> 19:34.280
+vaccine and
+
+19:34.280 --> 19:36.280
+That's what they told him I
+
+19:37.040 --> 19:39.040
+I
+
+19:40.520 --> 19:46.440
+Think that you know quite frankly we should be telling all of our old people all of our friends everybody not to take any
+
+19:46.600 --> 19:52.640
+Vaccines none new no they don't need new vaccines. They're old people. They should eat better take vitamin whatever, but not
+
+19:53.440 --> 19:56.440
+Vaccines we've got to stop this nonsense. I
+
+19:57.600 --> 20:03.560
+Did tell him I was an anti-vaxxer. I told him that I worked for one of the the top 12 anti-vaxxers for a while
+
+20:04.520 --> 20:06.520
+Yeah, it was pretty funny
+
+20:07.440 --> 20:11.040
+Pretty pretty funny conversation. Okay, so now Jimmy door
+
+20:11.840 --> 20:13.840
+Guess who I saw yesterday?
+
+20:13.840 --> 20:17.720
+I saw Jimmy door yesterday and I gave him a book
+
+20:18.800 --> 20:25.840
+Robert can it Robert F. Kennedy's book and I had highlighted all the places where I was where I was
+
+20:26.320 --> 20:32.040
+quoted I also put my phone number everything in there and I said in the inside of the cover I
+
+20:32.280 --> 20:37.360
+Wrote we are being lied to by the people now riding white horses
+
+20:37.360 --> 20:39.360
+we should talk and
+
+20:39.360 --> 20:46.120
+I have little tabs in every place in the book where I'm found so that he can find me and it says that's me and stuff
+
+20:46.120 --> 20:49.400
+I I ruined the book basically, but I used it as a business card
+
+20:49.960 --> 20:55.720
+I talked to him very briefly here in this little meet-and-greet where there were like 10 people so it wasn't very long
+
+20:55.720 --> 20:57.120
+I could have talked to him for longer
+
+20:57.160 --> 21:03.760
+We also got to meet Steph and we took a picture with her after the show and I'm not really sure why I'm not wearing the t-shirt
+
+21:03.760 --> 21:05.760
+But I will put it on
+
+21:05.760 --> 21:11.280
+And so we didn't talk for very long. I just said hey I helped Robert F. Kennedy, Jr.
+
+21:11.280 --> 21:16.360
+Write this book you can see my name here. Here's my phone number, you know, we should talk and it was really cool
+
+21:16.920 --> 21:21.800
+The guy who was selling the t-shirt said thanks for the book and then Steph on the way out took
+
+21:21.800 --> 21:25.280
+I said took a picture with us on the way out and said thanks for the book
+
+21:25.440 --> 21:28.760
+I don't know if they're gonna get back to me. I don't know what's gonna happen
+
+21:29.880 --> 21:31.080
+but
+
+21:31.080 --> 21:34.280
+That's as close as I can get to making some kind of
+
+21:35.520 --> 21:39.600
+Penetration into this more mainstream media area
+
+21:40.160 --> 21:43.000
+And it was really a great show. He took a lot of risks
+
+21:43.800 --> 21:48.040
+I have to commend him for the amount of time he spent talking about how
+
+21:48.600 --> 21:52.800
+angry he was about being lied to about the vaccine and and
+
+21:53.040 --> 21:56.520
+Defending the people in the room, you know
+
+21:56.520 --> 22:00.720
+He asked everybody to raise their hand if they had not taken the shot and a lot of people
+
+22:00.720 --> 22:04.880
+I mean it's Pittsburgh right and it's a Jimmy Dorshow a lot of people raised their hand
+
+22:04.880 --> 22:10.520
+But the people that didn't raise their hand he showed and spoke solidarity with them and said that you know
+
+22:10.520 --> 22:16.680
+You shouldn't be ashamed of being fooled. They frickin lied and it was really wonderful the way that he said it now
+
+22:16.680 --> 22:22.240
+There were caveats he he gave Robert Malone credit for having predicted that Omicron would be
+
+22:23.440 --> 22:26.400
+Would be less or less severe and more mild
+
+22:27.560 --> 22:33.080
+He's definitely convinced that there was a virus still right but he is very very
+
+22:33.640 --> 22:40.160
+Advanced in terms of his understanding that they lie about everything and so I don't think it would be that far of a leap for him
+
+22:40.480 --> 22:43.560
+To think that some of these people have lied about the biology
+
+22:43.560 --> 22:47.960
+I don't think it would be very hard for him to take that leap at all. He ended his
+
+22:48.440 --> 22:51.480
+So I'll tell you a first a funny story about Jimmy Dors
+
+22:52.360 --> 22:54.360
+He made a joke
+
+22:54.560 --> 22:55.480
+about
+
+22:55.480 --> 22:56.840
+circumcision and
+
+22:56.840 --> 23:00.680
+it was something to do with with cutting heads off and
+
+23:01.120 --> 23:07.160
+People don't care if they cut this off or whatever and it being Jewish. I can't remember exactly, but then he said
+
+23:08.200 --> 23:13.420
+And I'm not Jewish, but somehow I ended up circumcised and it just
+
+23:13.920 --> 23:19.520
+Blurted it out from my table in the back and it was dead quiet. Everybody heard it
+
+23:19.600 --> 23:22.680
+I said they needed it for cell culture and
+
+23:23.400 --> 23:28.920
+his immediate response like right whip snap fast as it could be hey
+
+23:28.920 --> 23:34.480
+Alex Jones is in the audience today ladies and gentlemen. Well welcome Alex and everybody laughed
+
+23:34.480 --> 23:38.200
+I got a couple fist bumps from people around me. It was really cute
+
+23:38.840 --> 23:41.080
+and he ended the stream with
+
+23:42.280 --> 23:48.280
+They're lying to us to divide us. They tell us lies to divide us. They don't want us to become united
+
+23:48.360 --> 23:52.440
+They don't want us to unite and we need to unite. We need to love our neighbor
+
+23:52.640 --> 23:58.240
+We need to come together as one country. He said a lot of really cool things. He wants a revolution
+
+23:58.240 --> 24:00.440
+He's be happy to be a leader of it. I
+
+24:02.200 --> 24:03.880
+Do think that he's a good soul
+
+24:03.880 --> 24:10.440
+I think he's a good guy and I just think that it's very easy to be in his position and not have the requisite
+
+24:10.600 --> 24:16.640
+Knowledge to know whether somebody like Robert Malone really is a whistleblower or or or kind of a two-faced
+
+24:17.080 --> 24:21.600
+You know insider and and I do think that that it's not impossible
+
+24:23.720 --> 24:26.760
+Jimmy's been doing some great stuff with regard to RFK
+
+24:26.880 --> 24:32.280
+He said I saw some people in the audience with some and and some people at the meet and greet that had
+
+24:32.680 --> 24:36.240
+Kennedy shirts on gosh. I really like that guy. He's really cool. It's too bad
+
+24:36.240 --> 24:40.200
+He's a fucking Zionist and it's sorry to swear. I was just quoting him
+
+24:40.280 --> 24:42.320
+But he got really mad about it
+
+24:42.320 --> 24:47.440
+He got really mad about Cornell West and really mad about Bernie Sanders and was a real
+
+24:47.920 --> 24:49.680
+Well spread out, you know
+
+24:49.680 --> 24:56.720
+I am very disappointed in how many people I have put my trust in and belief in that have let me down and I had a real I
+
+24:57.160 --> 25:02.320
+Had the feeling that he was really working things out. He's real be an honest on stage. It's real
+
+25:02.840 --> 25:07.060
+he's trying kind of to resurrect a little bit of the of the
+
+25:08.060 --> 25:14.420
+Of the George Carlin stick, but it's a much more raw presentation. It's a guy who got screwed
+
+25:14.420 --> 25:20.180
+He is not happy about having taken that shot. He's not happy about these people having gotten away with it
+
+25:20.180 --> 25:27.460
+And I like he's he's angry in the right way because he's also really he's a whip. He's whip funny. I mean he was really good
+
+25:29.380 --> 25:34.700
+He was really good and I really enjoyed it a lot. I know that fear the laughed a lot apparently
+
+25:34.780 --> 25:38.780
+He's been doing comedy since before women had dicks that was his first joke
+
+25:38.780 --> 25:44.020
+And I thought that at that point we were already lost like it was I was just laughing and the nice thing about it
+
+25:44.020 --> 25:47.500
+Was is fearless and I had not been out on any kind of date without the kids
+
+25:48.420 --> 25:49.700
+in
+
+25:49.700 --> 25:51.700
+In memory
+
+25:51.700 --> 25:54.340
+It's certainly the first time we've gone out like that
+
+25:54.340 --> 26:00.940
+I think since covid and so it was a really nice dinner together and really nice time together and
+
+26:01.820 --> 26:07.860
+The kids did really well while we were gone and and so overall was really great and who knows?
+
+26:07.860 --> 26:12.380
+I mean, we planted a seed with Jimmy right and and that's all we can really hope to do
+
+26:12.380 --> 26:18.420
+I hope that you agree with me that that's it couldn't have been better than that. I don't think
+
+26:20.060 --> 26:25.500
+Basically I used the book in the worst way possible in their imagination, I guess
+
+26:26.460 --> 26:28.460
+But yeah
+
+26:28.500 --> 26:29.820
+Anyway
+
+26:29.820 --> 26:33.460
+Judy McAvitt study hall cannabis sciences virtual event
+
+26:33.460 --> 26:37.540
+I thought this was interesting because of the emphasis on
+
+26:38.100 --> 26:41.820
+cannabinoids and the cannabinoid system with regard to immune regulation
+
+26:42.460 --> 26:50.060
+And I thought it was very curious that somebody like Judy McAvitt's would present this at the cannabis sciences virtual event
+
+26:50.940 --> 26:55.380
+In 2018 and since I haven't done very much work on Judy McAvitt's
+
+26:55.380 --> 26:57.740
+I don't really have a good idea of what's going on with her
+
+26:57.740 --> 27:01.740
+I thought this was also a really nice way for me to be able to plug
+
+27:02.620 --> 27:04.620
+my friend's work
+
+27:05.180 --> 27:07.420
+My friend mark usatonic so
+
+27:08.180 --> 27:10.620
+Mark Koolack has a website called
+
+27:11.580 --> 27:15.420
+usatonic ITS and if you go to his research page
+
+27:17.580 --> 27:19.580
+Like this and you go all
+
+27:19.860 --> 27:25.860
+Then you basically get to the A's and then you have this alphabet underneath here and you can look up anybody that he's
+
+27:26.180 --> 27:29.460
+He's stored things on and so you know
+
+27:29.460 --> 27:35.700
+You can find a page on Judy McAvitt's there and you can find a page on some of the people that have worked with her and and
+
+27:35.980 --> 27:40.900
+And a long you know all the all the stuff is there. That's the nice thing about it
+
+27:40.900 --> 27:47.860
+It's not a Wikipedia because a Wikipedia is pretty incomplete mark has taken a lot of these original sources and compiled them together
+
+27:48.660 --> 27:52.700
+And so you can get a good idea of her her background there
+
+27:52.700 --> 27:57.500
+And so I would like to encourage you to do that and also just to go back one step
+
+27:57.620 --> 28:03.780
+There's also quite a bit on shingles vaccination with the CDC and one of the things that's there
+
+28:03.980 --> 28:08.140
+You can find is occipital neurology, which is I think what my friend at the gym has
+
+28:08.700 --> 28:10.620
+And you can find
+
+28:10.620 --> 28:16.340
+Complications long term nerve pain nerve pain is the most common complications of shingles
+
+28:16.660 --> 28:18.660
+So it terrifies me to think that this
+
+28:19.220 --> 28:25.020
+Hossipital neurology that I think that my friend is now suffering from could be a long-term nerve pain problem
+
+28:25.660 --> 28:30.900
+Which is just disgusting the CDC recommends two doses of recombinant zoster vaccine
+
+28:31.220 --> 28:35.780
+To prevent shingles and related combinations in adults 50 years or older. I
+
+28:37.140 --> 28:41.020
+Just think it's disgusting and I think that this lie needs to be put to rest
+
+28:41.980 --> 28:48.420
+It just it frightens the heck out of me that we are we are doing this and that old people are in in the same
+
+28:48.740 --> 28:53.580
+Situation that that really where did the maybe I didn't have it in that one. Sorry. Oh
+
+28:55.020 --> 28:57.020
+Yeah, it's here
+
+28:57.020 --> 29:04.500
+That old that old people are now in the same situation that a lot of young parents are in except about themselves young parents are often
+
+29:04.700 --> 29:07.180
+You can characterize it as being bullied
+
+29:08.140 --> 29:14.060
+Into accepting the vaccine schedule as it is and even if you ask to have a delayed a couple years you will be
+
+29:14.940 --> 29:16.940
+given a lot of heck for that
+
+29:17.660 --> 29:19.660
+Nevermind if you want to
+
+29:19.660 --> 29:22.060
+abstain from participating in it and so
+
+29:23.260 --> 29:25.260
+It's it's a real
+
+29:27.020 --> 29:31.100
+It's really it's really a devastating place that we're in right now if we are coercing
+
+29:31.900 --> 29:37.700
+And it's normal to coerce elderly or even older people 50 years old. I'm 50
+
+29:37.700 --> 29:42.300
+I should take two of those things then right that's what they would say and that's just crazy talk
+
+29:42.300 --> 29:47.500
+I mean I had chickenpox real bad when I was 13 years old. I ain't messing with that shit again
+
+29:47.740 --> 29:51.100
+So there I'm swearing. I got a chill out. I got a cool out
+
+29:52.260 --> 29:56.460
+But yeah, here we go. This is a study hall
+
+29:56.860 --> 30:02.380
+And I am going to put the playback speed up to 1.5 until otherwise noted
+
+30:03.660 --> 30:05.660
+and
+
+30:05.660 --> 30:12.780
+Yeah, let's see what Judy mikovitch has got mikovitch has to say about these things cannabinoids as stem cell and immune therapy
+
+30:13.260 --> 30:16.060
+It's interesting right that sounds pretty much like a catch-all
+
+30:16.780 --> 30:20.940
+Like cannabinoids could be used for almost anything in future medicine
+
+30:21.340 --> 30:26.380
+Which is a really exciting thing that might be some that might be a very good reason why some
+
+30:26.460 --> 30:30.860
+But he might want to sequence cannabinoid genomes and work on variants
+
+30:31.740 --> 30:37.980
+In cannabinoids, you know, like get in on the ground floor with regard to the genetics of canada cannabis
+
+30:37.980 --> 30:41.180
+That might be a really good reason to get in on that
+
+30:41.980 --> 30:46.220
+Get out of that action. So let's see what Judy's got to say about that
+
+30:46.780 --> 30:54.620
+Action well everyone. I welcome to today's live broadcast cannabis as immunotherapy for 21st century acquired immune deficiencies presented by
+
+30:54.700 --> 31:01.180
+Dr. Judy mikovitch founder and consultant at mark ink and director of cancer biology at epi gen x pharmaceuticals
+
+31:01.260 --> 31:03.580
+I'm tz Valdez of lab roots and i'll be your moderator for today's event
+
+31:03.820 --> 31:11.900
+We're delighted to bring you this educational web seminar presented by lab roots lab roots is the leading scientific social networking website and producer of educational virtual events and webinars
+
+31:12.300 --> 31:15.660
+Before we begin. I want to remind you that this event is interactive
+
+31:15.660 --> 31:20.380
+We encourage you to participate by submitting as many questions as you want at any time you want during the presentation
+
+31:20.700 --> 31:22.700
+Just click on that ask a question box
+
+31:22.940 --> 31:28.060
+Located on the far left of your screen and type the questions into the dropdown box that appears on that screen
+
+31:28.220 --> 31:31.420
+We'll answer as many questions as we have time for at the end of the presentation
+
+31:31.740 --> 31:33.740
+If you have any trouble seeing or hearing this presentation
+
+31:33.980 --> 31:40.220
+Click on the help desk button located on the promotional board at the bottom center of your screen or use that ask a question and let us know
+
+31:40.220 --> 31:45.100
+You're having a problem this presentation is educational and offers continuing education credits
+
+31:45.340 --> 31:52.620
+Click on the continuing education credits tab located at the top right corner of your presentation window and follow the process to obtain those credits
+
+31:53.100 --> 31:57.420
+Please join me now and welcoming our presenter dr. Mikovitz. I will now turn the presentation over
+
+31:58.140 --> 32:01.820
+Welcome dr. Mikovitz. Thanks. Thanks so much. It's a delight to be here
+
+32:02.620 --> 32:10.380
+And talk about a really exciting topic as far as therapeutic potential for some of the most devastating diseases of our time
+
+32:11.180 --> 32:13.180
+And that's using cannabinoids
+
+32:13.820 --> 32:16.140
+as stem cell therapy and immune therapy
+
+32:16.860 --> 32:18.860
+So on that first slide
+
+32:18.860 --> 32:25.260
+There that you see ahead of you you see some of those diseases you see cancers a lot of hormone
+
+32:26.220 --> 32:28.700
+Sensitive cancers a lot of leukemia lymphoma
+
+32:30.060 --> 32:37.500
+Bladder cancers. These are these are cancers that that tend to respond to immune therapy. We also consider autoimmune diseases
+
+32:38.460 --> 32:42.400
+Lupus inflammatory bowel disease Crohn's disease polymyositis
+
+32:43.500 --> 32:46.620
+Syndrome Biches disease and primary biliary cirrhosis
+
+32:47.020 --> 32:51.420
+I think i'm already going to tap in here and suggest to you that this is already a list of
+
+32:53.740 --> 32:58.140
+Distractions and misnomers which are describing potential
+
+32:58.780 --> 33:02.780
+gene therapy side effects and vaccine side effects
+
+33:03.740 --> 33:09.980
+And so what we're looking at here is a list of things that happens with no explanation for why
+
+33:10.620 --> 33:15.180
+Nothing about the toxic environment and the toxic food that americans are given
+
+33:15.660 --> 33:23.900
+Nothing about the toxic lifestyle or the toxic environmental pollution that americans are exposed to and definitely not the toxic vaccine
+
+33:23.980 --> 33:27.100
+Schedule which i'm assuming in 2018
+
+33:27.660 --> 33:33.260
+Judy mikovitz is still totally and completely against right because it's not that long ago
+
+33:33.260 --> 33:36.860
+It's right before the pandemic. She must have been anti-vaccine already by now
+
+33:39.340 --> 33:46.540
+A chronic liver disease in the cns we think of myalgic encephalomyelitis skull for syndrome autism spectrum disorders
+
+33:46.860 --> 33:49.500
+ms parkinson's disease luke eric's disease
+
+33:50.220 --> 33:52.380
+on to the diseases which are
+
+33:53.660 --> 33:55.660
+Increasing in our world at
+
+33:56.540 --> 34:03.500
+It really extraordinary rates due to the environmental toxins in our world and interestingly as as we've learned
+
+34:04.140 --> 34:06.140
+only in the last two decades
+
+34:06.460 --> 34:08.140
+that are
+
+34:08.140 --> 34:15.100
+That are really diseases of the endo pinnabenoid system and and of stem cells where those toxins are
+
+34:15.500 --> 34:22.140
+Are affecting our immune system and the regulation of our immune system in really profound ways. So on the next slide
+
+34:26.620 --> 34:31.660
+On the next slide. I show a relatively recent paper review article
+
+34:32.300 --> 34:35.260
+from progress in lipid research and what this
+
+34:35.820 --> 34:42.700
+Review article talks about is is what we learned in in the early 90s the endo pinnabenoid system
+
+34:43.420 --> 34:46.860
+And how it's actually critical for stem cell development
+
+34:47.740 --> 34:52.780
+Really from the embryonic stem cell on and so what we're going to do today is we're going to talk about
+
+34:53.420 --> 34:54.380
+how
+
+34:54.380 --> 35:01.740
+The endo pinnabenoid system and the regulation of the endo pinnabenoid system is key to a healthy brain and a healthy immune system
+
+35:02.300 --> 35:06.860
+First of all, I want to make sure that everybody understands that they're they are going to
+
+35:07.900 --> 35:09.420
+confound
+
+35:09.420 --> 35:15.820
+the endo pinnabenoid system with cannabinoids as often as possible and it is a broad
+
+35:17.500 --> 35:19.660
+chemical family
+
+35:19.660 --> 35:26.460
+And you shouldn't assume that endo pinnabenoid receptors are all stimulated by cannabinoids and blah blah blah
+
+35:26.460 --> 35:28.460
+You shouldn't assume any of that
+
+35:28.460 --> 35:31.180
+Even though they're not going and I suspect
+
+35:31.660 --> 35:36.620
+She's not going to be very precise about this and in fact take advantage of that potential confusion
+
+35:37.180 --> 35:40.140
+and allow you and her listeners to
+
+35:40.940 --> 35:45.020
+Make as many of those assumptions as possible when she's talking about endo pinnabenoids
+
+35:45.420 --> 35:46.940
+She's also
+
+35:46.940 --> 35:52.540
+Implying because she's not saying it's not true implying that when you use cannabis that you can stimulate this
+
+35:53.100 --> 35:56.860
+System as well and so that's to a certain extent that's true
+
+35:56.940 --> 35:59.900
+But but you're missing the subtleties there of all the different
+
+36:00.460 --> 36:06.380
+You know chemical subcompounds and all you know and the receptor subtypes and all this other stuff that they know very well
+
+36:07.020 --> 36:12.780
+Individual people have studied these individual stories with individual mechanisms and so these are all
+
+36:13.500 --> 36:20.460
+Compartmentally well understood but to now we're going to misconstrue them as some kind of new way for us to
+
+36:21.100 --> 36:28.860
+You know sort of tap into the system as a whole and take advantage of something that we couldn't take advantage of before and I I think this
+
+36:30.300 --> 36:33.820
+This is essentially what what this talk is going to be about trying to
+
+36:34.460 --> 36:37.740
+Sell you on the idea that there is potent biologically
+
+36:38.300 --> 36:40.300
+there is so much potential for
+
+36:41.260 --> 36:45.180
+Cannabis produced cannabinoids to be designed
+
+36:47.340 --> 36:51.260
+To be used as immune modulators. They don't intend to grow pot
+
+36:51.980 --> 37:00.380
+They intend to use pot to to produce compounds that they can then identify and and synthetically synthesize
+
+37:01.180 --> 37:03.420
+I have they have no intention of using
+
+37:04.380 --> 37:06.780
+marijuana as a source
+
+37:07.740 --> 37:10.300
+Like like to use it as medicine or
+
+37:10.620 --> 37:15.500
+Consume it as medicine but to extract from it or to identify within it
+
+37:15.980 --> 37:20.780
+Compounds that can be made synthetically to use as medicine. So it's very different
+
+37:22.380 --> 37:24.380
+Couple things there anyway that are very different
+
+37:25.020 --> 37:31.500
+I know this paper is open access. So it's available to a lot of the audience and I've adapted or taken figures directly from
+
+37:32.380 --> 37:37.580
+This this paper and added some of our own as shown on slide three
+
+37:38.380 --> 37:43.820
+So so I would challenge you to go to mark's website and look up at the bottom of her her page
+
+37:44.700 --> 37:50.220
+Look up her resume because she does not have any problem getting employment
+
+37:51.260 --> 37:53.260
+Okay, so
+
+37:53.820 --> 38:00.460
+And and she doesn't not get good employment. It's not like she's worked at a basket robins because she can't be a scientist anymore
+
+38:01.740 --> 38:03.260
+and so
+
+38:03.260 --> 38:05.260
+There's a limited amount of
+
+38:05.260 --> 38:07.980
+Suffering that she's had and certainly in this
+
+38:08.860 --> 38:14.060
+In at this time in 2018. She's very gainfully employed from at least two different companies
+
+38:14.540 --> 38:15.500
+So
+
+38:15.500 --> 38:23.020
+And nevermind that also perhaps also advising investment firms, which appears also on her resume in various places
+
+38:23.420 --> 38:24.940
+stem cell level
+
+38:24.940 --> 38:31.420
+In the endocannabinoid system, there's really um cannabinoid receptor one and cannabinoid receptor two
+
+38:32.060 --> 38:37.980
+You see here in the lower part of the screen. Those are shown as these channel like receptors
+
+38:38.060 --> 38:41.020
+These are um deep protein coupled receptors
+
+38:41.260 --> 38:45.660
+And so they have um they they cross the membrane say six or seven times
+
+38:45.900 --> 38:51.100
+And the signal is occur and changes can occur in the loops and they have crossed off with many many
+
+38:51.260 --> 38:55.740
+Coupled receptors for signaling both in the brain and in the immune system
+
+38:56.380 --> 39:00.940
+What we've learned so a deep protein coupled receptor for those people who do not know
+
+39:01.340 --> 39:03.340
+um, this is
+
+39:03.340 --> 39:05.340
+What's that why didn't that work?
+
+39:06.300 --> 39:08.780
+Oh, no, sorry. That was not the right one. Um
+
+39:09.500 --> 39:11.020
+Yes, it is
+
+39:11.020 --> 39:14.380
+It's definitely the right one. Why didn't that work? This is not on
+
+39:14.380 --> 39:16.380
+Oh
+
+39:17.500 --> 39:21.660
+It wasn't on um g protein coupled receptors are different than
+
+39:22.860 --> 39:24.060
+a
+
+39:24.060 --> 39:29.580
+a let's say an ionic receptor and ionophore or something that just opens and allows things in
+
+39:30.300 --> 39:31.420
+um
+
+39:31.420 --> 39:33.500
+So you might have
+
+39:33.500 --> 39:39.180
+A couple different kinds of receptors just to think about things in general, right? There's receptors on the membrane
+
+39:39.740 --> 39:41.740
+That for example might gate
+
+39:42.300 --> 39:45.100
+The flow of things across the membrane
+
+39:45.660 --> 39:52.540
+And so if they do that, they might have an agonist that binds to them and then these proteins will change configuration
+
+39:53.180 --> 39:54.940
+to allow
+
+39:54.940 --> 40:02.380
+like an ion to transfer from one side of the membrane to another but a g protein coupled receptor is actually a
+
+40:03.260 --> 40:05.260
+a
+
+40:05.660 --> 40:08.860
+A receptor that has a number of subunits on it
+
+40:09.500 --> 40:12.860
+and there are g proteins are are these
+
+40:14.220 --> 40:21.100
+Like cyclic amp is usually these the messenger that they use so when the agonist binds the receptor
+
+40:21.900 --> 40:26.780
+Um, then a similar conformational change occurs, but then that allows
+
+40:27.500 --> 40:31.660
+uh cyclic amp to be released and it's a very local signal
+
+40:32.300 --> 40:36.060
+But that cyclic amp could open an ion channel
+
+40:36.620 --> 40:41.020
+That allows something in just like this one like this one did it could it could open
+
+40:41.660 --> 40:46.780
+That channel it could open many channels. It could also have downstream effects of causing
+
+40:47.660 --> 40:50.780
+gene expression and all kinds of other things as essentially
+
+40:51.660 --> 40:57.100
+Um a black box after the activation of g protein of a g protein coupled receptor
+
+40:57.100 --> 41:01.740
+They would like to tell you the story cyclic amp etc, but it's a cascade
+
+41:02.540 --> 41:08.700
+And so we don't have a very good idea of all the things that happen downstream from g protein coupled receptors
+
+41:09.180 --> 41:15.820
+because these these actions after agonist binding can have different timescales and
+
+41:16.220 --> 41:23.500
+Depending on the cell type can have very different ramifications depending on what happens after the initial activation here
+
+41:25.260 --> 41:28.540
+um, so a g protein coupled receptors kind of cool because
+
+41:29.260 --> 41:34.700
+Um, it could have a number of different effects on both a long a short-term effect could be
+
+41:35.340 --> 41:39.260
+That sodium comes in through channels, but a long-term effect could be
+
+41:39.820 --> 41:43.900
+Gene expression or actin skeleton remodeling or something like that
+
+41:44.380 --> 41:47.180
+And that's very different than a receptor which is
+
+41:47.980 --> 41:53.980
+Exclusively an ion channel opened and closed by the presence of the agonist or blocked by a toxin
+
+41:54.620 --> 41:55.580
+Um
+
+41:55.660 --> 42:02.860
+So that's interesting because if endocannabinoids are all g protein coupled receptors then even when we think we can activate them
+
+42:02.860 --> 42:11.340
+We we would still be much farther from understanding the consequences of their activation because it is not only the acute direct
+
+42:11.820 --> 42:13.820
+effects of ion
+
+42:13.980 --> 42:17.660
+Transfer or or proton pumping or something like that
+
+42:18.140 --> 42:24.140
+But rather it is downstream effects activated by cyclic amp and other second messengers inside of the cell
+
+42:24.540 --> 42:26.780
+That result from the activation of the receptor
+
+42:27.180 --> 42:31.580
+So it can can result in very very much bigger changes as well
+
+42:32.060 --> 42:35.020
+So it's not to say that that this isn't significant. It's to say
+
+42:35.740 --> 42:40.700
+That the complicated mechanisms that underlie the signaling of cannabinoid receptors
+
+42:41.100 --> 42:45.100
+Cannot be underestimated and when she says it's a g protein coupled receptor
+
+42:45.500 --> 42:48.220
+That's like the very very tip of the iceberg of that
+
+42:48.780 --> 42:53.100
+Complexity most of which we can't really adequately characterize. I hope I said that well
+
+42:53.660 --> 43:01.020
+Recently is the hematopoietic stem cell, which is the stem cell that's involved in your in the development of all of the lineages
+
+43:01.340 --> 43:06.460
+In your blood shown on this slide. We're showing. I'm showing you the myeloid lineage. That's um
+
+43:07.100 --> 43:11.980
+The megacariocytes the erythrocytes red blood cells mass cells myeloblast
+
+43:12.540 --> 43:15.740
+On the right hand side. I the figure wasn't long enough for this slide
+
+43:15.740 --> 43:21.340
+I just show also the base of field neutrophils eosinophils and critically the monocyte macrophage
+
+43:21.500 --> 43:24.940
+Which we're going to talk a lot about today the myeloid cells
+
+43:25.580 --> 43:33.500
+And and hematopoiesis of the myeloid cells. This is really your innate immune response your frontline defense from all of the toxins
+
+43:33.740 --> 43:38.620
+Um in our environment in our world not just so see she's saying it too complicated
+
+43:38.620 --> 43:43.740
+She wants you to the the myeloid cells the macrophages and the dendritic cells
+
+43:44.460 --> 43:49.980
+The hematopoiesis of these cells. Why does she use the word hematopoiesis?
+
+43:51.580 --> 43:56.940
+Why can't she just say that when these cells are in development hematopoiesis? Why not?
+
+43:57.740 --> 43:59.740
+Do I not define it?
+
+44:00.780 --> 44:03.020
+Again because I think this is a rehearsed
+
+44:03.580 --> 44:07.900
+Very carefully chosen set of words to bamboozle to make sure
+
+44:08.460 --> 44:10.860
+That if she lists all these words fast enough
+
+44:10.860 --> 44:16.140
+There's no way that you're going to notice that common is spelled wrong in her in her slides
+
+44:16.460 --> 44:19.740
+There's no way you're going to notice that that this is just uh
+
+44:21.820 --> 44:26.620
+An overwhelming set of data designed to get you to accept the conclusion slide
+
+44:27.660 --> 44:32.780
+Um, not just um environmental toxins, but including things like um viruses
+
+44:33.420 --> 44:42.300
+Um our expertise is in retroviruses and our work at epigenetics is is all about how retroviruses change the expression of genes and not the dna
+
+44:42.300 --> 44:50.220
+Or and including at the dna level, but primarily the expression of genes and this is one mechanisms how they cause diseases by so 2018
+
+44:50.220 --> 44:56.220
+She's still working for epigenetics. I don't think that that's really in her resume that mark has on his website
+
+44:56.220 --> 45:01.500
+I want to I want to look deeper into that, but this is 2018 and she's still talking like we
+
+45:02.220 --> 45:05.820
+Epigenetics, which is again a company that looks at
+
+45:06.380 --> 45:16.460
+Uh, epigenetic changes resulting in cancer and other other conditions. So, um, you're essentially dealing with somebody who is interested in sequencing everything
+
+45:16.860 --> 45:21.580
+You're dealing with somebody who is using blood samples to look for bloodborne markers of
+
+45:22.300 --> 45:25.020
+Of chronic fatigue syndrome for many many years
+
+45:25.500 --> 45:31.500
+Not that dissimilar from looking for bloodborne markers of other diseases like that blonde lady with the dark hair
+
+45:31.980 --> 45:36.940
+With the with the deep voice was doing before they before they discredited her as a fraud
+
+45:38.860 --> 45:40.620
+Just saying
+
+45:40.620 --> 45:44.220
+It's not like this is uh, obviously anti-vax talk where we're
+
+45:45.020 --> 45:51.020
+Where she is fighting for us to not believe in in the public health system or to doubt tony fauci here
+
+45:53.260 --> 45:55.420
+This is right now talking about how
+
+45:56.460 --> 46:02.460
+Canabenoids regulate the essential developmental processes of all blood cells and the amion system
+
+46:05.260 --> 46:11.980
+Disregulating, um, the, uh, hematopoietic stem cell and what you get is an accelerated aging
+
+46:12.140 --> 46:17.660
+Where we see cancers in those auto immune and neuro immune diseases on the first slide in younger
+
+46:17.900 --> 46:20.380
+I mean accelerated aging is what what
+
+46:22.220 --> 46:27.820
+Walter chestnut has been going on about the spike protein was going to do for like four years now
+
+46:28.540 --> 46:31.740
+and certainly going on and on about the transfections
+
+46:32.700 --> 46:36.060
+advancing aging and destroying mitochondria and
+
+46:36.620 --> 46:38.140
+And
+
+46:38.140 --> 46:41.580
+It's in it's incredible that this is 2018
+
+46:41.580 --> 46:49.980
+They're essentially seeding the narrative of the damage that will be done by the coming vaccine scheduled by coming counter measures by coming
+
+46:51.660 --> 46:53.660
+genetic technologies
+
+46:56.380 --> 46:58.380
+I don't understand
+
+46:58.620 --> 47:02.780
+Who judy mikovitz is but I do know from mark's work
+
+47:03.420 --> 47:08.860
+That it's hard to explain why the two people who came out and first published papers about her
+
+47:09.500 --> 47:12.060
+Data likely being fraudulent are dead
+
+47:13.740 --> 47:20.540
+It's weird that all of this stuff has to do with aids and vaccines. You could imagine a scenario
+
+47:22.060 --> 47:23.660
+credit to mark
+
+47:23.660 --> 47:24.780
+where
+
+47:24.780 --> 47:31.660
+The xm rv story was actually going to be queued up teed up as a way of pivoting from
+
+47:32.780 --> 47:35.980
+vaccine preparation to new methods like transfection
+
+47:38.140 --> 47:39.100
+But
+
+47:39.100 --> 47:41.100
+Unwitting non participating
+
+47:41.980 --> 47:49.100
+Biologists in the field said hey, this looks like bullshit and the story had to be changed. It had to be dealt with
+
+47:51.740 --> 47:54.220
+And now we have a different judy
+
+47:55.420 --> 47:57.100
+And twin
+
+47:57.100 --> 48:02.860
+Do you know the judy mikovitz just like jessica rose she has a twin too. It doesn't that eat didn't that meet
+
+48:03.740 --> 48:06.460
+Not twins are cool younger populations
+
+48:06.940 --> 48:15.740
+Driven by this somatopoietic stem cell. So what what this paper shows now is that in fact this cb2 endocannabinoid receptor
+
+48:16.540 --> 48:22.860
+Is is involved in the development of essentially every lineage of the myeloid
+
+48:23.180 --> 48:27.260
+Amatopoietic stem cell that it's involved in those diseases that I showed
+
+48:27.900 --> 48:36.540
+On the on the first slide if you notice the asterisks on the first slide what we were looking at is diseases associated with activated
+
+48:37.260 --> 48:49.580
+Macrophages activated micro glia cells in the brain. Um, so so now we know that there there's a primary disposition towards cb2 and the hematopoietic stem cell
+
+48:50.380 --> 48:54.940
+And that dysregulation of of these responses in these myeloid progenitors
+
+48:55.660 --> 49:00.780
+Is can be causal for these diseases and that we can reverse these diseases with
+
+49:02.300 --> 49:09.820
+With phytocannabinoids and modulating our endogenous produced cannabinoids on the next slide. We see that
+
+49:10.700 --> 49:17.820
+We continue to look at how the cb2 is associated with chronic inflammation of the nervous system
+
+49:17.820 --> 49:23.820
+Which is somewhat paradoxical and because in fact from the mesenchymal stems
+
+49:23.820 --> 49:31.260
+I'll shown on the left side of the slide. We see that the cb1 receptor that can have the canonical cannabinoid receptor number one
+
+49:31.660 --> 49:33.420
+Another g protein link
+
+49:33.420 --> 49:38.220
+signal its shown in blue and cb2 is shown in red for convenience is is actually
+
+49:38.940 --> 49:45.820
+Controls the development of neurons. So then development of neurons the development of a dipocytes bat set
+
+49:45.820 --> 49:48.300
+It's hard really to take this at face value
+
+49:48.380 --> 49:51.580
+You have to I just want to help you to see what I see here
+
+49:51.980 --> 49:57.020
+When somebody says that cannabinoid receptor one controls the development of neurons
+
+49:57.020 --> 50:02.460
+What they really mean is that if you mess around with it you can mess around with neuronal development of course
+
+50:03.020 --> 50:11.020
+She can't possibly mean that the development of neurons is controlled by a single receptor because that would be absurd
+
+50:11.500 --> 50:15.500
+Yet just like a lot of academic biologists that are still
+
+50:16.140 --> 50:20.380
+Not really teaching anybody including themselves the broad
+
+50:20.940 --> 50:28.460
+Sacred biology in which they operate she is not helping you understand that this is obviously infinitely more
+
+50:29.100 --> 50:32.380
+Complex than cannabinoid receptors controlling development
+
+50:33.100 --> 50:35.100
+And
+
+50:35.100 --> 50:41.420
+Yet they will continue to do this all biologists will continue to do it that are trained in this method of
+
+50:42.380 --> 50:48.780
+Creating a very sharp and narrow question that is so sharp and narrow that it actually doesn't even
+
+50:49.660 --> 50:53.420
+purport to validate the model that it purports to be a part of
+
+50:53.580 --> 50:55.580
+And
+
+50:57.020 --> 51:03.260
+So if you say that cannabinoid receptor one is involved in neuronal development
+
+51:04.940 --> 51:09.740
+What do you really mean? Well, she's saying that the receptor expression goes up
+
+51:10.700 --> 51:12.700
+Okay
+
+51:13.740 --> 51:18.940
+Peripheration is stopped by cannabinoids one over here and differentiation occurs
+
+51:19.420 --> 51:25.740
+So what can you increase differentiation? Is that stimulation required? Is it part of a suite of stimulations?
+
+51:26.220 --> 51:31.100
+Most of which have not even been identified never been manipulated in an experimental setting
+
+51:33.740 --> 51:38.140
+How many receptors are in neurons that we don't even have an even identified yet
+
+51:38.380 --> 51:49.820
+Don't take this at its words understand that this is the opposite of presenting you
+
+51:50.300 --> 51:56.700
+The complexity the irreducible complexity of the immune system the irreducible complexity of the development of the brain
+
+51:58.220 --> 51:59.980
+To simplify
+
+51:59.980 --> 52:04.700
+Down to cannabinoid receptors one and cannabinoid receptors two and how
+
+52:05.180 --> 52:09.100
+Finding substances which can stimulate those two might be fun
+
+52:10.540 --> 52:13.180
+Because of all this stuff that they're involved in
+
+52:16.460 --> 52:19.980
+Bells, pre and besides and and bone formation
+
+52:20.300 --> 52:28.940
+So that's somewhat paradoxical in thinking about that because if if I had on those slides cancers that metastasized to the bone
+
+52:29.100 --> 52:33.020
+And are primarily bone cancers such as multiple myeloma
+
+52:33.980 --> 52:39.100
+And in prostate cancer, which are two diseases in which bone formation is dysregulated
+
+52:39.420 --> 52:46.220
+So you see there on the left hand side though. The proteol osteoblasts is regulated by cannabinoid receptor number one
+
+52:46.940 --> 52:50.060
+and involved in in rankle is the receptor of
+
+52:50.620 --> 52:57.260
+NF Kappa B activation of NF. I mean isn't the implication here that you know way too much cannabinoid useful
+
+52:57.740 --> 53:03.980
+Will cause your your neurons to develop funny and your your bone resorption to go wrong and
+
+53:04.540 --> 53:06.860
+All of this stuff to go haywire. Isn't that
+
+53:08.620 --> 53:13.020
+Shouldn't that be the first question that's on your mind? How did all these hippies not just die?
+
+53:13.740 --> 53:18.380
+If everything in the body that's interesting is regulated by endocannabinoid one or two
+
+53:18.380 --> 53:20.380
+I
+
+53:22.380 --> 53:27.660
+Hope you're starting to see now what's happening here how this is done in academia where you try to take
+
+53:28.380 --> 53:32.540
+A story and conflate it to be the most important story to be told
+
+53:33.980 --> 53:36.460
+And what it does from the perspective of getting money
+
+53:37.020 --> 53:42.300
+What it does from the perspective of telling a story that's kind of I guess entertaining and singly focused
+
+53:43.020 --> 53:47.100
+but in no way shape or form acknowledges never mind tries to
+
+53:48.060 --> 53:52.700
+Pay any reverence to the irreducible complexity that all of these people are up against
+
+53:53.100 --> 53:57.820
+Applebee ligand and NF Kappa B, which we'll discuss in a moment is really key to
+
+53:58.300 --> 54:01.580
+Inflammatory responses and inflammation that drives
+
+54:02.220 --> 54:05.900
+In fact the breakdown of the proteol osteoclasts
+
+54:06.220 --> 54:12.380
+So what you see is you get osteoclasts favoring over osteoblasts that you're breaking down the bone progenitors
+
+54:12.860 --> 54:15.980
+And you're actually getting bone resort of resorption
+
+54:16.460 --> 54:24.460
+So we see in these cancers and in these diseases and of course osteoporosis in women of younger and younger ages driven by
+
+54:25.180 --> 54:27.580
+You know, it's now it's still a theory
+
+54:27.580 --> 54:31.740
+But driven by these interactions is the theory that we're working on in developing
+
+54:32.140 --> 54:37.500
+Therapeutics two months and so the problem with this model is how the hell do you test it?
+
+54:38.460 --> 54:45.420
+What kind of predictions does this model make? Are there predictions in the future that we can then verify using a measurement?
+
+54:47.900 --> 54:52.140
+That's what broken science is all about exposing this nonsense for what it is
+
+54:52.140 --> 54:56.940
+This is not a model and if it is a model, is it a model you intend to test?
+
+54:58.300 --> 55:00.300
+Absolutely not it's a model you assume
+
+55:01.820 --> 55:05.020
+Your experiments actually do not test this model
+
+55:05.100 --> 55:09.580
+They're not verifying it and you're not using this model to make any predictions
+
+55:11.100 --> 55:16.620
+You're collecting data to verify whether the parts of this model conform to data in the past
+
+55:17.020 --> 55:22.060
+You never make any predictions and they will never make any predictions because that's not how
+
+55:22.620 --> 55:24.620
+This kind of pseudoscience is done
+
+55:24.780 --> 55:30.220
+Ontulate the topic of this discussion. So on the right on the in the middle of the slide you can see how
+
+55:31.100 --> 55:37.900
+Red arrows blocking the the breakdown of the proteo osteo class and encouraging the build up and
+
+55:38.140 --> 55:47.500
+Development and lineage commitment to the osteoblasts and the bone formation is is critical is driven by blocking the cb1 receptor blocking
+
+55:48.060 --> 55:53.820
+And promoting I mean if this was done correctly you would drop these arrows in one at a time
+
+55:53.900 --> 55:59.980
+And every time you drop the arrows in there would be a little bibliography that would scroll past saying that these are the flabs that tested this
+
+56:00.540 --> 56:05.020
+And showed that mason chymal stem cells are inhibited by cb1 receptors
+
+56:05.500 --> 56:13.180
+In certain conditions in certain and every one of these steps would need to be explained in such a way so that we could really evaluate to what extent
+
+56:13.260 --> 56:20.540
+This part of this model cartoon is worth paying attention to holding in our mind or trying to mesh like a gear
+
+56:20.940 --> 56:25.260
+With some of these other things so that we can start to get a working model of how this system works
+
+56:25.580 --> 56:31.500
+But there's already 16 gears on this page and so no matter how good your your imagination is
+
+56:31.500 --> 56:35.580
+I don't care if you're nickel at tesla. You can't test this model in your head. You just can't
+
+56:37.500 --> 56:43.260
+And they can't test it with a simple experiment either using reductionist biological techniques. You can't do it
+
+56:44.220 --> 56:46.220
+Tan side where a cb2
+
+56:47.020 --> 56:53.100
+Is um is driving both it's directly activating the osteoplasts through a mechanism with the question mark
+
+56:53.100 --> 56:58.060
+We still don't know because that cb2 receptor hasn't necessarily been identified
+
+56:58.540 --> 57:02.380
+On that cell and and we have some ideas that we'll discuss in the next few slides
+
+57:02.620 --> 57:05.500
+Um, and that's why the question mark for the top arrow at arrow
+
+57:05.500 --> 57:09.020
+But we absolutely know when the cb1 receptor and cb2
+
+57:09.820 --> 57:14.700
+Cross talk interacts where the weight of the balance is I show on the left hand side
+
+57:15.020 --> 57:18.060
+It's not a honor off switch, but really a gradient
+
+57:18.300 --> 57:23.580
+So I look at um the endocannabinoid system as a dimmer switch on the immune system
+
+57:23.740 --> 57:26.220
+Really a master regulator at many different levels
+
+57:26.300 --> 57:32.540
+But via the stem cell via the mesenchymal stem cell via the amount of poetics stem cell and how it's a gradient
+
+57:32.540 --> 57:37.900
+So the more receptor that is expressed as it's up regulated the more you'll get the bad accumulation
+
+57:37.980 --> 57:45.500
+We can also think in our society about how the bad accumulation of metabolism is changing in in our teenagers and our young adults
+
+57:45.820 --> 57:53.020
+Um, you know through the dysregulation of this system. So one of the recent discoveries, um big discovery shown on the next slide
+
+57:53.340 --> 57:58.220
+Um, so the dysregulation of the endocannabinoid system is also causing kids to get fat
+
+57:59.340 --> 58:00.380
+Wow
+
+58:00.380 --> 58:07.020
+Is that that question mark may be addressed in a paper by brian gardener in his colleagues
+
+58:07.260 --> 58:12.620
+And that is that tetra hydro cannabinoid, which is the psychoactive t hc
+
+58:13.180 --> 58:17.180
+In medical marijuana actually turns on cb2
+
+58:17.900 --> 58:22.060
+Driving that g protein coupled receptor to breakdown atp
+
+58:22.140 --> 58:27.420
+This is called purinergic signaling where where atp is broken down into cyclic amp
+
+58:27.900 --> 58:35.420
+This activates the expression of a critical master regulator of chromatopoietic stem cells and stem cells in general
+
+58:35.420 --> 58:38.700
+Known as transforming growth factor beta or t so see here
+
+58:39.020 --> 58:42.940
+This is one of those cartoons where here you see a g protein coupled receptor
+
+58:43.740 --> 58:46.940
+G protein is now decreasing cyclic amp so
+
+58:47.580 --> 58:53.820
+Depending on the cell type depending on the context it can increase cyclic amp decrease cyclic amp
+
+58:54.300 --> 58:59.020
+And then those signals can be can result in expression of different proteins
+
+58:59.100 --> 59:06.460
+And so the the interesting thing about the cannabinoid system and indeed any g protein coupled system is that again
+
+59:07.260 --> 59:08.780
+like a
+
+59:08.780 --> 59:14.620
+A muscarinic receptor or a a muscarinic receptor is a subtype of a nicotinic receptor
+
+59:15.020 --> 59:20.300
+Where acetylcholine can bind and there are two kinds of acetylcholine receptors in general
+
+59:20.380 --> 59:25.900
+There's a nicotinic receptor, which is an ion channel and then a g protein coupled nicotinic receptor
+
+59:26.300 --> 59:32.620
+I'm sorry muscarinic receptor and they call it a muscarinic receptor because it is blocked by muscarin now are stimulated by muscarin
+
+59:33.260 --> 59:37.660
+So anyway, the point is is that depending on where those
+
+59:38.700 --> 59:39.900
+those
+
+59:39.900 --> 59:41.900
+G protein coupled receptors are
+
+59:43.020 --> 59:45.020
+And on what neuron?
+
+59:45.100 --> 59:50.140
+A muscarinic channel in some neurons could increase cyclic amp and increase
+
+59:51.340 --> 59:57.420
+Nmda channels in the membrane. It could change the mobility of actin membrane in a spine
+
+59:57.900 --> 59:59.420
+Um
+
+59:59.420 --> 01:00:05.260
+There's lots of possibilities with again with a g protein coupled receptor and that's why I think it's interesting here to note
+
+01:00:05.820 --> 01:00:11.580
+That every one of these receptors and every one of those contexts would need to be characterized in this way
+
+01:00:12.060 --> 01:00:17.900
+And you would never have a definitive answer. Is this the only thing that happens when cb do the cb
+
+01:00:18.540 --> 01:00:21.500
+cannabinoid receptor 2 in lymphocytes is stimulated
+
+01:00:22.060 --> 01:00:24.540
+So again, we're really at the very very very
+
+01:00:25.340 --> 01:00:27.340
+beginning of this whole thing
+
+01:00:27.820 --> 01:00:30.860
+And understanding cannabinoid receptors and
+
+01:00:31.740 --> 01:00:33.980
+cannabinoid receptor variants between people
+
+01:00:34.940 --> 01:00:37.820
+All of this stuff is going to be important because cb
+
+01:00:38.380 --> 01:00:43.260
+cannabinoid 2 receptor in you is different than me and so that's uh, this is this is all
+
+01:00:43.900 --> 01:00:45.900
+Just
+
+01:00:45.900 --> 01:00:50.540
+Any the other half of mark ink. It's my commits and resetting consulting here and and dr
+
+01:00:50.540 --> 01:00:51.900
+Aseti
+
+01:00:51.900 --> 01:00:59.020
+More than 25 years ago was the scientists who made the discovery that tgf beta acts on the stem cell as a
+
+01:00:59.740 --> 01:01:04.380
+Bifunctional regulator of hematophoresis. That means it can go both ways
+
+01:01:05.020 --> 01:01:09.740
+Tgf beta can be a really good general in in regulating immune responses
+
+01:01:10.460 --> 01:01:16.780
+A good soldier or a bad general. So if if if if if a pathway is on tgf beta can turn it off
+
+01:01:17.100 --> 01:01:20.860
+in as far as the immune system and if the pathway is off tgf beta
+
+01:01:21.500 --> 01:01:27.660
+Turns it on so it has both autocrine back on itself back on the stem cell to maintain the stem cells
+
+01:01:27.980 --> 01:01:32.940
+Thalness and paracrine to develop those effector lineages. I showed on that first slide
+
+01:01:33.020 --> 01:01:39.420
+So critical critical regulator and here we have thc. That's you know been really outlawed
+
+01:01:40.540 --> 01:01:42.540
+in our in our world for
+
+01:01:43.500 --> 01:01:49.260
+More than 70 years and and it's critical so cannabinoid formulations without thc
+
+01:01:49.820 --> 01:01:55.180
+Actually cannot regulate and cure diseases and in these therapies can be curative
+
+01:01:55.340 --> 01:02:02.940
+But you really can't spell health care without thc. So it's thc dependent and we have to think about formulations
+
+01:02:03.660 --> 01:02:05.660
+driving the cb2
+
+01:02:06.300 --> 01:02:12.460
+Interestingly enough the psychoactive effects of thc are are mediated through
+
+01:02:13.020 --> 01:02:16.940
+That cb1 receptor which I showed here on the last slide
+
+01:02:17.260 --> 01:02:24.860
+So it's those neurons and um that are are driven by thc because of course there's cross talk between the two receptors
+
+01:02:25.020 --> 01:02:31.980
+So so it's a it's a question of balance really but interestingly enough if we can develop and we're working to develop
+
+01:02:32.620 --> 01:02:39.740
+cb2 agonists that don't interact with cb1 that block that interaction and then you don't have the psychotropic effect
+
+01:02:40.220 --> 01:02:41.740
+um that is um
+
+01:02:41.740 --> 01:02:44.540
+um such a problem with with using these therapeutically
+
+01:02:45.180 --> 01:02:49.820
+Now that we can use them to still regulate the critical hematopoietic component
+
+01:02:50.140 --> 01:02:52.140
+So the next slide I show in some
+
+01:02:52.460 --> 01:02:56.780
+Respect that to go back to our first slide and think about what's causing
+
+01:02:57.340 --> 01:03:02.380
+the autoimmune neuroimmune and and um acquired immune deficiencies of our time
+
+01:03:02.700 --> 01:03:09.260
+Well, our expertise is in HIV aids and the reason I call these 21st century acquired immune deficiencies
+
+01:03:09.340 --> 01:03:13.260
+Because of course there's not HIV in all of these diseases
+
+01:03:13.260 --> 01:03:16.300
+But in every disease on the first slide where I showed an asterisk
+
+01:03:16.620 --> 01:03:21.500
+There's a retroviral component and um and we won't go into retrovirus biology
+
+01:03:21.740 --> 01:03:24.540
+But what we know is that in our treatment
+
+01:03:24.540 --> 01:03:29.020
+So she's saying there's a viral component in all of those things which I think is definitely
+
+01:03:29.740 --> 01:03:31.740
+definitely sketch
+
+01:03:31.820 --> 01:03:35.500
+um and so it seems like the broad stick
+
+01:03:36.220 --> 01:03:37.260
+of
+
+01:03:37.260 --> 01:03:40.700
+Judy mikovitz is that there are more viruses than we are told
+
+01:03:41.340 --> 01:03:44.380
+That are to be found in more places than we are told
+
+01:03:44.940 --> 01:03:47.420
+Causing more pain and suffering than we are told
+
+01:03:50.540 --> 01:03:56.060
+And she definitely doesn't question the existence of a novel virus that killed millions of people that millions more were saved from
+
+01:03:56.060 --> 01:03:59.020
+That probably came from a laboratory that was doing gave a function
+
+01:04:00.940 --> 01:04:03.100
+you see
+
+01:04:03.100 --> 01:04:08.620
+And at the beginning of the pandemic before the pandemic even started before it was anybody anybody's radar
+
+01:04:09.180 --> 01:04:11.180
+She was already out there
+
+01:04:13.740 --> 01:04:16.940
+Telling us that there would be this new 21st century
+
+01:04:17.580 --> 01:04:23.100
+acquired immune deficiency syndromes that don't all have aids viruses in them even though
+
+01:04:23.900 --> 01:04:27.820
+A lot of the people that she's worked with have worked with the aids people
+
+01:04:29.820 --> 01:04:31.820
+Like lots of papers with gallo
+
+01:04:32.620 --> 01:04:34.860
+Directly connected to gallo
+
+01:04:36.780 --> 01:04:39.100
+Remember that gallows
+
+01:04:39.100 --> 01:04:44.940
+Like buddy muri gardener was robert melones postdoc supervisor. This is a weird
+
+01:04:45.900 --> 01:04:47.900
+tiny little group of people
+
+01:04:48.860 --> 01:04:53.340
+Connected through a tiny little group of connected people all connected to the same
+
+01:04:54.380 --> 01:04:56.380
+Kind of parallel bullshit stories
+
+01:04:56.780 --> 01:04:58.780
+I
+
+01:04:58.780 --> 01:05:04.300
+Don't know the truth about hiv, but i'm pretty sure it's not a virus that came from bushmeat
+
+01:05:05.260 --> 01:05:07.260
+Brett Weinstein
+
+01:05:08.620 --> 01:05:14.460
+I don't know the story about polio vaccines, but i'm pretty sure it had a lot more to do with sanitation and
+
+01:05:15.580 --> 01:05:17.580
+pesticides and stuff like that
+
+01:05:19.580 --> 01:05:22.620
+And with regard to this talk
+
+01:05:23.500 --> 01:05:25.500
+And the discussion of
+
+01:05:25.660 --> 01:05:32.300
+21st century acquired immune deficiency syndromes that don't all include the aids virus. I think she's more or less seeding
+
+01:05:33.740 --> 01:05:37.180
+She's seeding the narrative of flying aids remember that's what
+
+01:05:37.900 --> 01:05:40.300
+Paul cottrell and those other people have been calling
+
+01:05:41.020 --> 01:05:45.580
+Coronavirus, it's it's flying aids. It's an acquired immune deficiency syndrome
+
+01:05:45.580 --> 01:05:51.900
+How many times have you heard it? They have been seeding the narrative of novel sources of an acquired immune
+
+01:05:51.980 --> 01:05:53.820
+Deficiency system
+
+01:05:53.820 --> 01:05:58.780
+Syndrome for a few years now so that long covid could be confounded with it
+
+01:05:59.100 --> 01:06:02.300
+And so that covid could be confounded with it ladies and gentlemen
+
+01:06:02.620 --> 01:06:07.740
+And they knew all along that they were seeding a narrative that would protect genetic vaccines
+
+01:06:08.300 --> 01:06:10.220
+genetic
+
+01:06:10.220 --> 01:06:15.820
+Genetic technologies they were they've been protecting them from the beginning and it takes a while
+
+01:06:17.180 --> 01:06:19.580
+That's why this talk is from 2018
+
+01:06:19.580 --> 01:06:21.580
+And
+
+01:06:21.580 --> 01:06:28.940
+Not saying anything about the vaccine schedule of uh in the development of have actually curative therapies for hiv
+
+01:06:29.020 --> 01:06:35.660
+Which dr. Said and I participated in at the national cancer institute in the 80s and in 90s those therapies
+
+01:06:36.300 --> 01:06:41.420
+Included at some level cannabis and so this the the people that survived
+
+01:06:41.820 --> 01:06:48.940
+And and and thrived with hiv were the ones that were using cannabinoids along with the anti retroviral therapies
+
+01:06:48.940 --> 01:06:56.220
+Which we developed in our laboratory and of course because of the stigma and and the legal problems with using it that that really wasn't known
+
+01:06:56.620 --> 01:06:58.780
+At that time and we've only recently known that
+
+01:06:59.180 --> 01:07:03.980
+So what we knew about cannabinoids is that they were antiviral and they reduce inflammation
+
+01:07:04.220 --> 01:07:11.100
+Because we see that blocking arrow on the right side so lps is uh lipopolysaccharide and it's on bacteria
+
+01:07:11.340 --> 01:07:15.660
+So bacteria and polyic mimics an RNA virus infection
+
+01:07:15.740 --> 01:07:18.860
+So RNA viruses are your flu viruses your
+
+01:07:19.820 --> 01:07:21.820
+hiv your retroviruses
+
+01:07:22.220 --> 01:07:25.660
+Your ebola your zika. These are all RNA viruses
+
+01:07:25.900 --> 01:07:30.460
+So probably i see mimics the activation of these all RNA viruses
+
+01:07:30.540 --> 01:07:35.660
+They're all RNA viruses and what do they have in common rna cannot pandemic
+
+01:07:36.940 --> 01:07:42.940
+And yet she lists all the viruses that these people responded to they're all the same small little family of
+
+01:07:43.420 --> 01:07:49.260
+Of outbreak specialists. Malone was on that list. She's on that list hat fills on that list
+
+01:07:50.140 --> 01:07:53.820
+Meryl nasa's on that list all these people are involved in this little list
+
+01:07:55.180 --> 01:07:56.300
+zika
+
+01:07:56.300 --> 01:07:58.300
+ebola
+
+01:07:58.300 --> 01:08:02.700
+Right. They're all in there somewhere complaining about that stuff at some point in time
+
+01:08:04.060 --> 01:08:07.020
+And for decades already for decades already
+
+01:08:07.020 --> 01:08:13.900
+When I was playing cyber ball
+
+01:08:15.900 --> 01:08:20.060
+At at the at at at oakwood mall and and ochlear, I mean
+
+01:08:21.340 --> 01:08:23.340
+These guys were already working on this
+
+01:08:24.620 --> 01:08:31.020
+Making sure that this virology as a field would be just impenetrable
+
+01:08:31.500 --> 01:08:33.500
+and
+
+01:08:35.420 --> 01:08:43.340
+Undifferentiable from a from a program that was just outright testing biological technologies on its population
+
+01:08:45.340 --> 01:08:47.340
+indistinguishable
+
+01:08:47.340 --> 01:08:49.340
+From a biotechnology
+
+01:08:50.380 --> 01:08:54.060
+National security priority that was looking for background signals
+
+01:08:55.260 --> 01:08:57.820
+That could be used and misconstrued as spread
+
+01:08:57.900 --> 01:09:01.100
+Characterizing background signals that they knew they were going to use
+
+01:09:01.740 --> 01:09:03.900
+as spread
+
+01:09:03.900 --> 01:09:05.660
+as evidence of
+
+01:09:05.660 --> 01:09:08.620
+Even more viruses in the background than before
+
+01:09:10.380 --> 01:09:13.420
+They all seem to have the basic same basic story here
+
+01:09:13.900 --> 01:09:16.140
+Now we're talking again about something
+
+01:09:16.700 --> 01:09:22.300
+and we're we're misconstruing the activation of the immune response by a bacterial protein
+
+01:09:22.860 --> 01:09:23.900
+with the
+
+01:09:23.900 --> 01:09:27.340
+the activation of the response to a virus and
+
+01:09:27.980 --> 01:09:32.300
+Without without giving adequate explanation for why those two can be parallels
+
+01:09:32.620 --> 01:09:33.820
+It's impressive
+
+01:09:33.820 --> 01:09:38.780
+And then these pathways that that generate type 1 interferons which are
+
+01:09:39.100 --> 01:09:43.420
+Curative for retroviruses almost all retroviruses and RNA viruses
+
+01:09:43.900 --> 01:09:52.300
+Actually tend to block this type 1 interferon pathway and we use type 1 interferons interferon alpha interferon beta as immune therapy
+
+01:09:52.460 --> 01:09:55.660
+In that disease I highlighted known as primary biliary cirrhosis
+
+01:09:55.740 --> 01:10:00.220
+Which is actually associated with a retrovirus known as human beta retrovirus
+
+01:10:00.380 --> 01:10:03.500
+So here we have and we know with HIV and hepatitis
+
+01:10:03.500 --> 01:10:06.940
+That's another disease she says is associated with yet another virus
+
+01:10:07.500 --> 01:10:12.540
+You see in various um liver diseases which are driven by um hepatitis B as a para retrovirus
+
+01:10:12.540 --> 01:10:16.380
+That means it has components of retroviruses and DNA retroviruses
+
+01:10:16.380 --> 01:10:19.500
+We use interferons as therapy. So here now we have
+
+01:10:19.900 --> 01:10:26.220
+An cannabinoids which are able to drive block these pro inflammatory mediators, which are so important
+
+01:10:26.860 --> 01:10:32.700
+For driving the disease process. It's the chronic inflammation and the chronic activation
+
+01:10:33.180 --> 01:10:38.460
+Of the monocyte lineage of that myeloid lineage which we discussed and we'll discuss a little a lot more today
+
+01:10:38.940 --> 01:10:43.740
+That is driving the disease processed in HIV associated dementias
+
+01:10:44.460 --> 01:10:48.220
+Um, we knew it had nothing to do with virus copy numbers. So
+
+01:10:49.020 --> 01:10:52.380
+Patients who were on anti retroviral therapy and had
+
+01:10:52.860 --> 01:10:54.860
+Non-detectable levels of HIV
+
+01:10:55.340 --> 01:11:02.060
+Still had a dementia and could develop diseases that look like early Alzheimer's disease that look like park and cineans
+
+01:11:02.540 --> 01:11:06.780
+And multiple sclerosis diseases and those are diseases that have all been associated
+
+01:11:07.260 --> 01:11:14.300
+But you don't need expression in the virus and it's the idea that we're driving these inflammatory mediators and and stopping the
+
+01:11:15.100 --> 01:11:19.580
+Interferon responses in in that way and this is where right in the middle of it
+
+01:11:19.580 --> 01:11:27.420
+The cannabinoids modulating that cb2 receptor are critical and actually curative if you drive it in the other direction
+
+01:11:27.740 --> 01:11:31.500
+So the next slide shows you a little bit more of that neural protection
+
+01:11:31.580 --> 01:11:36.780
+So we've talked about cannabinoids either phyto or endogenous those made by your body
+
+01:11:37.260 --> 01:11:43.180
+Being actually neuroprotective so therapeutics where you drive the neural protection through those
+
+01:11:43.500 --> 01:11:51.420
+Central mediators, but I show here in this slide critically. There are antioxidant cannabinoids and I show in the on the left hand side
+
+01:11:51.500 --> 01:11:54.540
+it's going through a factor known as um
+
+01:11:55.500 --> 01:12:01.900
+A rithroid factor to the nuclear rithroid factor to and that factor is is a key pathway
+
+01:12:01.900 --> 01:12:05.420
+It's a transcription factor in a pathway that is really key to sleep
+
+01:12:05.900 --> 01:12:08.060
+As you see it it drives the production
+
+01:12:08.140 --> 01:12:13.660
+It's upstream of the production of superoxide dismutase, which is a key liver enzyme for
+
+01:12:14.460 --> 01:12:16.460
+detoxing at the level of the liver and in
+
+01:12:17.020 --> 01:12:20.140
+Mutations and alterations genetically and epigenetically
+
+01:12:20.860 --> 01:12:24.780
+Silencing sod is critical to the development of Lou Gehrig's disease
+
+01:12:24.780 --> 01:12:31.020
+So these are the familial als and parkinsonians disease have a have a problem with making enough
+
+01:12:31.820 --> 01:12:38.380
+Superoxide dismutase or have dysfunctional enzyme at that level. So these antioxidant cannabinoids
+
+01:12:39.020 --> 01:12:46.300
+Actually, don't signal through cv1 or cv2 and we're unsure of what that of what the cross talk is and what the receptors are
+
+01:12:46.540 --> 01:12:52.060
+But no matter because they're lipid mediators and your membrane is shown here as lipid bilayers
+
+01:12:52.220 --> 01:12:57.500
+They go right through these lipids um cannabinoids or lipids and they go right through they stimulate and are up to
+
+01:12:57.980 --> 01:13:02.380
+Increase superoxide dismutase synthesis and decrease these
+
+01:13:02.860 --> 01:13:07.420
+Dounding brain damaging reactive oxygen and reactive nitrogen species
+
+01:13:07.980 --> 01:13:13.420
+So we all know about the antioxidants and so pro oxidation and oxidative stress
+
+01:13:13.500 --> 01:13:21.820
+It's known as is a key contributor to every disease on that first slide and particularly the neurological diseases. So it is those
+
+01:13:22.540 --> 01:13:24.540
+It's it's these pathways here
+
+01:13:25.500 --> 01:13:27.500
+That are really important for
+
+01:13:29.660 --> 01:13:31.660
+Turn off animals
+
+01:13:31.660 --> 01:13:35.660
+Are critically important for neural protection and neural inflammatory diseases
+
+01:13:35.660 --> 01:13:40.700
+So we can see the intersection right at that level for for the neural protection
+
+01:13:41.020 --> 01:13:43.980
+We also see introduced on the left hand side that the
+
+01:13:44.540 --> 01:13:51.660
+Not endogenous cannabinoids and cv1 agonists whether they be phyto cannabinoids other terpenes or synthetic
+
+01:13:51.980 --> 01:13:57.580
+um cv1 modulators are important for regulating brain derived neurotropic factor
+
+01:13:57.660 --> 01:14:02.860
+That's really a key neurotropic factor for developing new the development of new neurons
+
+01:14:03.260 --> 01:14:10.940
+So we the the key discovery here in the last um two decades since the um since the endogenous cannabinoid system
+
+01:14:10.940 --> 01:14:18.220
+Was discovered that we actually make and respond to cannabinoid molecules and they're critical to all of our development of both the brain and
+
+01:14:19.100 --> 01:14:21.980
+The immune system we can actually develop new brain cells
+
+01:14:21.980 --> 01:14:27.100
+We can actually drive through cv1 agonist and endogenous cannabinoids
+
+01:14:28.060 --> 01:14:33.420
+Neurogenesis, so that's really key to any of the diseases I showed like ALS
+
+01:14:33.660 --> 01:14:39.580
+Multiple sclerosis the demyelating diseases this actually shows the capacity to remyelinate to form
+
+01:14:40.300 --> 01:14:45.340
+New neurons and and and so far i'm not hearing a lot of downsides about weed, but
+
+01:14:46.300 --> 01:14:49.980
+You know, I'm not hearing a lot either. I mean it's a lot of word salad
+
+01:14:51.420 --> 01:14:55.500
+But there's lots of good things about stimulating the cannabinoid system
+
+01:14:56.300 --> 01:15:03.180
+Um, I don't think I disagree but again in general, right? We're talking about a very complex system. That's why
+
+01:15:03.900 --> 01:15:05.180
+you know
+
+01:15:05.180 --> 01:15:08.780
+Teenagers and young people that use extremely strong marijuana that are
+
+01:15:09.420 --> 01:15:15.020
+Already susceptible to depression or skits of Renee or any of these other conditions that we don't know very much about
+
+01:15:15.500 --> 01:15:17.900
+You can tip over into that attractor state
+
+01:15:19.420 --> 01:15:21.420
+And so when you when you
+
+01:15:21.820 --> 01:15:27.420
+You know, you make all these different claims about what's going on. These are just a very small tiny part
+
+01:15:27.980 --> 01:15:32.540
+Right, it's the tip of the iceberg of what this system does and how it works and
+
+01:15:33.180 --> 01:15:38.620
+How local versus systemic this signaling is and and what is affected by regular
+
+01:15:39.180 --> 01:15:44.940
+Cannabis use and how the body remodels those receptors remodels their expression in order to
+
+01:15:45.660 --> 01:15:50.780
+Tolerate or compensate for that being present in the system. So again
+
+01:15:52.300 --> 01:15:55.980
+We're talking about a million variables that are personal
+
+01:15:56.860 --> 01:16:03.260
+And we're simplifying down to a few arrows and a few pluses and minuses or reds and blue arrows up and down
+
+01:16:05.820 --> 01:16:08.540
+And the only real argument she's making is that
+
+01:16:09.420 --> 01:16:13.340
+Canabinoids are interesting because they're everywhere the receptors are everywhere
+
+01:16:13.420 --> 01:16:18.940
+They're involved in development and the immune system and the brain and everything that we are we think is important
+
+01:16:20.380 --> 01:16:24.780
+They're ubiquitous throughout the body. So what great that's interesting, but
+
+01:16:25.580 --> 01:16:31.660
+Again selling it as though this is the new be all end all is what I find most intriguing
+
+01:16:32.700 --> 01:16:37.820
+Really be cured of therapies for things even like autism spectrum disorders, um, which are
+
+01:16:39.020 --> 01:16:44.780
+In this family of myaltic encephalomyelitis that's inflammation of the brain and the muscles and adults
+
+01:16:44.860 --> 01:16:47.500
+They call it ME CFS and in in children
+
+01:16:47.900 --> 01:16:50.060
+They they end up with autism spectrum disorders
+
+01:16:50.140 --> 01:16:56.780
+But they're in the same they have the same types of immune disorders that an AIDS patient would have even in the absence of the virus
+
+01:16:56.940 --> 01:17:04.460
+Indicating other toxins going on so they're key to neural protection by cb1 driven endocannabinoids and phytopanhabinoids
+
+01:17:05.180 --> 01:17:08.780
+Right in the middle you see the intersection between the immune system
+
+01:17:09.580 --> 01:17:10.380
+and
+
+01:17:10.380 --> 01:17:14.540
+And the uh the brain and the immune system in the brain are really connected
+
+01:17:15.020 --> 01:17:21.820
+From conception and we and we know this now and the immune system is the brain is not what we used to consider
+
+01:17:22.060 --> 01:17:24.300
+immune privilege by immune privilege
+
+01:17:24.300 --> 01:17:31.100
+We means that you could have an inflammation of an antigen and it would not stimulate an inflammatory response
+
+01:17:31.420 --> 01:17:33.420
+That's simply not true
+
+01:17:33.500 --> 01:17:35.500
+Because the microglia
+
+01:17:35.980 --> 01:17:40.620
+Traffics the brain that means it starts in the bone marrow and those myeloid cells that I showed
+
+01:17:40.780 --> 01:17:46.460
+I'm that the first few slides and the brain derived monocyte macrophage is trafficked by
+
+01:17:47.180 --> 01:17:53.020
+Molecules known as chemokines those molecules known as chemokines are also regulated epigenetically that means
+
+01:17:53.500 --> 01:17:57.180
+At the expression level so while you can inherit changes in that
+
+01:17:57.580 --> 01:18:04.700
+Toxins in our environment like aluminum like mercury some of the things that they're shown to be so heavily associated with the development of
+
+01:18:05.420 --> 01:18:11.660
+Alzheimer's diseases those those and and autism spectrum disorders are that that pathogenesis is
+
+01:18:12.060 --> 01:18:17.180
+Hypothesized and and now more and more data support to be driven by activated microglia
+
+01:18:17.500 --> 01:18:22.460
+So you see the microglia is at the interface because they express both cb2
+
+01:18:22.460 --> 01:18:24.460
+um
+
+01:18:24.460 --> 01:18:26.460
+cannabinoid receptor number two
+
+01:18:26.460 --> 01:18:35.500
+And they cross talk they talk all day to the astraglia and the the astrocytes and the astraglia are important in glioblastoma the brain cancers
+
+01:18:35.500 --> 01:18:43.260
+We all um, you know, know of the upregulation and so really what we're listening to here is that endocannabinoid receptors are everywhere
+
+01:18:43.260 --> 01:18:45.820
+They're involved in a lot of things because they are everywhere
+
+01:18:46.620 --> 01:18:50.460
+And they can have some effect in an experimental setting on a lot of different things
+
+01:18:50.540 --> 01:18:52.140
+They can be shown to be
+
+01:18:52.140 --> 01:18:56.220
+Related to a lot of different systems again because they're g protein coupled receptors
+
+01:18:56.220 --> 01:19:04.700
+They can play a role in a lot of different systems and can be a a system wide regulator of things depending on how that that local circuit is organized
+
+01:19:05.260 --> 01:19:09.740
+But all these arrows pointing to neural protection all these arrows pointing to
+
+01:19:10.380 --> 01:19:13.900
+Regulation of the immune system is just making the argument to
+
+01:19:14.620 --> 01:19:16.780
+Look at cannabis as a plant
+
+01:19:16.780 --> 01:19:18.780
+To look at cannabis as a species
+
+01:19:19.100 --> 01:19:22.220
+To start dissecting its genome and start looking for
+
+01:19:22.780 --> 01:19:28.380
+candidate compounds that the pharmaceutical companies can synthetically make and use in these treatments
+
+01:19:28.460 --> 01:19:33.420
+Increase of the of the brain cancers the glioblastoma is in in our world
+
+01:19:34.220 --> 01:19:40.060
+And and it's it's proposed that cannabinoids and in fact really shown therapeutically
+
+01:19:40.380 --> 01:19:45.820
+That they can be not only helpful, but in this slide actually curative for these devastating brain cancers that
+
+01:19:46.620 --> 01:19:51.500
+That that killed vice president biden joe biden son a few years ago
+
+01:19:51.580 --> 01:19:54.060
+So crit it critical in thinking about therapeutic
+
+01:19:54.540 --> 01:20:00.460
+Opportunities where the micro glia by simply deactivating so it's the activated micro glia
+
+01:20:00.460 --> 01:20:04.700
+That is pathogenic because it releases that inflammatory nf cafe
+
+01:20:05.260 --> 01:20:12.300
+In that it releases the way way way way what this is 2018. Why did she say president biden son
+
+01:20:13.260 --> 01:20:17.180
+Did she say president biden son what in the hell wait?
+
+01:20:18.380 --> 01:20:20.380
+Is that right?
+
+01:20:22.140 --> 01:20:28.620
+What the full and thinking about therapeutic opportunities where the micro glia by simply deactivating
+
+01:20:28.860 --> 01:20:35.260
+So it's the activated micro glia that is pathogenic because it releases that inflammatory nf cafe
+
+01:20:35.740 --> 01:20:42.060
+In that it releases the activity pro inflammatory cytokines that reactivized oxygen and nitrogen species
+
+01:20:42.380 --> 01:20:49.340
+And really is driving the the breakdown so you want that cannabinoid receptor 2 through dgf beta through
+
+01:20:49.580 --> 01:20:57.820
+Thc to down regulate as we saw in the last slide to down regulate and actually allow cb1 to drive neural protection
+
+01:20:58.140 --> 01:20:59.020
+So
+
+01:20:59.100 --> 01:21:02.060
+The metabolic um substrates and the anti
+
+01:21:02.460 --> 01:21:05.500
+Undiant inflammatory tdf beta are really critical to it
+
+01:21:05.660 --> 01:21:13.580
+And it's this cross talk between the micro glia and the astraglia and the expression of both and probably through antioxidant in other
+
+01:21:14.060 --> 01:21:19.500
+Non-canonical cannabinoid receptors that modulate all of these processes non-canonical
+
+01:21:20.140 --> 01:21:25.100
+A non-canonical cannabinoid receptors are ones that they haven't identified and characterized yet
+
+01:21:25.980 --> 01:21:32.700
+See what we're talking about here. She's talking about cb1 and cb2, but then they're all non-canonical cannabinoid receptors
+
+01:21:32.700 --> 01:21:34.700
+How many of those are there Judy?
+
+01:21:35.100 --> 01:21:42.300
+The excitement is there for for all of us that um, um, that we we've probably uncovered a key therapeutic entity that can
+
+01:21:42.780 --> 01:21:47.260
+Um, that can actually cure some of the most devastating diseases of our time
+
+01:21:47.740 --> 01:21:51.020
+Um, the next slide shows even further to that
+
+01:21:51.420 --> 01:21:55.820
+Um, now they're being detected that they're actually cb1 receptors
+
+01:21:57.660 --> 01:21:58.940
+On the
+
+01:21:58.940 --> 01:22:00.060
+Mykandria
+
+01:22:00.060 --> 01:22:04.780
+So in on the astrocyte, I we blew up in in a paper that I've referenced
+
+01:22:05.340 --> 01:22:12.140
+Somewhere in here. I'll make sure I put the reference on paper. Um, but this is a january 2018 paper in the journal of neuro
+
+01:22:12.860 --> 01:22:14.860
+um, psychopharmacology
+
+01:22:15.100 --> 01:22:18.060
+And this paper talks about the the title of it is
+
+01:22:18.620 --> 01:22:21.820
+um, cb1 receptors from ubiquity to specificity
+
+01:22:21.980 --> 01:22:26.940
+So cb1 receptors in the endocannabinoid system they're expressed on essentially every cell
+
+01:22:27.340 --> 01:22:33.420
+In the body and every tissue and in every disease from cardiovascular disease to lung disease could be a part of those
+
+01:22:33.740 --> 01:22:37.260
+um neurons, um and and communications with the astrocytes
+
+01:22:37.740 --> 01:22:41.500
+Being dysregulated you see here the little um, G protein coupled receptor
+
+01:22:41.740 --> 01:22:47.820
+So they say they signaling through these G protein coupled receptors and the astrocyte there and the brain
+
+01:22:48.380 --> 01:22:50.380
+Um, we actually see these receptors
+
+01:22:50.700 --> 01:22:52.060
+um
+
+01:22:52.060 --> 01:22:57.820
+not only on the neuron and that the synaptic cleft driving um in the endogenous cannabinoid signaling
+
+01:22:58.060 --> 01:23:00.780
+For for neurological increase in apps and synapse
+
+01:23:00.860 --> 01:23:02.300
+This is driving all neurons
+
+01:23:02.300 --> 01:23:03.980
+So when we think about these
+
+01:23:03.980 --> 01:23:09.340
+fasticity diseases that that I talked about with ALS and and multiple sclerosis
+
+01:23:09.900 --> 01:23:11.900
+um, uh, lugere
+
+01:23:11.900 --> 01:23:17.740
+Parkinson's disease the fasciculations the um, the the seizures in the children with autism spectrum
+
+01:23:17.740 --> 01:23:23.900
+Disorders, it's these receptors that are being dysregulated the psychoses even the psychoses
+
+01:23:23.900 --> 01:23:31.900
+We see in young people who have dysregulated cb1 receptors. In fact, it's the it's the um, the agonist of the cb2
+
+01:23:32.380 --> 01:23:38.220
+Um, the thc that could actually stop the psychoses rather than driving the addiction as we think
+
+01:23:38.460 --> 01:23:42.300
+So here we have the communication between the neurons expressing
+
+01:23:42.620 --> 01:23:49.020
+Cross-talking receptors and the astrocytes and the calcium signaling that that is discussed in the ion channels
+
+01:23:49.260 --> 01:23:54.940
+And we show now the next point that the cannabinoids are actually there if we blow up in that
+
+01:23:55.260 --> 01:23:56.220
+um
+
+01:23:56.220 --> 01:24:01.260
+In that neuron the brain the heart and the muscles have the most mitochondria
+
+01:24:01.580 --> 01:24:09.580
+So this is because that's the energy powerhouses of of of your entire body with that without the mitochondria
+
+01:24:09.820 --> 01:24:13.980
+um, with the respiratory chain leading to 36 ATP versus two
+
+01:24:14.300 --> 01:24:18.300
+You can think about all of these diseases myaltic encephalomyelitis
+
+01:24:18.860 --> 01:24:25.340
+Um, is is inflammation of the brain and the muscles and it's long been been known to be a mitochondrial disease
+
+01:24:25.580 --> 01:24:29.020
+Um, and and now we can start begin to understand
+
+01:24:29.580 --> 01:24:35.260
+Um, that the cannabinoid signal through mitochondria right in the right hand slide. You see the mitochondria
+
+01:24:35.660 --> 01:24:39.580
+Actually has a mitochondrial cb1 signal
+
+01:24:40.220 --> 01:24:42.860
+So that so that you could actually generate
+
+01:24:43.820 --> 01:24:51.580
+Energy and and and read restore energy at the level of really restoring function and and these are the mitochondrial disease
+
+01:24:51.580 --> 01:24:56.940
+See wherever she finds a mitochondrial, uh, sorry wherever she finds a cannabinoid receptor
+
+01:24:56.940 --> 01:25:02.140
+Then she makes a story up about what you could potentially do with a cannabinoid that targeted that
+
+01:25:02.860 --> 01:25:07.980
+So now she's going to tell you that you could generate energy with cannabinoids you can you can be
+
+01:25:08.860 --> 01:25:15.420
+Protecting of neurons in five different ways because they're they're there and they're there and they're there and they're here and they're there and they
+
+01:25:15.980 --> 01:25:22.620
+They cause blood cells to differentiate into myeloid cells and they just you know it this kind of
+
+01:25:24.060 --> 01:25:27.260
+This kind of throwing a net over something
+
+01:25:27.740 --> 01:25:31.340
+Like a cannabinoid receptor and then claiming all of its
+
+01:25:31.900 --> 01:25:33.900
+relevance based on where it's found
+
+01:25:34.300 --> 01:25:41.020
+Is something that almost everyone in biology does when they have a pet receptor or a pet ion channel
+
+01:25:41.660 --> 01:25:48.140
+If you study calcium gated potassium channels and you notice that they're in every neuron
+
+01:25:49.100 --> 01:25:56.700
+That their expression changes during development that they're also found in cardiac neurons that they're also found in cardiac muscle
+
+01:25:56.700 --> 01:26:01.580
+That they're also found in all these places and then you can start to say that's that calcium
+
+01:26:02.380 --> 01:26:07.340
+Gated sodium channels are sorry calcium gated potassium channels are the most important
+
+01:26:08.140 --> 01:26:09.420
+channels
+
+01:26:09.420 --> 01:26:13.100
+In the whole body because they regulate neuronal function
+
+01:26:13.100 --> 01:26:18.220
+They regulate action potential half width they regulate and I could go on and on and on and on and on
+
+01:26:19.980 --> 01:26:26.140
+And then I can make a long argument about how conotoxins and and appamen from bees
+
+01:26:26.540 --> 01:26:34.620
+Are two things that interact with sk channels and we should look for more drugs that act with sk channels because sk channels are everywhere
+
+01:26:39.420 --> 01:26:46.220
+And it's no different than saying that well, we think we found some cannabinoid receptors subtypes on the mitochondria
+
+01:26:46.300 --> 01:26:50.460
+So obviously we can generate energy with it's just ridiculous
+
+01:26:51.420 --> 01:26:53.420
+But
+
+01:26:53.420 --> 01:26:57.100
+This is exactly how academic biology has been broken
+
+01:26:58.300 --> 01:27:02.540
+Because there is an impetus to to use this technique
+
+01:27:04.300 --> 01:27:09.740
+That gets you grants that makes you untouchable in this really narrow
+
+01:27:10.300 --> 01:27:18.140
+Fine band of understanding that no other academic can really encroach on because they don't study the cannabinoids that she does
+
+01:27:18.460 --> 01:27:25.420
+They don't study it at the level that she does they're they're not looking to modulate the things that she's looking to modulate
+
+01:27:25.500 --> 01:27:27.980
+And she doesn't they work for different companies. That's all
+
+01:27:29.660 --> 01:27:32.540
+These are devastated where children actually die before
+
+01:27:33.180 --> 01:27:38.700
+They're a few years old if they have a primary deficiency in any one of the chains of the mitochondria
+
+01:27:39.180 --> 01:27:44.780
+Respiratory chain in in any of these that that leads to certain death because you can't feel your brain
+
+01:27:45.100 --> 01:27:48.940
+Your heart or your muscles if you can't generate enough energy
+
+01:27:48.940 --> 01:27:54.620
+So here the cannabinoids are are even a key to the respiratory transport chain
+
+01:27:54.780 --> 01:28:00.860
+And there's that reference for that paper in neuropsycho pharmacology, but there's a question mark in the
+
+01:28:01.260 --> 01:28:07.340
+Cartoon for a discussion like this is we start to really dig into seeing it's a question mark
+
+01:28:07.900 --> 01:28:10.460
+Homeostasis that's a balance in our energy
+
+01:28:11.100 --> 01:28:17.980
+In in some of these devastating diseases of an inability to it's really an inability to fuel the brain and the heart
+
+01:28:18.380 --> 01:28:19.980
+So it's it's now energy
+
+01:28:19.980 --> 01:28:26.060
+It has nothing to do with misfolded proteins or any of the other stuff that we're supposed to pay attention to in those diseases
+
+01:28:26.060 --> 01:28:28.060
+Don't you see how cool this is?
+
+01:28:28.460 --> 01:28:34.300
+Some of those diseases have misfolded proteins in them and we're not even close to talking about that yet
+
+01:28:35.820 --> 01:28:38.300
+They haven't even come close. You see it
+
+01:28:39.260 --> 01:28:43.500
+Remember there's misfolded proteins in frickin cancer
+
+01:28:44.140 --> 01:28:48.220
+Don't you remember the lady from mit that we just watched a couple days ago
+
+01:28:48.940 --> 01:28:50.940
+She told us that these heat shock proteins
+
+01:28:51.660 --> 01:28:54.620
+Our vital responses in cancer and that cancer
+
+01:28:54.940 --> 01:28:57.660
+It happens because there's some misfolding stuff
+
+01:28:59.100 --> 01:29:01.100
+She works on cancer
+
+01:29:01.260 --> 01:29:06.460
+She worked at the national cancer institute for many a year. I don't hear anything about protein misfolding right now
+
+01:29:06.540 --> 01:29:08.460
+She's talking about all kinds of
+
+01:29:08.460 --> 01:29:14.700
+Cognitive developmental disorders that have protein mis I'm not hearing anything. It's just all cannabinoid receptors
+
+01:29:16.380 --> 01:29:20.860
+That is how academic biology has been broken ladies and gentlemen
+
+01:29:22.860 --> 01:29:27.820
+And the muscles at the same time because of of defects and pathogens on most viruses
+
+01:29:28.220 --> 01:29:34.540
+Will take out the mitochondria because they need the energy as well. So I show schematically on the next slide
+
+01:29:35.340 --> 01:29:40.700
+All of the ways that phyto cannabinoid so we've been talking about just our endogenous cannabinoids
+
+01:29:40.700 --> 01:29:46.740
+Which we which we produce on our own throughout our lifetime, but as toxins further and further
+
+01:29:47.100 --> 01:29:48.460
+dysregulate
+
+01:29:48.460 --> 01:29:54.060
+Our immune system in our endocannabinoid system because we haven't had plant sources
+
+01:29:54.540 --> 01:29:59.100
+Of cannabinoids whether it be hemp which has been outlawed since the 1930s
+
+01:30:00.060 --> 01:30:02.060
+Is from cannabis sativa
+
+01:30:02.620 --> 01:30:04.460
+And and the th she containing
+
+01:30:05.100 --> 01:30:11.260
+Medical marijuana. It's called they're all cannabis sativa or in the car the main major strains because that's been out of our diet
+
+01:30:11.340 --> 01:30:16.540
+Out of our world and the toxins that dysregulate the machinery that so now we need to eat
+
+01:30:17.100 --> 01:30:22.460
+Cannabinoids we need to ingest them because our body can't make them what is going on here
+
+01:30:24.860 --> 01:30:27.260
+That's a very interesting statement now, isn't it?
+
+01:30:29.660 --> 01:30:34.300
+Wow, I'm I'm and there they are all timers Parkinson's those are all
+
+01:30:34.940 --> 01:30:42.620
+Those are all misfolding disorders at least according to some academic biologists with a certain narrow point of view about them
+
+01:30:44.780 --> 01:30:51.420
+She thinks it's more related to endocannabinoid dysregulation of energy consumption and fueling the brain or whatever she said
+
+01:30:52.380 --> 01:30:56.460
+Maybe microglia responses being regulated by endocannabinoid receptors
+
+01:30:57.020 --> 01:31:02.780
+Amazing talk just shown you on the past few slides have been increasing in our world and we really have
+
+01:31:03.420 --> 01:31:06.860
+No response no therapeutic entity to simulate
+
+01:31:07.580 --> 01:31:14.140
+The phyto cannabinoids are are ones that have been used historically more than 14,000 years
+
+01:31:14.700 --> 01:31:19.980
+To to really mitigate and prevent the progression and development of these diseases
+
+01:31:20.060 --> 01:31:23.100
+So they mitigate neuro trauma ischemia is loss of oxidants
+
+01:31:23.100 --> 01:31:27.020
+So we talked about those reactive oxygen species and driving
+
+01:31:27.340 --> 01:31:34.460
+Oxidative stress starving off tissue. So ischemia is the problem in stroke major depressive disorders Alzheimer's disease. It's um
+
+01:31:35.340 --> 01:31:39.340
+Everything we've talked about in the last few slides are are interacting from that
+
+01:31:40.140 --> 01:31:45.740
+neuron where the immune cells the microglia the oligodendrocyte and the astrocyte are communicating
+
+01:31:45.980 --> 01:31:48.780
+Viya the cytokines chemokines growth factors
+
+01:31:49.020 --> 01:31:54.860
+Neuro transmitters like nrf2 and and neuro hormones like for instance vitamin D critical
+
+01:31:55.340 --> 01:32:01.660
+So these all of these things go to disrupt the balance we call it the homeostasis at the at the level of the brain
+
+01:32:02.300 --> 01:32:06.780
+And and this is what's driving. So if we can take phyto cannabinoids from plants
+
+01:32:07.100 --> 01:32:11.260
+We can dampen that tissue injury we can prevent the progression of diseases
+
+01:32:11.420 --> 01:32:18.060
+And in fact, as we saw a few slides ago, we could um, we could target neurogenesis once we once we've stopped the issue
+
+01:32:18.060 --> 01:32:22.540
+So essentially she's saying that none of these diseases have to do with diet
+
+01:32:22.700 --> 01:32:25.900
+None of these diseases have to do with environmental toxins
+
+01:32:26.860 --> 01:32:28.860
+They have to do with our lack of phyto
+
+01:32:29.900 --> 01:32:35.260
+cannabinoids and not using these and eating these plants anymore or something like that
+
+01:32:35.420 --> 01:32:39.260
+I'm assuming that there are other plants that have phyto cannabinoids besides marijuana
+
+01:32:39.900 --> 01:32:41.100
+um
+
+01:32:41.260 --> 01:32:43.260
+What an interesting talk
+
+01:32:44.140 --> 01:32:51.660
+And actually regenerate healthy neurons and neurological um function and and you know, literally, um cure these diseases
+
+01:32:51.980 --> 01:32:53.980
+Um, and cure these diseases
+
+01:32:54.620 --> 01:32:55.980
+scientific opinion
+
+01:32:55.980 --> 01:32:58.540
+Um, as as slide as the next slide shows
+
+01:32:58.940 --> 01:33:04.860
+It's really the tissue macrophage that is driving all of these processes. We've talked about micro glia
+
+01:33:05.100 --> 01:33:08.860
+Um, and and that's the brain macrophage. Well, the keratinocyte
+
+01:33:08.940 --> 01:33:13.260
+Let's stop here and just marvel at the number of macrophages there are
+
+01:33:14.220 --> 01:33:20.380
+Number marvel at the macrophage diversity that no one ever acknowledges at all
+
+01:33:25.980 --> 01:33:33.100
+Is the skin macrophage so we think of all of the uh, we think of all the skin diseases and that we see um, the very
+
+01:33:33.660 --> 01:33:42.300
+Devastating skin diseases that that could in fact, um, be be regulated by a cannabinoids via, um, the the cb2 receptor
+
+01:33:42.620 --> 01:33:48.780
+That that we show thc the psychoactive thc actually acts to drive, um, the various macrophages
+
+01:33:48.780 --> 01:33:55.260
+So each different organ system from the lung alveolar macrophage. So here we can use cannabinoids for
+
+01:33:56.060 --> 01:34:02.620
+Lung cancer as part of immune therapy in in our world. We've developed we developed, um, drugs at the national cancer institute
+
+01:34:02.780 --> 01:34:09.100
+And through various pharmaceutical companies like epigenetics, um, for the last 30 or 40 years getting old here
+
+01:34:09.500 --> 01:34:13.500
+But but you can you can target in copd the alveolar macrophage
+
+01:34:13.500 --> 01:34:18.860
+So we can think of all the allergens and microorganisms that are that are driving more and more copd
+
+01:34:18.860 --> 01:34:23.660
+Which is, um, chronic obstructive pulmonary diseases. Um, we look at the liver cup for cells
+
+01:34:23.660 --> 01:34:27.820
+So this is the cell that's critical to hepatitis c hepatitis b
+
+01:34:27.980 --> 01:34:34.300
+Um, hbrb and primary billery cirrhosis cirrhosis of the liver. We think of fatty liver disease
+
+01:34:34.300 --> 01:34:39.740
+I, um, I think, um of all of the um, stories. I've been reading, uh, in the in the journals lately
+
+01:34:39.740 --> 01:34:43.020
+It's the huge incidence in fatty liver diseases
+
+01:34:43.740 --> 01:34:46.220
+In people under 50 whether it be men or women
+
+01:34:46.300 --> 01:34:49.660
+And I showed you that the dipisite slide in the in the fat progenitor
+
+01:34:49.740 --> 01:34:54.780
+So if you're driving the cb1 because of toxins because you don't have enough cb2
+
+01:34:55.100 --> 01:35:00.700
+Driving the monocyte macrophage then you can see how all of the diseases and then some that I put
+
+01:35:00.700 --> 01:35:02.700
+See you don't have enough cbd
+
+01:35:03.580 --> 01:35:10.300
+Do you don't have enough cannabinoids driving the cb2 receptor? It is exactly this kind of ridiculous
+
+01:35:11.180 --> 01:35:18.940
+Simplification reductionist biology that has contaminated and destroyed our academic biological fields our medical science
+
+01:35:19.580 --> 01:35:22.220
+And this is just a use of that technique
+
+01:35:22.860 --> 01:35:30.460
+To present the primacy of the cb1 and cb2 receptors to make an argument that these are a new kind of
+
+01:35:31.180 --> 01:35:34.380
+Of receptor to target a new novel idea
+
+01:35:34.940 --> 01:35:39.740
+Um, that's just gaining traction that has all kinds of applications in the future
+
+01:35:40.300 --> 01:35:46.380
+For the coming 21st century of acquired immune deficiency syndromes, you know like flying aids
+
+01:35:47.340 --> 01:35:49.820
+on that on that first introductory slide
+
+01:35:50.220 --> 01:35:54.220
+Could be mitigated at some level by the right combination of
+
+01:35:54.780 --> 01:36:00.140
+Fido cannabinoids now from plants because of course our endogenous ones simply aren't enough to overcome
+
+01:36:00.540 --> 01:36:05.340
+Um, what is already not enough process because we've been without them. We don't have enough last time
+
+01:36:06.060 --> 01:36:10.940
+Most people experience the endogenous cannabinoids is during breastfeeding
+
+01:36:11.420 --> 01:36:17.260
+Because that's when mom is elaborating and producing many of them through the milk and babies getting that calming pain free
+
+01:36:17.820 --> 01:36:20.780
+Learn to suckle and mom and baby or go. That's the last time
+
+01:36:21.100 --> 01:36:24.620
+That's the last time we've had endocannabinoids is when we were breastfeeding
+
+01:36:25.100 --> 01:36:29.260
+Wow, that's a weird statement our brain makes them all the time
+
+01:36:30.140 --> 01:36:35.100
+Where does she think they come from idea of of joy anandamide one of the key
+
+01:36:35.820 --> 01:36:39.500
+Endogenous cannabinoids anandamide is sanskrit meaning joy
+
+01:36:39.580 --> 01:36:45.980
+So the cannabinoid system could be seen as joy pain free happy stress-free living and you can see at every level
+
+01:36:45.980 --> 01:36:47.980
+The macropage that cb2
+
+01:36:48.940 --> 01:36:50.860
+Endogenous
+
+01:36:50.860 --> 01:36:52.620
+Babies are broken
+
+01:36:52.620 --> 01:36:58.380
+Not in a like over, you know, I don't want to be overly dramatic but there is no question
+
+01:36:59.340 --> 01:37:03.980
+That breastfeeding if it can be done without pain and suffering by the mom
+
+01:37:04.620 --> 01:37:12.300
+Breastfeeding is so far beyond superior to anything else that should never be considered to be dropped
+
+01:37:14.060 --> 01:37:19.900
+There should be a full-time effort by the husband and the wife over many days to make that work
+
+01:37:20.780 --> 01:37:22.780
+with the help of a
+
+01:37:23.020 --> 01:37:25.020
+anyone
+
+01:37:25.340 --> 01:37:31.580
+And that should be given up at the very last resort and I don't I don't think everybody's going to be really happy hearing me say that
+
+01:37:32.700 --> 01:37:35.580
+But i'm saying it as I defend my my
+
+01:37:36.460 --> 01:37:38.460
+best friend
+
+01:37:38.460 --> 01:37:44.940
+For maybe the only reason why our daughter who's had the entire goddamn schedule since we got here in america
+
+01:37:45.420 --> 01:37:48.140
+Is not damaged as much as she could be
+
+01:37:48.540 --> 01:37:53.180
+Is because my wife had the wherewithal to breastfeed her until she was almost five years old
+
+01:37:55.580 --> 01:37:58.540
+Now our middle son was actually treated very differently
+
+01:37:58.620 --> 01:38:03.420
+But our middle son was grow grew up in with his toddler years in the netherland
+
+01:38:03.500 --> 01:38:08.300
+So he didn't have the same kind of assault on his immune system that my daughter did here
+
+01:38:11.580 --> 01:38:13.580
+But oh my gosh
+
+01:38:15.180 --> 01:38:19.500
+If there is anything that bonds a woman with a child that is breastfeeding
+
+01:38:20.300 --> 01:38:21.820
+And
+
+01:38:21.820 --> 01:38:26.780
+Just talking about missing out on that can make my wife break down in tears
+
+01:38:29.820 --> 01:38:34.780
+I think she considers these some of the most important moments of her life
+
+01:38:37.260 --> 01:38:43.420
+And I think that every day that she think that she's asked to think about it. She thinks maybe she would want another child
+
+01:38:44.700 --> 01:38:46.700
+That's how beautiful it is
+
+01:38:49.500 --> 01:38:51.500
+And
+
+01:38:53.980 --> 01:38:58.700
+It is impossible as a man to understand the kinds of things that a woman goes through
+
+01:38:59.420 --> 01:39:03.660
+From the moment of conception until a child leaves the house
+
+01:39:05.340 --> 01:39:11.740
+And no matter what you want to think of yourself as a father, there's no way that you can possibly understand we can possibly understand
+
+01:39:13.020 --> 01:39:17.500
+What it will means to carry a child to give birth to a child to breastfeed a child
+
+01:39:19.660 --> 01:39:21.660
+And the idea that we would
+
+01:39:22.380 --> 01:39:26.140
+Abbreviate that process or punctuate that process in any way
+
+01:39:28.220 --> 01:39:32.060
+It's just it's an abomination ladies and gentlemen. It's an abomination
+
+01:39:36.300 --> 01:39:39.420
+And so I don't know what she's talking about here with endocannabinoids and breastfeeding
+
+01:39:39.420 --> 01:39:43.740
+But I am pretty sure that your brain makes endocannabinoids all the time there necessary they're there
+
+01:39:44.140 --> 01:39:49.420
+But they are a modulator they play a role in the background like all the other instruments in a symphony does
+
+01:39:49.500 --> 01:39:56.300
+And if you take the piccolo out of the symphony, you can still recognize the song and it still goes and everybody can make it to the coda
+
+01:39:57.820 --> 01:40:03.660
+But there will be something missing and with cannabinoid receptors. This is a yet another knob to turn
+
+01:40:03.740 --> 01:40:04.860
+It's another
+
+01:40:04.860 --> 01:40:08.220
+Slider on the equalizer, but it's not the be-all end-all that
+
+01:40:08.700 --> 01:40:12.380
+Decides whether macrophages are working or whether they're sitting in the corner
+
+01:40:13.180 --> 01:40:19.260
+It's not the difference between well, my kid's brain is developing or it's not developing or my kids
+
+01:40:19.820 --> 01:40:24.140
+Got skits if any or it doesn't have skits if any because he doesn't have enough cannabinoids in his brain
+
+01:40:24.220 --> 01:40:26.220
+I guess we better give him some more
+
+01:40:29.900 --> 01:40:36.940
+Abenoid key to the development of the hematopaedic poetics stem cell is could be modulated in a in a way by cannabinoids
+
+01:40:36.940 --> 01:40:41.580
+In a positive way rather than a damaging way with the bone resorption here at the bottom of the screen
+
+01:40:41.740 --> 01:40:43.740
+some chronic um
+
+01:40:43.740 --> 01:40:44.540
+the
+
+01:40:44.540 --> 01:40:47.980
+IBD the inflammatory bio disease and Crohn's disease at the level of the
+
+01:40:48.780 --> 01:40:55.580
+Intestinal macrophages. So so many of these diseases by gently modulating the macrophages at the level of the mild
+
+01:40:55.580 --> 01:41:01.100
+So rather than take care of the result the pathogenic state whatever poison you have
+
+01:41:01.100 --> 01:41:02.300
+What other
+
+01:41:02.300 --> 01:41:06.220
+Environmental toxin you're exposed to or whatever other thing was dysregulated
+
+01:41:06.700 --> 01:41:12.620
+Let's just give them a substance which fixes that they're not on the right medication is the answer here
+
+01:41:13.500 --> 01:41:15.500
+People aren't on the right medications
+
+01:41:16.220 --> 01:41:19.900
+We need to get new medications to these people so we can cure their problems
+
+01:41:20.380 --> 01:41:25.260
+Rather than going to the root cause which would be real health and well-being right
+
+01:41:25.980 --> 01:41:29.660
+That's health and wellness. This is not medicine. This is pharmaceuticals
+
+01:41:30.460 --> 01:41:35.580
+Once you see it you can't unsee it. I think this is this was the best thing
+
+01:41:35.580 --> 01:41:36.940
+We could have done with Judy
+
+01:41:36.940 --> 01:41:40.940
+But stem cell could actually be curative by looking at in these ways
+
+01:41:41.260 --> 01:41:43.820
+I highlight the cross talk in in the next slide
+
+01:41:44.380 --> 01:41:51.580
+To show you the pairing so cross talk of receptor. So opioid receptors are also a little deep
+
+01:41:51.580 --> 01:41:57.500
+But that's the great this is the perfect slide for which to do this right? So what happens? How do they target this?
+
+01:41:58.460 --> 01:42:04.220
+How do they get the serotonin receptors to be hit or the dopamine receptors to be hit
+
+01:42:04.620 --> 01:42:09.820
+And modulated by the cv1 stimulation, but not the orexin receptors or the chemokine receptors
+
+01:42:09.820 --> 01:42:11.980
+How do they manage to do that?
+
+01:42:13.580 --> 01:42:15.580
+Put a tag on it
+
+01:42:15.580 --> 01:42:20.460
+Electropyrated in the right places. Come on guys. You can see it Pamela sees it
+
+01:42:21.020 --> 01:42:23.260
+Link receptors there to these channels
+
+01:42:23.260 --> 01:42:28.620
+I show you cv1 and that cross talk doesn't only have to happen between the cv1 and cv2
+
+01:42:29.020 --> 01:42:32.060
+It can happen through these to these opioid receptors
+
+01:42:32.220 --> 01:42:38.220
+So anxiety and depression and chronic diseases anxieties a type of pain. It's called it's a no-siception
+
+01:42:38.460 --> 01:42:42.940
+It's a different idea when we think of anxiety. So that's simply using cv1
+
+01:42:43.500 --> 01:42:48.220
+Rich and targeting agonists and preparations of cannabinoids can actually
+
+01:42:48.940 --> 01:42:55.660
+lead to tolerance and brain blocking pain blocking effects of opiate so it could actually reduce our opioid addiction
+
+01:42:56.060 --> 01:42:58.220
+And so again, we're talking about could
+
+01:42:58.780 --> 01:43:04.140
+Maybe because this receptor is there and that receptor is there and these things are involved in that
+
+01:43:04.460 --> 01:43:07.020
+We might be able to use this thing to do stuff
+
+01:43:10.060 --> 01:43:15.260
+And this is exactly how academic biology is broken because that's how they all talk
+
+01:43:15.740 --> 01:43:21.900
+That's how they always talk at the end of their talk. How many things can I catch with my net?
+
+01:43:23.100 --> 01:43:24.060
+Holy
+
+01:43:24.060 --> 01:43:31.980
+Cannabis, you know, and this is this is where understanding of biology and biochemistry helps us to break down these cultural walls that says oh no
+
+01:43:32.380 --> 01:43:34.540
+Cannabis is addictive and we can't have THC
+
+01:43:34.780 --> 01:43:39.980
+Well, as long as you prevent THC from signaling cv1 you won't get this psychoactive effects
+
+01:43:40.300 --> 01:43:43.260
+And we can do that because we can just build a stronger magnet
+
+01:43:44.060 --> 01:43:47.820
+Then THC to block those effects with that that happens now
+
+01:43:48.060 --> 01:43:55.340
+See so what she's actually suggesting is is that in order to get this right we're going to have to have a THC receptor one blocker
+
+01:43:56.140 --> 01:44:03.820
+Put in your brain so you don't get high and then we'll we'll we'll use a different one that the oh my gosh
+
+01:44:03.980 --> 01:44:05.980
+It's just disturbing how
+
+01:44:06.540 --> 01:44:13.180
+Ridiculous she sounds not only do you have no way of targeting any of these specific targets with your
+
+01:44:14.140 --> 01:44:18.540
+Hit cv1 receptor and every one of these pictures. So how is it specific?
+
+01:44:20.780 --> 01:44:27.340
+And then you're going to block specific cv2 receptors or cv1 receptors in the brain to get the cv2 receptors
+
+01:44:27.820 --> 01:44:29.820
+it's just all
+
+01:44:32.860 --> 01:44:35.020
+It's all hot air actually through
+
+01:44:36.380 --> 01:44:39.980
+Blockers of various immune molecules like inflammatory cytokine
+
+01:44:40.220 --> 01:44:45.660
+IL-1 which is central to many diseases of pain as an IL-1 receptor and hagginess
+
+01:44:45.740 --> 01:44:52.940
+So it actually is expressed in high levels IL-1 RA to block IL-1 once IL-1's job is done
+
+01:44:53.180 --> 01:44:58.380
+So that you don't overdo it and cause these addictions so on to depression and anxiety
+
+01:44:58.380 --> 01:45:05.260
+We think of serotonin receptors so soo spider billions of dollars are spent spinning wheels like this
+
+01:45:05.500 --> 01:45:11.580
+billions of dollars in grants are given to people who can talk exactly like this about a million different
+
+01:45:12.220 --> 01:45:16.460
+subjects of a tiny little flimsy part of some story
+
+01:45:18.540 --> 01:45:25.340
+And there are there are actually hundreds and hundreds of g protein coupled receptors that people are interested in
+
+01:45:25.340 --> 01:45:28.700
+Hundreds and hundreds of ionic receptors that people are interested in
+
+01:45:29.180 --> 01:45:32.380
+And it's it's each one of those can tell the same story
+
+01:45:32.380 --> 01:45:35.500
+I wasn't joking when I was saying that calcium
+
+01:45:36.300 --> 01:45:38.300
+small conductance
+
+01:45:38.620 --> 01:45:42.940
+Calcium activated potassium channels are one of many
+
+01:45:43.660 --> 01:45:46.300
+different subtypes of potassium channels
+
+01:45:47.020 --> 01:45:53.660
+Potassium channel biophysicists are very firm in their belief that potassium channels because they turn off
+
+01:45:54.300 --> 01:46:00.460
+the action potential because they reset the membrane of neurons and all electrical
+
+01:46:01.260 --> 01:46:03.260
+membrane
+
+01:46:03.260 --> 01:46:05.020
+in the body
+
+01:46:05.020 --> 01:46:08.140
+The potassium channels are the most important things to regulate
+
+01:46:08.140 --> 01:46:10.300
+They're the most important things to target
+
+01:46:10.300 --> 01:46:14.140
+They're the most important things that conduct the timing of the symphony
+
+01:46:14.140 --> 01:46:18.060
+And you can hear all of these people over many decades talking about how
+
+01:46:18.780 --> 01:46:22.620
+Primal they are to brain function even though they are a very tiny
+
+01:46:23.500 --> 01:46:29.020
+Channel that produces a very tiny amount of current only in response to the presence of calcium
+
+01:46:30.460 --> 01:46:36.380
+And so only at when synapses are learning which is also really reason why everybody's so interested in them for a long time
+
+01:46:36.780 --> 01:46:41.020
+And she's doing exactly the same thing with cannabinoids right now
+
+01:46:41.420 --> 01:46:46.780
+With regard to the brain and the immune system and inflammation and all of the major
+
+01:46:47.660 --> 01:46:51.740
+Acquired immune deficiencies of the 21st century. It's an incredible
+
+01:46:52.540 --> 01:46:56.380
+Talk so here again. This is where a therapeutic opportunity exists
+
+01:46:57.180 --> 01:47:01.020
+With with these memory impairments and these these diseases of serotonin
+
+01:47:01.420 --> 01:47:05.900
+receptors, which of course serotonin and dopamine receptors are key to Parkinson's disease
+
+01:47:06.700 --> 01:47:08.700
+And and a number of other
+
+01:47:09.100 --> 01:47:14.940
+You know, literally untreatable diseases at least thought of and until very recently Huntington's disease
+
+01:47:15.340 --> 01:47:19.660
+Is these adenosine receptors which are highly immune suppressive and and this is again
+
+01:47:19.740 --> 01:47:24.060
+It's usually a familial disease by a problem with the a2a receptors the adenosine receptors
+
+01:47:24.300 --> 01:47:30.860
+Where if you can come in here and have some cross talk in agonists of cb1 and up regulate you can ameliorate
+
+01:47:30.860 --> 01:47:32.860
+You can lessen the damage
+
+01:47:33.260 --> 01:47:39.500
+Of that genetic disease and stop the expression. So in in epigenetic worlds. It's it's the expression of the diseases
+
+01:47:40.300 --> 01:47:46.940
+Not not the genetic component which which are these familial diseases. So Huntington's disease runs in families
+
+01:47:46.940 --> 01:47:51.500
+But you don't have to die and you don't have to progress if you think of curative therapies
+
+01:47:52.140 --> 01:47:54.140
+Via modulating cb1
+
+01:47:54.540 --> 01:47:56.620
+You know finally at the bottom of the screen we have
+
+01:47:57.340 --> 01:48:01.660
+The chemokine receptors. Um, so the chemokine receptors are the trafficking molecules
+
+01:48:01.900 --> 01:48:04.940
+There what takes those blood monocytes to the brain
+
+01:48:05.340 --> 01:48:10.380
+So if you can down module there what takes cancer cells and leads to tumor metastasis
+
+01:48:10.700 --> 01:48:16.460
+If a prostate canter or any other cancer doesn't metastasize to the bone doesn't spread to the bone
+
+01:48:16.780 --> 01:48:22.540
+Via the trafficking molecule that takes them along by the hand and takes them to the place where they can live and thrive
+
+01:48:22.860 --> 01:48:26.220
+Then you don't die of cancer if you stop see that's weird
+
+01:48:26.220 --> 01:48:30.140
+She's talking about chemokines as if they deliver things that I don't think they do
+
+01:48:30.140 --> 01:48:34.300
+I think chemokines are are a concentration gradient signal
+
+01:48:36.380 --> 01:48:38.620
+And immune cells
+
+01:48:39.740 --> 01:48:41.740
+Will migrate
+
+01:48:42.380 --> 01:48:47.580
+Based on the concentration of chemokines and follow the concentration gradient to the source
+
+01:48:48.540 --> 01:48:53.500
+Which is a very different set of biological mechanisms and circumstances than a
+
+01:48:53.980 --> 01:48:57.740
+Something that takes things somewhere or delivers them places
+
+01:48:58.220 --> 01:49:01.740
+Which that's I don't think chemokine receptors do that
+
+01:49:02.460 --> 01:49:04.460
+It's so weird
+
+01:49:04.460 --> 01:49:11.180
+To the bone via the trafficking molecule that takes them along by the hand and takes them to the place where they can live and thrive
+
+01:49:11.420 --> 01:49:15.500
+Then you don't they do not get taken along by the hand. This is not this is wrong
+
+01:49:15.580 --> 01:49:21.180
+I I don't I don't know why we're die of cancer if you stop them metastasis
+
+01:49:21.180 --> 01:49:26.860
+And we have any number of drugs we've made over the last few years like andeogenesis inhibitors to stop cancer
+
+01:49:27.180 --> 01:49:32.700
+Spread because then you can you can live with it and and not die of it. So the next slide
+
+01:49:33.420 --> 01:49:39.900
+Highlights that that very cross talk idea when we talk about the pure allergic receptors. So purines
+
+01:49:40.780 --> 01:49:44.380
+Are our molecules like caffeine is a purine adenosine
+
+01:49:44.780 --> 01:49:49.180
+Guanine we have purines and perimeters that make up the base pairs of our DNA
+
+01:49:49.580 --> 01:49:56.540
+So in this open pain journal from 2010 it again earlier than then the the papers I could discussing today
+
+01:49:56.940 --> 01:50:03.660
+It showed where there were actually there was actually cross talk between that adenosine receptor on that monocyte macrophage
+
+01:50:03.900 --> 01:50:09.500
+And that activated M1 is it's the bad macrophage no matter if you're in cancer or anything else
+
+01:50:09.900 --> 01:50:13.020
+They're they're they're bad pro inflammatory when they get to M2
+
+01:50:13.100 --> 01:50:20.940
+That's driving the cancer or driving the neurological disease. And as you've shown here. It's affecting what we call it damage in a distance
+
+01:50:21.740 --> 01:50:23.740
+Venera, so that's by ATP
+
+01:50:24.300 --> 01:50:31.820
+Which is appearing and and so when these when ATP and those energy molecules get outside the cells because the cells are dying
+
+01:50:32.140 --> 01:50:33.660
+They become danger signals
+
+01:50:33.660 --> 01:50:37.420
+So they tell the immune system to shut down and become immune suppressive
+
+01:50:37.500 --> 01:50:41.820
+And so it's this cross talk and and and the suppression of these inflammatory cytokines
+
+01:50:42.540 --> 01:50:50.220
+That that is a problem because an immune suppressed person will develop cancer or progress in cancer because you need the right immunity
+
+01:50:50.380 --> 01:50:57.500
+And that's what I'm pretty sure that this very poorly cited volume three pain journal from 2010 does not
+
+01:50:58.300 --> 01:51:01.020
+Actually establish this any of this is fact
+
+01:51:01.420 --> 01:51:05.020
+But it's really neat that she can explain it as though it does
+
+01:51:05.500 --> 01:51:09.580
+And that again is exactly how academic biology has been broken
+
+01:51:09.980 --> 01:51:15.100
+Where you need that stem cell at the very beginning with TGFa to driving that hematopoietic stem cell
+
+01:51:15.340 --> 01:51:20.060
+Away from the myeloid lineage that is toxic the activated and inflammatory
+
+01:51:20.300 --> 01:51:25.980
+See she's going all the way back to the first stage to try and tell you that we're already talking about how
+
+01:51:26.620 --> 01:51:29.740
+Blood cells are generated how their differentiation is is
+
+01:51:30.220 --> 01:51:35.260
+Is controlled like a plinko machine with different. I mean this is amazing
+
+01:51:36.380 --> 01:51:40.940
+It is amazing because this is not informing anyone. This is not
+
+01:51:41.580 --> 01:51:48.860
+Teaching anybody this has nothing to do with protein misfolding nothing to do with vaccines and it's 2018
+
+01:51:51.580 --> 01:51:57.660
+If you just paid attention to Judy mikovitt since the start of the pandemic you would never know that she didn't work for chd
+
+01:51:58.460 --> 01:52:02.620
+You would know you would think that she has done lots of streams with like
+
+01:52:03.180 --> 01:52:07.660
+All the major anti-vaxxers for a very long time and has been on their team for years
+
+01:52:09.020 --> 01:52:11.020
+Apparently not
+
+01:52:11.260 --> 01:52:15.740
+Apparently she made her money in other ways apparently she wasn't always an anti-vaccine grifter
+
+01:52:19.500 --> 01:52:23.820
+If that's what people characterize her as now it's the resting um microglia
+
+01:52:23.820 --> 01:52:26.940
+Which is doing its job of surveilling and removing toxins
+
+01:52:27.260 --> 01:52:31.340
+So the next slide shows you just a list of all of the effects
+
+01:52:31.340 --> 01:52:35.820
+So the plant derived phytocannabinoids are known as dHC as we've discussed it linked
+
+01:52:36.060 --> 01:52:39.660
+CBD which canabidiols are really the main constituents of
+
+01:52:40.380 --> 01:52:42.940
+Canab a big girl. I didn't know what that was. What's that?
+
+01:52:43.580 --> 01:52:48.380
+THC opportunity in most but from sativa and indica these have been traditionally known
+
+01:52:48.940 --> 01:52:55.020
+To to benefit patients with these various diseases and the canabajera which metabolizes into more
+
+01:52:55.260 --> 01:52:56.140
+THC
+
+01:52:56.140 --> 01:53:00.940
+Also again now we understand that's because of its regulation of the amatopoietic stem cell
+
+01:53:01.580 --> 01:53:08.380
+Having the anti-inflammatory and inflammatory agents so we can use these depending on the concentrations of the drugs
+
+01:53:08.780 --> 01:53:14.140
+To to actually help anti-psychotics work better. Um, essentially every drug we use
+
+01:53:14.460 --> 01:53:16.460
+Oh
+
+01:53:16.540 --> 01:53:18.540
+There it is
+
+01:53:18.540 --> 01:53:24.780
+We're going to use canabinoids to make every drug we have work better
+
+01:53:29.740 --> 01:53:34.540
+You just heard it right there. I'm going to play it again. That's the end. That's that's it
+
+01:53:34.620 --> 01:53:37.420
+That there we solved the problem now. That was pretty easy
+
+01:53:37.820 --> 01:53:45.420
+Health anti-psychotics work better. Um, essentially every drug we used in in cancer or immune diseases right now
+
+01:53:45.740 --> 01:53:48.860
+We can just supplement and we can take advantage of synergies
+
+01:53:48.940 --> 01:53:55.980
+Absolutely take advantage of synergies now we can repurpose all kinds of previously on useless patented drugs
+
+01:53:56.300 --> 01:54:03.980
+And and confound the effects of those drugs by applying them co-applying them with cannabinoids that stimulate everything
+
+01:54:04.540 --> 01:54:08.380
+That makes perfect sense. How else were we going to end all
+
+01:54:09.260 --> 01:54:12.460
+Clinical trials of anything meaningful if we didn't do it like this
+
+01:54:12.460 --> 01:54:14.460
+And derive
+
+01:54:15.020 --> 01:54:23.980
+Um, the phytocannabinoids here shown here and and and lessen the actual drug that the therapy that we're using and lessen the off-target or side effects
+
+01:54:24.540 --> 01:54:30.780
+So lesson that side effects. Do you see it? This is exactly the plan
+
+01:54:32.380 --> 01:54:38.140
+Cannabis is going to come to the rescue as we change our vaccine schedule over to genetic therapies
+
+01:54:38.620 --> 01:54:47.500
+It's going to come to the rescue as we as we barrel forward into this era of health public health injury disguised as
+
+01:54:49.020 --> 01:54:52.700
+21st century acquired immune deficiency syndromes whole
+
+01:54:53.260 --> 01:54:58.700
+There are so can cannabinoids phytocannabinoids are part of a class of compounds known as terpies
+
+01:54:58.940 --> 01:55:06.380
+So on this next slide. I show you um, all of the immunomodulatory and anti-inflammatory terpies
+
+01:55:06.700 --> 01:55:14.060
+So this starts to give us some insight starts to give us some insight in the fact that a lot of these terpines that are found in pine are actually
+
+01:55:14.540 --> 01:55:18.140
+I think probably the least investigated most valuable
+
+01:55:18.940 --> 01:55:25.340
+Potential organic compounds out there. I actually had a really interesting conversation with a crazy person
+
+01:55:25.820 --> 01:55:31.020
+When I was at society for neuroscience meeting in new Orleans in 2008
+
+01:55:31.980 --> 01:55:36.780
+I was walking on the street and some random guy stopped me. He was carrying a gigantic
+
+01:55:37.980 --> 01:55:41.420
+Walking staff and at the top of the walking staff had a carved
+
+01:55:41.660 --> 01:55:43.660
+Uh a pinecone
+
+01:55:43.660 --> 01:55:48.780
+And he insisted that I sit down on this bench and listen to him talk about how pinecone and
+
+01:55:49.260 --> 01:55:54.540
+The terpines in pine actually were a secret that have been known since the Egyptians
+
+01:55:55.260 --> 01:55:57.500
+And that's the reason why the papal
+
+01:55:57.980 --> 01:55:59.500
+the papal
+
+01:55:59.500 --> 01:56:06.060
+Crucifix has a pinecone on it and why there's pine cones in in Egypt and all sort of stuff and it was crazy how
+
+01:56:06.620 --> 01:56:08.620
+I mean this dude
+
+01:56:08.860 --> 01:56:11.020
+Was telling me something like he thought
+
+01:56:12.860 --> 01:56:15.420
+It was his last chance to tell somebody the truth
+
+01:56:16.220 --> 01:56:19.340
+Was a very moving presentation that ended with me
+
+01:56:19.900 --> 01:56:24.380
+Shaking his hand and walking back to my hotel, but it was it's interesting that she brings this up
+
+01:56:25.020 --> 01:56:26.380
+as to the plants
+
+01:56:26.380 --> 01:56:32.860
+So one of the things that indica or hemp have the most of is the other terpine known as mercy
+
+01:56:33.660 --> 01:56:40.060
+And so this is why the indica is thought to be relaxing because the mercy as an essential oil
+
+01:56:40.140 --> 01:56:46.140
+These could be thought of as essential oils or oils and though they're they help induce sleep and relaxation
+
+01:56:46.300 --> 01:56:50.380
+Well, the indica strains are very much higher in these additional terpines
+
+01:56:51.180 --> 01:56:54.700
+And and and they obviously have the smells that you taste with various
+
+01:56:55.180 --> 01:56:59.420
+Cannabis tinctures and oils other terpines like lemonine linole
+
+01:57:00.460 --> 01:57:06.780
+Carbofyline the peppery spicy is a is a compound known it interacts with a receptor known as tarpv1
+
+01:57:07.100 --> 01:57:10.140
+Tarpv1 is a key pain receptor
+
+01:57:10.380 --> 01:57:17.340
+And the only known natural ligand is the only unknown natural product that binds that is tarpv1 is hot chili peppers
+
+01:57:17.580 --> 01:57:22.380
+So a lot of the preparation we make with cannabinoids where they're from from cannabis
+
+01:57:22.940 --> 01:57:25.260
+The the activity of the cannabis could be
+
+01:57:26.060 --> 01:57:29.100
+modulated more by the terpine and not at all by
+
+01:57:29.740 --> 01:57:32.700
+The cannabinoids the cbds the cbns or the cbgs
+
+01:57:33.420 --> 01:57:38.780
+And even thc, so we could think of thinking about the anti-inflammatory terpines and and
+
+01:57:39.260 --> 01:57:45.900
+Since cannabis is terpines and thinking about how we can formulate and reduce as much as possible to psychoactive effects and yet get
+
+01:57:46.380 --> 01:57:49.180
+A healing therapeutic. She said that a few times
+
+01:57:49.260 --> 01:57:57.340
+We have to find a way to get rid of the psychoactive effects of of cannabis while keeping all of these wonderful pharmaceutical effects
+
+01:57:58.220 --> 01:58:01.020
+Benefit really at almost no cost
+
+01:58:01.740 --> 01:58:07.260
+So I've talked a lot about the cannabinoids and here's two recent reviews and I think your audience can see
+
+01:58:07.820 --> 01:58:12.540
+Um, maybe 2015 and 2000 the lead author of this is named bandana
+
+01:58:12.620 --> 01:58:19.820
+I just thought you'd like that in tenor 11 where there's there's um, these are very long lengthy reviews that give you all kinds of
+
+01:58:19.900 --> 01:58:21.900
+Agonists that we've used in the lab
+
+01:58:21.900 --> 01:58:26.300
+Nearly hundreds of respirances to show you what I just talked about briefly here today
+
+01:58:26.700 --> 01:58:33.020
+How these cannabinoids and how targeting and building the specificity out of the ubiquity getting specificity out of
+
+01:58:33.500 --> 01:58:37.740
+Everywhere and making it yes, they're everywhere, but can we can we be sure it is?
+
+01:58:38.460 --> 01:58:42.140
+Using a shall it be a rational or a thoughtful process in using
+
+01:58:42.140 --> 01:58:44.780
+They're everywhere see i'm starting to see it
+
+01:58:44.780 --> 01:58:48.540
+I'm starting to feel that there needs to be a huge survey of cannabinoids
+
+01:58:49.020 --> 01:58:55.100
+I'm starting to feel that there needs to be a huge genetic survey of all plants that produce cannabinoids and terpenes
+
+01:58:55.500 --> 01:59:00.140
+So that we can understand them and better identify them and maybe even genetically modify them
+
+01:59:00.700 --> 01:59:08.540
+So we can do it both for cancer and we can do it both for Parkinson's disease and really alleviate the motor neuron symptoms and regenerate
+
+01:59:09.260 --> 01:59:14.620
+New neurons and replacing those damage neurons. So very much in the literature, not at all
+
+01:59:15.740 --> 01:59:21.420
+Hypothesis at this point in time and you will see hundreds of references there. That's why I included it
+
+01:59:21.900 --> 01:59:24.140
+So finally we can just summarize to say that
+
+01:59:24.780 --> 01:59:28.380
+The endocannabinoid system is the new regulation and neural
+
+01:59:28.380 --> 01:59:34.300
+I don't know what that sound was all a balance of the brain and the immune system could be thought to be mediated through receptor
+
+01:59:34.380 --> 01:59:35.420
+crosstalk
+
+01:59:35.420 --> 01:59:40.300
+Not only with perinergic receptors. I just gave that example because it's key in our therapies today
+
+01:59:40.780 --> 01:59:42.220
+but also through
+
+01:59:42.220 --> 01:59:49.020
+The regulation and blocking the toxic effects of aluminum glyphosate and many of the causative agents
+
+01:59:50.060 --> 01:59:53.260
+An autoimmune and neural new diseases. They're lipid mediators
+
+01:59:53.260 --> 01:59:54.140
+They exert you know
+
+01:59:54.140 --> 01:59:58.620
+Pliotropic effects and complex effects on on the immune system and the brain
+
+01:59:59.020 --> 02:00:04.540
+The endocannabinoids are really the master regulators of the innate and the adaptive immune axis just like
+
+02:00:05.340 --> 02:00:11.900
+Small conductance calcium activated potassium channels are the master regulators of neuronal function. You see
+
+02:00:13.740 --> 02:00:15.100
+It's really the same thing
+
+02:00:15.100 --> 02:00:22.540
+And we used to say it all the time when I was working in college lab that sk channels do everything because they regulate the width of the action potential
+
+02:00:22.540 --> 02:00:24.060
+therefore
+
+02:00:24.060 --> 02:00:26.300
+signaling in the brain is
+
+02:00:26.380 --> 02:00:28.780
+master regulated by sk channels
+
+02:00:29.980 --> 02:00:36.940
+She's making the exact same kind of statement. It's an academic biological statement that is designed to get grants and funding
+
+02:00:37.980 --> 02:00:42.540
+And make your little sliver of expertise the most important one
+
+02:00:42.940 --> 02:00:45.980
+That's why you use words like master regulators
+
+02:00:46.300 --> 02:00:50.060
+But some reason or another when people use pot for 60 years
+
+02:00:50.540 --> 02:00:55.100
+That master regulator doesn't seem to go too far off center like I don't I don't
+
+02:00:55.900 --> 02:00:57.900
+It's really it's really
+
+02:00:58.700 --> 02:01:01.180
+disingenuous, but it's perfect academic
+
+02:01:02.220 --> 02:01:07.420
+It's a perfect academic biology presentation given by the perfect academic
+
+02:01:08.140 --> 02:01:13.500
+What that's that axis between astroglia and t you know t-cells and the monocyte
+
+02:01:14.940 --> 02:01:21.100
+So we can use these we can we can affect you we can effectively think about them on the orchestrators of immune response
+
+02:01:21.260 --> 02:01:25.020
+And make these a key therapeutic target and just like we could turn
+
+02:01:25.500 --> 02:01:30.860
+HIV aids into a disease you could live with we can we can use these combination therapies to
+
+02:01:31.260 --> 02:01:37.020
+To cure these 21st century acquired immune deficiencies and with that I'll thank you and take question
+
+02:01:37.100 --> 02:01:42.220
+We can cure these 21st century acquired immune deficiencies
+
+02:01:44.220 --> 02:01:48.700
+And I think that's a wonderful place to end this you can see it right this is this is
+
+02:01:49.500 --> 02:01:55.100
+Pre-pandemic biological bamboozlement. This is pre-pandemic confusion
+
+02:01:56.140 --> 02:01:58.140
+and and misconstruing
+
+02:01:59.580 --> 02:02:01.900
+understanding with noise
+
+02:02:03.020 --> 02:02:11.020
+And it is seeding a narrative where many of these 21st century acquired immune deficiency syndromes are expected to increase
+
+02:02:11.500 --> 02:02:14.140
+And why would that be well? We don't know
+
+02:02:15.020 --> 02:02:21.020
+But i'm sure endocannabinoids and the sequencing of all the pot in the world and looking at all these different
+
+02:02:21.420 --> 02:02:28.940
+Compounds and screening them for their ability to synergistically work with other things that we already have patents for and already want to sell you
+
+02:02:29.420 --> 02:02:31.420
+Would be perfect
+
+02:02:33.260 --> 02:02:38.460
+I think you can see now why there might be other people that are interested in sequencing the cannabis genome
+
+02:02:38.780 --> 02:02:40.780
+Um
+
+02:02:41.740 --> 02:02:44.140
+Why it's not such a trivial thing after all
+
+02:02:47.580 --> 02:02:52.220
+Hope you can see it ladies and gentlemen. I definitely hope that you can see it
+
+02:02:52.860 --> 02:02:54.860
+um
+
+02:02:54.860 --> 02:02:56.860
+It's really important that you can see it
+
+02:02:59.260 --> 02:03:04.860
+Uh because they are trying very very hard for you not to be able to see it
+
+02:03:05.500 --> 02:03:11.100
+I'm going to go right back down here and I am going to say it once and
+
+02:03:11.820 --> 02:03:15.580
+Always as I usually do ladies and gentlemen, they are trying to
+
+02:03:16.540 --> 02:03:21.820
+Eliminate the control group by any means necessary. I don't know if they transfected my friend at the gym
+
+02:03:22.780 --> 02:03:24.780
+But I do know that that
+
+02:03:25.100 --> 02:03:27.100
+Reinforced this idea
+
+02:03:27.740 --> 02:03:34.060
+Vaccines are something that he couldn't say no to vaccines are something that you can't question and he defended himself as he
+
+02:03:34.700 --> 02:03:38.700
+Described to me the pain that he's in and I just my heart breaks for these people
+
+02:03:39.180 --> 02:03:41.660
+And it's only through our work through our
+
+02:03:42.540 --> 02:03:46.460
+What we're doing these are one of the few ways that we can save these people and so
+
+02:03:47.100 --> 02:03:48.220
+um
+
+02:03:48.220 --> 02:03:52.540
+Stop all transfections stop all vaccinations and adults for shit sake
+
+02:03:54.940 --> 02:03:59.100
+And uh remember that they are trying to eliminate the control group now that they've got him
+
+02:03:59.740 --> 02:04:02.140
+Now that he's got all sippetal neuropathy
+
+02:04:02.940 --> 02:04:05.420
+You know they can give him all the shots they want now
+
+02:04:09.020 --> 02:04:11.020
+Once they transfect your kids
+
+02:04:11.660 --> 02:04:13.660
+How the hell you gonna know where it comes from
+
+02:04:14.620 --> 02:04:16.620
+the Crohn's disease
+
+02:04:16.620 --> 02:04:18.620
+or the allergies
+
+02:04:18.620 --> 02:04:20.620
+eczema
+
+02:04:21.260 --> 02:04:25.740
+How are you gonna know where the where it comes from when they get cancer when they're 22 years old
+
+02:04:26.700 --> 02:04:28.860
+You'll know
+
+02:04:28.860 --> 02:04:33.100
+Because transfection in healthy humans was always criminally negligent because RNA
+
+02:04:33.500 --> 02:04:40.700
+Campendemic and because gosh dang it intramuscular injection of any combination of substances with the intent of augmenting our
+
+02:04:42.140 --> 02:04:44.300
+Beautiful immune system is dumb
+
+02:04:47.660 --> 02:04:50.220
+It's been an independent bright web presentation
+
+02:04:51.180 --> 02:04:54.220
+Um Star Trek is coming soon as is the wheel
+
+02:04:55.180 --> 02:04:57.180
+um
+
+02:04:57.180 --> 02:05:03.180
+Ladies and gentlemen, you can find me at giggle on biological.com deal that bio and stream dot giggle home dot bio also
+
+02:05:03.820 --> 02:05:07.740
+uh jc on a bike on youtube and on twitter and on twitch
+
+02:05:09.180 --> 02:05:14.300
+Thanks very much to everybody who subscribes to this channel who subscribes to my sub stack who sent me
+
+02:05:15.260 --> 02:05:17.260
+letters emails
+
+02:05:17.820 --> 02:05:22.540
+anything um you're all very very much appreciated by me and my family and
+
+02:05:23.500 --> 02:05:27.900
+This wouldn't happen without you ladies and gentlemen. Thank you very much share this stream
+
+02:05:27.900 --> 02:05:32.380
+We'll see you tomorrow 1313 is the time we may be switching
+
+02:05:33.580 --> 02:05:36.620
+We may be switching to 10 10 in the morning for the first show
+
+02:05:37.420 --> 02:05:38.860
+um
+
+02:05:38.860 --> 02:05:42.700
+I'm pretty sure i'm going to be switching to 10 10 a.m. In the morning
+
+02:05:42.700 --> 02:05:46.300
+I hope that's not going to be too much trouble for a lot of people. It's going to be better
+
+02:05:46.300 --> 02:05:50.140
+A little bit better for me and it will open up the afternoon for possible second shows
+
+02:05:50.300 --> 02:05:51.340
+um
+
+02:05:51.340 --> 02:05:53.340
+right now
+
+02:05:53.340 --> 02:05:56.940
+The the variable show can't be the first one so I can't do it that way
+
+02:05:56.940 --> 02:05:58.300
+I think I have to shift to the morning
+
+02:05:58.300 --> 02:06:02.700
+So it's probably going to be 10 10 in the morning next week and the nice thing about 10 10
+
+02:06:03.260 --> 02:06:07.980
+Is that that's the time that you set your watch to when you want to sell it right? That's the prettiest
+
+02:06:08.780 --> 02:06:10.780
+Time on an analog clock
+
+02:06:11.580 --> 02:06:16.140
+So I think it's kind of a fun time to start in 10 10 is is the second cup of coffee
+
+02:06:16.220 --> 02:06:20.460
+That's also really good and it'll give me time to walk the dog would be and and that kind of thing in the morning
+
+02:06:20.460 --> 02:06:25.580
+So 10 10 next week. I think the schedule will be changed to reflect that. Um, so don't worry
+
+02:06:25.820 --> 02:06:29.180
+I won't it won't happen at random and in the meantime this week
+
+02:06:29.180 --> 02:06:36.300
+It's uh 13 13 for the remainder of the week as far as I can tell and we are working on setting up some people to
+
+02:06:36.780 --> 02:06:39.900
+Uh join us for an interview over a fire this kind of thing
+
+02:06:40.540 --> 02:06:46.060
+Um, we have a few people in mind. It's just uh getting this other momentum in the background
+
+02:06:46.220 --> 02:06:51.100
+Solid and I think we're really close to getting there. So I can't thank everybody enough
+
+02:06:51.340 --> 02:06:52.300
+Um
+
+02:06:52.300 --> 02:06:58.540
+I'm pretty convinced that this illusion of consensus is about to break because a lot of people actually do know the truth
+
+02:06:59.260 --> 02:07:01.500
+And uh, they're going to do something about it soon
+
+02:07:02.700 --> 02:07:05.100
+Thanks very much ladies and gentlemen and we'll see you tomorrow
+
+02:07:16.140 --> 02:07:19.020
+You
+
diff --git a/twitch/2126749083 (2024-04-22) - Dr Mikovits 2008 STUDY HALL -- (22 Apr 2024)/README.md b/twitch/2126749083 (2024-04-22) - Dr Mikovits 2008 STUDY HALL -- (22 Apr 2024)/README.md
new file mode 100644
index 0000000..ca2a7b4
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+++ b/twitch/2126749083 (2024-04-22) - Dr Mikovits 2008 STUDY HALL -- (22 Apr 2024)/README.md	
@@ -0,0 +1,5 @@
+# Dr Mikovits 2008 STUDY HALL -- (22 Apr 2024) -- Gigaohm Biological High Resistance Low Noise Information Brief
+
+## Streams
+- https://twitch.tv/videos/2126749083
+